100 research outputs found
Ways to increase adherence to antihypertensive therapy
With a high prevalence in the Russian population and insufficient effectiveness of treatment, hypertension remains a poorly controlled cardiovascular risk factor, including due to the low compliance of patients. Noncompliance is due to a large number of factors, some of which were studied in post-hoc analysis of the Russian observational STIL’ and TRICOLOR studies. It demonstrated that fixed-dose combinations of antihypertensive drugs can make a significant contribution to solving such a complex problem as low compliance
INVERSE SCATTERING TRANSFORM ANALYSIS OF STOKES-ANTI-STOKES STIMULATED RAMAN SCATTERING
Zakharov-Shabat--Ablowitz-Kaup-Newel-Segur representation for
Stokes-anti-Stokes stimulated Raman scattering is proposed. Periodical waves,
solitons and self-similarity solutions are derived. Transient and bright
threshold solitons are discussed.Comment: 16 pages, LaTeX, no figure
Search for invisible decays of sub-GeV dark photons in missing-energy events at the CERN SPS
We report on a direct search for sub-GeV dark photons (A') which might be
produced in the reaction e^- Z \to e^- Z A' via kinetic mixing with photons by
100 GeV electrons incident on an active target in the NA64 experiment at the
CERN SPS. The A's would decay invisibly into dark matter particles resulting in
events with large missing energy. No evidence for such decays was found with
2.75\cdot 10^{9} electrons on target. We set new limits on the \gamma-A' mixing
strength and exclude the invisible A' with a mass < 100 MeV as an explanation
of the muon g_\mu-2 anomaly.Comment: 6 pages, 3 figures; Typos corrected, references adde
Transverse-momentum-dependent Multiplicities of Charged Hadrons in Muon-Deuteron Deep Inelastic Scattering
A semi-inclusive measurement of charged hadron multiplicities in deep
inelastic muon scattering off an isoscalar target was performed using data
collected by the COMPASS Collaboration at CERN. The following kinematic domain
is covered by the data: photon virtuality (GeV/), invariant
mass of the hadronic system GeV/, Bjorken scaling variable in the
range , fraction of the virtual photon energy carried by the
hadron in the range , square of the hadron transverse momentum
with respect to the virtual photon direction in the range 0.02 (GeV/ (GeV/). The multiplicities are presented as a
function of in three-dimensional bins of , , and
compared to previous semi-inclusive measurements. We explore the
small- region, i.e. (GeV/), where
hadron transverse momenta are expected to arise from non-perturbative effects,
and also the domain of larger , where contributions from
higher-order perturbative QCD are expected to dominate. The multiplicities are
fitted using a single-exponential function at small to study
the dependence of the average transverse momentum on , and . The power-law behaviour of the
multiplicities at large is investigated using various
functional forms. The fits describe the data reasonably well over the full
measured range.Comment: 28 pages, 20 figure
Hunting down the X17 boson at the CERN SPS
Recently, the ATOMKI experiment has reported new evidence for the excess of
events with a mass 17 MeV in the nuclear transitions of He,
that they previously observed in measurements with Be. These observations
could be explained by the existence of a new vector boson. So far, the
search for the decay with the NA64 experiment at the
CERN SPS gave negative results. Here, we present a new technique that could be
implemented in NA64 aiming to improve the sensitivity and to cover the
remaining parameter space. If a signal-like event is detected, an
unambiguous observation is achieved by reconstructing the invariant mass of the
decay with the proposed method. To reach this goal an optimization of the
production target, as well as an efficient and accurate reconstruction of
two close decay tracks, is required. A dedicated analysis of the available
experimental data making use of the trackers information is presented. This
method provides independent confirmation of the NA64 published results [Phys.
Rev. D101, 071101 (2020)], validating the tracking procedure. The detailed
Monte Carlo study of the proposed setup and the background estimate shows that
the goal of the proposed search is feasible
Constraints on New Physics in the Electron g-2 from a Search for Invisible Decays of a Scalar, Pseudoscalar, Vector, and Axial Vector
We performed a search for a new generic boson, which could be a scalar
(), pseudoscalar (), vector () or an axial vector () particle
produced in the 100 GeV electron scattering off nuclei, ,
followed by its invisible decay in the NA64 experiment at CERN. No evidence for
such process was found in the full NA64 data set of
electrons on target. We place new bounds on the coupling strengths
to electrons, and set constraints on their contributions to the electron
anomalous magnetic moment ,
for the mass region GeV. These results are an order of
magnitude more sensitive compared to the current accuracy on from the
electron experiments and recent high-precision determination of the fine
structure constant.Comment: 6 pages, 4 figure
КЛИНИЧЕСКИЙ СЛУЧАЙ УСПЕШНОГО ЛЕЧЕНИЯ ПОДРОСТКА С САРКОМОЙ ЮИНГА IV СТАДИИ
Background. Ewing’s sarcoma is one of the most common musculoskeletal cancers in children and adolescents. Extremely aggressive clinical course of Ewing’s sarcoma makes a successful treatment of this tumor difficult. Despite a comprehensive multidisciplinary approach to the treatment of this cancer, including chemotherapy, surgery and radiation therapy, rapid tumor progression, recurrence and resistance to chemotherapy are still common.Our purpose was to present the results of a personalized approach to multidisciplinary combination treatment for musculoskeletal cancer involving polychemotherapy, 3D conformal radiation therapy and modern surgical technologies.Description of the clinical case. A female patient presented to Rostov Research Institute of Oncology complaining of a tumor and moderate pain in soft tissues of the left iliac region, left lower extremity, and lameness when walking. After complete examination, the patient was diagnosed with Ewing’s sarcoma of the left ilium with lung metastases (Т3N0M1). The patient received 6 cycles of neoadjuvant chemotherapy according to EURO EWING 2008 protocol; tumor progression and lung metastasis were registered. Two cycles of second-line chemotherapy were performed; by the decision of the doctors’ council, the first stage of surgical treatment was performed: resection of the left ilium and the defect replacement with a temporary cement spacer. In the postoperative period, the patient underwent 8 cycles of adjuvant chemotherapy, external beam radiation therapy to the lungs (12 Gy total dose) and the primary tumor (46 iGy total dose), and 12 cycles of supporting therapy. A delayed second reconstructive stage of surgical treatment involved removal of a temporary cement spacer and implantation of an individual pelvic stability system. The patient was followed-up for 25 months after the combination treatment, had no complaints, and was able to ambulate without assistance; the motor function of the left hip joint was fully preserved. Conclusion. The use of non-standard high-technology approaches to surgical treatment of unfavorably localized Ewing’s Sarcoma in combination with chemo-radiation therapy allows patients with advanced tumors to achieve satisfactory results and good quality of life. Актуальность. Саркома Юинга занимает одно из лидирующих мест в онкологической патологии опорно-двигательной системы у детей и подростков. Успешное лечение затрудняет крайне агрессивное течение опухолевого процесса. Несмотря на мультидисциплинарный подход в лечении, включающий наряду с химиотерапевтическим и хирургическим методами лечения лучевую терапию, быстрая генерализация опухолевого процесса, рецидивы и резистентные к химиотерапии формы опухоли попрежнему часты.Целью работы явилось представление результатов персонифицированного подхода в комплексном мультидисциплинарном лечении злокачественной патологии опорно-двигательной системы с использованием многокомпонентной полихимиотерапии, 3D-конформной лучевой терапии и высоких хирургических технологий.Описание клинического случая. Больная обратилась в ФГБУ «РНИОИ» МЗ РФ в апреле 2016 г. с жалобами на наличие опухолевого образования и умеренных болей в мягких тканях левой подвздошной области, левой нижней конечности, хромоту при ходьбе. По данным обследования установлен диагноз: саркома Юинга левой подвздошной кости с метастазами в легкие, IV стадия (Т3N0M1). После 6 курсов неоадъювантной полихимиотерапии, согласно протоколу EWING 2008, отмечено прогрессирование опухоли с метастазами в легкие. Проведено 2 противорецидивных курса полихимиотерапии второй линии, решением консилиума врачей проведен первый этап хирургического лечения: резекция левой подвздошной кости с замещением дефекта временным цементным спейсером. В послеоперационном периоде больной проведено 8 курсов адъювантной полихимиотерапии, ДГТ на область обоих легких (СОД 12 Гр) и зону первичного очага (СОД 46 изоГР), 12 курсов поддерживающей терапии. Выполнен отсроченный реконструктивно-пластический этап хирургического лечения – удаление временного цементного спейсера с установкой индивидуальной тазовой стабилизирующей системы. Больная находится под наблюдением 25 мес после комплексного лечения, жалоб не предъявляет, передвигается самостоятельно, двигательная функция левого тазобедренного сустава сохранена в полном объеме.Заключение. Использование нестандартных высокотехнологичных подходов в хирургическом лечении саркомы Юинга неблагоприятных локализаций в сочетании с химиолучевой терапией позволяет достичь удовлетворительных результатов при лечении больных с распространенным опухолевым процессом и сохранения высокого уровня качества жизни.
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