Prediction of mechanical and radiation parameters of glasses with high Bi2O3 concentration

This study aims to perform multidirectional characterizations on nuclear shielding efficiencies on some bismuth-based glasses. Accordingly, the γattenuation coefficients for xBi2O3-(75-x)B2O3–25Li2O (x = 0, 10, 20, 30, 40, 50, 60 the 70 mol%) were widely evaluated using simulations and theoretical methods. Linear attenuation coefficient (LAC) of the glasses was obtained by the Monte Carlo general-purpose simulation code FLUKA and compared with the XCOM database up to 15 MeV. Moreover, LAC values have been utilized to evaluate related parameters like mass attenuation coefficient (MAC), total molecular cross-section (σt), total atomic cross-section (σa), half-value layer (HVL), total electronic cross-section (σe), mean free path (MFP), effective atomic number (Zeff), and effective electron density (Neff). The results noted that the XCOM and FLUKA data of the shielding parameters are in great agreement. Relatively higher density (5.818 g/cm3), greater LAC, MAC, Zeff, and lower HVL, MFP values are achieved for 70Bi2O3-5B2O3–25Li2O glass. Accordingly, this glass sample is a better gamma shield. © 2021 The AuthorsTaif University Researchers Supporting Project number (TURSP-2020/45) Taif University, Taif, Saudi Arabia

Hand-held spectrophotometer design for textile fabrics

In this study, a hand-held spectrophotometer was designed by taking advantage of the developments in modern optoelectronic technology. Spectrophotometer devices are used to determine the color information from the optic properties of the materials. As an alternative to a desktop spectrophotometer device we have implemented, it is the first prototype, low cost and portable. The prototype model designed for the textile industry can detect the color tone of any fabric. The prototype model consists of optic sensor, processor, display floors. According to the color applied on the optic sensor, it produces special frequency information on its output at that color value. In Arduino type processor, the frequency information is evaluated by the program we have written and the color tone information between 0-255 ton is decided and displayed on the screen

The mechanical and electronic properties of spinel oxides VX2O4 (X = Mn and Fe) by first principle calculations

We have performed first-principles density functional theory calculations within generalized-gradient approximation to obtain the mechanical properties and the electronic behavior of Vanadium based Spinel Oxides VX2O4 (X=Mn and Fe) which conform Fm-3m space group with 225 space number and are promising good candidates for spintronic applications due to their half-metallic band gaps (Eg=1.71 eV for VFe2O4 and Eg = 0.53 eV for VMn2O4) in the plotted spin-polarized electronic band structure. Also, the calculated negative formation enthalpies indicate that these materials have thermodynamic stability and structural synthesizability. Additionally, the calculated elastic constants by using stress-strain approach indicate mechanical stability of above-mentioned materials. © 2019 Author(s)

Synthesis, characterization and computational investigation of novel metalloporphyrazines containing 15-membered O2 S2-donor macrocyclic moieties

New metalloporphyrazines (MgPz, ZnPz) containing peripheral tetrasubstitutions derived from 7,8-dihydro-6H,14H,19H-dibenzo[bj][1,12,5,8]-dioxadithiacyclopentadecine-16,17-dicarbonitrile (6) have been synthesized by a multistep reaction sequence and characterized. Compound 6 has been prepared by the reaction of 1,3-di(2-bromomethyl phenoxy) propane (3) or 1,3-di(2-iodomethylphenoxy) propane (4) which were prepared via bromination or iodination of {2-[3-(2-hydroxymethylphenoxy)propoxy]-phenyl}methanol (2) and cis-1,2-dicyano-1,2-ethylenedithiolate (5). The novel magnesium porphyrazine was prepared by the cyclotetramerization reaction of 6 with magnesium butoxide. The one-step synthesis of porphyrazinato zinc complex has been achieved without a reaction sequence by using dicyano compound (6) and zinc butoxide. The prediction of the geometry optimization, normal mode frequencies, 1H, 13C NMR, UV absorption spectra, chemical shifts, electronic properties and NBO analysis of the compound were examined by using B3LYP method with a 6-31G(d, p) basis set. These novel compounds were characterized by a combination of elemental analysis, 1H, 13C NMR, FT-IR, UV-vis and MS spectral data. An X-ray crystal structure of dicarbodinitrile compound (6) was also investigated. © 2018 World Scientific Publishing Company

Association of Tumor Necrosis Factor-Alpha (TNF-α) and Suppressor of Cytokine Signaling-1 (SOCS-1) Gene Variants in Children with COVID-19

© 2023 Georg Thieme Verlag. All rights reserved.Objective The suppressor of cytokine signaling-1 (SOCS-1) gene is an essential physiological regulator of cytokine signaling. Tumor necrosis factor-α (TNF-α) is an important component of the immunological response. Herein, we aimed to investigate the effects of SOCS-1 (-1478 CA > Del) and TNF-α (-308) polymorphisms on disease susceptibility and prognosis in pediatric patients with coronavirus disease 2019 (COVID-19). Methods One-hundred fifty COVID-19 patients in the COVID-19 emergency department between September 2020 and April 2021 and 80 healthy volunteers (control group) without any additional disease were included. Baseline gene polymorphisms were compared between the patient and healthy control groups. Afterward, the gene polymorphism distribution was examined by forming two separate clinical patients' subgroups. Results While CA/CA and CA/Del gene variants of SOCS-1 were higher in the patient group, Del/Del genotype was more common in the control group (p < 0.05). The GG genotype of the TNF-α was significantly more common in the severe subgroup (p = 0.044). The GA genotype of TNF-α was associated with the risk of hospitalization (2.83-fold), while the GG genotype was found to be protective in terms of hospitalization (2.95-fold). Conclusions This study will be a guide in terms of the presence of high cytokine release genotypes and COVID-19-related cytokine release syndromes

Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

PubMedID: 29353264The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. The cohort numbered 67. The diagnosis age was 12.4±8.6 months, peak GH stimulation test response (at diagnosis) as 1.0±1.4 ng/mL. The first and second years length gain was 15.0±4.3 and 10.4±3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n=50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n=17) (p=0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n=24) was significantly greater than those who started treatment between 12 and 36 months of age (n=43) (p<0.001). These differences were not seen in the second year. ? Length/height standard deviation score (SDS), ? body weight SDS, length/height SDS, weight SDS in MPHD without hypogonadism for the first year of the GH treatment were found as significantly better than MPHD with hypogonadism. Early onsets of GH treatment, good weight gain in the first year of the treatment and good weight gain-GH dose in the second year of the treatment are the factors that have the greatest effect on length gain in early onset GHD. The presence of the sex steroid hormones during minipubertal period influence growth pattern positively under GH treatment (closer to the normal percentage according to age and gender). © 2018 Walter de Gruyter GmbH, Berlin/Boston.22014Acknowledgments: For technical support, we would like to thank the ÇEDD-NET Web Registry System and its staff, as well as the Turkish Society of Endocrinology and Diabetes. Author contributions:S. Cetinkaya, F. Darendeliler: Concept, design, analysis, interpretation of data, writing the manuscript or revising it critically for content, S.  Poyrazoglu, F.  Baş, O. Ercan, M. Yıldız, E. Adal, A. Bereket, S. Abalı, Z. Aycan, Ş. Savaş Erdeve, M. Berberoglu, Z. Sıklar, M. Tayfun, Ş. Darcan, E. Mengen, İ. Bircan, F. M. Çizmecioğlu Jones, E. Şimşek, E. D. Papatya, M. N. Özbek, S. Bolu, A. Abacı, M. Büyükinan: Interpretation of data. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Research funding: This work was supported by the Turkish Pediatric Endocrinology and Diabetes Society (Grant Number: 022014). Employment or leadership: None declared. Honorarium: None declared. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication