the role of mast cells in alzheimer s disease

Immunity and inflammation are deeply involved in Alzheimer's disease. The most important properties of pathological Alzheimer's disease are the extracellular deposits of amyloid â-protein plaque aggregates along with other unknown mutated proteins, which are implicated in immunity and inflammation. Mast cells are found in the brain of all mammalian species and in the periphery, and their biological mediators, including cytokines/chemokines, arachidonic acid products and stored enzymes, play an import role in Alzheimer's disease. Cytokines/chemokines, which are generated mostly by microglia and astrocytes in Alzheimer's disease, contribute to nearly every aspect of neuroinflammation and amyloid â-protein plaque aggregates may induce in mast cells the release of a plethora of mediators, including pro-inflammatory cytokines/chemokines such as interleukin-1, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, vascular endothelial growth factor, transforming growth factor beta, CXCL8 and CCL2-3-4. These proinflammatory cytokines/chemokines are prominent mediators of neuroinflammation in brain disorders such as Alzheimer's disease, and their inhibition may be associated with improved recovery. In this review, we summarize the current knowledge regarding the roles of mast cell mediators (stored and de novo synthesis) in the pathogenesis of Alzheimer's disease

Två Iranska kvinnors erfarenheter av patriarkaltvåld under livet - en narrativ studie

The purpose of this study is to tell two Iranian women’s stories about how they experienced patriarchal violence during their lives, but also to find answers to what common experiences both women share and how their stories differ and what the reason for this might be, as well as to highlight how patriarchal violence can be understood through experience-based narratives. The method used is qualitative and consists of an interview study. The research approach has been “Restorying”. In order to also get answers to the study’s questions, the stories have also been analyzed using thematic analysis. The themes that emerged in the study regarding the women's common experience are; Lack of rights, opportunities and support from family and society; A feeling of loneliness, insecurity and injustice; We know we are not to blame for the abuse; our resistance and own strength which means we don’t give up. The themes that emerged in terms of how the stories differ are; The feeling of shame; Economic opportunities as prerequisites for being able tochange one’s life situation. The themes that emerged regarding how patriarchy can be understood through experience-based narratives are; That various forms of violence are present throughout life; That, as a girl or a woman you must constantly try new ways of relating to violence or the risk for violence; That violence in the family is sanctioned and supported by society; That these women’s sexuality constitutes their material value. The conclusion of this study shows how these women share a sense of injustice towards them as women, but that it is more difficult for them to understand where to place the blame for the violence but also that the women share a feeling of being victims of circumstances to a greater extent than blaming patriarchal structure. These women share a loneliness but also an enormous strength and determination of their own and a strong sense of justice and a desire for a different life free from violence.2023-06-07</p

Två Iranska kvinnors erfarenheter av patriarkaltvåld under livet - en narrativ studie

The purpose of this study is to tell two Iranian women’s stories about how they experienced patriarchal violence during their lives, but also to find answers to what common experiences both women share and how their stories differ and what the reason for this might be, as well as to highlight how patriarchal violence can be understood through experience-based narratives. The method used is qualitative and consists of an interview study. The research approach has been “Restorying”. In order to also get answers to the study’s questions, the stories have also been analyzed using thematic analysis. The themes that emerged in the study regarding the women's common experience are; Lack of rights, opportunities and support from family and society; A feeling of loneliness, insecurity and injustice; We know we are not to blame for the abuse; our resistance and own strength which means we don’t give up. The themes that emerged in terms of how the stories differ are; The feeling of shame; Economic opportunities as prerequisites for being able tochange one’s life situation. The themes that emerged regarding how patriarchy can be understood through experience-based narratives are; That various forms of violence are present throughout life; That, as a girl or a woman you must constantly try new ways of relating to violence or the risk for violence; That violence in the family is sanctioned and supported by society; That these women’s sexuality constitutes their material value. The conclusion of this study shows how these women share a sense of injustice towards them as women, but that it is more difficult for them to understand where to place the blame for the violence but also that the women share a feeling of being victims of circumstances to a greater extent than blaming patriarchal structure. These women share a loneliness but also an enormous strength and determination of their own and a strong sense of justice and a desire for a different life free from violence.2023-06-07</p

Trösklar : Ett samtal om kronotopia och kroppar i en konstnärlig praktik

Med utgångspunkt i min konstnärliga praktik behandlar jag begreppet kronotopi; tröskelfenomen, tidrum i relation till kroppar. Tiden tjocknar, laddar rummet och svarar på tidens rörelser. Texten ställer sig frågan hur skillnad kan fördela tid. Jag situerar mig i relation till Laura Marks såkallade haptiskta seende, Jennifer M. Barker om taktilitet samt Deleuze och Merleau-Pontys arbeten om varseblivning, med en förhoppning om att komma närmare en idé om samtidighetens omöjlighet. En samling frågor producerar genomgående språk och texten bär på möjligheten att låta oss befinna oss kvar i vissa tankeobjekt som framskrivs genom tidrummet. Det tankeobjekt som behandlas i texten är föremålet fönster. Fönstret som en tröskel, som en teknik, som ett tillstånd, som en tanke, som en kropp, som ett öga, som en perceptionsgräns, som ett språk, som en dikt, som en bok. Jag önskar sträcka ut våra intima utrymmen genom att försätta oss i ett precist tillstånd, i en förtjockad tid

The Role of Mast Cells in Alzheimer’s Disease

Immunity and inflammation are deeply involved in Alzheimer's disease. The most important properties of pathological Alzheimer's disease are the extracellular deposits of amyloid â-protein plaque aggregates along with other unknown mutated proteins, which are implicated in immunity and inflammation. Mast cells are found in the brain of all mammalian species and in the periphery, and their biological mediators, including cytokines/chemokines, arachidonic acid products and stored enzymes, play an import role in Alzheimer's disease. Cytokines/chemokines, which are generated mostly by microglia and astrocytes in Alzheimer's disease, contribute to nearly every aspect of neuroinflammation and amyloid â-protein plaque aggregates may induce in mast cells the release of a plethora of mediators, including pro-inflammatory cytokines/chemokines such as interleukin-1, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, vascular endothelial growth factor, transforming growth factor beta, CXCL8 and CCL2-3-4. These proinflammatory cytokines/chemokines are prominent mediators of neuroinflammation in brain disorders such as Alzheimer's disease, and their inhibition may be associated with improved recovery. In this review, we summarize the current knowledge regarding the roles of mast cell mediators (stored and de novo synthesis) in the pathogenesis of Alzheimer's disease

Cooperative guidance system for auv docking with an active free-floating docking station

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