4 research outputs found
High-mobility group box 1 is a promising diagnostic and therapeutic monitoring biomarker in Cancers: A review
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No full textElucidating the novel biomarker and therapeutic potentials of High-mobility group box 1 in Subarachnoid hemorrhage: A review
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No full textInterrelationship of Autophagy and Oxidative Stress in Malignant Transformation of Oral Submucous Fibrosis
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No full textGenetic studies of body mass index yield new insights for obesity biology
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- Salumets A
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- Sanghera DK
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- Scheffold T
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- Schlessinger D
- Schlessinger David
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- Schreiber S
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- Schumacher Fredrick R.
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- Schunkert H
- Schunkert H
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- Schunkert Heribert
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- Schwartz SM
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- Schwarz PE
- Schwarz PE
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- Sennblad B
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- Seshadri S
- Seufferlein Thomas
- Sever Peter
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- Shah S
- Shah SH
- Sharma P
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- Sheu WH
- Shi G
- Shi Jianxin
- Shin SY
- Shin SY
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- Shrine NR
- Shriner D
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- Shuldiner AR
- Shuldiner AR
- Shuldiner AR
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- Soranzo N
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- Takahashi Atsushi
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- Tanaka Toshihiro
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- van der Schoot CE
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- Völker U
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- Wareham N
- Wareham NJ
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- Warrington NM
- Watanabe RM
- Waterworth D
- Waterworth D
- Waterworth DM
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- Waterworth Dawn
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- Wells GA
- Westra Harm-Jan
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- Wheeler HE
- Whincup PH
- Whitfield JB
- Wichmann H
- Wichmann HE
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- Wichmann HE
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- Wichmann HE
- Wichmann H.-Erich
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- Widen E
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- Willemsen Gonneke
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- Willenborg Christina
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- Willer CJ
- Willer Cristen J.
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- Wilsgaard Tom
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- Wilson JF
- Wilson JF
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- Wilson S
- Wilson James F.
- Winkler Thomas W.
- Witteman JC
- Witteman JC
- Witteman Jacqueline C.
- Wojczynski Mary K.
- Wolffenbuttel BH
- Wolffenbuttel BH
- Wolffenbuttel BH
- Wong A
- Wong A
- Wong TY
- Wong Andrew
- Wood Andrew R.
- Workalemahu Tsegaselassie
- Wright AF
- Wright AF
- Wright AF
- Wright AF
- Wright AF
- Wright BJ
- Wright Alan F.
- Wu C
- Wu Y
- Wu Y
- Wu Y
- Würtz P
- Xie C
- Yajnik CS
- Yang Q
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- Yang Jian
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- Young A
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- Zanen Pieter
- Zelenika D
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- Zemunik T
- Zerbini G
- Zgaga L
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- Zhai G
- Zhai G
- Zhai G
- Zhang F
- Zhang W
- Zhang W
- Zhang W
- Zhang Qunyuan
- Zhang Weihua
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao JH
- Zhao W
- Zhao Jing Hua
- Zhao Wei
- Zheng W
- Zheng Wei
- Zhu H
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- Zhuang WV
- Zhuang WV
- Ziegler A
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- Zillikens MC
- Zillikens M. Carola
- Zimmermann ME
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- Zondervan KT
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- Zonzin P
- Zukowska-Szczechowska E
- Zygmunt M
- Ärnlöv J
- Ärnlöv Johan
- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
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Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
