Experimental and theoretical analyses of three-dimensional surface crack propagation

2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Assessing the Quality of Reports about Randomized Controlled Trials of Acupuncture Treatment on Diabetic Peripheral Neuropathy

BACKGROUND: To evaluate the reports' qualities which are about randomized controlled trials (RCTs) of acupuncture treatment on Diabetic Peripheral Neuropathy (DPN). METHODOLOGY/PRINCIPAL FINDINGS: Eight databases including The Cochrane Library(1993-Sept.,2011), PubMed (1980-Sept., 2011), EMbase (1980-Sept.,2011), SCI Expanded (1998-Sept.,2011), China Biomedicine Database Disc (CBMdisc, 1978-Sept., 2011), China National Knowledge Infrastructure (CNKI, 1979-Sept., 2011 ), VIP (a full text issues database of China, 1989-Sept., 2011), Wan Fang (another full text issues database of China 1998-Sept., 2011) were searched systematically. Hand search for further references was conducted. Language was limited to Chinese and English. We identified 75 RCTs that used acupuncture as an intervention and assessed the quality of these reports with the Consolidated Standards for Reporting of Trials statement 2010 (CONSORT2010) and Standards for Reporting Interventions Controlled Trials of Acupuncture 2010(STRICTA2010). 24 articles (32%) applied the method of random allocation of sequences. No article gave the description of the mechanism of allocation concealment, no experiment applied the method of blinding. Only one article (1.47%) could be identified directly from its title as about the Randomized Controlled Trials, and only 4 articles gave description of the experimental design. No article mentioned the number of cases lost or eliminated. During one experiment, acupuncture syncope led to temporal interruption of the therapy. Two articles (2.94%) recorded the number of needles, and 8 articles (11.76%) mentioned the depth of needle insertion. None of articles reported the base of calculation of sample size, or has any analysis about the metaphase of an experiment or an explanation of its interruption. One (1.47%) mentioned intentional analysis (ITT). CONCLUSIONS/SIGNIFICANCE: The quality of the reports on RCTs of acupuncture for Diabetic Peripheral Neuropathy is moderate to low. The CONSORT2010 and STRICTA2010 should be used to standardize the reporting of RCTs of acupuncture in future

Genetics, recombination and clinical features of human rhinovirus species C (HRV-C) infections; interactions of HRV-C with other respiratory viruses

To estimate the frequency, molecular epidemiological and clinical associations of infection with the newly described species C variants of human rhinoviruses (HRV), 3243 diagnostic respiratory samples referred for diagnostic testing in Edinburgh were screened using a VP4-encoding region-based selective polymerase chain reaction (PCR) for HRV-C along with parallel PCR testing for 13 other respiratory viruses. HRV-C was the third most frequently detected behind respiratory syncytial virus (RSV) and adenovirus, with 141 infection episodes detected among 1885 subjects over 13 months (7.5%). Infections predominantly targeted the very young (median age 6–12 months; 80% of infections in those <2 years), occurred throughout the year but with peak incidence in early winter months. HRV-C was detected significantly more frequently among subjects with lower (LRT) and upper respiratory tract (URT) disease than controls without respiratory symptoms; HRV-C mono-infections were the second most frequently detected virus (behind RSV) in both disease presentations (6.9% and 7.8% of all cases respectively). HRV variants were classified by VP4/VP2 sequencing into 39 genotypically defined types, increasing the current total worldwide to 60. Through sequence comparisons of the 5′untranslated region (5′UTR), the majority grouped with species A (n = 96; 68%, described as HRV-Ca), the remainder forming a phylogenetically distinct 5′UTR group (HRV-Cc). Multiple and bidirectional recombination events between HRV-Ca and HRV-Cc variants and with HRV species A represents the most parsimonious explanation for their interspersed phylogeny relationships in the VP4/VP2-encoding region. No difference in age distribution, seasonality or disease associations was identified between HRV-Ca and HRV-Cc variants. HRV-C-infected subjects showed markedly reduced detection frequencies of RSV and other respiratory viruses, providing evidence for a major interfering effect of HRV-C on susceptibility to other respiratory virus infections. HRV-C's disease associations, its prevalence and evidence for interfering effects on other respiratory viruses mandates incorporation of rhinoviruses into future diagnostic virology screening

Spin Caloritronics

This is a brief overview of the state of the art of spin caloritronics, the science and technology of controlling heat currents by the electron spin degree of freedom (and vice versa).Comment: To be published in "Spin Current", edited by S. Maekawa, E. Saitoh, S. Valenzuela and Y. Kimura, Oxford University Pres

A multi-perspective dynamic feature concept in adaptive NC machining of complex freeform surfaces

This paper presents a new concept of feature for freeform surface machining that defines the changes in feature status during real manufacturing situations which have not been sufficiently addressed by current international standards and previous research in feature technology. These changes are multi-perspective, including (i) changes in depth-of-cut: the geometry of a feature in the depth-of-cut direction changes during different machining operations such as roughing, semi-finishing and finishing; (ii) changes across the surface: a surface may be divided into different machining regions (effectively sub-features) for the selection of appropriate manufacturing methods for each region such as different cutting tools, parameters, set-ups or machine tools; and (iii) changes in resources or manufacturing capabilities may require the re-planning of depth-of-cuts, division of machining regions and manufacturing operations (machines, tools, set-ups and parameters). Adding the above dynamic information to the part information models in current CAD systems (which only represent the final state of parts) would significantly improve the accuracy, efficiency and timeliness of manufacturing planning and optimisation, especially for the integrated NC machining planning for complex freeform surfaces. A case study in an aircraft manufacturing company will be included in this paper

Terahertz metamaterials on flexible polypropylene substrate

The final publication is available at Springer via http://dx.doi.org/10.1007/s11468-014-9724-1In this work, we present a metamaterial working at terahertz frequencies made over a flexible polypropylene sub-strate. The experimental measurements, in accordance with the numerical calculations, show the metamaterial reliance on the impinging electric field polarization. The structure s symmetry yields purely electrical resonant responses eliminating bianisotropy effects. The widely used bendable polypropylene polymer may promote the insertion of metamaterial-based structures with special electromagnetic response in a number of objects of our daily lives such as textiles, automotive components, and sensingThis work was supported by the Spanish MICINN under contracts CONSOLIDER EMET CSD2008-00066 and TEC2011-28664-C02-02 and by the Universitat Politecnica de Valencia under the program INNOVA 2011.Ortuño Molinero, R.; García Meca, C.; Martínez Abietar, AJ. (2014). Terahertz metamaterials on flexible polypropylene substrate. Plasmonics. 9(5):1143-1147. https://doi.org/10.1007/s11468-014-9724-1S1143114795Smith DR, Padilla WJ, Vier DC, Nemat-Nasser SC, Schultz S (2000) Composite medium with simultaneously negative permeability and permittivity. Phys Rev Lett 84:4184–4187Pendry JB (2000) Negative refraction makes a perfect lens. Phys Rev Lett 85:3966–3969Zhang X, Liu Z (2008) Superlenses to overcome the diffraction limit. Nat Mater 7:435–441Pendry JB, Schurig D, Smith DR (2006) Controlling electromagnetic fields. Science 312:1780–1782Schurig D, Mock JJ, Justice BJ, Cummer SA, Pendry JB, Starr AF, Smith DR (2006) Metamaterial electromagnetic cloak at microwave frequencies. Science 314:977–980Rodríguez-Cantó PJ, Martínez-Marco M, Rodríguez-Fortuño FJ, Tomás-Navarro B, Ortuño R, Peransí-Llopis S, Martínez A (2011) Demonstration of near infrared gas sensing using gold nanodisks on functionalized silicon. Opt Express 19:7664–7672Rodríguez-Fortuño FJ, Martínez-Marco M, Tomás-Navarro B, Ortuño R, Martí J, Martínez A, Rodríguez-Cantó PJ (2011) Highly-sensitive chemical detection in the infrared regime using plasmonic gold nanocrosses. Appl Phys Lett 98:133118O’Hara FJ, Singh R, Brener I, Smirnova E, Han J, Taylor AJ, Zhang W (2008) Thin-film sensing with planar terahertz metamaterials: sensitivity and limitations. Opt Express 16:1786–1795Tao H, Landy NI, Bingham CM, Zhang X, Averitt RD, Padilla WJ (2008) A metamaterial absorber for the terahertz regime: design, fabrication and characterization. Opt Express 16:7181–7188Iwaszczuk K, Strikwerda AC, Fan K, Zhang X, Averitt RD, Jepsen PU (2012) Flexible metamaterial absorbers for stealth applications at terahertz frequencies. Opt Express 20:635–643Tao H, Bingham CM, Strikwerda AC, Pilon D, Shrekenhamer D, Landy NI, Fan K, Zhang X, Padilla WJ, Averitt RD (2008) Highly flexible wide angle of incidence terahertz metamaterial absorber: design, fabrication, and characterization. Phys Rev B 78:241103(R)Tao H, Bingham CM, Pilon D, Fan K, Strikwerda AC, Shrekenhamer D, Padilla WJ, Zhang X, Averitt RD (2010) A dual band terahertz metamaterial absorber. J Phys D: Appl Phys 43:225102Padilla WJ, Taylor AJ, Highstrete C, Lee M, Averitt RD (2006) Dynamical electric and magnetic metamaterial response at terahertz frequencies. Phys Rev Lett 96:107401Chen HT, Padilla WJ, Zide JMO, Gossard AC, Taylor AJ, Averitt RD (2006) Active terahertz metamaterial devices. Nature 444:597–600Chen HT, O’Hara FJ, Azad AK, Taylor AJ, Averitt RD, Shrekenhamer DB, Padilla WJ (2008) Experimental demonstration of frequency-agile terahertz metamaterials. Nature Photon 2:295–298Chen HT, Padilla WJ, Zide JMO, Bank SR, Gossard AC, Taylor AJ, Averitt RD (2007) Ultrafast optical switching of terahertz metamaterials fabricated on ErAs/GaAs nanoisland superlattices. Opt Lett 32:1620–1622Chen HT, Palit S, Tyler T, Bingham CM, Zide JMO, O’Hara FJ, Smith DR, Gossard AC, Averitt RD, Padilla WJ, Jokerst NM, Taylor AJ (2008) Hybrid metamaterials enable fast electrical modulation of freely propagating terahertz waves. Appl Phys Lett 93:091117Chen HT, Padilla WJ, Cich MJ, Azad AK, Averitt RD, Taylor AJ (2009) A metamaterial solid-state terahertz phase modulator. Nat Photon 3:148Driscoll T, Andreev GO, Basov DN, Palit S, Cho SY, Jokerst NM, Smith DR (2007) Tuned permeability in terahertz split-ring resonators for devices and sensors. Appl Phys Lett 91:062511Debus C, Bolivar PH (2007) Frequency selective surfaces for high sensitivity terahertz sensing. Appl Phys Lett 91:184102Al-Naib IAI, Jansen C, Koch M (2008) Thin-film sensing with planar asymmetric metamaterial resonators. Appl Phys Lett 93:083507Leonhardt U, Philbin TG (2010) Geometry and light: the science of invisibility. Dover, MineolaDi Falco A, Ploschner M, Krauss TF (2010) Flexible metamaterials at visible wavelengths. New J Phys 12:113006Tao H, Strikwerda AC, Fan K, Bingham CM, Padilla WJ, Zhang X, Averitt RD (2008) Terahertz metamaterials on free-standing highly-flexible polyimide substrates. Appl Phys 41:232004Tao H, Amsden JJ, Strikwerda AC, Fan K, Kaplan DL, Zhang X, Averitt RD, Omenetto FJ (2010) Metamaterial silk composites at terahertz frequencies. Adv Mater 22:3527–3531Chen ZC, Han NR, Pan ZY, Gong YD, Chong TC, Hong MH (2011) Tunable resonance enhancement of multi-layer terahertz metamaterials fabricated by parallel laser micro-lens array lithography on flexible substrates. Opt Mat Express 1:151–157Miyamaru F, Takeda MW, Taima K (2009) Characterization of terahertz metamaterials fabricated on flexible plastic films: toward fabrication of bulk metamaterials in terahertz region. Appl Phys Express 2:042001Peralta XG, Wanke MC, Arrington CL, Williams JD, Brener I, Strikwerda A, Averitt RD, Padilla WJ, Smirnova W, Taylor AJ, O’Hara FJ (2009) Large-area metamaterials on thin membranes for multilayer and curved applications at terahertz and higher frequencies. Appl Phys Lett 94:161113Choi M, Lee SH, Kim Y, Kang SB, Shin J, Kwak MH, Kang KY, Lee YH, Park N, Min B (2011) A terahertz metamaterial with unnaturally high refractive index. Nature 470:369–373Han NR, Chen ZC, Lim CS, Ng B, Hong MH (2011) Broadband multi-layer terahertz metamaterials fabrication and characterization on flexible substrates. Opt Express 19:6990–6998Aznabet M, Navarro-Cia N, Kuznetsov SA, Gelfand AV, Fedorinina NI, Goncharov YG, Beruete M, Mrabet OE, Sorolla M (2008) Polypropylene-substrate-based SRR- and CSRR- metasurfaces for submillimeter waves. Opt Express 16:18312–18319Padilla WJ, Aronsson MT, Highstrete C, Lee M, Taylor AJ, Averitt RD (2007) Electrically resonant terahertz metamaterials: theoretical and experimental investigations. Phys Rev B 75:041102(R)Chen HT, O’Hara FJ, Taylor AJ, Averitt RD, Highstrete C, Lee M, Padilla WJ (2007) Complementary planar terahertz metamaterials. Opt Express 15:1084–1095Pendry JB, Holden AJ, Robbins DJ, Stewart WJ (1999) Magnetism from conductors and enhanced nonlinear phenomena. IEEE Trans Microwave Theory Tech 47:2075–208

PF-4var/CXCL4L1 Predicts Outcome in Stable Coronary Artery Disease Patients with Preserved Left Ventricular Function

Background: Platelet-derived chemokines are implicated in several aspects of vascular biology. However, for the chemokine platelet factor 4 variant (PF-4var/CXCL4L1), released by platelets during thrombosis and with different properties as compared to PF-4/CXCL4, its role in heart disease is not yet studied. We evaluated the determinants and prognostic value of the platelet-derived chemokines PF-4var, PF-4 and RANTES/CCL5 in patients with stable coronary artery disease (CAD). Methodology/Principal Findings: From 205 consecutive patients with stable CAD and preserved left ventricular (LV) function, blood samples were taken at inclusion and were analyzed for PF-4var, RANTES, platelet factor-4 and N-terminal pro-B-type natriuretic peptide (NT-proBNP). Patients were followed (median follow-up 2.5 years) for the combined endpoint of cardiac death, non-fatal acute myocardial infarction, stroke or hospitalization for heart failure. Independent determinants of PF-4var levels (median 10 ng/ml; interquartile range 8-16 ng/ml) were age, gender and circulating platelet number. Patients who experienced cardiac events (n = 20) during follow-up showed lower levels of PF-4var (8.5 [5.3-10] ng/ml versus 12 [8-16] ng/ml, p = 0.033). ROC analysis for events showed an area under the curve (AUC) of 0.82 (95% CI 0.73-0.90, p<0.001) for higher NT-proBNP levels and an AUC of 0.32 (95% CI 0.19-0.45, p = 0.009) for lower PF-4var levels. Cox proportional hazard analysis showed that PF-4var has an independent prognostic value on top of NT-proBNP. Conclusions: We conclude that low PF-4var/CXCL4L1 levels are associated with a poor outcome in patients with stable CAD and preserved LV function. This prognostic value is independent of NT-proBNP levels, suggesting that both neurohormonal and platelet-related factors determine outcome in these patients

Large-scale Synthesis of β-SiC Nanochains and Their Raman/Photoluminescence Properties

Although the SiC/SiO2 nanochain heterojunction has been synthesized, the chained homogeneous nanostructure of SiC has not been reported before. Herein, the novel β-SiC nanochains are synthesized assisted by the AAO template. The characterized results demonstrate that the nanostructures are constructed by spheres of 25–30 nm and conjoint wires of 15–20 nm in diameters. Raman and photoluminescence measurements are used to explore the unique optical properties. A speed-alternating vapor–solid (SA-VS) growth mechanism is proposed to interpret the formation of this typical nanochains. The achieved nanochains enrich the species of one-dimensional (1D) nanostructures and may hold great potential applications in nanotechnology

A Search for Dark Higgs Bosons

Recent astrophysical and terrestrial experiments have motivated the proposal of a dark sector with GeV-scale gauge boson force carriers and new Higgs bosons. We present a search for a dark Higgs boson using 516 fb-1 of data collected with the BABAR detector. We do not observe a significant signal and we set 90% confidence level upper limits on the product of the Standard Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots for b/w printin