A Computationally Efficient Method for Calculation of Strand Eddy Current Losses in Electric Machines

In this paper, a fast finite element (FE)-based method for the calculation of eddy current losses in the stator windings of randomly wound electric machines with a focus on fractional slot concentrated winding (FSCW) permanent magnet (PM) machines will be presented. The method is particularly suitable for implementation in large-scale design optimization algorithms where a qualitative characterization of such losses at higher speeds is most beneficial for identification of the design solutions which exhibit the lowest overall losses including the ac losses in the stator windings. Unlike the common practice of assuming a constant slot fill factor, sf, for all the design variations, the maximum sf in the developed method is determined based on the individual slot structure/dimensions and strand wire specifications. Furthermore, in lieu of detailed modeling of the conductor strands in the initial FE model, which significantly adds to the complexity of the problem, an alternative rectangular coil modeling subject to a subsequent flux mapping technique for determination of the impinging flux on each individual strand is pursued. The research focus of the paper is placed on development of a computationally efficient technique for the ac winding loss derivation applicable in design-optimization, where both the electromagnetic and thermal machine behavior are accounted for. The analysis is supplemented with an investigation on the influence of the electrical loading on ac winging loss effects for a particular machine design, a subject which has received less attention in the literature. Experimental ac loss measurements on a 12-slot 10-pole stator assembly will be discussed to verify the existing trends in the simulation results

Computationally Efficient Strand Eddy Current Loss Calculation in Electric Machines

A fast finite element (FE) based method for the calculation of eddy current losses in the stator windings of randomly wound electric machines is presented in this paper. The method is particularly suitable for implementation in large-scale design optimization algorithms where a qualitative characterization of such losses at higher speeds is most beneficial for identification of the design solutions that exhibit the lowest overall losses including the ac losses in the stator windings. Unlike the common practice of assuming a constant slot fill factor s f for all the design variations, the maximum s f in the developed method is determined based on the individual slot structure/dimensions and strand wire specifications. Furthermore, in lieu of detailed modeling of the conductor strands in the initial FE model, which significantly adds to the complexity of the problem, an alternative rectangular coil modeling subject to a subsequent flux mapping technique for determination of the impinging flux on each individual strand is pursued. Rather than pursuing the precise estimation of ac conductor losses, the research focus of this paper is placed on the development of a computationally efficient technique for the derivation of strand eddy current losses applicable in design optimization, especially where both the electromagnetic and thermal machine behavior are accounted for. A fractional-slot concentrated winding permanent magnet synchronous machine is used for the purpose of this study due to the higher slot leakage flux and slot opening fringing flux of such machines, which are the major contributors to strand eddy current losses in the windings. The analysis is supplemented with an investigation on the influence of the electrical loading on ac winding loss effects for this machine design, a subject that has received less attention in the literature. Experimental ac loss measurements on a 12-slot 10-pole stator assembly will be discussed to verify the existing trends in the simulation result

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

The epidemic of obesity imposes unprecedented challenges on human adipose tissue (WAT) storage capacity that may benefit from adaptive mechanisms to maintain adipocyte functionality. Here, we demonstrate that changes in the regulatory feedback set point control of Insig1/SREBP1 represent an adaptive response that preserves WAT lipid homeostasis in obese and insulin-resistant states. In our experiments, we show that Insig1 mRNA expression decreases in WAT from mice with obesity-associated insulin resistance and from morbidly obese humans and in in vitro models of adipocyte insulin resistance. Insig1 downregulation is part of an adaptive response that promotes the maintenance of SREBP1 maturation and facilitates lipogenesis and availability of appropriate levels of fatty acid unsaturation, partially compensating the antilipogenic effect associated with insulin resistance. We describe for the first time the existence of this adaptive mechanism in WAT, which involves Insig1/SREBP1 and preserves the degree of lipid unsaturation under conditions of obesity-induced insulin resistance. These adaptive mechanisms contribute to maintain lipid desaturation through preferential SCD1 regulation and facilitate fat storage in WAT, despite on-going metabolic stress

A New Model of Delirium Care in the Acute Geriatric Setting: Geriatric Monitoring Unit

<p>Abstract</p> <p>Background</p> <p>Delirium is a common and serious condition, which affects many of our older hospitalised patients. It is an indicator of severe underlying illness and requires early diagnosis and prompt treatment, associated with poor survival, functional outcomes with increased risk of institutionalisation following the delirium episode in the acute care setting. We describe a new model of delirium care in the acute care setting, titled Geriatric Monitoring Unit (GMU) where the important concepts of delirium prevention and management are integrated. We hypothesize that patients with delirium admitted to the GMU would have better clinical outcomes with less need for physical and psychotropic restraints compared to usual care.</p> <p>Methods/Design</p> <p>GMU models after the Delirium Room with adoption of core interventions from Hospital Elder Life Program and use of evening bright light therapy to consolidate circadian rhythm and improve sleep in the elderly patients. The novelty of this approach lies in the amalgamation of these interventions in a multi-faceted approach in acute delirium management. GMU development thus consists of key considerations for room design and resource planning, program specific interventions and daily core interventions. Assessments undertaken include baseline demographics, comorbidity scoring, duration and severity of delirium, cognitive, functional measures at baseline, 6 months and 12 months later. Additionally we also analysed the pre and post-GMU implementation knowledge and attitude on delirium care among staff members in the geriatric wards (nurses, doctors) and undertook satisfaction surveys for caregivers of patients treated in GMU.</p> <p>Discussion</p> <p>This study protocol describes the conceptualization and implementation of a specialized unit for delirium management. We hypothesize that such a model of care will not only result in better clinical outcomes for the elderly patient with delirium compared to usual geriatric care, but also improved staff knowledge and satisfaction. The model may then be transposed across various locations and disciplines in the acute hospital where delirious patients could be sited.</p> <p>Trial Registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN52323811">ISRCTN52323811</a></p

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

The authors describe a new approach to studying cellular lipid profiles and propose a compensatory mechanism that may help maintain the normal membrane function of adipocytes in the context of obesity

A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative

Introduction: The integrated care pathways for atopic dermatitis (AD-ICPs) aim to bridge the gap between existing AD treatment evidence-based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co-ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems. Methods: The GA2LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD-ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL2EN ADCARE centres. Results: The AD-ICPs outline the diagnostic procedures, possible co-morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD. Conclusion: The AD-ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD

A concept for integrated care pathways for atopic dermatitis-A GA2 LEN ADCARE initiative

INTRODUCTION: The integrated care pathways for atopic dermatitis (AD-ICPs) aim to bridge the gap between existing AD treatment evidence-based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co-ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems. METHODS: The GA2 LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD-ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL2 EN ADCARE centres. RESULTS: The AD-ICPs outline the diagnostic procedures, possible co-morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD. CONCLUSION: The AD-ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD