2,019 research outputs found
Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.
Abstract
OBJECTIVE:
To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.
METHODS:
Multicenter retrospective study of 16 children with NMO/NMOSD receiving 652 rituximab courses. According to CD19 counts, events during rituximab were categorized as "repopulation," "depletion," or "depletion failure" relapses (repopulation threshold CD19 6510
7 10(6) cells/L).
RESULTS:
The 16 patients (14 girls; mean age 9.6 years, range 1.8-15.3) had a mean of 6.1 events (range 1-11) during a mean follow-up of 6.1 years (range 1.6-13.6) and received a total of 76 rituximab courses (mean 4.7, range 2-9) in 42.6-year cohort treatment. Before rituximab, 62.5% had received azathioprine, mycophenolate mofetil, or cyclophosphamide. Mean time from rituximab to last documented B cell depletion and first repopulation was 4.5 and 6.8 months, respectively, with large interpatient variability. Earliest repopulations occurred with the lowest doses. Significant reduction between pre- and post-rituximab annualized relapse rate (ARR) was observed (p = 0.003). During rituximab, 6 patients were relapse-free, although 21 relapses occurred in 10 patients, including 13 "repopulation," 3 "depletion," and 4 "depletion failure" relapses. Of the 13 "repopulation" relapses, 4 had CD19 10-50
7 10(6) cells/L, 10 had inadequate monitoring ( 641 CD19 in the 4 months before relapses), and 5 had delayed redosing after repopulation detection.
CONCLUSION:
Rituximab is effective in relapse prevention, but B cell repopulation creates a risk of relapse. Redosing before B cell repopulation could reduce the relapse risk further.
CLASSIFICATION OF EVIDENCE:
This study provides Class IV evidence that rituximab significantly reduces ARR in pediatric NMO/NMOSD. This study also demonstrates a relationship between B cell repopulation and relapses
The upgrade of GEO600
The German / British gravitational wave detector GEO 600 is in the process of
being upgraded. The upgrading process of GEO 600, called GEO-HF, will
concentrate on the improvement of the sensitivity for high frequency signals
and the demonstration of advanced technologies. In the years 2009 to 2011 the
detector will undergo a series of upgrade steps, which are described in this
paper.Comment: 9 pages, Amaldi 8 conference contributio
Ecological immunogenetics of life-history traits in a model amphibian
Major histocompatibility complex (MHC) genes determine immune repertoires and social preferences of vertebrates. Immunological regulation of microbial assemblages associated with individuals influences their sociality, and should also affect their life-history traits. We exposed Xenopus laevis tadpoles to water conditioned by adult conspecifics. Then, we analysed tadpole growth, development and survivorship as a function of MHC class I and class II peptide-binding region amino acid sequence similarities between tadpoles and frogs that conditioned the water to which they were exposed. Tadpoles approached metamorphosis earlier and suffered greater mortality when exposed to immunogenetically dissimilar frogs. The results suggest that developmental regulatory cues, microbial assemblages or both are specific to MHC genotypes. Tadpoles may associate with conspecifics with which they share microbiota to which their genotypes are well adapted
Phenomenological template family for black-hole coalescence waveforms
Recent progress in numerical relativity has enabled us to model the
non-perturbative merger phase of the binary black-hole coalescence problem.
Based on these results, we propose a phenomenological family of waveforms which
can model the inspiral, merger, and ring-down stages of black hole coalescence.
We also construct a template bank using this family of waveforms and discuss
its implementation in the search for signatures of gravitational waves produced
by black-hole coalescences in the data of ground-based interferometers. This
template bank might enable us to extend the present inspiral searches to
higher-mass binary black-hole systems, i.e., systems with total mass greater
than about 80 solar masses, thereby increasing the reach of the current
generation of ground-based detectors.Comment: Minor changes, Submitted to Class. Quantum Grav. (Proc. GWDAW11
Aadi in situ hypoxia monitoring solutions applied in the framework of the eu fp7 project hypox
Peer Reviewe
Mobility of thorium ions in liquid xenon
We present a measurement of the Th ion mobility in LXe at 163.0 K and
0.9 bar. The result obtained, 0.2400.011 (stat) 0.011 (syst)
cm/(kV-s), is compared with a popular model of ion transport.Comment: 6.5 pages,
Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival. A highly efficient technique of T-lymphocyte depletion using rat bone marrow is described. It involves the binding of OX-19, a MoAb directed against all rat thy-mocytes and mature peripheral T lymphocytes, to monosized, magnetic polymer spheres. Magnetic separation of T lymphocytes after mixing the allogeneic bone marrow with the bead/OX-19 complex provides for a simple, rapid depletion of T lymphocytes from the bone marrow. In vitro studies using flow cytometry and the prevention of GVHD in a fully allogeneic rat bone marrow model have been used to demonstrate the effectiveness of the depletion procedure. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Revisiting Event Horizon Finders
Event horizons are the defining physical features of black hole spacetimes,
and are of considerable interest in studying black hole dynamics. Here, we
reconsider three techniques to localise event horizons in numerical spacetimes:
integrating geodesics, integrating a surface, and integrating a level-set of
surfaces over a volume. We implement the first two techniques and find that
straightforward integration of geodesics backward in time to be most robust. We
find that the exponential rate of approach of a null surface towards the event
horizon of a spinning black hole equals the surface gravity of the black hole.
In head-on mergers we are able to track quasi-normal ringing of the merged
black hole through seven oscillations, covering a dynamic range of about 10^5.
Both at late times (when the final black hole has settled down) and at early
times (before the merger), the apparent horizon is found to be an excellent
approximation of the event horizon. In the head-on binary black hole merger,
only {\em some} of the future null generators of the horizon are found to start
from past null infinity; the others approach the event horizons of the
individual black holes at times far before merger.Comment: 30 pages, 15 figures, revision
A linear RFQ ion trap for the Enriched Xenon Observatory
The design, construction, and performance of a linear radio-frequency ion
trap (RFQ) intended for use in the Enriched Xenon Observatory (EXO) are
described. EXO aims to detect the neutrinoless double-beta decay of Xe
to Ba. To suppress possible backgrounds EXO will complement the
measurement of decay energy and, to some extent, topology of candidate events
in a Xe filled detector with the identification of the daughter nucleus
(Ba). The ion trap described here is capable of accepting, cooling, and
confining individual Ba ions extracted from the site of the candidate
double-beta decay event. A single trapped ion can then be identified, with a
large signal-to-noise ratio, via laser spectroscopy.Comment: 18 pages, pdflatex, submitted to NIM
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