Efficient high-resolution TMS mapping of the human motor cortex by nonlinear regression

Transcranial magnetic stimulation (TMS) is a powerful tool to investigate causal structure-function relationships in the human brain. However, a precise delineation of the effectively stimulated neuronal populations is notoriously impeded by the widespread and complex distribution of the induced electric field. Here, we propose a method that allows rapid and feasible cortical localization at the individual subject level. The functional relationship between electric field and behavioral effect is quantified by combining experimental data with numerically modelled fields to identify the cortical origin of the modulated effect. Motor evoked potentials (MEPs) from three finger muscles were recorded for a set of random stimulations around the primary motor area. All induced electric fields were nonlinearly regressed against the elicited MEPs to identify their cortical origin. We could distinguish cortical muscle representation with high spatial resolution and localized them primarily on the crowns and rims of the precentral gyrus. A post-hoc analysis revealed exponential convergence of the method with the number of stimulations, yielding a minimum of about 180 random stimulations to obtain stable results. Establishing a functional link between the modulated effect and the underlying mode of action, the induced electric field, is a fundamental step to fully exploit the potential of TMS. In contrast to previous approaches, the presented protocol is particularly easy to implement, fast to apply, and very robust due to the random coil positioning and therefore is suitable for practical and clinical applications

Binding energy referencing for XPS in Alkali metal-based battery materials research (II): Application to complex composite electrodes

X-ray photoelectron spectroscopy (XPS) is a key method for studying (electro-)chemical changes in metal-ion battery electrode materials. In a recent publication, we pointed out a conflict in binding energy (BE) scale referencing at alkali metal samples, which is manifested in systematic deviations of the BEs up to several eV due to a specific interaction between the highly reactive alkali metal in contact with non-conducting surrounding species. The consequences of this phenomenon for XPS data interpretation are discussed in the present manuscript. Investigations of phenomena at surface-electrolyte interphase regions for a wide range of materials for both lithium and sodium-based applications are explained, ranging from oxide-based cathode materials via alloys and carbon-based anodes including appropriate reference chemicals. Depending on material class and alkaline content, specific solutions are proposed for choosing the correct reference BE to accurately define the BE scale. In conclusion, the different approaches for the use of reference elements, such as aliphatic carbon, implanted noble gas or surface metals, partially lack practicability and can lead to misinterpretation for application in battery materials. Thus, this manuscript provides exemplary alternative solutions

Tidal Disruption of Stellar Objects by Hard Supermassive Black Hole Binaries

Supermassive black hole binaries (SMBHBs) are expected by the hierarchical galaxy formation model in $\Lambda$CDM cosmology. There is some evidence in the literature for SMBHBs in AGNs, but there are few observational constraints on the evolution of SMBHBs in inactive galaxies and gas-poor mergers. On the theoretical front, it is unclear how long is needed for a SMBHB in a typical galaxy to coalesce. In this paper we investigate the tidal interaction between stars and binary BHs and calculate the tidal disruption rates of stellar objects by the BH components of binary. We derive the interaction cross sections between SMBHBs and stars from intensive numerical scattering experiments with particle number $\sim10^7$ and calculate the tidal disruption rates by both single and binary BHs for a sample of realistic galaxy models, taking into account the general relativistic effect and the loss cone refilling because of two-body interaction. We estimate the frequency of tidal flares for different types of galaxies using the BH mass function in the literature. We find that because of the three-body slingshot effect, the tidal disruption rate in SMBHB system is more than one order of magnitude smaller than that in single SMBH system. The difference is more significant in less massive galaxies and does not depend on detailed stellar dynamical processes. Our calculations suggest that comparisons of the calculated tidal disruption rates for both single and binary BHs and the surveys of X-ray or UV flares at galactic centers could tell us whether most SMBHs in nearby galaxies are single and whether the SMBHBs formed in gas-poor galaxy mergers coalesce rapidly.Comment: 43 pages, 12 figures, 2 tables; accepted for publication in Ap

Active Galactic Nuclei: Sources for ultra high energy cosmic rays?

The origin of ultra high energy cosmic rays promises to lead us to a deeper understanding of the structure of matter. This is possible through the study of particle collisions at center-of-mass energies in interactions far larger than anything possible with the Large Hadron Collider, albeit at the substantial cost of no control over the sources and interaction sites. For the extreme energies we have to identify and understand the sources first, before trying to use them as physics laboratories. Here we describe the current stage of this exploration. The most promising contenders as sources are radio galaxies and gamma ray bursts. The sky distribution of observed events yields a hint favoring radio galaxies. Key in this quest are the intergalactic and galactic magnetic fields, whose strength and structure are not yet fully understood. Current data and statistics do not yet allow a final judgment. We outline how we may progress in the near future.Comment: proceedings for "Origin, Mass, Composition and Acceleration Mechanisms of UHECRs (CRIS 2008)" in Malfa (Salina Island - Italy) on September 15-19, 200

Mentoring programs for medical students - a review of the PubMed literature 2000 - 2008

Abstract Background Although mentoring is acknowledged as a key to successful and satisfying careers in medicine, formal mentoring programs for medical students are lacking in most countries. Within the framework of planning a mentoring program for medical students at Zurich University, an investigation was carried out into what types of programs exist, what the objectives pursued by such programs are, and what effects are reported. Methods A PubMed literature search was conducted for 2000 - 2008 using the following keywords or their combinations: mentoring, mentoring program, medical student, mentor, mentee, protégé, mentorship. Although a total of 438 publications were identified, only 25 papers met the selection criteria for structured programs and student mentoring surveys. Results The mentoring programs reported in 14 papers aim to provide career counseling, develop professionalism, increase students' interest in research, and support them in their personal growth. There are both one-to-one and group mentorships, established in the first two years of medical school and continuing through graduation. The personal student-faculty relationship is important in that it helps students to feel that they are benefiting from individual advice and encourages them to give more thought to their career choices. Other benefits are an increase in research productivity and improved medical school performance in general. Mentored students also rate their overall well-being as higher. - The 11 surveys address the requirements for being an effective mentor as well as a successful mentee. A mentor should empower and encourage the mentee, be a role model, build a professional network, and assist in the mentee's personal development. A mentee should set agendas, follow through, accept criticism, and be able to assess performance and the benefits derived from the mentoring relationship. Conclusion Mentoring is obviously an important career advancement tool for medical students. In Europe, more mentoring programs should be developed, but would need to be rigorously assessed based on evidence of their value in terms of both their impact on the career paths of juniors and their benefit for the mentors. Medical schools could then be monitored with respect to the provision of mentorships as a quality characteristic.</p

FIRST `Winged' and `X'-shaped Radio Source Candidates

A small number of double-lobed radio galaxies (17 from our own census of the literature) show an additional pair of low surface brightness `wings', thus forming an overall `X'-shaped appearance. The origin of the wings in these radio sources is unclear. They may be the result of back-flowing plasma from the currently active radio lobes into an asymmetric medium surrounding the active nucleus, which would make these ideal systems in which to study thermal/non-thermal plasma interactions in extragalactic radio sources. Another possibility is that the wings are the aging radio lobes left over after a (rapid) realignment of the central supermassive black-hole/accretion disk system due perhaps to a merger. Generally, these models are not well tested; with the small number of known examples, previous works focused on detailed case studies of selected sources with little attempt at a systematic study of a large sample. Using the VLA-FIRST survey database, we are compiling a large sample of winged and X-shaped radio sources for such studies. As a first step toward this goal, an initial sample of 100 new candidate objects of this type are presented in this paper. ...[abridged]Comment: (all comments same as v2 except updated external link) AJ, accepted. 36 pgs. Added low resolution figures but table 2 still incomplete. Otherwise, unchanged from previous astro-ph version. For complete version and table 2: http://www.slac.stanford.edu/~teddy/Preprints/xshaped.pdf.g

Individual characteristics and student's engagement in scientific research : a cross-sectional study

Background: In light of the increasing recognition of the importance of physician scientists, and given the association between undergraduate research experiences with future scientific activity, it is important to identify and understand variables related to undergraduate student’s decision to engage in scientific research activities. The present study assessed the influence of individual characteristics, including personality traits and socio-demographic characteristics, on voluntary engagement in scientific research of undergraduate medical students. Methods: For this study, all undergraduate students and alumni of the School of Health Sciences in Minho, Portugal were invited to participate in a survey about voluntary engagement in scientific research activities. Data were available on socio-demographic, personality and university admission variables, as part of an ongoing longitudinal study. A regression model was used to compare (1) engaged with (2) not engaged students. A classification and regression tree model was used to compare students engaged in (3) elective curricular research (4) and extra-curricular research. Results: A total of 466 students (88%) answered the survey. A complete set of data was available for 435 students (83%).Higher scores in admission grade point average and the personality dimensions of “openness to experience” and “conscientiousness” increased chances of engagement. Higher “extraversion” scores had the opposite effect. Male undergraduate students were two times more likely than females to engage in curricular elective scientific research and were also more likely to engage in extra-curricular research activities. Conclusions: This study demonstrated that student’s grade point average and individual characteristics, like gender, openness and consciousness have a unique and statistically significant contribution to student’s involvement in undergraduate scientific research activities.Fundação para a Ciência e a Tecnologia (FCT) - PTDC/ESC/65116/200