Validation of Sentinel-2, MODIS, CGLS, SAF, GLASS and C3S leaf area index products in maize crops

Altres ajuts: this research was funded by the Copernicus Global Land Service (CGLOPS-1, 199494-JRC).We proposed a direct approach to validate hectometric and kilometric resolution leaf area index (LAI) products that involved the scaling up of field-measured LAI via the validation and recalibration of the decametric Sentinel-2 LAI product. We applied it over a test study area of maize crops in northern China using continuous field measurements of LAINet along the year 2019. Sentinel-2 LAI showed an overall accuracy of 0.67 in terms of Root Mean Square Error (RMSE) and it was used, after recalibration, as a benchmark to validate six coarse resolution LAI products: MODIS, Copernicus Global Land Service 1 km Version 2 (called GEOV2) and 300 m (GEOV3), Satellite Application Facility EUMETSAT Polar System (SAF EPS) 1.1 km, Global LAnd Surface Satellite (GLASS) 500 m and Copernicus Climate Change Service (C3S) 1 km V2. GEOV2, GEOV3 and MODIS showed a good agreement with reference LAI in terms of magnitude (RMSE ≤ 0.29) and phenology. SAF EPS (RMSE = 0.68) and C3S V2 (RMSE = 0.41), on the opposite, systematically underestimated high LAI values and showed systematic differences for phenological metrics: a delay of 6 days (d), 20 d and 24 d for the start, peak and the end of growing season, respectively, for SAF EPS and an advance of −4 d, −6 d and −6 d for C3S

Extracting Deciduous Forests Spring Phenology From Sentinel-1 Cross Ratio Index

Deciduous forests spring phenology plays a major role in balancing the carbon cycle. The cloud cover affects images acquired from optical sensors and reduces their performance in monitoring phenology. Synthetic aperture radar (SAR) can regularly acquire images day and night independent of weather conditions, which offers more frequent observations of vegetation phenology compared to optical sensors. However, it remains unclear how SAR data-derived indices vary across different growth stages of forests. Here, we explored the relationship between the cross ratio (CR) index derived from Sentinel-1 data and the deciduous forest growth process. We proposed a deciduous forests spring phenology extraction method using CR and compared the extracted start of growing season (SOS) with those extracted using normalized difference vegetation index (NDVI) derived from Sentinel-2 optical satellite data and green chromatic coordinate (GCC) derived from ground PhenoCam data. We extracted the SOS of 41 PhenoCam sites over the Continental United States in 2018 using the dynamic threshold method. Our results showed that the variations of CR time series are closely related to the phenological processes of deciduous forests. The SOS extracted using CR data showed high consistency with those extracted using GCC (R2 = 0.46), with slightly lower accuracy compared with NDVI-derived results (R2 = 0.62). Our study illustrates the value and mechanism of deciduous forests spring phenology extraction using SAR data and provides a reference for using SAR data to improve forest phenology extraction in addition to using optical remote sensing data, especially in rainy and cloudy regions

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation

Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation, however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the inflammatory reaction of rats or macrophages exposed to lipopolysaccharide (LPS), increased tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β) levels and decreased IL-10 levels. hUCMSC-exosome administration successfully reversed this reaction. Further studies showed that miR-181c in the exosomes played a pivotal role in regulating inflammation. Compared to control hUCMSC-exosomes, hUCMSC-exosomes overexpressing miR-181c more effectively suppressed the TLR4 signaling pathway and alleviated inflammation in burned rats. Administration of miR-181c-expressing hUCMSC-exosomes or TLR4 knockdown significantly reduced LPS-induced TLR4 expression by macrophages and the inflammatory reaction. In summary, miR-181c expression in hUCMSC-exosomes reduces burn-induced inflammation by downregulating the TLR4 signaling pathway

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation

Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the inflammatory reaction of rats or macrophages exposed to lipopolysaccharide (LPS), increased tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β) levels and decreased IL-10 levels. hUCMSC-exosome administration successfully reversed this reaction. Further studies showed that miR-181c in the exosomes played a pivotal role in regulating inflammation. Compared to control hUCMSC-exosomes, hUCMSC-exosomes overexpressing miR-181c more effectively suppressed the TLR4 signaling pathway and alleviated inflammation in burned rats. Administration of miR-181c-expressing hUCMSC-exosomes or TLR4 knockdown significantly reduced LPS-induced TLR4 expression by macrophages and the inflammatory reaction. In summary, miR-181c expression in hUCMSC-exosomes reduces burn-induced inflammation by downregulating the TLR4 signaling pathway

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation

Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation, however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the inflammatory reaction of rats or macrophages exposed to lipopolysaccharide (LPS), increased tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β) levels and decreased IL-10 levels. hUCMSC-exosome administration successfully reversed this reaction. Further studies showed that miR-181c in the exosomes played a pivotal role in regulating inflammation. Compared to control hUCMSC-exosomes, hUCMSC-exosomes overexpressing miR-181c more effectively suppressed the TLR4 signaling pathway and alleviated inflammation in burned rats. Administration of miR-181c-expressing hUCMSC-exosomes or TLR4 knockdown significantly reduced LPS-induced TLR4 expression by macrophages and the inflammatory reaction. In summary, miR-181c expression in hUCMSC-exosomes reduces burn-induced inflammation by downregulating the TLR4 signaling pathway

Internet-based and mobile-based cognitive behavioral therapy for chronic diseases: a systematic review and meta-analysis

Abstract Positive adjustment to chronic diseases reduces psychiatric comorbidity and enhances quality of life. Very little is known about the benefit of internet-based and mobile-based Cognitive Behavioral Therapy (IM-CBT) on physical outcomes and its reciprocal interactions with psychiatric outcomes, the active therapeutic elements, and effect moderators among people with major chronic medical conditions. In this systematic review and meta-analysis (PROSPERO: CRD42022265738), CINAHL of Systematic Reviews, MEDLINE, PsycINFO, PubMed, Web of Science are systematically searched up to 1 June 2022, for randomized controlled trials (RCTs) comparing IM-CBT against non-CBT control condition(s) among people with chronic disease(s). Primary outcomes include improvements in psychiatric symptoms (depressive, anxiety, PTSD symptoms, general psychological distress) from baseline to post-intervention and follow-ups. Secondary outcomes include improvements in physical distress (physical symptoms, functional impairment, self-rated ill health, objective physiological dysfunction). Among 44 RCTs (5077 patients with seven different chronic diseases), IM-CBT improves depressive symptoms, anxiety symptoms, and general psychological distress at post-intervention and across follow-ups, and improves physical distress and functional impairment at post-intervention. Preliminary evidence suggests that behavioral modification and problem-solving could be necessary components to reduce psychiatric symptoms in IM-CBT, whereas cognitive restructuring, psychoeducation, and mindfulness elements relate to reduced physical distress. IM-CBT shows stronger benefits in chronic pain, cancer, arthritis, and cardiovascular disease, relative to other conditions. Changes in psychiatric symptoms and physical distress prospectively predict each other over time. IM-CBT is an effective intervention for comprehensive symptom management among people with chronic diseases

Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

Summary: Enhancing chemosensitivity is one of the largest unmet medical needs in cancer therapy. Cyclic GMP-AMP synthase (cGAS) connects genome instability caused by platinum-based chemotherapeutics to type I interferon (IFN) response. Here, by using a high-throughput small-molecule microarray-based screening of cGAS interacting compounds, we identify brivanib, known as a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor, as a cGAS modulator. Brivanib markedly enhances cGAS-mediated type I IFN response in tumor cells treated with platinum. Mechanistically, brivanib directly targets cGAS and enhances its DNA binding affinity. Importantly, brivanib synergizes with cisplatin in tumor control by boosting CD8+ T cell response in a tumor-intrinsic cGAS-dependent manner, which is further validated by a patient-derived tumor-like cell clusters model. Taken together, our findings identify cGAS as an unprecedented target of brivanib and provide a rationale for the combination of brivanib with platinum-based chemotherapeutics in cancer treatment

YINSHUN'S RECOVERY OF SHIZHU PIPOSHA LUN A MADHYAMAKA-BASED PURE LAND PRACTICE IN TWENTIETH-CENTURY TAIWAN

<p>Yinshun (1906-2005) is regarded as one of the eminent monks of twentieth-century Chinese Buddhism. In the mission of reinventing Chinese Buddhism Yinshun engaged particularly in the revival and restatement of Madhyamaka. His interpretation of Ngrjuna's texts, the reassessment of the links between pre-Mahyna Buddhism and the Prajnpramit tradition, and the critical analysis of the Chinese San-lun became the core of the new Mahyna that he planned for the twentieth-century China. Yinshun also adopted Madhyamaka criteria to reconsider the Mahyna schools that were popular in China, and theorized a Madhyamaka-framed Pure Land based on his reading of the Shizhu piposha lun [T26 n1521]. This article discusses Yinshun's views on the Easy Path (yixing dao) and Difficult Path (nanxing dao) in the Pure Land practice, and contextualizes Yinshun's interpretation within the past history of the Chinese Pure Land School, as well as within the new debates on Pure Land that emerged in twentieth-century China.</p>