83 research outputs found
Probing the role of excited states in ionization of acetylene
Ionization of acetylene by linearly-polarized, vacuum ultraviolet (VUV) laser
pulses is modelled using time-dependent density functional theory. Several
laser wavelengths are considered including one that produces direct ionization
to the first excited cationic state while another excites the molecules to a
Rydberg series incorporating an autoionizing state. We show that for the
wavelengths and intensities considered, ionization is greatest whenever the
molecule is aligned along the laser polarization direction. By considering high
harmonic generation we show that populating excited states can lead to a large
enhancement in the harmonic yield. Lastly, angularly-resolved photoelectron
spectra are calculated which show how the energy profile of the emitted
electrons significantly changes in the presence of these excited states
Los Derechos Sucesorios en las Parejas de Hecho
Este trabajo versa acerca de los derechos sucesorios de las parejas de hecho en España, dado que este tipo de uniones son cada vez más frecuentes en nuestro país y carecemos de una regulación de las mismas a nivel estatal. el desarrollo de legislación civil es una competencia del Estado, pero de acuerdo con el artículo 149.1.8 de la Constitución Española se permite en algunos casos ceder competencias en materia civil a las Comunidades Autónomas, lo que han aprovechado en numerosas ocasiones para desarrollar su propia normativa, dando lugar a un panorama legislativo sobre las parejas de hecho muy diverso entre las diferentes Comunidades Autónomas españolas.Por tanto, abordo en este trabajo el análisis de las parejas de hecho, así como las diferentes regulaciones de las parejas de hecho existentes en las diferentes Comunidades Autónomas españolas.<br /
Los derechos fundamentales y la Convención Europea
Mesa redonda. Participantes : Moreiro González, Carlos Javier; Carnero González, Carlos; Abellán García de Diego, Alejandro; Rodríguez Bereijo, Álvaro. Modera : Tostón de la Calle, José Ramó
A method for automatically extracting infectious disease-related primers and probes from the literature
BACKGROUND: Primer and probe sequences are the main components of nucleic acid-based detection systems. Biologists use primers and probes for different tasks, some related to the diagnosis and prescription of infectious diseases. The biological literature is the main information source for empirically validated primer and probe sequences. Therefore, it is becoming increasingly important for researchers to navigate this important information. In this paper, we present a four-phase method for extracting and annotating primer/probe sequences from the literature. These phases are: (1) convert each document into a tree of paper sections, (2) detect the candidate sequences using a set of finite state machine-based recognizers, (3) refine problem sequences using a rule-based expert system, and (4) annotate the extracted sequences with their related organism/gene information. RESULTS: We tested our approach using a test set composed of 297 manuscripts. The extracted sequences and their organism/gene annotations were manually evaluated by a panel of molecular biologists. The results of the evaluation show that our approach is suitable for automatically extracting DNA sequences, achieving precision/recall rates of 97.98% and 95.77%, respectively. In addition, 76.66% of the detected sequences were correctly annotated with their organism name. The system also provided correct gene-related information for 46.18% of the sequences assigned a correct organism name. CONCLUSIONS: We believe that the proposed method can facilitate routine tasks for biomedical researchers using molecular methods to diagnose and prescribe different infectious diseases. In addition, the proposed method can be expanded to detect and extract other biological sequences from the literature. The extracted information can also be used to readily update available primer/probe databases or to create new databases from scratch.The present work has been funded, in part, by the European Commission through the ACGT integrated project (FP6-2005-IST-026996) and the ACTION-Grid support action (FP7-ICT-2007-2-224176), the Spanish Ministry of Science and Innovation through the OntoMineBase project (ref. TSI2006-13021-C02-01), the ImGraSec project (ref. TIN2007-61768), FIS/AES PS09/00069 and COMBIOMED-RETICS, and the Comunidad de Madrid, Spain.S
Biological Evaluation of New Thienopyridinium and Thienopyrimidinium Derivatives as Human Choline Kinase Inhibitors
This research was funded by Convocatoria 2019 Proyectos de I + D + i − RTI Tipo B
“Ministerio de Innovación y Ciencia” grant number PID2019-109294RB-I00 and “Convocatoria 2020
Proyectos I + D + i del Programa Operativo FEDER 2020”, grant number B-CTS-216-UGR20. E.P
thanks the European Regional Development Fund (ERDF) project BioDrug (No. 1.1.1.5/19/A/004)
and the Latvian Council of Science (grant No. lzp-2020/2-0013) for financial support.Due to its role in lipid biosynthesis, choline kinase α1 (CKα1) is an interesting target for the
development of new antitumor agents. In this work, we present a series of 41 compounds designed
based on the well-known and successful strategy of introducing thienopyridine and pyrimidine as
bioisosteres of other heterocycles in active antitumor compounds. Notwithstanding the fact that
some of these compounds do not show significant enzymatic inhibition, others, in contrast, feature
substantially improved enzymatic and antiproliferative inhibition values. This is also confirmed
by docking analysis, whereby compounds with longer linkers and thienopyrimidine cationic head
have been identified as the most compelling. Among the best compounds is Ff-35, which inhibits the
growth of different tumor cells at submicromolar concentrations. Moreover, Ff-35 is more potent in
inhibiting CKα1 than other previous biscationic derivatives. Treatment of A549, Hela, and MDA-MB-231 cells with Ff-35 results in their arrest at the G1 phase of the cell cycle. Furthermore, the compound
induces cellular apoptosis in a concentration-dependent manner. Altogether, these findings indicate
that Ff-35 is a promising new chemotherapeutic agent with encouraging preclinical potential.Ministerio de Innovación y Ciencia PID2019-109294RB-I00FEDER 2020 B-CTS-216-UGR20European Regional Development Fund (ERDF) 1.1.1.5/19/A/004Latvian Council of Science lzp-2020/2-00
Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2
Objective
To describe the characteristics and prognosis of patients with COPD admitted to the hospital due to SARS-CoV-2 infection.
Methods
The SEMI-COVID registry is an ongoing retrospective cohort comprising consecutive COVID-19 patients hospitalized in Spain since the beginning of the pandemic in March 2020. Data on demographics, clinical characteristics, comorbidities, laboratory tests, radiology, treatment, and progress are collected. Patients with COPD were selected and compared to patients without COPD. Factors associated with a poor prognosis were analyzed.
Results
Of the 10,420 patients included in the SEMI-COVID registry as of May 21, 2020, 746 (7.16%) had a diagnosis of COPD. Patients with COPD are older than those without COPD (77 years vs 68 years) and more frequently male. They have more comorbidities (hypertension, hyperlipidemia, diabetes mellitus, atrial fibrillation, heart failure, ischemic heart disease, peripheral vascular disease, kidney failure) and a higher Charlson Comorbidity Index (2 vs 1, p<0.001). The mortality rate in COPD patients was 38.3% compared to 19.2% in patients without COPD (p<0.001). Male sex, a history of hypertension, heart failure, moderate–severe chronic kidney disease, presence of cerebrovascular disease with sequelae, degenerative neurological disease, dementia, functional dependence, and a higher Charlson Comorbidity Index have been associated with increased mortality due to COVID-19 in COPD patients. Survival was higher among patients with COPD who were treated with hydroxychloroquine (87.1% vs 74.9%, p<0.001) and with macrolides (57.9% vs 50%, p<0.037). Neither prone positioning nor non-invasive mechanical ventilation, high-flow nasal cannula, or invasive mechanical ventilation were associated with a better prognosis.
Conclusion
COPD patients admitted to the hospital with SARS-CoV-2 infection have more severe disease and a worse prognosis than non-COPD patients
The role of Cis-Regulatory elements in morphological adaptation to cave environment in Astyanax mexicanus
Trabajo presentado en EMBO Workshop Enhanceropathies: Understanding enhancer function to understand human disease, celebrado en Santander (España) del 06 al 09 de octubre de 2021
Genome evolution in morphological adaptation to cave environment in Astyanax mexicanus
Trabajo presentado en el EMBO Workshop The evolution of animal genomes, celebrado en modalidad virtual del 13 al 17 de septiembre de 2021
Nanoinformatics: developing new computing applications for nanomedicine
Nanoinformatics has recently emerged to address the need of computing applications at the nano level. In this regard, the authors have participated in various initiatives to identify its concepts, foundations and challenges. While nanomaterials open up the possibility for developing new devices in many industrial and scientific areas, they also offer breakthrough perspectives for the prevention, diagnosis and treatment of diseases. In this paper, we analyze the different aspects of nanoinformatics and suggest five research topics to help catalyze new research and development in the area, particularly focused on nanomedicine. We also encompass the use of informatics to further the biological and clinical applications of basic research in nanoscience and nanotechnology, and the related concept of an extended ?nanotype? to coalesce information related to nanoparticles. We suggest how nanoinformatics could accelerate developments in nanomedicine, similarly to what happened with the Human Genome and other -omics projects, on issues like exchanging modeling and simulation methods and tools, linking toxicity information to clinical and personal databases or developing new approaches for scientific ontologies, among many others
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