Blinded assessment of treatment effects utilizing information about the randomization block length

It is essential for the integrity of double-blind clinical trials that during the study course the individual treatment allocations of the patients as well as the treatment effect remain unknown to any involved person. Recently, methods have been proposed for which it was claimed that they would allow reliable estimation of the treatment effect based on blinded data by using information about the block length of the randomization procedure. If this would hold true, it would be difficult to preserve blindness without taking further measures. The suggested procedures apply to continuous data. We investigate the properties of these methods thoroughly by repeated simulations per scenario. Furthermore, a method for blinded treatment effect estimation in case of binary data is proposed, and blinded tests for treatment group differences are developed both for continuous and binary data. We report results of comprehensive simulation studies that investigate the features of these procedures. It is shown that for sample sizes and treatment effects which are typical in clinical trials, no reliable inference can be made on the treatment group difference which is due to the bias and imprecision of the blinded estimates

High power impulse magnetron sputtering discharges: Instabilities and plasma self-organization

We report on instabilities in high power impulse magnetron sputtering plasmas which are likely to be of the generalized drift wave type. They are characterized by well defined regions of high and low plasma emissivity along the racetrack of the magnetron and cause periodic shifts in floating potential. The azimuthal mode number m depends on plasma current, plasma density, and gas pressure. The structures rotate in × direction at velocities of ∼10 km s−1 and frequencies up to 200 kHz. Collisions with residual gas atoms slow down the rotating wave, whereas increasing ionization degree of the gas and plasma conductivity speeds it up

PEN as self-vetoing structural Material

Polyethylene Naphtalate (PEN) is a mechanically very favorable polymer. Earlier it was found that thin foils made from PEN can have very high radio-purity compared to other commercially available foils. In fact, PEN is already in use for low background signal transmission applications (cables). Recently it has been realized that PEN also has favorable scintillating properties. In combination, this makes PEN a very promising candidate as a self-vetoing structural material in low background experiments. Components instrumented with light detectors could be built from PEN. This includes detector holders, detector containments, signal transmission links, etc. The current R\&D towards qualification of PEN as a self-vetoing low background structural material is be presented.Comment: 4 pages, 7 figures, contribution to Proceedings of the sixth workshop on Low Radioactivity Techniques 2017, 23-27 May 2017 Seoul, to be published at AIP, editor: D. Leonar

Neutral absorber dips in the periodic burster LMXB XB 1323-619 from Suzaku

We present results of an observation with Suzaku of the dipping, periodic bursting low mass X-ray binary XB 1323-619. Using the energy band 0.8 - 70 keV, we show that the source spectrum is well-described as the emission of an extended accretion disk corona, plus a small contribution of blackbody emission from the neutron star. The dip spectrum is well-fitted by the progressive covering model in which the extended ADC is progressively overlapped by the absorbing bulge of low ionization state in the outer accretion disk and that dipping is basically due to photoelectric absorption in the bulge. An energy-independent decrease of flux at high energies (20 - 70 keV) is shown to be consistent with the level of Thomson scattering expected in the bulge. An absorption feature at 6.67 keV (Fe XXV) is detected in the non-dip spectrum and other possible weak features. In dipping, absorption lines of medium and highly ionized states are seen suggestive of absorption in the ADC but there is no evidence that the lines are stronger than in non-dip. We show that the luminosity of the source has changed substantially since the Exosat observation of 1985, increasing in luminosity between 1985 and 2003, then in 2003 - 2007 falling to the initial low value. X-ray bursting has again become periodic, which it ceased to do in its highest luminosity state, and we find that the X-ray bursts exhibit both the fast decay and later slow decay characteristic of the rp burning process. We present arguments against the recent proposal that the decrease of continuum flux in the dipping LMXB in general can be explained as absorption in an ionized absorber rather than in the bulge in the outer disk generally accepted to be the site of absorption.Comment: 12 pages, 6 figures, Astronomy and Astrophysics in pres

Hubble Space Telescope Observations of NGC 6240: a Case Study of an Ultra-Luminous Infrared Galaxy with Obscured Activity

We present results from an HST study of the morphology and kinematics of NGC 6240. This merging galaxy with a double nucleus is one of the nearest and best-studied ultraluminous infrared galaxies. HST resolves both nuclei into seperate components. The distance between the northern and southern optical/near-infrared components is greater than that observed in radio and X-ray studies, arguing that even in K-band we may not be seeing all the way through the dust to the true nuclei. The ionized gas does not display rotation around either of the nuclei, or equilibrium motion in general. There is a strong velocity gradient between the nuclei, similar to what is seen in CO data. There is no such gradient in our stellar kinematics. The velocity dispersion of the gas is larger than expected for a cold disk. We also map and model the emission-line velocity field at an off-nuclear position where a steep velocity gradient was previously detected in ground-based data. Overall, the data indicate that line-of-sight projection effects, dust absorption, non-equilibrium merger dynamics, and the possible influence of a wind may be playing an important role in the observed kinematics. Chandra observations of hard X-rays have shown that both of the nuclei contain an Active Galactic Nucleus (AGN). The HST data show no clear sign of the two AGNs: neither continuum nor narrow-band imaging shows evidence for unresolved components in the nuclei, and there are no increased emission line widths or rapid rotation near the nuclei. This underscores the importance of X-ray data for identifying AGNs in highly dust-enshrouded environments.Comment: LaTeX, 32 pages, 9 figures, 2 tables, accepted for publication in The Astronomical Journal (Jan 2004). Paper with high-resolution (non-compressed) color figures in gzipped postscript format available at http://www.stsci.edu/~marel/psgzdir/ngc6240v11.ps.g

The Structure of Active Merger Remnant NGC 6240 from IRAC Observations

NGC 6240 is a rare object in the local universe: an active merger remnant viewed at the point of merging where two active galactic nuclei are visible. We present IRAC data of this object, providing high sensitivity maps of the stellar and PAH distribution in this complicated system. We use photometry to analyze the variation in these distributions with radius and provide an SED in the four IRAC bands: 3.6 microns, 4.5 microns, 5.8 microns and 8.0 microns. We fit the radial profiles of the 3.6 micron band to r^.25 and exponential profiles to evaluate the structure of the remnant. Finally, we compare the IRAC images with multi-wavelength data and examine how outflows in the X-ray, Halpha and CO correlate with 8 micron emission. The results support the general picture of NGC 6240 as a system experiencing a major merger and transitioning from a disk galaxy to a spheroid. The sensitivity of IRAC to low surface brightness mid-infrared features provides detailed information on the extended distributions of stars and dust in this rare system.Comment: Accepted for publication in Ap

The X-ray fast-time variability of Sco X-2 (GX 349+2) with RXTE

Sco X-2 (GX 349+2) is a low-mass X-ray binary and Z source. We have analysed 156 ks of Rossi X-ray Timing Explorer data, obtained in 1998 January, on this source. We investigated the fast-time variability as a function of position on the Z track. During these observations, Sco X-2 traced out the most extensive Z track ever reported from this object, making this the most comprehensive study thus far. We found the broad peaked flaring branch noise that is typical of Sco X-2, with a centroid frequency in the range 3.3--5.8 Hz. We also discovered low frequency noise, and a new peaked noise feature, with centroid frequencies in the range 5.4--7.6 Hz and 11--54 Hz, respectively. We discuss the phenomenology of these features, their relationship with the power spectral components found in other low-mass X-ray binaries, and the implications for current models. In particular, the low frequency noise we observed was strongest at intermediate energies, in contrast to the low frequency noise seen in other Z sources. We also detected very low frequency noise, and have calculated complex cross spectra between intensity and hardness. We found that the very low frequency noise is not entirely due to motion along the Z track.Comment: 17 pages, 9 figures, minor improvements, accepted for publication in MNRA

Ionization wave propagation on a micro cavity plasma array

Microcavity plasma arrays of inverse pyramidal cavities have been fabricated in p-Si wafers. Each cavity acts as a microscopic dielectric barrier discharge. Operated at atmospheric pressure in argon and excited with high voltage at about 10 kHz, each cavity develops a localized microplasma. Experiments have shown a strong interaction of individual cavities, leading to the propagation of wave-like optical emission structures along the surface of the array. This phenomenon is numerically investigated using computer simulation. The observed ionization wave propagates with a speed of about 5 km/s, which agrees well the experimental findings. It is found that the wave propagation is due to sequential contributions of a drift of electrons followed by drift of ions between cavities seeded by photoemission of electrons by the plasma in adjacent cavities

Follicle-Stimulating Hormone Regulates igfbp Gene Expression Directly or via Downstream Effectors to Modulate Igf3 Effects on Zebrafish Spermatogenesis

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