Distribution of HLA-DPB1, -DQB1 -DQA1 alleles among Sardinian celiac patients.

The Sardinian population in many aspects differs from other Caucasoid populations, particularly for its degree of homogeneity. For this reason we have studied 50 adult Sardinian patients with celiac disease (CD) and 50 control healthy Sardinian individuals by RFLP analysis and by extensive oligotyping for 17 HLA-DPB 1, 8-DQB I and 9-DQA 1 alleles, and established their -DPB I alleles and -DQB I -DQA I genotypes. The heterodimer HLA-DQB 1 *0201/-DQA 1 *0501, present in 96% of our patients, is strongly associated with CD susceptibility, confirming published reports. On the other hand we found in 11 of 50 probands (22%) the presence of the allele -DQB 1 *05021 DQA1*0102. This genotype is extremely rare in other Caucasian populations and appears to confer limited protection in CD Sardinian patients

Primitive filtrations of the modules of invariant logarithmic forms of Coxeter arrangements

We define {\bf primitive derivations} for Coxeter arrangements which may not be irreducible. Using those derivations, we introduce the {\bf primitive filtrations} of the module of invariant logarithmic differential forms for an arbitrary Coxeter arrangement with an arbitrary multiplicity. In particular, when the Coxeter arrangement is irreducible with a constant multiplicity, the primitive filtration has already been studied, which generalizes the Hodge filtration introduced by K. Saito

Automotive timing belt life laws and a user design guide

The paper presents a computer-based guide of the effect of layout and loading (tension and torque) on the timing belt life and uses it to show the sensitivity of life to changed conditions in an automotive camshaft drive. The predictions are in line with experience. The guide requires belt property information, such as the tooth and tension member stiffness, the friction coefficient between the belt lands and pulleys and the pitch difference from the pulley, in order to calculate the tooth deflections caused by the belt loadings on the various pulleys in the layout. It also requires information on how the belt life depends on the tooth deflections. Experimental data are presented on the life±deflection relations of a commercial automotive timing belt tested between 100 and 140 8C, although the bulk of the data has been obtained at 120 8C. Four different life laws have been found, depending on whether the failure-initiating deflection occurred on a driver or a driven pulley, and whether at entry to or exit from the pulley. Theoretical analysis of the tooth loading in the partial meshing state shows that, in three cases out of the four, the different life±deflection laws transform to a single relation between the life and the tooth root strain. The exception is failure caused by driven entry conditions; work is continuing to understand better the causes of failure in this circumstanc

Did the Hilda collisional family form during the late heavy bombardment?

We model the long-term evolution of the Hilda collisional family located in the 3/2 mean-motion resonance with Jupiter. Its eccentricity distribution evolves mostly due to the Yarkovsky/YORP effect and assuming that: (i) impact disruption was isotropic, and (ii) albedo distribution of small asteroids is the same as for large ones, we can estimate the age of the Hilda family to be $4_{-1}^{+0}\,{\rm Gyr}$. We also calculate collisional activity in the J3/2 region. Our results indicate that current collisional rates are very low for a 200\,km parent body such that the number of expected events over Gyrs is much smaller than one. The large age and the low probability of the collisional disruption lead us to the conclusion that the Hilda family might have been created during the Late Heavy Bombardment when the collisions were much more frequent. The Hilda family may thus serve as a test of orbital behavior of planets during the LHB. We tested the influence of the giant-planet migration on the distribution of the family members. The scenarios that are consistent with the observed Hilda family are those with fast migration time scales $\simeq 0.3\,{\rm Myr}$ to $3\,{\rm Myr}$, because longer time scales produce a family that is depleted and too much spread in eccentricity. Moreover, there is an indication that Jupiter and Saturn were no longer in a compact configuration (with period ratio $P_{\rm S}/P_{\rm J} > 2.09$) at the time when the Hilda family was created

Electronic and Vibrational Properties of PbI 2 : From Bulk to Monolayer

Using first-principles calculations, we study the dependence of the electronic and vibrational properties of multi-layered PbI 2 crystals on the number of layers and focus on the electronic-band structure and the Raman spectrum. Electronic-band structure calculations reveal that the direct or indirect semiconducting behavior of PbI 2 is strongly influenced by the number of layers. We find that at 3L-thickness there is a direct-to-indirect band gap transition (from bulk-to-monolayer). It is shown that in the Raman spectrum two prominent peaks, A 1g and E g , exhibit phonon hardening with increasing number of layers due to the inter-layer van der Waals interaction. Moreover, the Raman activity of the A 1g mode significantly increases with increasing number of layers due to the enhanced out-of-plane dielectric constant in the few-layer case. We further characterize rigid-layer vibrations of low-frequency inter-layer shear (C) and breathing (LB) modes in few-layer PbI 2 . A reduced mono-atomic (linear) chain model (LCM) provides a fairly accurate picture of the number of layers dependence of the low-frequency modes and it is shown also to be a powerful tool to study the inter-layer coupling strength in layered PbI 2 .Comment: To appear in Phys. Rev.