371 research outputs found

    Interactively solving school timetabling problems using extensions of constraint programming

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    Timetabling problems have been frequently studied due to their wide range of applications. However, they are often solved manually because of the lack of appropriate computer tools. Although many approaches mainly based on local search or constraint programming seem to have been quite successful in recent years, they are often highly dedicated to specific problems and encounter difficulties to take the dynamic and over-constrained nature of such problems. We were confronted with such an over-constrained and dynamic problem in our institution. This paper deals with a timetabling system based on constraint programming with the use of explanations to offer a dynamic behaviour and to allow automatic relaxations of constraints. Our tool has successfully answered the needs of the current planner by providing solutions in a few minutes instead of a week of manual design.We present in this paper the techniques used, the results obtained and a discussion on the effects of the automation of the timetabling process

    Polarization degrees of freedom in photoinduced two-nucleon knockout from finite nuclei

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    The polarization degrees of freedom in photoinduced two-nucleon knockout from finite nuclei are studied. It is pointed out that they open good perspectives to study the dynamics of dinucleons in the medium in detail. The (γ,pp\gamma,pp) and (γ,pn\gamma,pn) angular cross sections, photon asymmetries and outgoing nucleon polarizations are calculated for the target nuclei 16^{16}O and 12^{12}C and photonenergies ranging from 100 up to 500 MeV. It is investigated to which degree the two-nucleon emission reaction is dominated by photoabsorption on 3S1(T=0)^3S_1(T=0) proton-neutron and 1S0(T=1)^1S_0(T=1) proton-proton pairs in the nuclear medium. The calculations demonstrate that dominance of SS wave photoabsorption in the (γ,pn\gamma,pn) channel does not necessarily imply that the reaction mechanism is similar to what is observed in deuteron photodisintegration.Comment: 27 pages, REVTeX 3.0 with epsf.sty, 11 figures in EPS forma

    Constraint solving in uncertain and dynamic environments - a survey

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    International audienceThis article follows a tutorial, given by the authors on dynamic constraint solving at CP 2003 (Ninth International Conference on Principles and Practice of Constraint Programming) in Kinsale, Ireland. It aims at offering an overview of the main approaches and techniques that have been proposed in the domain of constraint satisfaction to deal with uncertain and dynamic environments

    Collateral Health Issues Derived from the Covid-19 Pandemic.

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    At the end of 2019, a new coronavirus (Covid-19) outbreak occurred in Wuhan, China, and spread throughout the world despite efforts to contain the virus. At the end of January 2020, the General Director of the World Health Organization (WHO) declared a Public Health Emergency of International Concern, and by mid-May 2020, the worldwide number of known Covid-19 cases had surpassed 4.4 million including more than 300,000 deaths..

    Nuclear transparency from quasielastic A(e,e'p) reactions uo to Q^2=8.1 (GeV/c)^2

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    The quasielastic (e,e′^\primep) reaction was studied on targets of deuterium, carbon, and iron up to a value of momentum transfer Q2Q^2 of 8.1 (GeV/c)2^2. A nuclear transparency was determined by comparing the data to calculations in the Plane-Wave Impulse Approximation. The dependence of the nuclear transparency on Q2Q^2 and the mass number AA was investigated in a search for the onset of the Color Transparency phenomenon. We find no evidence for the onset of Color Transparency within our range of Q2Q^2. A fit to the world's nuclear transparency data reflects the energy dependence of the free proton-nucleon cross section.Comment: 11 pages, 6 figure

    Circadian Modulation of Gene Expression, but not Glutamate Uptake, in Mouse and Rat Cortical Astrocytes

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    Circadian clocks control daily rhythms including sleep-wake, hormone secretion, and metabolism. These clocks are based on intracellular transcription-translation feedback loops that sustain daily oscillations of gene expression in many cell types. Mammalian astrocytes display circadian rhythms in the expression of the clock genes Period1 (Per1) and Period2 (Per2). However, a functional role for circadian oscillations in astrocytes is unknown. Because uptake of extrasynaptic glutamate depends on the presence of Per2 in astrocytes, we asked whether glutamate uptake by glia is circadian.We measured glutamate uptake, transcript and protein levels of the astrocyte-specific glutamate transporter, Glast, and the expression of Per1 and Per2 from cultured cortical astrocytes and from explants of somatosensory cortex. We found that glutamate uptake and Glast mRNA and protein expression were significantly reduced in Clock/Clock, Per2- or NPAS2-deficient glia. Uptake was augmented when the medium was supplemented with dibutyryl-cAMP or B27. Critically, glutamate uptake was not circadian in cortical astrocytes cultured from rats or mice or in cortical slices from mice.We conclude that glutamate uptake levels are modulated by CLOCK, PER2, NPAS2, and the composition of the culture medium, and that uptake does not show circadian variations

    Display of probability densities for data from a continuous distribution

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    Based on cumulative distribution functions, Fourier series expansion and Kolmogorov tests, we present a simple method to display probability densities for data drawn from a continuous distribution. It is often more efficient than using histograms.Comment: 5 pages, 4 figures, presented at Computer Simulation Studies XXIV, Athens, GA, 201
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