46 research outputs found
Pre-therapeutic histological and cytological assessment in head and neck squamous cell carcinomas. French Society of Otorhinolaryngology Guidelines â 2012
SummaryObjectivesThe authors present the French Society of Otorhinolaryngology (SFORL) guidelines for histopathologic assessment of head and neck cancer.Materiel and methodsA multidisciplinary workgroup set up by the SFORL performed an exhaustive review of the literature according to levels of evidence, following the 2000 guidelines of the French national health approvals and assessment agency (ANAES).ResultsComparison between histologic and clinical data is essential. In case of discrepancy between clinical, radiological and histological findings, reinterpretation or new biopsy may be required (professional consensus). Mere suspicion of carcinoma on fine-needle aspiration lymph-node biopsy only exceptionally warrants aggressive treatment (professional consensus). Exploration for HPV is not recommended as routine practice, being without therapeutic impact (professional consensus). Anti-p16 immunohistochemistry is optional, for epidemiological purposes (professional consensus). Tumor-bank tissue storage must conform strictly to prevailing legislation and good practice rules for sampling and preservation (professional consensus).ConclusionPathology assessment is mandatory in suspected H&N squamous cell carcinoma. The present guidelines are intended to optimize management
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SEIS: Insight's Seismic Experiment for Internal Structure of Mars.
By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ⌠2500 at 1 Hz and ⌠200 000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of M w ⌠3 at 40 â epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialThe online version of this article (10.1007/s11214-018-0574-6) contains supplementary material, which is available to authorized users
Anti-HIV-1 activity of anionic polymers: a comparative study of candidate microbicides
BACKGROUND: Cellulose acetate phthalate (CAP) in soluble form blocks coreceptor binding sites on the virus envelope glycoprotein gp120 and elicits gp41 six-helix bundle formation, processes involved in virus inactivation. CAP is not soluble at pH < 5.5, normal for microbicide target sites. Therefore, the interaction between insoluble micronized CAP and HIV-1 was studied. Carbomer 974P/BufferGel; carrageenan; cellulose sulfate; dextran/dextrin sulfate, poly(napthalene sulfonate) and poly(styrene-4-sulfonate) are also being considered as anti-HIV-1 microbicides, and their antiviral properties were compared with those of CAP. METHODS: Enzyme linked immunosorbent assays (ELISA) were used to (1) study HIV-1 IIIB and BaL binding to micronized CAP; (2) detect virus disintegration; and (3) measure gp41 six-helix bundle formation. Cells containing integrated HIV-1 LTR linked to the ÎČ-gal gene and expressing CD4 and coreceptors CXCR4 or CCR5 were used to measure virus infectivity. RESULTS: 1) HIV-1 IIIB and BaL, respectively, effectively bound to micronized CAP. 2) The interaction between HIV-1 and micronized CAP led to: (a) gp41 six-helix bundle formation; (b) virus disintegration and shedding of envelope glycoproteins; and (c) rapid loss of infectivity. Polymers other than CAP, except Carbomer 974P, elicited gp41 six-helix bundle formation in HIV-1 IIIB but only poly(napthalene sulfonate), in addition to CAP, had this effect on HIV-1 BaL. These polymers differed with respect to their virucidal activities, the differences being more pronounced for HIV-1 BaL. CONCLUSIONS: Micronized CAP is the only candidate topical microbicide with the capacity to remove rapidly by adsorption from physiological fluids HIV-1 of both the X4 and R5 biotypes and is likely to prevent virus contact with target cells. The interaction between micronized CAP and HIV-1 leads to rapid virus inactivation. Among other anionic polymers, cellulose sulfate, BufferGel and aryl sulfonates appear most effective in this respect
Lunar Gravitational-Wave Detection
A new era of lunar exploration has begun bringing immense opportunities for science as well. It has been proposed to deploy a new generation of observatories on the lunar surface for deep studies of our Universe. This includes radio antennas, which would be protected on the far side of the Moon from terrestrial radio interference, and gravitational-wave (GW) detectors, which would profit from the extremely low level of seismic disturbances on the Moon. In recent years, novel concepts have been proposed for lunar GW detectors based on long-baseline laser interferometry or on compact sensors measuring the lunar surface vibrations caused by GWs. In this article, we review the concepts and science opportunities for such instruments on the Moon. In addition to promising breakthrough discoveries in astrophysics and cosmology, lunar GW detectors would also be formidable probes of the lunar internal structure and improve our understanding of the lunar geophysical environment
An Autonomous Lunar Geophysical Experiment Package (ALGEP) for future space missions
Geophysical observations will provide key information about the inner structure of the planets and satellites and understanding the internal structure is a strong constraint on the bulk composition and thermal evolution of these bodies. Thus, geophysical observations are a key to uncovering the origin and evolution of the Moon. In this article, we propose the development of an autonomous lunar geophysical experiment package, composed of a suite of instruments and a central station with standardized interface, which can be installed on various future lunar missions. By fixing the interface between instruments and the central station, it would be possible to easily configure an appropriate experiment package for different missions. We describe here a series of geophysical instruments that may be included as part of the geophysical package: a seismometer, a magnetometer, a heat flow probe, and a laser reflector. These instruments will provide mechanical, thermal, and geodetic parameters of the Moon that are strongly related to the internal structure. We discuss the functionality required for future geophysical observations of the Moon, including the development of the central station that will be used commonly by different payloads
Constraints on the shallow elastic and anelastic structure of Mars from InSight seismic data
Marsâs seismic activity and noise have been monitored since January 2019 by the seismometer of the InSight (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) lander. At night, Mars is extremely quiet; seismic noise is about 500 times lower than Earthâs microseismic noise at periods between 4 s and 30 s. The recorded seismic noise increases during the day due to ground deformations induced by convective atmospheric vortices and ground-transferred wind-generated
lander noise. Here we constrain properties of the crust beneath InSight, using signals from atmospheric vortices and from the
hammering of InSightâs Heat Flow and Physical Properties (HP3) instrument, as well as the three largest Marsquakes detected
as of September 2019. From receiver function analysis, we infer that the uppermost 8â11 km of the crust is highly altered and/
or fractured. We measure the crustal diffusivity and intrinsic attenuation using multiscattering analysis and find that seismic
attenuation is about three times larger than on the Moon, which suggests that the crust contains small amounts of volatiles
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Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
Data availability:
Research data are not shared.Supplementary Information oi available online at: https://www.nature.com/articles/s41598-021-98012-w#Sec14 .Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMIâcitrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patientsâ50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 ÎŒmol/L (12.0â26.0) vs. 23.3 ÎŒmol/L (18.3â29.8), pâ=â0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence intervalâ=â0.58â0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.Grants from MSD-Avenir and APHP funded the SURVIBIO study; Alexandre Nuzzo received Ph.D. Grants from âFondation de l'Avenirâ and the French Gastroenterology Society (SNFGE)
SEIS: Insightâs Seismic Experiment for Internal Structure of Mars
By the end of 2018, 42 years after the landing of the two Viking seismometers
on Mars, InSight will deploy onto Marsâ surface the SEIS (Seismic Experiment for Internal
Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes
Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These
six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz,
with possible extension to longer periods. Data will be transmitted in the form of three
continuous VBB components at 2 sample per second (sps), an estimation of the short period
energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at
10 sps. The continuous streams will be augmented by requested event data with sample
rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Vikingâs Mars
seismic monitoring by a factor of ⌠2500 at 1 Hz and ⌠200 000 at 0.1 Hz. An additional
major improvement is that, contrary to Viking, the seismometers will be deployed via a
robotic arm directly onto Marsâ surface and will be protected against temperature and wind
by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is
reasonable to infer a moment magnitude detection threshold of Mw ⌠3 at 40⊠epicentral
distance and a potential to detect several tens of quakes and about five impacts per year. In
this paper, we first describe the science goals of the experiment and the rationale used to
define its requirements. We then provide a detailed description of the hardware, from the
sensors to the deployment system and associated performance, including transfer functions
of the seismic sensors and temperature sensors. We conclude by describing the experiment
ground segment, including data processing services, outreach and education networks and
provide a description of the format to be used for future data distribution