Before the bar:kinematic detection of a spheroidal metal-poor bulge component

We present 947 radial velocities of RR Lyrae variable stars in four fields located toward the Galactic bulge, observed within the data from the ongoing Bulge RR Lyrae Radial Velocity Assay (BRAVA-RR). We show that these RR Lyrae stars (RRLs) exhibit hot kinematics and null or negligible rotation and are therefore members of a separate population from the bar/pseudobulge that currently dominates the mass and luminosity of the inner Galaxy. Our RRLs predate these structures and have metallicities, kinematics, and spatial distribution that are consistent with a "classical" bulge, although we cannot yet completely rule out the possibility that they are the metal-poor tail of a more metal-rich ($[\mathrm{Fe}/{\rm{H}}]\sim -1$ dex) halo–bulge population. The complete catalog of radial velocities for the BRAVA-RR stars is also published electronically

MOA-2011-BLG-028Lb: A Neptune-Mass Microlensing Planet in the Galactic Bulge

We present the discovery of a Neptune-mass planet orbiting a $0.8\pm 0.3M_{\odot}$ star in the Galactic bulge. The planet manifested itself during the microlensing event MOA-2011-BLG-028/OGLE-2011-BLG-0203 as a low-mass companion to the lens star. The analysis of the light curve provides the measurement of the mass ratio $(1.2 \pm 0.2) \times 10^{-4}$, which indicates that the mass of the planet is 12–60 Earth masses. The lensing system is located at 7.3 ± 0.7 kpc away from the Earth near the direction of Baade's Window. The projected separation of the planet at the time of the microlensing event was 3.1–5.2 au. Although the microlens parallax effect is not detected in the light curve of this event, preventing the actual mass measurement, the uncertainties of mass and distance estimation are narrowed by the measurement of the source star proper motion on the OGLE-III images spanning eight years, and by the low amount of blended light seen, proving that the host star cannot be too bright and massive. We also discuss the inclusion of undetected parallax and orbital motion effects into the models and their influence onto the final physical parameters estimates

The role of the complement system in traumatic brain injury: a review

Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do not become irreversible until some time after the start of the cascade. This may present a window of opportunity for therapeutic interventions aiming to improve outcomes subsequent to TBI. A prominent contributor to the secondary injury is a multifaceted inflammatory reaction. The complement system plays a notable role in this inflammatory reaction; however, it has often been overlooked in the context of TBI secondary injury. The complement system has homeostatic functions in the uninjured central nervous system (CNS), playing a part in neurodevelopment as well as having protective functions in the fully developed CNS, including protection from infection and inflammation. In the context of CNS injury, it can have a number of deleterious effects, evidence for which primarily comes not only from animal models but also, to a lesser extent, from human post-mortem studies. In stark contrast to this, complement may also promote neurogenesis and plasticity subsequent to CNS injury. This review aims to explore the role of the complement system in TBI secondary injury, by examining evidence from both clinical and animal studies. We examine whether specific complement activation pathways play more prominent roles in TBI than others. We also explore the potential role of complement in post-TBI neuroprotection and CNS repair/regeneration. Finally, we highlight the therapeutic potential of targeting the complement system in the context of TBI and point out certain areas on which future research is needed

The First Simultaneous Microlensing Observations by Two Space Telescopes: <i>Spitzer</i> and <i>Swift</i> Reveal a Brown Dwarf in Event OGLE-2015-BLG-1319

Simultaneous observations of microlensing events from multiple locations allow for the breaking of degeneracies between the physical properties of the lensing system, specifically by exploring different regions of the lens plane and by directly measuring the “microlens parallax.” We report the discovery of a 30–65MJ brown dwarf orbiting a K dwarf in the microlensing event OGLE-2015-BLG-1319. The system is located at a distance of ∼5 kpc toward the Galactic Bulge. The event was observed by several ground-based groups as well as by Spitzer and Swift, allowing a measurement of the physical properties. However, the event is still subject to an eight-fold degeneracy, in particular the well-known close-wide degeneracy, and thus the projected separation between the two lens components is either ∼0.25 au or ∼45 au. This is the first microlensing event observed by Swift, with the UVOT camera. We study the region of microlensing parameter space to which Swift is sensitive, finding that though Swift could not measure the microlens parallax with respect to ground-based observations for this event, it can be important for other events. Specifically, it is important for detecting nearby brown dwarfs and free-floating planets in high magnification events

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Simple scoring system to predict in-hospital mortality after surgery for infective endocarditis

BACKGROUND: Aspecific scoring systems are used to predict the risk of death postsurgery in patients with infective endocarditis (IE). The purpose of the present study was both to analyze the risk factors for in-hospital death, which complicates surgery for IE, and to create a mortality risk score based on the results of this analysis. METHODS AND RESULTS: Outcomes of 361 consecutive patients (mean age, 59.1\ub115.4 years) who had undergone surgery for IE in 8 European centers of cardiac surgery were recorded prospectively, and a risk factor analysis (multivariable logistic regression) for in-hospital death was performed. The discriminatory power of a new predictive scoring system was assessed with the receiver operating characteristic curve analysis. Score validation procedures were carried out. Fifty-six (15.5%) patients died postsurgery. BMI >27 kg/m2 (odds ratio [OR], 1.79; P=0.049), estimated glomerular filtration rate 55 mm Hg (OR, 1.78; P=0.032), and critical state (OR, 2.37; P=0.017) were independent predictors of in-hospital death. A scoring system was devised to predict in-hospital death postsurgery for IE (area under the receiver operating characteristic curve, 0.780; 95% CI, 0.734-0.822). The score performed better than 5 of 6 scoring systems for in-hospital death after cardiac surgery that were considered. CONCLUSIONS: A simple scoring system based on risk factors for in-hospital death was specifically created to predict mortality risk postsurgery in patients with IE