Ionospheric electron number densities from CUTLASS dual-frequency velocity measurements using artificial backscatter over EISCAT

Using quasi-simultaneous line-of-sight velocity measurements at multiple frequencies from the Hankasalmi Cooperative UK Twin Auroral Sounding System (CUTLASS) on the Super Dual Auroral Radar Network (SuperDARN), we calculate electron number densities using a derivation outlined in Gillies et al. (2010, 2012). Backscatter targets were generated using the European Incoherent Scatter (EISCAT) ionospheric modification facility at Tromsø, Norway. We use two methods on two case studies. The first approach is to use the dual-frequency capability on CUTLASS and compare line-of-sight velocities between frequencies with a MHz or greater difference. The other method used the kHz frequency shifts automatically made by the SuperDARN radar during routine operations. Using ray tracing to obtain the approximate altitude of the backscatter, we demonstrate that for both methods, SuperDARN significantly overestimates Ne compared to those obtained from the EISCAT incoherent scatter radar over the same time period. The discrepancy between the Ne measurements of both radars may be largely due to SuperDARN sensitivity to backscatter produced by localized density irregularities which obscure the background levels

Coronal and heliospheric magnetic flux circulation and its relation to open solar flux evolution

Solar cycle 24 is notable for three features that can be found in previous cycles but which have been unusually prominent: (1) sunspot activity was considerably greater in the northern/southern hemisphere during the rising/declining phase; (2) accumulation of Open Solar Flux (OSF) during the rising phase was modest, but rapid in the early declining phase; (3) the Heliospheric Current Sheet (HCS) tilt showed large fluctuations. We show these features had a major influence on the progression of the cycle. All flux emergence causes a rise then a fall in OSF, but only OSF with footpoints in opposing hemispheres progresses the solar cycle via the evolution of the polar fields. Emergence in one hemisphere, or symmetric emergence without some form of footpoint exchange across the heliographic equator, causes poleward-migrating fields of both polarities in one or both (respectively) hemispheres which temporarily enhance OSF but do not advance the polar field cycle. The heliospheric field observed near Mercury and Earth reflects the asymmetries in emergence. Using magnetograms, we find evidence that the poleward magnetic flux transport (of both polarities) is modulated by the HCS tilt, revealing an effect on OSF loss rate. The declining phase rise in OSF was caused by strong emergence in the southern hemisphere with an anomalously low HCS tilt. This implies the recent fall in the southern polar field will be sustained and that the peak OSF has limited implications for the polar field at the next sunspot minimum and hence for the amplitude of cycle 25

The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study

Background Autoimmune Hepatitis is a chronic liver disease which affects young people and can result in liver failure leading to death or transplantation yet there is a lack of information on the incidence and prevalence of this disease and its natural history in the UK. A means of obtaining this information is via the use of clinical databases formed of electronic primary care records. How reliably the diagnosis is coded in such records is however unknown. The aim of this study therefore was to assess the proportion of consultant hepatologist diagnoses of Autoimmune Hepatitis which were accurately recorded in General Practice computerised records. Methods Our study population were patients with Autoimmune Hepatitis diagnosed by consultant hepatologists in the Queens Medical Centre, Nottingham University Hospitals (UK) between 2004 and 2009. We wrote to the general practitioners of these patients to obtain the percentage of patients who had a valid READ code specific for Autoimmune Hepatitis. Results We examined the electronic records of 51 patients who had biopsy evidence and a possible diagnosis of Autoimmune Hepatitis. Forty two of these patients had a confirmed clinical diagnosis of Autoimmune Hepatitis by a consultant hepatologist: we contacted the General Practitioners of these patients obtaining a response rate of 90.5% (39/42 GPs). 37/39 of these GPs responded with coding information and 89% of these patients (33/37) used Read code J638.00 (Autoimmune Hepatitis) to record a diagnosis. Conclusions The diagnosis of Autoimmune Hepatitis made by a Consultant Hepatologist is accurately communicated to and electronically recorded by primary care in the UK. As a large proportion of cases of Autoimmune Hepatitis are recorded in primary care, this minimises the risk of introducing selection bias and therefore selecting cases using these data will be a valid method of conducting population based studies on Autoimmune Hepatitis

Polarization squeezing and continuous-variable polarization entanglement

The Stokes-parameter operators and the associated Poincare sphere, which describe the quantum-optical polarization properties of light, are defined and their basic properties are reviewed. The general features of the Stokes operators are illustrated by evaluation of their means and variances for a range of simple polarization states. Some of the examples show polarization squeezing, in which the variances of one or more Stokes parameters are smaller than the coherent-state value. The main object of the paper is the application of these concepts to bright squeezed light. It is shown that a light beam formed by interference of two orthogonally-polarized quadrature-squeezed beams exhibits squeezing in some of the Stokes parameters. Passage of such a primary polarization-squeezed beam through suitable optical components generates a pair of polarization-entangled light beams with the nature of a two-mode squeezed state. The use of pairs of primary polarization-squeezed light beams leads to substantially increased entanglement and to the generation of EPR-entangled light beams. The important advantage of these nonclassical polarization states for quantum communication is the possibility of experimentally determining all of the relevant conjugate variables of both squeezed and entangled fields using only linear optical elements followed by direct detection.Comment: 27 pages, including 10 figure

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Transient Ionospheric Convection Features Associated with Substorms and BBFs

High time resolution operation of the SuperDARN HF radars regularly results in observations of pulsed, vortical ionospheric convection velocities during the substorm expansion phase. Pulsed flow is often preceded by an interval of suppressed flow and enhanced ionospheric Hall conductance. Such features, which propagate both westward and eastward away from the meridian where the substorm is centred, have been interpreted as ionospheric current vortices associated with field-aligned current pairs. HF radar observations will be discussed, and related to ground based magnetic field and optical observations of similar phenomena, as well as spacecraft measurements in the near magnetotail. Their possible relationship with bursty Earthward plasma flow and magnetotail reconnection is discussed. Yeoman, T. K. and J. A. Wild (2000). Transient ionospheric convection features associated with substorms and BBFs, ESA Special Publication 443. Proceedings of the 5th Interntational Conference on Substorms, ISBN: 9781107512368, 243–248.</p

HF radar polar patch formation revisited: summer and winter variations in dayside plasma structuring

Three intervals of polar patch formation, as observed by the CUTLASS Finland HF coherent radar, are presented. Simultaneous observations from a vertical ionosonde located at Longyearbyen on Svalbard, situated in the dayside convection throat region, allow for F-region plasma structuring, leading to polar cap patch formation to be determined. Solar wind and interplanetary magnetic field (IMF) precursors of polar patch formation are investigated with MFI and SWE measurements from the Wind spacecraft. We find that in the cases studied polar cap patches are formed in response to changes in the orientation of the IMF, especially in the By component. The resultant changes in the dayside convection pattern alter the source of plasma drifting through the convection throat region into the polar cap. When the convection flow is directed predominantly polewards, high density sub-auroral or mid-latitude plasma enters the polar cap; when flow is directed zonally, low density plasma entrained in the convection return flow replaces it. This mechanism can act to significantly structure the plasma density at sub-auroral or mid-latitudes as well as in the polar cap. In winter months, polar patches appear to be produced by depletions in an otherwise high plasma density tongue of ionisation. In summer months, patches are enhancements of an otherwise low density tongue of ionisation

Phase calibration of interferometer arrays at high-frequency radars

Elevation angles of backscattered signals are calculated at the Super Dual Auroral Radar Network (SuperDARN) high-frequency radars using interferometric techniques. These elevation angles make it possible to estimate the geographic location of the scattering point, an essential piece of information for many ionospheric studies. One of the most difficult parameters to measure is the effective time delay caused by the difference in the electrical path length that connects the main array and the interferometer arrays to the correlator (δtc). This time delay causes a bias in the measured difference in the signal phase, also known as a phase bias. Phase calibration is difficult due to unknown physical attributes of the hardware and the remote location of many radars. This leads to the possibility of sudden external changes, slow temporal drift, and a dependence on transmission frequency. However, it is possible to estimate δtc using the radar observations themselves. This article presents a method for estimating δtc using backscatter with a known location, such as backscatter from artificially generated irregularities, meteor echoes, or distinct groundscatter, which incorporates the uncertainty in the observations and may be used autonomously. Applying the estimated δtc is shown to improve elevation angle uncertainties at one of the SuperDARN radars from their current potential tens of degrees to less than a degree