Stormwater Basins and Aesthetics – Not a Contradiction!

https://digitalcommons.usm.maine.edu/cbep-presentations/1061/thumbnail.jp

Spinor vortices in non-relativistic Chern-Simons theory

The non-relativistic `Dirac' equation of L\'evy-Leblond is used to describe a spin {\small 1/2} particle interacting with a Chern-Simons gauge field. Static, purely magnetic, self-dual spinor vortices are constructed. The solution can be `exported' to a uniform magnetic background field.Comment: 7 pages, Plain Te

A framework for evaluating image segmentation algorithms

The purpose of this paper is to describe a framework for evaluating image segmentation algorithms. Image segmentation consists of object recognition and delineation. For evaluating segmentation methods, three factors—precision (reliability), accuracy (validity), and efficiency (viability)—need to be considered for both recognition and delineation. To assess precision, we need to choose a figure of merit, repeat segmentation considering all sources of variation, and determine variations in figure of merit via statistical analysis. It is impossible usually to establish true segmentation. Hence, to assess accuracy, we need to choose a surrogate of true segmentation and proceed as for precision. In determining accuracy, it may be important to consider different 'landmark' areas of the structure to be segmented depending on the application. To assess efficiency, both the computational and the user time required for algorithm training and for algorithm execution should be measured and analyzed. Precision, accuracy, and efficiency factors have an influence on one another. It is difficult to improve one factor without affecting others. Segmentation methods must be compared based on all three factors, as illustrated in an example wherein two methods are compared in a particular application domain. The weight given to each factor depends on application

The light variability of the helium strong star HD 37776 as a result of its inhomogeneous elemental surface distribution

We simulate light curves of the helium strong chemically peculiar star HD 37776 assuming that the observed periodic light variations originate as a result of inhomogeneous horizontal distribution of chemical elements on the surface of a rotating star. We show that chemical peculiarity influences the monochromatic radiative flux, mainly due to bound-free processes. Using the model of the distribution of silicon and helium on HD 37776 surface, derived from spectroscopy, we calculate a photometric map of the surface and consequently the uvby light curves of this star. Basically, the predicted light curves agree in shape and amplitude with the observed ones. We conclude that the basic properties of variability of this helium strong chemically peculiar star can be understood in terms of the model of spots with peculiar chemical composition.Comment: 11 pages, accepted for the publication in Astronomy & Astrophysic

Revision of the 15N(p,{\gamma})16O reaction rate and oxygen abundance in H-burning zones

The NO cycle takes place in the deepest layer of a H-burning core or shell, when the temperature exceeds T {\simeq} 30 {\cdot} 106 K. The O depletion observed in some globular cluster giant stars, always associated with a Na enhancement, may be due to either a deep mixing during the RGB (red giant branch) phase of the star or to the pollution of the primordial gas by an early population of massive AGB (asymptotic giant branch) stars, whose chemical composition was modified by the hot bottom burning. In both cases, the NO cycle is responsible for the O depletion. The activation of this cycle depends on the rate of the 15N(p,{\gamma})16O reaction. A precise evaluation of this reaction rate at temperatures as low as experienced in H-burning zones in stellar interiors is mandatory to understand the observed O abundances. We present a new measurement of the 15N(p,{\gamma})16O reaction performed at LUNA covering for the first time the center of mass energy range 70-370 keV, which corresponds to stellar temperatures between 65 {\cdot} 106 K and 780 {\cdot}106 K. This range includes the 15N(p,{\gamma})16O Gamow-peak energy of explosive H-burning taking place in the external layer of a nova and the one of the hot bottom burning (HBB) nucleosynthesis occurring in massive AGB stars. With the present data, we are also able to confirm the result of the previous R-matrix extrapolation. In particular, in the temperature range of astrophysical interest, the new rate is about a factor of 2 smaller than reported in the widely adopted compilation of reaction rates (NACRE or CF88) and the uncertainty is now reduced down to the 10% level.Comment: 6 pages, 5 figure

Versatile drug nanocarrier assembly via conjugation of distinct carbon dots

With constant emergencies and severe consequences of various central nervous system (CNS)-related diseases, drug delivery gradually reveals its significance in the modern medicine. The biggest challenge of drug delivery resides in the selection of appropriate drug delivery carrier. 21th century witnessed the prosperous development of diverse nanomaterials. Due to many excellent properties revealed in nanoscale, nanomaterials have been widely investigated as drug nanocarriers. As a new family member of carbon-based nanomaterials, carbon dots (CDs) have proved to be promising drug nanocarriers. They have been successfully conjugated with various therapeutic agents for targeted drug delivery. However, considering the limitation of single CD preparation in drug delivery, in this study, two distinct CD preparations (G-CDs and Y-CDs) were conjugated to compensate for each other’s deficiencies. Different dialysis bags were employed to purify the CD conjugate (G-Y CDs) and reveal the difference between small and large-conjugated systems. After a series of physicochemical characterizations, G-Y CDs exhibited many nanocarrier-favored properties such as excitation-dependent photoluminescence (PL), diversified surface functionality, controlled morphology and versatile amphiphilicity. To further analyze the formation mechanism of G-Y CDs, self-conjugation was separately surveyed with G-CDs and Y-CDs, which showed that self-conjugation was able to occur between Y-CDs. Eventually, to evaluate the capacity of G-Y CDs as drug nanocarriers for future CNS-related diseases, G-Y CDs were intravascularly injected into the heart of zebrafish. The fluorescence signal in the spinal cord suggested the capability of G-Y CDs to cross the blood-brain barrier (BBB). Therefore, this study reveals a novel strategy to assemble versatile drug nanocarriers through conjugation of distinct CDs.     

Operator Ordering Problem of the Nonrelativistic Chern-Simons Theory

The operator ordering problem due to the quantization or regularization ambiguity in the Chern-Simons theory exists. However, we show that this can be avoided if we require Galilei covariance of the nonrelativistic Abelian Chern-Simons theory even at the quantum level for the extended sources. The covariance can be recovered only by choosing some particular operator orderings for the generators of the Galilei group depending on the quantization ambiguities of the $gauge-matter$ commutation relation. We show that the desired ordering for the unusual prescription is not the same as the well-known normal ordering but still satisfies all the necessary conditions. Furthermore, we show that the equations of motion can be expressed in a similar form regardless of the regularization ambiguity. This suggests that the different regularization prescriptions do not change the physics. On the other hand, for the case of point sources the regularization prescription is uniquely determined, and only the orderings, which are equivalent to the usual one, are allowed.Comment: 18 page

Interaction of Rio1 Kinase with Toyocamycin Reveals a Conformational Switch That Controls Oligomeric State and Catalytic Activity

Rio1 kinase is an essential ribosome-processing factor required for proper maturation of 40 S ribosomal subunit. Although its structure is known, several questions regarding its functional remain to be addressed. We report that both Archaeoglobus fulgidus and human Rio1 bind more tightly to an adenosine analog, toyocamycin, than to ATP. Toyocamycin has antibiotic, antiviral and cytotoxic properties, and is known to inhibit ribosome biogenesis, specifically the maturation of 40 S. We determined the X-ray crystal structure of toyocamycin bound to Rio1 at 2.0 Å and demonstrated that toyocamycin binds in the ATP binding pocket of the protein. Despite this, measured steady state kinetics were inconsistent with strict competitive inhibition by toyocamycin. In analyzing this interaction, we discovered that Rio1 is capable of accessing multiple distinct oligomeric states and that toyocamycin may inhibit Rio1 by stabilizing a less catalytically active oligomer. We also present evidence of substrate inhibition by high concentrations of ATP for both archaeal and human Rio1. Oligomeric state studies show both proteins access a higher order oligomeric state in the presence of ATP. The study revealed that autophosphorylation by Rio1 reduces oligomer formation and promotes monomerization, resulting in the most active species. Taken together, these results suggest the activity of Rio1 may be modulated by regulating its oligomerization properties in a conserved mechanism, identifies the first ribosome processing target of toyocamycin and presents the first small molecule inhibitor of Rio1 kinase activity