190 research outputs found
Statistical properties of Pu, and Pu(n,) cross section calculation
The level density and gamma-ray strength function (gammaSF) of 243Pu have
been measured in the quasi-continuum using the Oslo method. Excited states in
243Pu were populated using the 242Pu(d,p) reaction. The level density closely
follows the constant-temperature level density formula for excitation energies
above the pairing gap. The gammaSF displays a double-humped resonance at low
energy as also seen in previous investigations of actinide isotopes. The
structure is interpreted as the scissors resonance and has a centroid of
omega_{SR}=2.42(5)MeV and a total strength of B_{SR}=10.1(15)mu_N^2, which is
in excellent agreement with sum-rule estimates. The measured level density and
gammaSF were used to calculate the 242Pu(n,gamma) cross section in a neutron
energy range for which there were previously no measured data.Comment: 9 pages, 8 figure
Statistical properties of the well deformed Sm nuclei and the scissors resonance
The Nuclear Level Densities (NLDs) and the -ray Strength Functions
(SFs) of Sm have been extracted from (d,p)
coincidences using the Oslo method. The experimental NLD of Sm is
higher than the NLD of Sm, in accordance with microscopic calculations.
The SFs of Sm are in fair agreement with QRPA calculations
based on the D1M Gogny interaction. An enhancement is observed in the
SF for both Sm nuclei around 3 MeV in excitation energy and
is attributed to the M1 Scissors Resonance (SR). Their integrated strengths
were found to be in the range 1.3 - 2.1 and 4.4 - 6.4 for
Sm and Sm, respectively. The strength of the SR for Sm
is comparable to those for deformed even-even Sm isotopes from nuclear
resonance fluorescence measurements, while that of Sm is lower than
expected
Nuclear Level Density and -ray Strength Function of and the impact on the i-process
Proton- coincidences from reactions between
a beam and a deuterated polyethylene target have been
analyzed with the inverse Oslo method to find the nuclear level density (NLD)
and -ray strength function (SF) of . The
capture cross section has been calculated
using the Hauser-Feshbach model in TALYS using the measured NLD and SF
as constraints. We confirm that acts as a
bottleneck when relying on one-zone nucleosynthesis calculations. However, we
find that the impact of this reaction is strongly damped in multi-zone
low-metallicity AGB stellar models experiencing i-process nucleosynthesis.Comment: Submitted to Phys. Rev.
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model
IRX-2, a natural cytokine biological with multiple components, has been used in preclinical and clinical studies to promote antitumor activity of T lymphocytes. To define cellular mechanisms responsible for antitumor effects of IRX-2, its ability to induce effector T cells (Teff) was examined in a model simulating the tumor microenvironment. An in vitro model containing conventional CD4+CD25− cells co-cultured with autologous immature dendritic cells, irradiated tumor cells, and cytokines was used to study differentiation and expansion of regulatory T cells (Treg) and Teff in the presence and absence of IRX-2. Phenotype, suppressor function, signaling, and cytokine production were serially measured using flow cytometry, Western blots, CFSE-based suppressor assays, and Luminex-based analyses. The presence of IRX-2 in the co-cultures promoted the induction and expansion of IFN-γ+Tbet+ Teff and significantly (p < 0.01) decreased the induction of inducible IL-10+TGF-β+ Treg. The responsible mechanism involved IFN-γ-driven T cell polarization towards Teff and suppression of Treg differentiation. In an in vitro model simulating the human tumor microenvironment, IRX-2 promoted Teff expansion and antitumor activity without inducing Treg. Thus, IRX-2 could be considered as a promising component of future antitumor therapies
Computational Models of the Notch Network Elucidate Mechanisms of Context-dependent Signaling
The Notch signaling pathway controls numerous cell fate decisions during development and adulthood through diverse mechanisms. Thus, whereas it functions as an oscillator during somitogenesis, it can mediate an all-or-none cell fate switch to influence pattern formation in various tissues during development. Furthermore, while in some contexts continuous Notch signaling is required, in others a transient Notch signal is sufficient to influence cell fate decisions. However, the signaling mechanisms that underlie these diverse behaviors in different cellular contexts have not been understood. Notch1 along with two downstream transcription factors hes1 and RBP-Jk forms an intricate network of positive and negative feedback loops, and we have implemented a systems biology approach to computationally study this gene regulation network. Our results indicate that the system exhibits bistability and is capable of switching states at a critical level of Notch signaling initiated by its ligand Delta in a particular range of parameter values. In this mode, transient activation of Delta is also capable of inducing prolonged high expression of Hes1, mimicking the “ON” state depending on the intensity and duration of the signal. Furthermore, this system is highly sensitive to certain model parameters and can transition from functioning as a bistable switch to an oscillator by tuning a single parameter value. This parameter, the transcriptional repression constant of hes1, can thus qualitatively govern the behavior of the signaling network. In addition, we find that the system is able to dampen and reduce the effects of biological noise that arise from stochastic effects in gene expression for systems that respond quickly to Notch signaling
The potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy
Our progress in understanding pathological disease mechanisms has led to the identification of biomarkers that have had a considerable impact on clinical practice. It is hoped that the move from generalized to stratified approaches, with the grouping of patients into clinical/therapeutic subgroups according to specific biomarkers, will lead to increasingly more effective clinical treatments in the near future. This success depends on the identification of biomarkers that reflect disease evolution and can be used to predict disease state and therapy response, or represent themselves a target for treatment. Biomarkers can be identified by studying relationships between serum, tissue, or tumor microenvironment parameters and clinical or therapeutic parameters at onset and during the progression of the disease, using systems biology. Given that multiple pathways, such as those responsible for redox and immune regulation, are deregulated or altered in tumors, the future of tumor therapy could lie in the simultaneous targeting of these pathways using extracellular and intracellular targets and biomarkers. With this aim in mind, we evaluated the role of thioredoxin 1, a key redox regulator, and CD30, a cell membrane receptor, in immune regulation. Our results lead us to suggest that the combined use of these biomarkers provides more detailed information concerning the multiple pathways affected in disease and hence the possibility of more effective treatment
Anomalies in the Charge Yields of Fission Fragments from the U(n,f)238 Reaction
Fast-neutron-induced fission of 238U at an energy just above the fission threshold is studied with a novel technique which involves the coupling of a high-efficiency γ-ray spectrometer (MINIBALL) to an inverse-kinematics neutron source (LICORNE) to extract charge yields of fission fragments via γ−γ coincidence spectroscopy. Experimental data and fission models are compared and found to be in reasonable agreement for many nuclei; however, significant discrepancies of up to 600% are observed, particularly for isotopes of Sn and Mo. This indicates that these models significantly overestimate the standard 1 fission mode and suggests that spherical shell effects in the nascent fission fragments are less important for low-energy fast-neutron-induced fission than for thermal neutron-induced fission. This has consequences for understanding and modeling the fission process, for experimental nuclear structure studies of the most neutron-rich nuclei, for future energy applications (e.g., Generation IV reactors which use fast-neutron spectra), and for the reactor antineutrino anomaly
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