861 research outputs found

    Questioning a ā€œone size fits allā€ city brand: Developing a branded house strategy for place brand management

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    Purpose: City branding has gained popularity as governance strategy. However, the academic underpinning is still poor, and city branding needs a more critical conceptualization, as well as more complex management systems. This paper the use of a ā€œone size fits allā€ city brand, which is still common practice in many places. The paper proposes that city branding involves much more complexity than is commonly thought and outlines a strategy that enables urban policy-makers, marketing researchers and (place) marketers alike to better deal with city branding. Design/methodology/approach: The authors integrate insights from literature on place branding, brand architecture and customer-focused marketing. Findings: The article argues that place brands (in general and communicated place brands in particular) are by definition very complex, due to their different target groups, diverse place offerings and various associations place customers could have. Thus, an advanced brand management including target group-specific sub-brands is needed. Practical implications: The model will be helpful for place brand managers dealing with a diverse target audience, and is likely to improve the target group-specific communication. Originality/value: The paper provides an insight into the complexity of city brands and acknowledges that the perception of city brands can differ considerably among different target groups. Additionally, it offers a more comprehensive definition of place brands. This will be helpful for city brand managers and researchers alike in dealing with city brand complexity

    Total invtravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery

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    Sixteen captive female red deer were successfully anesthetized to surgically implant a telemetry system. The deer were immobilized with (meanĀ±SD) 1.79Ā±0.29 mg/kg xylazine and 1.79Ā±0.29 mg/kg tiletamine/zolazepam given intramuscularly with a dart gun. Anesthesia was maintained for 69Ā±2 min using a total intravenous protocol with a catheter placed in the jugular vein. Group X received xylazine (0.5Ā±0.055 mg/kg/hr) and group D, detomidine (2Ā±0.22 Āµg/kg/hr), both in combination with ketamine (2Ā±0.02 mg/kg/hr) and midazolam (0.03Ā±0.0033 mg/kg/hr), as a constant rate infusion. Anesthesia was reversed with 0.09Ā±0.01 mg/kg atipamezole and 8.7Ā±1.21 Āµg/kg sarmazenil given intravenously in both groups. These drug combinations provided smooth induction, stable anesthesia for surgery, and rapid recovery. Respiratory depression and mild hypoxemia were seen, and we, therefore, recommend using supplemental intranasal oxygen

    Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway

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    Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. These residues are recognized by E3 ubiquitin ligases called N-recognins. Ubr1 is the N-recognin of the yeast Saccharomyces cerevisiae. Extracellular amino acids or short peptides up-regulate the peptide transporter gene PTR2, thereby increasing the capacity of a cell to import peptides. Cup9 is a transcriptional repressor that down-regulates PTR2. The induction of PTR2 by peptides or amino acids involves accelerated degradation of Cup9 by the N-end rule pathway. We report here that the Ubr1 N-recognin, which conditionally targets Cup9 for degradation, is phosphorylated in vivo at multiple sites, including Ser300 and Tyr277. We also show that the type-I casein kinases Yck1 and Yck2 phosphorylate Ubr1 on Ser300, and thereby make possible (ā€œprimeā€) the subsequent (presumably sequential) phosphorylations of Ubr1 on Ser296, Ser292, Thr288, and Tyr277 by Mck1, a kinase of the glycogen synthase kinase 3 (Gsk3) family. Phosphorylation of Ubr1 on Tyr277 by Mck1 is a previously undescribed example of a cascade-based tyrosine phosphorylation by a Gsk3-type kinase outside of autophosphorylation. We show that the Yck1/Yck2-mediated phosphorylation of Ubr1 on Ser300 plays a major role in the control of peptide import by the N-end rule pathway. In contrast to phosphorylation on Ser300, the subsequent (primed) phosphorylations, including the one on Tyr277, have at most minor effects on the known properties of Ubr1, including regulation of peptide import. Thus, a biological role of the rest of Ubr1 phosphorylation cascade remains to be identified

    The Dilemma of Authentic Tourist Experiences and Residential Life in Urban Areas

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    Traditionally, tourists spend their holidays in tourist spaces that provide the needed infrastructure for their experiences (i.e., hotels, restaurants, sight-seeing spots). However, nowadays tourists often occupy more residential space than in the past; this development is fuelled at least by two important trends in tourism. First, destination marketing organizations (DMOā€™s) increasingly seek to intertwine touristsā€˜ paths with local neighbourhood in order to create perceived tourist authenticity (e.g. the ā€˜localhoodā€™ strategy of various city tourism organizations; Wonderful Copenhagen, 2017). Second, shared economy offerings, such as Airbnb, create tourist spaces in residential areas (Gutierrez et al., 2017). Both developments result in the integration of tourists into the residentsā€™ living sphere, and anecdotal evidence indicates that this does not come without fraction between residents and tourists (e.g., Andereck et al., 2005; Gutierrez et al., 2017; Yang et al., 2013)

    Use numbers not words! Communicating hotelsā€™ cleaning programs for COVID-19 from the brand perspective

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    After hotels in many countries were forced to close in government-imposed lockdowns during the COVID-19 pandemic, there is an inherent need to communicate how they deal with the coronavirus to motivate guests to visit. However, lack of knowledge about how to persuasively communicate about hotelsā€™ cleaning programs for COVID-19 can challenge the industry's survival. We investigated how hotels that position their brand as a particular personality (sincere vs. exciting) could benefit from different communication styles (inclusion of numerical vs. verbal quantifiers) when presenting their COVID-19 cleaning procedures. Study 1 explored touristsā€™ central attitudinal responses toward hotelsā€™ cleaning programs. Study 2 demonstrated that sincere hotel brands would benefit from using numerical and verbal quantifiers to communicate their cleaning policies, whereas exciting hotel brands would benefit only from numerical quantifiers. Our results invite hotel managers to use their brand personality positioning to influence touristsā€™ attitudes and intentions in a pandemic context

    Oral HRAS Mutation in Orofacial Nevus Sebaceous Syndrome (Schimmelpenning-Feuerstein-Mims-Syndrome): A Case Report With a Literature Survey

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    Background/Aim: The aim of this study was to present the long-term course of a patient with nevus sebaceous syndrome (NSS). Recent genetic studies place the syndrome in the emerging group of so-called RASopathies. The focus of the report is on surgical treatment and morphological and genetic findings of the face and oral cavity. Case Report: A female patient was treated for congenital alterations of facial skin and oral mucosa. The oral lesions were removed repeatedly. Eruption of teeth on the lesion sites was made easier by the measures taken. However, after repeated ablation of the affected gingiva, the periodontal papillomatous epithelium re-differentiated into the same reddish, conspicuous, hyperplastic epithelium. The teeth in the affected region showed noticeable changes in position, surface, and shape. A HRAS mutation was detected only in the regions of altered oral epithelia and not in adjacent soft tissues. Conclusion: Reports on NSS rarely address oral manifestations. The recorded alterations of oral soft and hard tissues in NSS indicate a topographical relationship between the development of oral mucosa and teeth as well as the long-lasting impact of a sporadic mutation on organ development at this site

    Post-holiday memory work: Everyday encounters with fridge magnets

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    While souvenirs have generated considerable interest within tourism research, less attention has been paid to their post-holiday ā€˜afterlifeā€™. Utilising perspectives from memory research and more-than-representational theory, this paper focuses on interactions with a ubiquitous souvenir: the fridge magnet. Drawing on semi-structured interviews we illustrate how, because of their embeddedness within everyday domestic rhythms, magnets are active agents in the stimulation of post-holiday memory work. We show how magnets work to generate and protect memories, triggering a diversity of (usually positive) emotional and affective responses. They can also be associated with ambivalent memories; with their role sometimes being more about forgetting. Although being seemingly banal objects, fridge magnets have a complex capacity to affect everyday life long after a holiday ends

    Linear response within the projection-based renormalization method: Many-body corrections beyond the random phase approximation

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    The explicit evaluation of linear response coefficients for interacting many-particle systems still poses a considerable challenge to theoreticians. In this work we use a novel many-particle renormalization technique, the so-called projector-based renormalization method, to show how such coefficients can systematically be evaluated. To demonstrate the prospects and power of our approach we consider the dynamical wave-vector dependent spin susceptibility of the two-dimensional Hubbard model and also determine the subsequent magnetic phase diagram close to half-filling. We show that the superior treatment of (Coulomb) correlation and fluctuation effects within the projector-based renormalization method significantly improves the standard random phase approximation results.Comment: 17 pages, 7 figures, revised versio

    Place branding: Are we wasting our time? Report of an AMA special session

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    Ā© Emerald Group Publishing Limited.Purpose ā€“ The purpose of this paper is to report on a special session entitled ā€œPlace branding: Are we wasting our time?ā€, held at the American Marketing Associationā€™s Summer Marketing Educatorsā€™ conference in 2014. Design/methodology/approach ā€“ The report details the outcome of an Oxford-style debate with two opposing teams of two persons ā€“ one team supporting and one team opposing the motion. The opening speaker of each team had 10 minutes to put their case across, and the closing speaker had 8 minutes. Teams took to the stand alternately, matching up against each otherā€™s arguments. Findings ā€“ The outcome of the debate points towards a need for place brands to develop as more inclusive and organic entities, in which case it may be best for place practitioners to avoid creating and imposing a place brand and instead help shape it from the views of stakeholder constituencies. This shifts the notion of place branding towards an activity centred on ā€œcurationā€. Originality/value ā€“ The use of a competitive debating format as a means for exploring academic ideas and concepts in the place management field
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