159 research outputs found
A 1.82 m^2 ring laser gyroscope for nano-rotational motion sensing
We present a fully active-controlled He-Ne ring laser gyroscope, operating in
square cavity 1.35 m in side. The apparatus is designed to provide a very low
mechanical and thermal drift of the ring cavity geometry and is conceived to be
operative in two different orientations of the laser plane, in order to detect
rotations around the vertical or the horizontal direction. Since June 2010 the
system is active inside the Virgo interferometer central area with the aim of
performing high sensitivity measurements of environmental rotational noise. So
far, continuous not attempted operation of the gyroscope has been longer than
30 days. The main characteristics of the laser, the active remote-controlled
stabilization systems and the data acquisition techniques are presented. An
off-line data processing, supported by a simple model of the sensor, is shown
to improve the effective long term stability. A rotational sensitivity at the
level of ten nanoradiants per squareroot of Hz below 1 Hz, very close to the
required specification for the improvement of the Virgo suspension control
system, is demonstrated for the configuration where the laser plane is
horizontal
Characteristics of Soil Environment Variation in Oasis–Desert Ecotone in the Process of Oasis Growth
Orlistat exerts anti-obesity and anti-tumorigenic effects in a transgenic mouse model of endometrial cancer
Introduction: Among all cancers, endometrial cancer is most strongly associated with obesity, with more than 65% of endometrial cancers attributable to obesity and being overweight. Fatty acid synthase (FAS), a key lipogenic enzyme, is expressed in endometrial cancer tumors and is associated with a worse prognosis for this disease. Orlistat, an FAS inhibitor, is an FDA-approved weight loss medication that has demonstrated anti-tumor activity in a variety of preclinical cancer models. Methods: In this study, the Lkb1fl/flp53fl/fl mouse model of endometroid endometrial cancer was exposed to three diet interventions, including a high fat diet (obese), a low fat diet (lean) and switch from a high fat to a low fat diet, and then exposed to orlistat or placebo. Results: The mice fed a high-fat diet had significantly increased body weight and tumor weight compared to mice fed a low-fat diet. Switching from a high-fat diet to a low fat diet led to a reduction in mouse weight and suppressed tumor growth, as compared to both the high fat diet and low fat diet groups. Orlistat effectively decreased body weight in obese mice and inhibited tumor growth in obese, lean, and the high fat diet switch to low fat diet mouse groups through induction of apoptosis. Orlistat also showed anti-proliferative activity in nine of 11 primary cultures of human endometrial cancer. Discussion: Our findings provide strong evidence that dietary intervention and orlistat have anti-tumor activity in vivo and supports further investigation of orlistat in combination with dietary interventions for the prevention and treatment of endometrial cancer
Theoretical study of the two-proton halo candidate Ne including contributions from resonant continuum and pairing correlations
With the relativistic Coulomb wave function boundary condition, the energies,
widths and wave functions of the single proton resonant orbitals for Ne
are studied by the analytical continuation of the coupling constant (ACCC)
approach within the framework of the relativistic mean field (RMF) theory.
Pairing correlations and contributions from the single-particle resonant
orbitals in the continuum are taken into consideration by the resonant
Bardeen-Cooper-Schrieffer (BCS) approach, in which constant pairing strength is
used. It can be seen that the fully self-consistent calculations with NL3 and
NLSH effective interactions mostly agree with the latest experimental
measurements, such as binding energies, matter radii, charge radii and
densities. The energy of 2s orbital is slightly higher than that
of orbital, and the occupation probability of the
2s orbital is about 20%, which are in accordance with the
shell model calculation and three-body model estimation
Protons in near earth orbit
The proton spectrum in the kinetic energy range 0.1 to 200 GeV was measured
by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS-91 at
an altitude of 380 km. Above the geomagnetic cutoff the observed spectrum is
parameterized by a power law. Below the geomagnetic cutoff a substantial second
spectrum was observed concentrated at equatorial latitudes with a flux ~ 70
m^-2 sec^-1 sr^-1. Most of these second spectrum protons follow a complicated
trajectory and originate from a restricted geographic region.Comment: 19 pages, Latex, 7 .eps figure
Search for antihelium in cosmic rays
The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle
Discovery during flight STS-91 in a 51.7 degree orbit at altitudes between 320
and 390 km. A total of 2.86 * 10^6 helium nuclei were observed in the rigidity
range 1 to 140 GV. No antihelium nuclei were detected at any rigidity. An upper
limit on the flux ratio of antihelium to helium of < 1.1 * 10^-6 is obtained.Comment: 18 pages, Latex, 9 .eps figure
A Study of Cosmic Ray Secondaries Induced by the Mir Space Station Using AMS-01
The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics
experiment that will study cosmic rays in the to range and will be installed on the International Space Station
(ISS) for at least 3 years. A first version of AMS-02, AMS-01, flew aboard the
space shuttle \emph{Discovery} from June 2 to June 12, 1998, and collected
cosmic ray triggers. Part of the \emph{Mir} space station was within the
AMS-01 field of view during the four day \emph{Mir} docking phase of this
flight. We have reconstructed an image of this part of the \emph{Mir} space
station using secondary and emissions from primary cosmic rays
interacting with \emph{Mir}. This is the first time this reconstruction was
performed in AMS-01, and it is important for understanding potential
backgrounds during the 3 year AMS-02 mission.Comment: To be submitted to NIM B Added material requested by referee. Minor
stylistic and grammer change
Quantum dots coordinated with conjugated organic ligands: new nanomaterials with novel photophysics
CdSe quantum dots functionalized with oligo-(phenylene vinylene) (OPV) ligands (CdSe-OPV nanostructures) represent a new class of composite nanomaterials with significantly modified photophysics relative to bulk blends or isolated components. Single-molecule spectroscopy on these species have revealed novel photophysics such as enhanced energy transfer, spectral stability, and strongly modified excited state lifetimes and blinking statistics. Here, we review the role of ligands in quantum dot applications and summarize some of our recent efforts probing energy and charge transfer in hybrid CdSe-OPV composite nanostructures
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