The Absence of Extra-Tidal Structure in the Sculptor Dwarf Spheroidal Galaxy

The results of a wide-field survey of the Sculptor dwarf spheroidal galaxy are presented. Our aims were to obtain an accurate map of the outer structure of Sculptor, and to determine the level of interaction between this system and the Galaxy. Photometry was obtained in two colours down to the magnitude limits of V=20 and I=19, covering a 3.1 times 3.1 square deg area centred on Sculptor. The resulting colour-magnitude data were used as a mask to select candidate horizontal branch and red giant branch stars for this system. Previous work has shown that the red horizontal branch (HB) stars are more concentrated than the blue HB stars. We have determined the radial distributions of these two populations and show that the overall Sculptor density profile is well described by a two component model based on a combination of these radial distributions. Additionally, spectra of the Ca ii triplet region were obtained for over 700 candidate red giant stars over the 10 square deg region using the 2dF instrument on the Anglo-Australian Telescope. These spectra were used to remove foreground Galactic stars based on radial velocity and Ca ii triplet strength. The final list of Sculptor members contained 148 stars, seven of which are located beyond the nominal tidal radius. Both the photometric and spectroscopic datasets indicate no significant extra-tidal structure. These results support at most a mild level of interaction between this system and the Galaxy, and we have measured an upper mass limit for extra-tidal material to be 2.3 +/- 0.6% of the Sculptor luminous mass. This lack of tidal interaction indicates that previous velocity dispersion measurements (and hence the amount of dark matter detected) in this system are not strongly influenced by the Galactic tidal field.Comment: 53 pages, 23 figures. Accepted for publication in the Astronomical Journal. Some figures are reduced in size, and a full version is available at: ftp://ftp.mso.anu.edu.au/pub/coleman/sculptor.pd

Exploring Halo Substructure with Giant Stars. VI. Extended Distributions of Giant Stars Around the Carina Dwarf Spheroidal Galaxy -- How Reliable Are They?

The question of the existence of active tidal disruption around various dSph galaxies remains controversial. That debate often centers on the nature (bound vs. unbound) of extended populations of stars. However, the more fundamental issue of the very existence of the extended populations is still contentious. We present an evaluation of the debate centering on one particular dSph, Carina, for which claims both for and against the existence of stars beyond the King radius have been made. Our review includes an examination of all previous studies bearing on the Carina radial profile and shows that the survey method which achieves the highest detected dSph signal-to-background in the outer parts of the galaxy is the Washington M, T2 + DDO51 (MTD) filter approach from Paper II in this series. We then address statistical methods used to evaluate the reliability of MTD surveys in the presence of photometric errors and for which a new, a posteriori statistical analysis methodology is provided. Finally, these statistical methods are tested by new spectroscopy of stars in the MTD-selected Carina candidate sample. Of 74 candidate giants with follow-up spectroscopy, the MTD technique identified 61 new Carina members, including 8 stars outside the King radius. From a sample of 29 stars not initially identified as candidate Carina giants but that lie just outside of our selection criteria, 12 have radial velocities consistent with membership, including 5 extratidal stars. Carina is shown to have an extended population of giant stars extending to a major axis radius of 40' (1.44x the nominal King radius).Comment: 56 pages, 10 figures. Submitted to the Astronomical Journal, 2004 Sep 2

The Globular Cluster Omega Centauri and the Oosterhoff Dichotomy

CCD observations obtained by the OGLE team for 128 RR Lyrae variables in Omega Cen have been analysed. The P-L and P-A plots indicate that, in addition to fundamental (RRab) and first overtone (RRc) pulsators, the Omega Cen RR Lyrae population seems to include second overtone (RRe) and possibly third overtone pulsators. The mean periods derived for the RRab and RRc stars are typical values for an Oosterhoff type II (OoII) cluster. Nevertheless, the P-A plot plot also shows that some of the RR Lyrae variables have `Oosterhoff type I' (OoI) characteristics. Relative luminosities derived for the RRc variables from Fourier coefficients correlate with the observed apparent magnitudes. Masses for the RRc stars have been calculated from Fourier coefficients. A comparison of the derived masses for RRc stars in the four OoII clusters Omega Cen, M15, M55 and M68 indicates that the masses of the RRc stars in M15 and M68 are almost 0.2 solar masses greater than those in the other two. Since M15 and M68 have a high frequency of RRd stars among their first overtone pulsators, while none have been identified in Omega Cen or M55, this suggests that the double-mode pulsation phenomenon may be associated with mass. Among the RRc variables in Omega Cen, the OoII variables have lower derived masses and higher luminosities than the OoI variables. An application of the period-density law to pairs of OoI and OoII RRab stars selected according to their position in the P-A plot also indicates that the OoII variables in general have lower masses and higher luminosities. These findings support the hypothesis that RR Lyrae variables in OoII systems are evolved HB stars that spend their ZAHB phase on the blue side of the instability strip.Comment: 52 pages, 10 figures, to appear in the AJ (November 2000

Abundance Patterns in the Draco, Sextans and Ursa Minor Dwarf Spheroidal Galaxies

The Keck I telescope has been used to obtain HIRES spectra for red giants belonging to the Draco, Sextans and Ursa Minor dwarf spheroidal (dSph) galaxies. An analysis of these spectra is presented, along with abundance ratios for more than 20 elements. The resulting database of element abundances for 17 stars is the most extensive yet assembled for stars in dSph environments. Our main findings are summarized as follows: (1) There is unambiguous evidence for a large internal spread in metallicity in all three galaxies: our program stars span a range of [Fe/H] = 1.53, 1.40 and 0.73 dex in Draco, Sextans and Ursa Minor, respectively. (2) The abundance patterns among the dSph stars are remarkably uniform, suggesting that all three galaxies have similar nucleosynthetic histories. (3) A comparison of the measured abundance ratios for our sample of dSph stars with published values for Galactic halo and disk field stars suggests that the dSph galaxies have 0.02 < [alpha/Fe] < 0.13 dex, whereas the halo field star sample has [alpha/Fe] ~ 0.28 dex over the same range in metallicity. (4) The most metal-rich dSph stars in our sample have [Y/Fe] abundances which are significantly lower than those measured for halo field stars of similar metallicity, while the measured [Ba/Eu] ratios for the dSph stars suggest that the early chemical evolution of these galaxies was dominated by the r-process. Taken together, these results suggest that the Galactic halo is unlikely to have assembled, in its entirety, through the disruption of dwarf galaxies similar to the low-luminosity dSphs studied here. (ABRIDGED).Comment: 24 pages, 8 postscript figures (including 6 color figures). Accepted for publication in the Astrophysical Journa

Effectiveness and cost-effectiveness of an internet intervention for family caregivers of people with dementia: design of a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>The number of people with dementia is rising rapidly as a consequence of the greying of the world population. There is an urgent need to develop cost effective approaches that meet the needs of people with dementia and their family caregivers. Depression, feelings of burden and caregiver stress are common and serious health problems in these family caregivers. Different kinds of interventions are developed to prevent or reduce the negative psychological consequences of caregiving. The use of internet interventions is still very limited, although they may be a cost effective way to support family caregivers in an earlier stage and diminish their psychological distress in the short and longer run.</p> <p>Methods/design</p> <p>A pragmatic randomized controlled trial is designed to evaluate the effectiveness and cost-effectiveness of ‘Mastery over Dementia’, an internet intervention for caregivers of people with dementia. The intervention aims at prevention and decrease of psychological distress, in particular depressive symptoms. The experimental condition consists of an internet course with 8 sessions and a booster session over a maximum period of 6 months guided by a psychologist. Caregivers in the comparison condition receive a minimal intervention. In addition to a pre and post measurement, an intermediate measurement will be conducted. In addition, there will be two follow-up measurements 3 and 6 months after post-treatment in the experimental group only. To study the effectiveness of the intervention, depressive symptoms are used as the primary outcome, whereas symptoms of anxiety, role overload and caregiver perceived stress are used as secondary outcomes. To study which caregivers profit most of the internet intervention, several variables that may modify the impact of the intervention are taken into account. Regarding the cost-effectiveness, an economic evaluation will be conducted from a societal perspective.</p> <p>Discussion</p> <p>This study will provide evidence about the effectiveness and cost-effectiveness of an internet intervention for caregivers. If both can be shown, this might set the stage for the development of a range of internet interventions in the field of caregiving for people with dementia. This is even more important because future generations of caregivers will be more familiar with the use of internet.</p> <p>Trial registration</p> <p>NTR-2051/RCT-DDB</p

Cognitive Behavioral Therapy versus Short Psychodynamic Supportive Psychotherapy in the outpatient treatment of depression: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>Previous research has shown that Short Psychodynamic Supportive Psychotherapy (SPSP) is an effective alternative to pharmacotherapy and combined treatment (SPSP and pharmacotherapy) in the treatment of depressed outpatients. The question remains, however, how Short Psychodynamic Supportive Psychotherapy compares with other established psychotherapy methods. The present study compares Short Psychodynamic Supportive Psychotherapy to the evidence-based Cognitive Behavioral Therapy in terms of acceptability, feasibility, and efficacy in the outpatient treatment of depression. Moreover, this study aims to identify clinical predictors that can distinguish patients who may benefit from either of these treatments in particular. This article outlines the study protocol. The results of the study, which is being currently carried out, will be presented as soon as they are available.</p> <p>Methods/Design</p> <p>Adult outpatients with a main diagnosis of major depressive disorder or depressive disorder not otherwise specified according to DSM-IV criteria and mild to severe depressive symptoms (<it>Hamilton Depression Rating Scale </it>score ≥ 14) are randomly allocated to Short Psychodynamic Supportive Psychotherapy or Cognitive Behavioral Therapy. Both treatments are individual psychotherapies consisting of 16 sessions within 22 weeks. Assessments take place at baseline (week 0), during the treatment period (week 5 and 10) and at treatment termination (week 22). In addition, a follow-up assessment takes place one year after treatment start (week 52). Primary outcome measures are the number of patients refusing treatment (acceptability); the number of patients terminating treatment prematurely (feasibility); and the severity of depressive symptoms (efficacy) according to an independent rater, the clinician and the patient. Secondary outcome measures include general psychopathology, general psychotherapy outcome, pain, health-related quality of life, and cost-effectiveness. Clinical predictors of treatment outcome include demographic variables, psychiatric symptoms, cognitive and psychological patient characteristics and the quality of the therapeutic relationship.</p> <p>Discussion</p> <p>This study evaluates Short Psychodynamic Supportive Psychotherapy as a treatment for depressed outpatients by comparing it to the established evidence-based treatment Cognitive Behavioral Therapy. Specific strengths of this study include its strong external validity and the clinical relevance of its research aims. Limitations of the study are discussed.</p> <p>Trial registration</p> <p>Current Controlled Trails ISRCTN31263312</p

Functional Interactions between Retinoblastoma and c-MYC in a Mouse Model of Hepatocellular Carcinoma

Inactivation of the RB tumor suppressor and activation of the MYC family of oncogenes are frequent events in a large spectrum of human cancers. Loss of RB function and MYC activation are thought to control both overlapping and distinct cellular processes during cell cycle progression. However, how these two major cancer genes functionally interact during tumorigenesis is still unclear. Here, we sought to test whether loss of RB function would affect cancer development in a mouse model of c-MYC-induced hepatocellular carcinoma (HCC), a deadly cancer type in which RB is frequently inactivated and c-MYC often activated. We found that RB inactivation has minimal effects on the cell cycle, cell death, and differentiation features of liver tumors driven by increased levels of c-MYC. However, combined loss of RB and activation of c-MYC led to an increase in polyploidy in mature hepatocytes before the development of tumors. There was a trend for decreased survival in double mutant animals compared to mice developing c-MYC-induced tumors. Thus, loss of RB function does not provide a proliferative advantage to c-MYC-expressing HCC cells but the RB and c-MYC pathways may cooperate to control the polyploidy of mature hepatocytes

Contributions of phonological and verbal working memory to language development in adolescents with fragile X syndrome

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Although language delays are frequently observed in FXS, neither the longitudinal course of language development nor its cognitive predictors are well understood. The present study investigated whether phonological and working memory skills are predictive of growth in vocabulary and syntax in individuals with FXS during adolescence. Forty-four individuals with FXS (mean age = 12.61 years) completed assessments of phonological memory (nonword repetition and forward digit recall), verbal working memory (backward digit recall), vocabulary, syntax, and nonverbal cognition. Vocabulary and syntax skills were reassessed at a 2-year follow-up. In a series of analyses that controlled for nonverbal cognitive ability and severity of autism symptoms, the relative contributions of phonological and working memory to language change over time were investigated. These relationships were examined separately for boys and girls. In boys with FXS, phonological memory significantly predicted gains in vocabulary and syntax skills. Further, verbal working memory was uniquely associated with vocabulary gains among boys. In girls with FXS, phonological and working memory skills showed no relationship with language change across the 2-year time period. Our findings indicate that, for adolescent boys with FXS, acquisition of vocabulary and syntax may be constrained by the ability to maintain and manipulate phonological representations online. Implications for the identification and treatment of language disorders in this population are discussed. The present study is the first to identify specific cognitive mechanisms contributing to language growth over time in individuals with FXS

First measurement of coherent ρ0 photoproduction in ultra-peripheral Xe–Xe collisions at √sNN = 5.44 TeV

The first measurement of the coherent photoproduction of ρ0 vector mesons in ultra-peripheral Xe–Xe collisions at sNN=5.44 TeV is presented. This result, together with previous HERA γp data and γ–Pb measurements from ALICE, describes the atomic number (A) dependence of this process, which is particularly sensitive to nuclear shadowing effects and to the approach to the black-disc limit of QCD at a semi-hard scale. The cross section of the Xe+Xe→ρ0+Xe+Xe process, measured at midrapidity through the decay channel ρ0→π+π−, is found to be dσ/dy=131.5±5.6(stat.)−16.9+17.5(syst.) mb. The ratio of the continuum to resonant contributions for the production of pion pairs is also measured. In addition, the fraction of events accompanied by electromagnetic dissociation of either one or both colliding nuclei is reported. The dependence on A of cross section for the coherent ρ0 photoproduction at a centre-of-mass energy per nucleon of the γA system of WγA,n=65 GeV is found to be consistent with a power-law behaviour σ(γA→ρ0A)∝Aα with a slope α=0.96±0.02(syst.). This slope signals important shadowing effects, but it is still far from the behaviour expected in the black-disc limit.publishedVersio