The acquisition of Italian as L3 by L1-Chinese learners under the influence of L2-English: a study on determiners and adjectives.

openThis dissertation presents a comprehensive study on the acquisition of Italian articles and adjective order by Chinese learners who are influenced by their prior acquisition of English. The study adopts a syntactic DP perspective and aims to investigate the challenges and difficulties faced by Chinese students when learning Italian, specifically focusing on DP structures. It further explores how Chinese students gradually acquire DP structures in Italian by comparing them with the syntactic DP structures in English. Additionally, the research analyzes the developmental paths and evolutionary patterns of Chinese students' acquisition of DP structures. Factors influencing their acquisition, such as language background, learning strategies, and language input, are also examined. The study concludes by proposing teaching strategies and methods that can assist Chinese students in mastering the DP structure in Italian more effectively. The research questions addressed in this study are as follows: What are the patterns and challenges in the acquisition of determiners in L3-Italian by L1-Chinese learners under the influence of L2-English? How does the acquisition of adjectives in L3-Italian by L1-Chinese learners under the influence of L2-English occur and progress? To address these questions, quantitative research and corpus methodology are employed, involving data collection through written tasks and oral interviews. The collected data were analyzed using a combination of statistical analysis and qualitative techniques such as error analysis and comparative analysis. The results of this study indicate that In the case of Chinese students learning Italian, there are both positive and negative language transfer effects influenced by English, but the process follows the general language learning process, such as from simple to complex, and so on. These findings have significant implications for the guide for Chinese students to learn L3-Italian with the acquisition of L2-English. However, it is important to note the limitations of this study: this study focuses on school students and cannot be extended to all Chinese learners of Italian.This dissertation presents a comprehensive study on the acquisition of Italian articles and adjective order by Chinese learners who are influenced by their prior acquisition of English. The study adopts a syntactic DP perspective and aims to investigate the challenges and difficulties faced by Chinese students when learning Italian, specifically focusing on DP structures. It further explores how Chinese students gradually acquire DP structures in Italian by comparing them with the syntactic DP structures in English. Additionally, the research analyzes the developmental paths and evolutionary patterns of Chinese students' acquisition of DP structures. Factors influencing their acquisition, such as language background, learning strategies, and language input, are also examined. The study concludes by proposing teaching strategies and methods that can assist Chinese students in mastering the DP structure in Italian more effectively. The research questions addressed in this study are as follows: What are the patterns and challenges in the acquisition of determiners in L3-Italian by L1-Chinese learners under the influence of L2-English? How does the acquisition of adjectives in L3-Italian by L1-Chinese learners under the influence of L2-English occur and progress? To address these questions, quantitative research and corpus methodology are employed, involving data collection through written tasks and oral interviews. The collected data were analyzed using a combination of statistical analysis and qualitative techniques such as error analysis and comparative analysis. The results of this study indicate that In the case of Chinese students learning Italian, there are both positive and negative language transfer effects influenced by English, but the process follows the general language learning process, such as from simple to complex, and so on. These findings have significant implications for the guide for Chinese students to learn L3-Italian with the acquisition of L2-English. However, it is important to note the limitations of this study: this study focuses on school students and cannot be extended to all Chinese learners of Italian

Mid- to late Holocene geomorphological and hydrological changes in the south Taihu area of the Yangtze delta plain, China

The Taihu Plain of the Lower Yangtze valley, China was a centre of rice agriculture during the Neolithic period. Reasons for the rapid development of rice cultivation during this period, however, have not been fully understood for this coastal lowland, which is highly sensitive to sea-level change. To improve understanding of the morphological and hydrological context for evolution of prehistoric rice agriculture, two sediment cores (DTX4 and DTX10) in the East Tiaoxi River Plain, south Taihu Plain, were collected, and analysed for radiocarbon dating, diatoms, organic carbon and nitrogen stable isotopes (δ13C and δ15N), grain size and lithology. These multiproxy analyses revealed that prior to ca. 7500 cal. yr BP, the East Tiaoxi River Plain was a rapidly aggrading high-salinity estuary (the Palaeo-Taihu Estuary). After ca. 7500 cal. yr BP, low salinity conditions prevailed as a result of strong Yangtze freshwater discharge. Subsequently, seawater penetration occurred and saltmarsh developed between ca. 7000 and 6500 cal. yr BP due to accelerated relative sea-level rise. This transgression event influenced a large area of the Taihu Plain during the Holocene, as shown by multiple sediment records from previous studies. Persistent freshwater marsh (or subaerial land) formed due to dramatic shrinkage/closure of the Palaeo-Taihu Estuary after ca. 5600 cal. yr BP when sea level was relatively stable. We speculate that morphological and hydrological changes of the East Tiaoxi River Plain played an important role in agricultural development across the Taihu Plain during the Neolithic period. The closure of the Palaeo-Taihu Estuary and the formation of stable freshwater marsh (or subaerial land) after ca. 5600 cal. yr BP were critical preconditions encouraging the rapid rise of rice productivity in the Liangzhu period (5500-4500 cal. yr BP). This development changed the landscape and river systems, and thus provided adequate freshwater supply to the Taihu Plain

Survey, Excavation, and Geophysics at Songjiaheba—A Small Bronze Age Site in the Chengdu Plain

Archaeological survey in the Chengdu Plain of Sichuan Province has revealed settlement patterns surrounding Late Neolithic walled sites, including large numbers of small settlements from the Neolithic, Bronze Age, and Han Dynasty eras. Here geophysical survey and excavation at one of these small-scale sites dating to the Middle Bronze Age are reported, showing for the first time the value of high-resolution geophysics for evaluating site size and integrity in the Chengdu region

Investigating ancient landscapes and settlement patterns in the Chengdu Plain, Sichuan, China

Introduction This paper introduces an integrated survey methodology that is being employed by the Chengdu Plain Archaeological Survey (CPAS) to examine settlement patterns in the context of natural and social landscapes in Sichuan Province, China. The discoveries of the Bronze Age sites of Sangxingdui and Jinsha in the Chengdu Plain have raised questions about the emergence of a complex society in this region, especially as it compares with other societies in the Yellow River valley in Northe..

Middle Holocene marine flooding and human response in the south Yangtze coastal plain, East China

Coastal flooding catastrophes have affected human societies on coastal plains around the world on several occasions in the past, and are threatening 21st century societies under global warming and sea-level rise. However, the role of coastal flooding in the interruption of the Neolithic Liangzhu culture in the lower Yangtze valley, East China coast has been long contested. In this study, we used a well-dated Neolithic site (the Yushan site) close to the present coastline to demonstrate a marine drowning event at the terminal stage of the Liangzhu culture and discuss its linkage to relative sea-level rise. We analysed sedimentology, chronology, organic elemental composition, diatoms and dinoflagellate cysts for several typical profiles at the Yushan site. The field and sedimentary data provided clear evidence of a palaeo-typhoon event that overwhelmed the Yushan site at ∼2560 BCE, which heralded a period of marine inundation and ecological deterioration at the site. We also infer an acceleration in sea-level rise at 2560–2440 BCE from the sedimentary records at Yushan, which explains the widespread signatures of coastal flooding across the south Yangtze coastal plain at that time. The timing of this mid-Holocene coastal flooding coincided with the sudden disappearance of the advanced and widespread Liangzhu culture along the lower Yangtze valley. We infer that extreme events and flooding accompanying accelerated sea-level rise were major causes of vulnerability for prehistoric coastal societies

Survey, Excavation, and Geophysics at Songjiaheba—A Small Bronze Age Site in the Chengdu Plain

The Chengdu 成都 Plain, in the northwest corner of the Sichuan 四川Basin (Figure 1), was the setting for the emergence of a complex civilization in the second millennium BC. This civilization is most notably associated with the site of Sanxingdui 三星堆, in Guanghan 廣漢, where two sacrificial pits discovered in 1986 revealed a rich and unexpected collection of jade objects, ceramics, elephant tusks, and elaborate bronze and gold objects (Bagley 2001; Flad 2012; Sichuan 1999). The discovery of the Sanxingdui pits was followed by research at other sites in the Chengdu Plain, including several loci in the city of Chengdu that post-date Sanxingdui, such as an elite residential location called Shi’erqiao 十二橋 (Sichuan et al. 1987; Jiang 1998), a zone of ritual deposits, cemeteries, and settlement areas named Jinsha 金沙 (Chengdu Institute 2006; Chengdu & Beijing 2002; Zhu et al. 2003), and Shangyejie 商業街, a Late Bronze Age elite burial site with large log coffins filled with lacquers and other elite objects (Chengdu 2002). Based on the excavations of these sites, we now know that bronze-producing communities that commanded multi-community networks of resource acquisition existed in the 2 Chengdu Plain starting at least as early as the middle of the second millennium BC (Flad and Chen 2013).Anthropolog

Tripterygium glycosides sensitizes cisplatin chemotherapeutic potency by modulating gut microbiota in epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is a fatal gynecological malignancy with limited therapeutic options. Previous research has demonstrated that Tripterygium glycosides (GTW) can enhance effectiveness of cisplatin (DDP) chemotherapy against EOC. However, the underlying mechanism of GTW alleviating EOC still remains unclear. In this article, an ID8 cell-derived xenograft mouse model was established to evaluate the anti-tumor efficacy of GTW combined with DDP. Consistent with previous findings, the results suggested that GTW combined with DDP can exhibit a stronger tumor suppressive effect than DDP alone. Additionally, GTW was found can further exert gastrointestinal protection against DDP by reducing pathological damage on colon tissue. Secondly, to verify whether gut microbiota play an instrumental role in GTW’s anticancer effect, we treated mice models with antibiotic to eliminate gut microbiota. And our experimental results indicated that all drug groups showed a weaker tumor suppressive effect and more severe gastrointestinal damage post antibiotic supplement. At genus level, the relative abundance of Lactobacillus was dramatically diminished by the antibiotic treatment, while combined treatment of GTW and DDP can significantly restore the level. Moreover, we performed Lactobacillus acidophilus transplantation and healthy mice fecal microbiota transplantation experiments to further investigate the link between the anticancer effect of GTW and gut microbiota. Our results suggested that both cisplatin-sensitizing and intestinal barrier-protecting effects of GTW can be recovered to a different extent. In conclusion, our results indicated that GTW is a promising chemosensitization and intestinal barrier repair drug for EOC, and the potential mechanism may corelate with the restoration of the compromised intestinal microbial balance

ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance

Cell dormancy is a widespread mechanism used by bacteria to evade environmental threats including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth at the single-cell level and found that each individual survival cell shows different ‘dormancy depth’, which in return regulates the lag time for cell resuscitation after removal of antibiotic. We further established that protein aggresome - a collection of endogenous protein aggregates - is an important indicator of bacterial dormancy depth, whose formation is promoted by decreased cellular ATP level. For cells to leave the dormant state and resuscitate, clearance of protein aggresome and recovery of proteostasis are required. We revealed the ability to recruit functional DnaK-ClpB machineries, which facilitate protein disaggregation in an ATP-dependent manner, determines the lag time for bacterial regrowth. Better understanding of the key factors regulating bacterial regrowth after surviving antibiotic attack could lead to new therapeutic strategies for combating bacterial antibiotic tolerance

Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis