MiCroKit 3.0: an integrated database of midbody, centrosome and kinetochore

During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle pole, kinetochore/centromere and midbody/cleavage furrow/phragmoplast/bud neck, and modulates cell division process faithfully. Although many experimental efforts have been carried out to investigate the characteristics of these proteins, no integrated database was available. Here, we present the MiCroKit database (http://microkit.biocuckoo.org) of proteins that localize in midbody, centrosome and/or kinetochore. We collected into the MiCroKit database experimentally verified microkit proteins from the scientific literature that have unambiguous supportive evidence for subcellular localization under fluorescent microscope. The current version of MiCroKit 3.0 provides detailed information for 1489 microkit proteins from seven model organisms, including Saccharomyces cerevisiae, Schizasaccharomyces pombe, Caenorhabditis elegans, Drosophila melanogaster, Xenopus laevis, Mus musculus and Homo sapiens. Moreover, the orthologous information was provided for these microkit proteins, and could be a useful resource for further experimental identification. The online service of MiCroKit database was implemented in PHP + MySQL + JavaScript, while the local packages were developed in JAVA 1.5 (J2SE 5.0)

Observation of many-body Fock space dynamics in two dimensions

Quantum many-body simulation provides a straightforward way to understand fundamental physics and connect with quantum information applications. However, suffering from exponentially growing Hilbert space size, characterization in terms of few-body probes in real space is often insufficient to tackle challenging problems such as quantum critical behavior and many-body localization (MBL) in higher dimensions. Here, we experimentally employ a new paradigm on a superconducting quantum processor, exploring such elusive questions from a Fock space view: mapping the many-body system onto an unconventional Anderson model on a complex Fock space network of many-body states. By observing the wave packet propagating in Fock space and the emergence of a statistical ergodic ensemble, we reveal a fresh picture for characterizing representative many-body dynamics: thermalization, localization, and scarring. In addition, we observe a quantum critical regime of anomalously enhanced wave packet width and deduce a critical point from the maximum wave packet fluctuations, which lend support for the two-dimensional MBL transition in finite-sized systems. Our work unveils a new perspective of exploring many-body physics in Fock space, demonstrating its practical applications on contentious MBL aspects such as criticality and dimensionality. Moreover, the entire protocol is universal and scalable, paving the way to finally solve a broader range of controversial many-body problems on future larger quantum devices.Comment: 8 pages, 4 figures + supplementary informatio

NiFe₂O₄ Nanoparticles/NiFe Layered Double-Hydroxide Nanosheet Heterostructure Array for Efficient Overall Water Splitting at Large Current Densities

Constructing catalysts with new and optimizational chemical components and structures, which can operate well for both the anodic oxygen evolution reaction (OER) and the cathodic hydrogen evolution reaction (HER) at large current densities, is of primary importance in practical water splitting technology. Herein, the NiFe₂O₄ nanoparticles/NiFe layered double hydroxide (LDH) nanosheet heterostructure array on Ni foam was prepared via a simple one-step solvothermal approach. The as-prepared heterostructure array displays high catalytic activity toward the OER with a small overpotential of 213 mV at 100 mA cm^–2 and can afford a current density of 500 mA cm^–2 at an overpotential of 242 mV and 1000 mA cm^–2 at 265 mV. Moreover, it also presents outstanding HER activity, only needing a small overpotential of 101 mV at 10 mA cm^–2, and can drive large current densities of 500 and 750 mA cm^–2 at individual overpotentials of 297 and 314 mV. A two-electrode electrolyzer using NiFe₂O₄ nanoparticles/NiFe LDH nanosheets as both the anode and the cathode implements active overall water splitting, demanding a low voltage of 1.535 V to drive 10 mA cm^–2, and can deliver 500 mA cm^–2 at 1.932 V. The NiFe₂O₄ nanoparticles/NiFe LDH nanosheet array electrodes also show excellent stability against OER, HER, and overall water splitting at large current densities. Significantly, the overall water splitting with NiFe₂O₄ nanoparticles/NiFe LDH nanosheets as both the anode and the cathode can be continuously driven by a battery of only 1.5 V. The intrinsic advantages and strong coupling effects of NiFe₂O₄ nanoparticles and NiFe LDH nanosheets make NiFe₂O₄ nanoparticles/NiFe LDH nanosheet heterostructure array abundant catalytically active sites, high electronic conductivity, and high catalytic reactivity, which remarkably contributed to the catalytic activities for OER, HER, and overall water splitting. Our work can inspire the optimal design of the NiFe bimetallic heterostructure electrocatalyst for application in practical water electrolysis

NiFe₂O₄ Nanoparticles/NiFe Layered Double-Hydroxide Nanosheet Heterostructure Array for Efficient Overall Water Splitting at Large Current Densities

Constructing catalysts with new and optimizational chemical components and structures, which can operate well for both the anodic oxygen evolution reaction (OER) and the cathodic hydrogen evolution reaction (HER) at large current densities, is of primary importance in practical water splitting technology. Herein, the NiFe₂O₄ nanoparticles/NiFe layered double hydroxide (LDH) nanosheet heterostructure array on Ni foam was prepared via a simple one-step solvothermal approach. The as-prepared heterostructure array displays high catalytic activity toward the OER with a small overpotential of 213 mV at 100 mA cm^–2 and can afford a current density of 500 mA cm^–2 at an overpotential of 242 mV and 1000 mA cm^–2 at 265 mV. Moreover, it also presents outstanding HER activity, only needing a small overpotential of 101 mV at 10 mA cm^–2, and can drive large current densities of 500 and 750 mA cm^–2 at individual overpotentials of 297 and 314 mV. A two-electrode electrolyzer using NiFe₂O₄ nanoparticles/NiFe LDH nanosheets as both the anode and the cathode implements active overall water splitting, demanding a low voltage of 1.535 V to drive 10 mA cm^–2, and can deliver 500 mA cm^–2 at 1.932 V. The NiFe₂O₄ nanoparticles/NiFe LDH nanosheet array electrodes also show excellent stability against OER, HER, and overall water splitting at large current densities. Significantly, the overall water splitting with NiFe₂O₄ nanoparticles/NiFe LDH nanosheets as both the anode and the cathode can be continuously driven by a battery of only 1.5 V. The intrinsic advantages and strong coupling effects of NiFe₂O₄ nanoparticles and NiFe LDH nanosheets make NiFe₂O₄ nanoparticles/NiFe LDH nanosheet heterostructure array abundant catalytically active sites, high electronic conductivity, and high catalytic reactivity, which remarkably contributed to the catalytic activities for OER, HER, and overall water splitting. Our work can inspire the optimal design of the NiFe bimetallic heterostructure electrocatalyst for application in practical water electrolysis