Asymptotic Level State Density for Parabosonic Strings

Making use of some results concerning the theory of partitions, relevant in number theory, the complete asymptotic behavior, for large $n$, of the level density of states for a parabosonic string is derived. It is also pointed out the similarity between parabosonic strings and membranes.Comment: 9 pages , LaTe

Interannual variability of gps heights and environmental parameters over europe and the mediterranean area

Vertical deformations of the Earth’s surface result from a host of geophysical and geological processes. Identification and assessment of the induced signals is key to addressing outstanding scientific questions, such as those related to the role played by the changing climate on height variations. This study, focused on the European and Mediterranean area, analyzed the GPS height time series of 114 well-distributed stations with the aim of identifying spatially coherent signals likely related to variations of environmental parameters, such as atmospheric surface pressure (SP) and terrestrial water storage (TWS). Linear trends and seasonality were removed from all the time series before applying the principal component analysis (PCA) to identify the main patterns of the space/time interannual variability. Coherent height variations on timescales of about 5 and 10 years were identified by the first and second mode, respectively. They were explained by invoking loading of the crust. Single-value decomposition (SVD) was used to study the coupled interannual space/time variability between the variable pairs GPS height–SP and GPS height–TWS. A decadal timescale was identified that related height and TWS variations. Features common to the height series and to those of a few climate indices—namely, the Arctic Oscillation (AO), the North Atlantic Oscillation (NAO), the East Atlantic (EA), and the multivariate El Niño Southern Oscillation (ENSO) index (MEI)—were also investigated. We found significant correlations only with the MEI. The first height PCA mode of variability, showing a nearly 5-year fluctuation, was anticorrelated (– 0.23) with MEI. The second mode, characterized by a decadal fluctuation, was well correlated (+0.58) with MEI; the spatial distribution of the correlation revealed, for Europe and the Mediterranean area, height decrease till 2015, followed by increase, while Scandinavian and Baltic countries showed the opposite behavior

Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect

Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by tubulo-interstitial fibrosis. Ten days before and during the experimental periods, low-salt diet was administered to Sprague Dawley rats. Cyclosporine-A (15mg/kg/day, i.p.) and cyclosporine-A plus C21 (0.3 mg/kg /day, i.p) were administered for 1 and 4 weeks. Control groups was left without any treatment. Blood pressure (plethysmographic method) and 24 hour albuminuria were measured once a week. At the end of the experiments, the kidneys were excised for histomorphometric analysis of renal fibrosis and for immunohistochemical evaluation of inflammatory infiltrates and type I and IV collagen expression.After 1 and 4 weeks, the rats treated with cyclosporine showed a significant increase (p <0.01) in blood pressure, no significant changes in albuminuria, a significant increase (p <0.01) in glomerular and tubulo-interstitial fibrosis and inflammatory infiltrates as compared to the control rats. Treatment with C21 did not modify the cyclosporine dependent increase of blood pressure, which was higher than in control rats, but after 4 weeks of treatment significantly reduced (p <0.01) glomerular and tubulo-interstitial fibrosis, type 1 collagen expression and macrophage infiltration, as compared to rats treated with cyclosporine.The administration of C21 showed a protective effect on cyclosporine nephropathy, decreasing renal fibrosis and macrophage infiltration. These data suggest that C21 may counteract tubulo-interstitial fibrosis, the most potent predictor of the progression of renal diseases

Organic and healthy: assessing the impact of claims and third-party certifications on premium price

Organic food consumption is steadily growing across a variety of product categories. While consumers are increasingly focused on the healthiness of the food they purchase, companies are experimenting alternative ways to communicate and guarantee the organic and health-related benefits of their products. This study explores the effect of different combinations of front-of-package (FoP) components on premium price. Specifically, we focus on the interaction and visual salience of FoP organic claims, health-related claims, and third-party organic certifications. Based on an analysis of grocery sales data and product packaging visuals, the study identifies FoP component combinations that could maximise premiums. We offer insights to marketing managers and companies involved in enhancing the communication of organic food benefits to consumers

Bulk versus brane running couplings

A simplified higher dimensional Randall-Sundrum-like model in 6 dimensions is considered. It has been observed previously by Goldberger and Wise that in such a self-interacting scalar theory on the bulk with a conical singularity there is mixing of renormalization of 4d brane couplings with that of the bulk couplings. We study the influence of the running bulk couplings on the running of the 4d brane couplings. We find that bulk quantum effects may completely alter the running of brane couplings. In particular, the structure of the Landau pole may be drastically altered and non-asymptotically free running may turn into asymptotically safe (or free) behavior.Comment: 11 pages, no figures, REVTeX

Synergism and negative interference during co-infection of tomato and Nicotiana benthamiana with two bipartite begomoviruses

In Brazil, at least eight begomoviruses including Tomato rugose mosaic virus (ToRMV) and Tomato yellow spot virus (ToYSV) infect tomatoes. ToYSV symptoms in tomato and Nicotiana benthamiana appear earlier and are more severe compared to those of ToRMV. We investigated the role of several factors in this differential adaptation. To analyze infection kinetics, a single leaf was inoculated and subsequently detached after different periods of time. Viral DNA accumulation was quantified in plants, viral replication was analyzed in protoplasts, and tissue tropism was determined by in situ hybridization. Results indicate that ToYSV establishes a systemic infection and reaches a higher concentration earlier than ToRMV in both hosts. ToRMV negatively interferes with ToYSV during the initial stages of infection, but once systemic infection is established this interference ceases. In N. benthamiana, ToYSV invades the mesophyll, while ToRMV is phloem-restricted. During dual infection in this host, ToYSV releases ToRMV from the phloem

Occurrence of geminivirus in tomato-producing areas in Submedio Sao Francisco.

This is the first report of geminivirus in Submedio Sao Francisco and reveals a wide dispersal of this virus that was previously described in the Federal District (1994) and state of Sao Paulo (1997), Minas Gerais (1996) and Bahia (1996).Suplemento. Edição dos Resumos do 30 Congresso Brasileiro de Fitopatologia, Poços de Caldas, 1997

Hydrogeological behaviour and geochemical features of waters in evaporite-bearing low-permeability successions: A case study in Southern Sicily, Italy

Knowledge about the hydrogeological behaviour of heterogeneous low-permeability media is an important tool when designing anthropogenic works (e.g., landfills) that could potentially have negative impacts on the environment and on people’s health. The knowledge about the biogeochemical processes in these media could prevent “false positives” when studying groundwater quality and possible contamination caused by anthropogenic activities. In this research, we firstly refined knowledge about the groundwater flow field at a representative site where the groundwater flows within an evaporite-bearing low-permeability succession. Hydraulic measurements and tritium analyses demonstrated the coexistence of relatively brief to very prolonged groundwater pathways. The groundwater is recharged by local precipitation, as demonstrated by stable isotopes investigations. However, relatively deep groundwater is clearly linked to very high tritium content rainwater precipitated during the 1950s and 1960s. The deuterium content of some groundwater samples showed unusual values, explained by the interactions between the groundwater and certain gases (H2S and CH4), the presences of which are linked to sulfate-reducing bacteria and methanogenic archaea detected within the saturated medium through biomolecular investigations in the shallow organic reach clayey deposits. In a wider, methodological context, the present study demonstrates that interdisciplinary approaches provide better knowledge about the behaviour of heterogeneous low-permeability media and the meaning of each data type

in silico verification and parallel reaction monitoring prevalidation of potential prostate cancer biomarkers

Purpose: Targeted proteomics of potential biomarkers is often challenging. Hence, we developed an intermediate workflow to streamline potential urinary biomarkers of prostate cancer (PCa). Materials & methods: Using previously discovered potential PCa biomarkers; we selected proteotypic peptides for targeted validation. Preliminary in silico immunohistochemical and single reaction monitoring (SRM) verification was performed. Successful PTPs were then prevalidated using parallel reaction monitoring (PRM) and reconfirmed in 15 publicly available databases. Results: Stringency-based targetable potential biomarkers were shortlisted following in silico screening. PRM reveals top 12 potential biomarkers including the top ranking seven in silico verification-based biomarkers. Database reconfirmation showed differential expression between PCa and benign/normal prostatic urine samples. Conclusion: The pragmatic penultimate screening step, described herein, would immensely improve targeted proteomics validation of ..