Simulation methods in the modelling of bioaffinity assays

Computational model-based simulation methods were developed for the modelling of bioaffinity assays. Bioaffinity-based methods are widely used to quantify a biological substance in biological research, development and in routine clinical in vitro diagnostics. Bioaffinity assays are based on the high affinity and structural specificity between the binding biomolecules. The simulation methods developed are based on the mechanistic assay model, which relies on the chemical reaction kinetics and describes the forming of a bound component as a function of time from the initial binding interaction. The simulation methods were focused on studying the behaviour and the reliability of bioaffinity assay and the possibilities the modelling methods of binding reaction kinetics provide, such as predicting assay results even before the binding reaction has reached equilibrium. For example, a rapid quantitative result from a clinical bioaffinity assay sample can be very significant, e.g. even the smallest elevation of a heart muscle marker reveals a cardiac injury. The simulation methods were used to identify critical error factors in rapid bioaffinity assays. A new kinetic calibration method was developed to calibrate a measurement system by kinetic measurement data utilizing only one standard concentration. A nodebased method was developed to model multi-component binding reactions, which have been a challenge to traditional numerical methods. The node-method was also used to model protein adsorption as an example of nonspecific binding of biomolecules. These methods have been compared with the experimental data from practice and can be utilized in in vitro diagnostics, drug discovery and in medical imaging.Siirretty Doriast

Dybdeøkologi og kosmisk livserotik - Introduktion til Ludwig Klages’ ”Menneske og jord”

Ludwig Klages’ famous essay from 1913 is here translated into Danish for the first time. According to Klages, the planet-wide destruction of nature is a disastrous outcome of a runaway mad civilisation focused on progress. Famously, he finds the root of the madness to be an intricate entanglement of science, technology, capitalism and Christianity. Ultimately, these are all aspects of what he calls Spirit (Geist) – an alienating and life-disruptive power that tears man away from its original being interwoven with living nature. Its benign adversary, Soul, is characterised by caring for life. This elementary or cosmic love is linked to Soul’s way of recognizing reality through a dynamical flow of sensual pictures. On the other hand, Spirit’s drive to destroy and kill is related to its way of fixating knowledge of the world by means of concepts. Klages diagnoses modern ‘civilisation’ as an era of downfall of the Soul. The devastating events the following summer of 1914 may be seen as a consequence of the bad cultural standing. An anthropological ecology, spirit-dominated and with civilised man’s interest as its core value, is not enough to save nature. Only a deep ecology, where Soul dominates Spirit, can do so, moving the value focus away from man to Earth

Aggressive dominance can decrease behavioral complexity on subordinates through synchronization of locomotor activities

Social environments are known to influence behavior. Moreover, within small social groups, dominant/subordinate relationships frequently emerge. Dominants can display aggressive behaviors towards subordinates and sustain priority access to resources. Herein, Japanese quail (Coturnix japonica) were used, given that they establish hierarchies through frequent aggressive interactions. We apply a combination of different mathematical tools to provide a precise quantification of the effect of social environments and the consequence of dominance at an individual level on the temporal dynamics of behavior. Main results show that subordinates performed locomotion dynamics with stronger long-range positive correlations in comparison to birds that receive few or no aggressions from conspecifics (more random dynamics). Dominant birds and their subordinates also showed a high level of synchronization in the locomotor pattern, likely emerging from the lack of environmental opportunities to engage in independent behavior. Findings suggest that dominance can potentially modulate behavioral dynamics through synchronization of locomotor activities.publishedVersionAlcala, Rocio. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Caliva, Jorge Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Caliva, Jorge Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Flesia, Ana Georgina. Facultad de Matemática, Astronomía, Física y Computación; Argentina.Flesia, Ana Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Estudios de Matemática; Argentina.Marin, Raúl Hector. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Marin, Raúl Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina

AGGRESSION HOIDOLLINEN HALLINTA KOULUTUKSEN MERKITYS SATAKUNNAN SAIRAANHOITOPIIRIN PSYKIATRIAN TOIMIALUEEN HOITOHENKILÖKUNNALLE

Tämän tutkimuksen tarkoituksena oli selvittää Aggression hoidollinen hallinta-koulutuksen eli AHHA-koulutuksen merkitystä Satakunnan sairaanhoitopiirin psykiatrin toimialueen hoitohenkilökunnalle. Vastaajista kaikki olivat käyneet kyseisen koulutuksen. Tutkimuksen aineisto kerättiin kyselylomakkeilla. Kysely toteutettiin kesäkuussa 2010. Kyselylomakkeita lähetettiin 115 kappaleita, takaisin saatiin 58 kappaletta jolloin vastausprosentiksi muodostui 50,4 %. Aineisto analysoitiin SPSS-ohjelmaa käyttäen. Aggression hoidollinen hallinta-koulutus koettiin tarpeelliseksi työn kannalta. Koulutus antoi työyhteisölle yhteiset toimintatavat ja valmiudet kohdata aggressiivinen potilas. Vastaajista 87,9 % (n=51) oli käynyt Aggression hoidollinen hallinta-koulutuksen kertauspäivissä. Tutkimustuloksista ilmenee, että kertauspäiviä toivotaan lisää.The purpose of this study was to find out how the staff working on the psychiatric department of Satakunta Hospital District evaluated the training on Therapeutic Management of Violence and Aggression (AHHA in Finnish). All of the respondents of this study had participated in the training. The data was collected by a questionnaire in June 2010. The total amount of 115 questionnaires was delivered of which amount 58 were returned filled. The response rate was 50,4 %. The data was analysed by SPSS- statistic programme. Therapeutic Management of Violence and Aggression (AHHA in Finnish) training was reckoned as rewarding from the work’s point of view. The training provided for the staff common patterns and tools to encounter and handle with an aggressive patent. 87,9 % (n=51) of the respondents had participated in the follow-up trainings provided afterwards. The respondents expressed the need for more frequently provided follow-up courses

Ammatillisen peruskoulutuksen auto-osaston toimintojen sovittaminen laatu- ja ympäristöjärjestelmään

Tiivistelmä Työn tarkoituksena oli auto-osaston sisäinen sopeuttaminen ISO 9001 laatujärjestelmän ja ISO 14001 ympäristöjärjestelmän mukaiseen toimintajäjestelmään koskien työsalin tiloja ja työsaliopetusta. Lähdin toteuttamaan työtäni työelämälähtöisen ajoneuvokorjaamon suunnittelusta, jotta toisaalta voisimme saada enemmän lähiopetus- ja "kädestä pitäen" opetusaikaa. Työkalutaulujen ja työkalujen järkevään uudelleen sijoitukseen, kyseessä olevien autopaikkojen ja autonostimien läheisyyteen, ja toisaalta opiskelijoiden tutustuttamiseen asiakaspalvelu toimintaan ja vastaamaan erikoistyökalu- ja pientarvikevarastosta. Nämä kaikki asiat yhdistettynä opettajille jää huomattavasti enemmän aikaa paneutua varsinaiseen työhönsä ja opiskelijoiden "passaaminen" jää vähemmälle kun ei tarvitse juosta ympäri työsalia antamassa milloin mitäkin erikoistyökalua lukituista kaapeista. Hankkeen tuloksena on syntynyt asiakaspalvelupiste ja lukittava erikoistyökalu- ja pientarvike varasto työsaliin. Myös työturvallisuus- ja jäteasiat on saatettu laatu- ja ympäristöjärjestelmien tasalle. Työn lopullista onnistumista voidaan seurata 2011 syyslukukaudesta alkaen, kun työsaliin saadaan yhtä aikaa toisen ja kolmannen vuosikurssin opiskelijoita

The Impact of ‘One Belt, One Road’ and its Effects on GDP Growth in China

After the global financial crisis in 2008, the world economy started to slowdown. Due to decelerated growth rates in China, and with the endeavour to increase control over global trade, the Chinese President, Xi Jinping, launched the initiative ‘One Belt, One Road’, in September 2013. The initiative aims to encourage and stimulate economic growth in China, as well as enhance integration between countries connected to the new initiative. This research aimed to study the impact of ‘One Belt, One Road’ and its effects on GRP growth in Chinese provinces affected by the initiative. The calculated forecasts in this study indicate on decreased GRP growth in coming years. In order to prove that ‘One Belt, One Road’ and its infrastructure projects will have an impact on GRP, regressions analyses, including several variables that have an effect on GRP, were conducted. According to the results of this study, extended railways, highways as well as other factors connected to infrastructure projects prove that ‘One Belt, One Road’ will have positive effects on GRP growth in the selected provinces

Urban Riots in Sweden : Is there Continuity or Change in the Political Discourse?

In the last ten years several violent protests have emerged in Sweden´s largest cities. Some of them have developed into real riots, resulting in burned cars and large police operations. These violent events, or ‘urban riots’, are a relatively new phenomenon in Sweden. The aim of this qualitative study is to investigate the structure of the discourse among the Swedish political elite in power. I will observe if the political discourse on disadvantaged areas in Sweden is characterized by continuity or change after urban riots. This study examines four urban riot cases, between 2005 and 2013.    To study how the political discourse is constructed, framing theory elements are combined with elements from discourse analysis. The characteristic features of the two framing dimensions are outlined which gives me a framework to categorize the political discourse. The two dimensions are; diagnostic and prognostic frames. The discourse analytical elements are used in order to systemize who is included in the political discourse by the political elite in power. A discourse analysis is then conducted on the collected empirical material, which consists of newspaper articles and parliamentarian debates from the Swedish parliament.   The results from the analysis suggest that the disadvantaged districts are not salient both before and after the riots among the political elite in power, except for the last case. In this case the riot as such has no observable ‘effect’ on political discourse about disadvantaged districts. The political actors tend to separate riots as events from the disadvantaged districts. The last riot did not change how the government defined the problem in the suburbs and how it should be solved. In all cases the political discourse has a strong divide between the state and the inhabitants in the suburbs. The state acts and residents are acted upon.   

Urban Riots in Sweden : Is there Continuity or Change in the Political Discourse?

In the last ten years several violent protests have emerged in Sweden´s largest cities. Some of them have developed into real riots, resulting in burned cars and large police operations. These violent events, or ‘urban riots’, are a relatively new phenomenon in Sweden. The aim of this qualitative study is to investigate the structure of the discourse among the Swedish political elite in power. I will observe if the political discourse on disadvantaged areas in Sweden is characterized by continuity or change after urban riots. This study examines four urban riot cases, between 2005 and 2013.    To study how the political discourse is constructed, framing theory elements are combined with elements from discourse analysis. The characteristic features of the two framing dimensions are outlined which gives me a framework to categorize the political discourse. The two dimensions are; diagnostic and prognostic frames. The discourse analytical elements are used in order to systemize who is included in the political discourse by the political elite in power. A discourse analysis is then conducted on the collected empirical material, which consists of newspaper articles and parliamentarian debates from the Swedish parliament.   The results from the analysis suggest that the disadvantaged districts are not salient both before and after the riots among the political elite in power, except for the last case. In this case the riot as such has no observable ‘effect’ on political discourse about disadvantaged districts. The political actors tend to separate riots as events from the disadvantaged districts. The last riot did not change how the government defined the problem in the suburbs and how it should be solved. In all cases the political discourse has a strong divide between the state and the inhabitants in the suburbs. The state acts and residents are acted upon.