26 research outputs found
No evidence of dioxin cancer threshold.
The U.S. Environmental Protection Agency (EPA) has developed an estimate of the human cancer risk from dioxin, using the standard low-dose linear extrapolation approach. This estimate has been controversial because of concern that it may overestimate the cancer risk. An alternative approach has been published and was presented to the U.S. EPA Science Advisory Board's Dioxin Review Panel in November 2000. That approach suggests that dioxin is a threshold carcinogen and that the threshold is an order of magnitude above the exposure levels of the general population. We have reexamined the threshold analysis and found that the data have been incorrectly weighted by cohort size. In our reanalysis, without the incorrect weighting, the threshold effect disappears
The Color Bimodality in Galaxy Clusters since z = 0.9
We present the evolution of the color-magnitude distribution of galaxy
clusters from z = 0.45 to z = 0.9 using a homogeneously selected sample of
~1000 clusters drawn from the Red-Sequence Cluster Survey (RCS). The red
fraction of galaxies decreases as a function of increasing redshift for all
cluster-centric radii, consistent with the Butcher-Oemler effect, and
suggesting that the cluster blue population may be identified with newly
infalling galaxies. We also find that the red fraction at the core has a
shallower evolution compared with that at the cluster outskirts. Detailed
examination of the color distribution of blue galaxies suggests that they have
colors consistent with normal spirals and may redden slightly with time.
Galaxies of starburst spectral type contribute less than 5% of the increase in
the blue population at high redshift, implying that the observed Butcher-Oemler
effect is not caused by a unobscured starbursts, but is more consistent with a
normal coeval field population.Comment: 27 pages, 7 figures, accepted for publication in the Ap
A Survey of z>5.7 Quasars in the Sloan Digital Sky Survey II: Discovery of Three Additional Quasars at z>6
We present the discovery of three new quasars at z>6 in 1300 deg^2 of SDSS
imaging data, J114816.64+525150.3 (z=6.43), J104845.05+463718.3 (z=6.23) and
J163033.90+401209.6 (z=6.05). The first two objects have weak Ly alpha emission
lines; their redshifts are determined from the positions of the Lyman break.
They are only accurate to 0.05 and could be affected by the presence of broad
absorption line systems. The last object has a Ly alpha strength more typical
of lower redshift quasars. Based on a sample of six quasars at z>5.7 that cover
2870 deg^2 presented in this paper and in Paper I, we estimate the comoving
density of luminous quasars at z 6 and M_{1450} < -26.8 to be (8 +/-
3)x10^{-10} Mpc^{-3} (for H_0 = 50 km/s/Mpc, Omega = 1). HST imaging of two
z>5.7 quasars and high-resolution ground-based images (seeing 0.4'') of three
additional z>5.7 quasars show that none of them is gravitationally lensed. The
luminosity distribution of the high-redshfit quasar sample suggests the bright
end slope of the quasar luminosity function at z 6 is shallower than Psi
L^{-3.5} (2-sigma), consistent with the absence of strongly lensed objects.Comment: AJ in press (Apr 2003), 26 pages, 9 figure
Cross-Correlation of the Cosmic Microwave Background with the 2MASS Galaxy Survey: Signatures of Dark Energy, Hot Gas, and Point Sources
We cross-correlate the Cosmic Microwave Background (CMB) temperature
anisotropies observed by the Wilkinson Microwave Anisotropy Probe (WMAP) with
the projected distribution of extended sources in the Two Micron All Sky Survey
(2MASS). By modelling the theoretical expectation for this signal, we extract
the signatures of dark energy (Integrated Sachs-Wolfe effect;ISW), hot gas
(thermal Sunyaev-Zeldovich effect;thermal SZ), and microwave point sources in
the cross-correlation. Our strongest signal is the thermal SZ, at the 3.1-3.7
\sigma level, which is consistent with the theoretical prediction based on
observations of X-ray clusters. We also see the ISW signal at the 2.5 \sigma
level, which is consistent with the expected value for the concordance LCDM
cosmology, and is an independent signature of the presence of dark energy in
the universe. Finally, we see the signature of microwave point sources at the
2.7 \sigma level.Comment: 35 pages (preprint format), 8 figures. In addition to minor revisions
based on referee's comments, after correcting for a bug in the code, the SZ
detection is consistent with the X-ray observations. Accepeted for
publication in Physical Review
The UV-Optical Color Dependence of Galaxy Clustering in the Local Universe
We measure the UV-optical color dependence of galaxy clustering in the local
universe. Using the clean separation of the red and blue sequences made
possible by the NUV - r color-magnitude diagram, we segregate the galaxies into
red, blue and intermediate "green" classes. We explore the clustering as a
function of this segregation by removing the dependence on luminosity and by
excluding edge-on galaxies as a means of a non-model dependent veto of highly
extincted galaxies. We find that \xi (r_p, \pi) for both red and green galaxies
shows strong redshift space distortion on small scales -- the "finger-of-God"
effect, with green galaxies having a lower amplitude than is seen for the red
sequence, and the blue sequence showing almost no distortion. On large scales,
\xi (r_p, \pi) for all three samples show the effect of large-scale streaming
from coherent infall. On scales 1 Mpc/h < r_p < 10 Mpc/h, the projected
auto-correlation function w_p(r_p) for red and green galaxies fits a power-law
with slope \gamma ~ 1.93 and amplitude r_0 ~ 7.5 and 5.3, compared with \gamma
~ 1.75 and r_0 ~ 3.9 Mpc/h for blue sequence galaxies. Compared to the
clustering of a fiducial L* galaxy, the red, green, and blue have a relative
bias of 1.5, 1.1, and 0.9 respectively. The w_p(r_p) for blue galaxies display
an increase in convexity at ~ 1 Mpc/h, with an excess of large scale
clustering. Our results suggest that the majority of blue galaxies are likely
central galaxies in less massive halos, while red and green galaxies have
larger satellite fractions, and preferentially reside in virialized structures.
If blue sequence galaxies migrate to the red sequence via processes like
mergers or quenching that take them through the green valley, such a
transformation may be accompanied by a change in environment in addition to any
change in luminosity and color.Comment: accepted by MNRA
Detection of the Baryon Acoustic Peak in the Large-Scale Correlation Function of SDSS Luminous Red Galaxies
We present the large-scale correlation function measured from a spectroscopic
sample of 46,748 luminous red galaxies from the Sloan Digital Sky Survey. The
survey region covers 0.72 h^{-3} Gpc^3 over 3816 square degrees and
0.16<z<0.47, making it the best sample yet for the study of large-scale
structure. We find a well-detected peak in the correlation function at
100h^{-1} Mpc separation that is an excellent match to the predicted shape and
location of the imprint of the recombination-epoch acoustic oscillations on the
low-redshift clustering of matter. This detection demonstrates the linear
growth of structure by gravitational instability between z=1000 and the present
and confirms a firm prediction of the standard cosmological theory. The
acoustic peak provides a standard ruler by which we can measure the ratio of
the distances to z=0.35 and z=1089 to 4% fractional accuracy and the absolute
distance to z=0.35 to 5% accuracy. From the overall shape of the correlation
function, we measure the matter density Omega_mh^2 to 8% and find agreement
with the value from cosmic microwave background (CMB) anisotropies. Independent
of the constraints provided by the CMB acoustic scale, we find Omega_m = 0.273
+- 0.025 + 0.123 (1+w_0) + 0.137 Omega_K. Including the CMB acoustic scale, we
find that the spatial curvature is Omega_K=-0.010+-0.009 if the dark energy is
a cosmological constant. More generally, our results provide a measurement of
cosmological distance, and hence an argument for dark energy, based on a
geometric method with the same simple physics as the microwave background
anisotropies. The standard cosmological model convincingly passes these new and
robust tests of its fundamental properties.Comment: Submitted to the ApJ. Additional pedagogical material and numerical
data at http://cmb.as.arizona.edu/~eisenste/acousticpea
The Second Data Release of the Sloan Digital Sky Survey
The Sloan Digital Sky Survey (SDSS) has validated and made publicly available its Second Data Release. This data release consists of 3324 deg2 of five-band (ugriz) imaging data with photometry for over 88 million unique objects, 367,360 spectra of galaxies, quasars, stars, and calibrating blank sky patches selected over 2627 deg2 of this area, and tables of measured parameters from these data. The imaging data reach a depth of r â 22.2 (95% completeness limit for point sources) and are photometrically and astrometrically calibrated to 2% rms and 100 mas rms per coordinate, respectively. The imaging data have all been processed through a new version of the SDSS imaging pipeline, in which the most important improvement since the last data release is fixing an error in the model fits to each object. The result is that model magnitudes are now a good proxy for point-spread function magnitudes for point sources, and Petrosian magnitudes for extended sources. The spectroscopy extends from 3800 to 9200 Ă
at a resolution of 2000. The spectroscopic software now repairs a systematic error in the radial velocities of certain types of stars and has substantially improved spectrophotometry. All data included in the SDSS Early Data Release and First Data Release are reprocessed with the improved pipelines and included in the Second Data Release. Further characteristics of the data are described, as are the data products themselves and the tools for accessing them
The First Data Release of the Sloan Digital Sky Survey
The Sloan Digital Sky Survey has validated and made publicly available its
First Data Release. This consists of 2099 square degrees of five-band (u, g, r,
i, z) imaging data, 186,240 spectra of galaxies, quasars, stars and calibrating
blank sky patches selected over 1360 square degrees of this area, and tables of
measured parameters from these data. The imaging data go to a depth of r ~ 22.6
and are photometrically and astrometrically calibrated to 2% rms and 100
milli-arcsec rms per coordinate, respectively. The spectra cover the range
3800--9200 A, with a resolution of 1800--2100. Further characteristics of the
data are described, as are the data products themselves.Comment: Submitted to The Astronomical Journal. 16 pages. For associated
documentation, see http://www.sdss.org/dr
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodiumâglucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with reninâangiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years