Inventari del tresor litúrgic de l'altar de Sant Pere de la Catedral de Vic de principi del segle XIII

L'autora presenta l'inventari inèdit del mobiliari litúrgic de l'altar de Sant Pere de la catedral de Vic, possiblement de principi del segle XIII. L'inventari ocupa el marginal del f. 152 del Liber dotationum antiquarum (ACV). S'analitzen testaments amb deixes d'interès, així com les figures del sagristà Pere de Tavertet (1157-1218) i de Guillem de Tavertet, nebot seu i bisbe de Vic (1195-1233), ambdós lligats per la cronologia de l'inventari. Es fa un estudi de les peces relacionades. Un dels ítems més significatius és un calze magnum que Pere de Tavertet havia deixat a l'esmentat altar.The author presents the unpublished inventory of liturgical objects of Saint Peters altar in Vic Cathedral, possibly dating to the early 13th century. The inventory can be found in folio 152 of Liber dotationum antiquarum (ACV). This article analyzes the wills and the figures of Pere de Tavertet (1157-1218), sacristan, and Guillem de Tavertet, his nephew and bishop of Vic from 1195 to 1233. The author provides a study of the pieces included in the inventory, the most important of which is the magnum chalice which Pere de Tavertet bequeathed to the altar

Surface movement and cascade processes on debris cones in temperate high mountain (Picos de Europa, northern Spain)

Producción CientíficaDebris talus is a very common landform in the temperate high mountain, so much so that it is the most representative of the periglacial and nival processes. This work studies debris cones in the Picos de Europa, an Atlantic mountain range in the north of the Iberian Peninsula. A detailed geomorphological map was prepared, fieldwork was carried out on the debris cone surface, the ground and air thermal regime was analyzed, and a five-year Terrestrial Laser Scan survey carried out. Annual volume changes on the surface of the debris cones were detected and related to active processes and sediment transfer. Two different behaviors were observed in each cone. Cone A is linear, with equilibrium between accumulation and sediment transfer, while Cone B is concave-convex denoting accumulation processes in the upper part deriving from the greater frequency of snow avalanches. Changes in morphology surpass 50 cm/year with most of the activity taking place in the highest and lowest areas. The presence and action of the ice on the debris slope are moderate or non-existent and freeze-thaw processes are only active on the walls at over 2000 m a.s.l. The main processes on debris cones are debris flow and creep related to snowcover, but sediment transfer on the slopes involves high intensity-low frequency (debris flow, avalanches) and high frequency-low intensity processes (creep, shift, solifluction and wasting).Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional (project CGL2015-68144-R)Junta de Extremadura - Fondo Europeo de Desarrollo Regional (project GR10071

Modelling and Terrestrial Laser Scanning Methodology (2009–2018) on Debris Cones in Temperate High Mountains

Producción CientíficaDebris cones are a very common landform in temperate high mountains. They are the most representative examples of the periglacial and nival processes. This work studies the dynamic behavior of two debris cones (Cone A and Cone B) in the Picos de Europa, in the north of the Iberian Peninsula. Their evolution was measured uninterruptedly throughout each August for 10 years (2009–2018) using the Terrestrial Laser Scanning (TLS) technique. The observations and calculations of the two debris cones were treated independently, but both showed the same behavior. Therefore, if these results are extrapolated to other debris cones in similar environments (temperate high mountain), they should show behavior similar to that of the two debris cones analyzed. Material falls onto the cones from the walls, and transfer of sediments follows linear trajectories according to the maximum slope. In order to understand the linear evolution of the two debris cones, profiles were created along the maximum slope lines of the Digital Elevation Model (DEM) of 2009, and these profile lines were extrapolated to the remaining years of measurement. In order to determine volumetric surface behavior in the DEMs, each year for the period 2009–2018 was compared. In addition, the statistical predictive value for position (Z) in year 2018 was calculated for the same planimetric position (X,Y) throughout the profiles of maximum slopes. To do so, the real field data from 2009–2017 were interpolated and used to form a sample of curves. These curves are interpreted as the realization of a functional random variable that can be predicted using statistical techniques. The predictive curve obtained was compared with the 2018 field data. The results of both coordinates (Z), the real field data, and the statistical data are coherent within the margin of error of the data collection.Fondo Europeo de Desarrollo Regional - Agencia Estatal de Investigación (grant TIN2016-76843-C4-2-R)Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional (grant CGL2015-68144-R

Impact of model calibration on cost-effectiveness analysis of cervical cancer prevention

Markov chain models are commonly used to simulate the natural history of human papillomavirus infection and subsequent cervical lesions with the aim of predicting future benefits of health interventions. Developing and calibrating these models entails making a number of critical decisions that will influence the ability of the model to reflect real conditions and predict future situations. Accuracy of selected inputs and calibration procedures are two of the crucial aspects for model performance and understanding their influence is essential, especially when involves policy decisions. The aim of this work is to assess the health and economic impact on cervical cancer prevention strategies currently under discussion according to the most common methods of model calibration combined with different accuracy degree of initial inputs. Model results show large differences on the goodness of fit and cost-effectiveness outcomes depending on the calibration approach used, and these variations may affect health policy decisions. Our findings strengthen the importance of obtaining good calibrated probability matrices to get reliable health and cost outcomes, and are directly generalizable to any cost-effectiveness analysis based on Markov chain models

Caracterización geométrica y visualización interactiva 3d del patrimonio histórico y artístico en la provincia de Cáceres (España)

[EN] The three-dimensional (3D) visualization of historical and cultural heritage in the province of Cáceres is essential for tourism promotion. This study uses panoramic spherical photography and terrestrial laser scanning (TLS) for the geometric characterization and cataloguing of sites of cultural interest, according to the principles of the Charter of Krakow. The benefits of this project include improved knowledge dissemination of the cultural heritage of Cáceres in a society that demands state-of-the-art tourist information. In this sense, this study has three specific aims: to develop a highly reliable methodology for modeling heritage based on a combination of non-destructive geomatics methods; to design and develop software modules for interactive 3D visualization of models; and to promote knowledge of the historical and cultural heritage of Cáceres by creating a hypermedia atlas accessible via the Internet. Through this free-of-charge hypermedia atlas, the tourist accesses 3D photographic and interactive scenes, videos created by 3D point clouds obtained from laser scanning and 3D models available for downloading in ASCII format, and thus acquire a greater knowledge of the touristic attractions in the province of Cáceres.[ES] La visualización tridimensional (3D) del patrimonio histórico-cultural en la provincia de Cáceres es una herramienta vital para su promoción turística. Este trabajo emplea la fotografía panorámica esférica y el uso del escáner láser terrestre para la caracterización geométrica de los bienes de interés cultural, así como su catalogación, de acuerdo a los principios de la Carta de Cracovia. El beneficio de este proyecto es alcanzar un mayor conocimiento del patrimonio cultural de Cáceres para una sociedad que demanda información turística actualizada. En este sentido, hay tres objetivos específicos en el trabajo: desarrollar una metodología de alto grado de fiabilidad para la modelización del patrimonio basado en la combinación de diferentes métodos geomáticos no destructivos; diseñar y desarrollar módulos de software para la visualización interactiva de modelos 3D; y promover el conocimiento del patrimonio histórico de Cáceres mediante la creación de un atlas hipermedia accesible en Internet. A través del atlas hipermedia, el turista accede gratuitamente a los escenarios fotográficos tridimensionales e interactivos, los videos a partir de las nubes de puntos 3D adquiridas con láser escáner y a la descarga de los modelos 3D en formato ASCII, adquiriendo un mayor conocimiento de los atractivos turísticos de la provincia de Cáceres.The article has been possible thanks to the funding granted by the Junta de Extremadura and the Fondo Europeo de Desarrollo Regional (FEDER), through the reference aid GR15069 for the research groups NEXUS and DESOSTE. In addition, the present work was developed under the 2013 Plan of Initiation to Research of the University of Extremadura within the Program Orientated at Projects of Initiation to Research called Action VII, financed by the Provincial Government in Cáceres. We also thank the Regional Government of Extremadura for providing aerial images. The authors would like to thank Alan D.J. Atkinson Gordo, José Antonio Gutiérrez Gallego, Juan Antonio Pérez Alvárez, Mercedes Jiménez Muñoz, Manuel Sánchez Fernández and David Díaz Paredes for the guidance received. Likewise, thanks are also extended to Mr. Fergus Crystal and Mr. Giles Petty for help with revising the English version of this text.Naranjo, JM.; Parrilla, Á.; De Sanjosé, JJ. (2018). Geometric characterization and interactive 3D visualization of historical and cultural heritage in the province of Cáceres (Spain). Virtual Archaeology Review. 9(18):1-11. https://doi.org/10.4995/var.2018.601011191

Geomatic methods applied to the change study of the la Paúl Rock Glacier, Spanish Pyrenees

Producción CientíficaRock glaciers are one of the most important features of the mountain permafrost in the Pyrenees. La Paúl is an active rock glacier located in the north face of the Posets massif in the La Paúl glacier cirque (Spanish Pyrenees). This study presents the preliminary results of the La Paúl rock glacier monitoring works carried out through two geomatic technologies since 2013: Global Navigation Satellite System (GNSS) receivers and Terrestrial Laser Scanning (TLS) devices. Displacements measured on the rock glacier surface have demonstrated both the activity of the rock glacier and the utility of this equipment for the rock glaciers dynamic analysis. The glacier has exhibited the fastest displacements on its west side (over 35 cm yr-1), affected by the Little Ice Age, and frontal area (over 25 cm yr-1). As an indicator of permafrost in marginal environments and its peculiar morphology, La Paúl rock glacier encourages a more prolonged study and to the application of more geomatic techniques for its detailed analysis.Ministerio de Economía, Industria y Competitividad - Fondo Europeo de Desarrollo Regional (project CGL2015-68144-R)Junta de Extremadura - Fondo Europeo de Desarrollo Regional (project GR10071

HPV vaccination of immunocompromised hosts.

It is well-established that immunocompromised people are at increased risk of HPV-related disease compared with those who are immunocompetent. Prophylactic HPV sub-unit vaccines are safe and immunogenic in immunocompromised people and it is strongly recommended that vaccination occur according to national guidelines. When delivered to immunocompromised populations, HPV vaccines should be given as a 3-dose regimen

Genome-wide association study identifies multiple susceptibility loci for diffuse large B-cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL

Crist a la glòria: l'obra de Llemotges i la majestat de la creu de Sant Joan de les Abadesses

En aquest article analitzem el Crist en la glòria, model que fou creat pel taller de Llemotges devers el final del segle XII. Hem contemplat dos apartats, el teològic i l'artístic. En el primer, s'emfatitza la connotació de sacerdos et rex amb Crist coronat i vestit amb una túnica amb mànigues i hem sustentat la nostra hipòtesi basant-nos en l'Antic i el Nou Testament; en el segon, hem analitzat el colobium (túnica sense mànigues), el Volto Santo de Lucca (Itàlia) i les majestats catalanes (talles de fusta) considerades uns possibles antecedents. Finalment, hem estudiat el que considerem el millor grup d'imatges de metall de Llemotges d'aquesta tipologia per extreure'n les característiques i aplicar-les a la Majestat de la Creu de Sant Joan de les Abadesses (Museu Episcopal de Vic, inv. 766).In this paper we analyse the figure of Christ in Glory, a model that was created by the Limoges workshop towards the end of the 12th century. We have considered two aspects: the theological and the artistic. Thus, in the first section of this paper, we emphasise the connotation of sacerdos et rex with the crowned Christ dressed in a sleeved tunic, basing our hypothesis on the Old and New Testaments. In the second section, we analyse the colobium (sleeveless tunic) and the wood carvings of dressed Majesties such as the Volto Santo of Lucca and the Catalan Majesties, which are considered a possible antecedent. Lastly, we study what we deem to be the best group of Limoges metal images of this typology in order to determine their characteristics and apply them to the Majesty of the Cross of Sant Joan de les Abadesses (Museu Episcopal de Vic, inv. 766)