Online eye tracking and real-time sentence processing: On opportunities and efficacy for capturing psycholinguistic effects of different magnitudes and diversity

Online research methods have the potential to facilitate equitable accessibility to otherwise-expensive research resources, as well as to more diverse populations and language combinations than currently populate our studies. In psycholinguistics specifcally, webcam-based eye tracking is emerging as a powerful online tool capable of capturing sentence processing efects in real time. The present paper asks whether webcam-based eye tracking provides the necessary granularity to replicate efects—crucially both large and small—that tracker-based eye tracking has shown. Using the Gorilla Experiment Builder platform, this study set out to replicate two psycholinguistic efects: a robust one, the verb semantic constraint efect, frst reported in Altmann and Kamide, Cognition 73(3), 247–264 (1999), and a smaller one, the lexical interference efect, frst examined by Kukona et al. Journal of Experimental Psychology: Learning, Memory, and Cognition, 40(2), 326 (2014). Webcam-based eye tracking was able to replicate both efects, thus showing that its functionality is not limited to large efects. Moreover, the paper also reports two approaches to computing statistical power and discusses the diferences in their outputs. Beyond discussing several important methodological, theoretical, and practical implications, we ofer some further technical details and advice on how to implement webcam-based eye-tracking studies. We believe that the advent of webcam-based eye tracking, at least in respect of the visual world paradigm, will kickstart a new wave of more diverse studies with more diverse populations

Fingerprint of dynamical charge/spin correlations in the tunneling spectra of colossal magnetoresistive manganites

We present temperature-dependent scanning tunneling spectroscopy measurements on $La_{1-x}Ca_{x}MO_{3}$ ($x\sim0.33$) films with different degrees of biaxial strain. A depletion in normalized conductance around the Fermi level is observed both above and below the insulator-to-metal transition temperature $T_{MI}$, for weakly as well as highly-strained films. This pseudogap-like depletion globally narrows on cooling. The zero-bias conductance decreases on cooling in the insulating phase, reaches a minimum close to $T_{MI}$ and increases on cooling in the metallic phase, following the trend of macroscopic conductivity. These results support a recently proposed scenario in which dynamical short-range antiferromagnetic/charge order correlations play a preeminent role in the transport properties of colossal magnetoresistive manganites [R. Yu \textit{et al}., Phys. Rev. B \textbf{77}, 214434 (2008)].Comment: 9 pages, 4 figure

First order phase transition from the vortex liquid to an amorphous solid

We present a systematic study of the topology of the vortex solid phase in superconducting Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8}$ samples with low doses of columnar defects. A new state of vortex matter imposed by the presence of geometrical contours associated with the random distribution of columns is found. The results show that the first order liquid-solid transition in this vortex matter does not require a structural symmetry change.Comment: 4 pages, 5 figure

Bordetella parapertussis survives the innate interaction with human neutrophils by impairing bactericidal trafficking inside the cell through a lipid raft-dependent mechanism mediated by the lipopolysaccharide O antigen

Whooping cough is a reemerging disease caused by two closely related pathogens, Bordetella pertussis and Bordetella parapertussis. The incidence of B. parapertussis in whooping cough cases has been increasing since the introduction of acellular pertussis vaccines containing purified antigens that are common to both strains. Recently published results demonstrated that these vaccines do not protect against B. parapertussis due to the presence of the O antigen on the bacterial surface that impairs antibody access to shared antigens. We have investigated the effect of the lack of opsonization of B. parapertussis on the outcome of its interaction with human neutrophils (polymorphonuclear leukocytes [PMNs]). In the absence of opsonic antibodies, PMN interaction with B. parapertussis resulted in nonbactericidal trafficking upon phagocytosis. A high percentage of nonopsonized B. parapertussis was found in nonacidic lysosome marker (lysosome-associated membrane protein [LAMP])-negative phagosomes with access to the host cell-recycling pathway of external nutrients, allowing bacterial survival as determined by intracellular CFU counts. The lipopolysaccharide (LPS) O antigen was found to be involved in directing B. parapertussis to PMN lipid rafts, eventually determining the nonbactericidal fate inside the PMN. IgG opsonization of B. parapertussis drastically changed this interaction by not only inducing efficient PMN phagocytosis but also promoting PMN bacterial killing. These data provide new insights into the immune mechanisms of hosts against B. parapertussis and document the crucial importance of opsonic antibodies in immunity to this pathogen.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Fermentaciones Industriale

Cephalic salt gland evolution in Mesozoic pelagic crocodylomorphs

Secondarily marine tetrapod lineages have independently evolved osmoregulatory adaptations for life in salt water but inferring physiological changes in extinct marine tetrapods is difficult. The Mesozoic crocodylomorph clade Thalattosuchia is unique in having both direct evidence from natural endocasts and several proposed osteological correlates for salt exocrine glands. Here, we investigate salt gland evolution in thalattosuchians by creating endocranial reconstructions from CT scans of eight taxa (one basal thalattosuchian, one teleosauroid, two basal metriorhynchoids and four metriorhynchids) and four outgroups (three extant crocodylians and the basal crocodyliform Protosuchus) to identify salt gland osteological correlates. All metriorhynchoids show dorsolateral nasal cavity expansions corresponding to the location of nasal salt glands in natural casts, but smaller expansions in teleosauroids correspond more with the cartilaginous nasal capsule. The different sizes of these expansions suggest the following evolutionary sequence: (1) plesiomorphically small glands present in semi-aquatic teleosauroids draining through the nasal vestibule; (2) moderately sized glands in the basalmost metriorhynchoid Pelagosaurus; and (3) hypertrophied glands in the clade comprising Eoneustes and metriorhynchids, with a pre-orbital fenestra providing a novel exit for salt drainage. The large gland size inferred from basal metriorhynchoids indicates advanced osmoregulation occurred while metriorhynchoids were semi-aquatic. This pattern does not precisely fit into current models of physiological evolution in marine tetrapods and suggests a unique sequence of changes as thalattosuchians transitioned from land to sea.Fil: Cowgill, T.. University of Edinburgh; Reino UnidoFil: Young, M.. University of Edinburgh; Reino UnidoFil: Schwab, J.. University of Edinburgh; Reino UnidoFil: Walsh, S.. National Museum Of Scotland; Reino UnidoFil: Witmer, Lawrence. Ohio University; Estados UnidosFil: Herrera, Laura Yanina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Dollman, K.. University of the Witwatersrand; SudáfricaFil: Turner, A. H.. State University of New York. Stony Brook University; Estados UnidosFil: Brusatte, S.. University of Edinburgh; Reino Unid

Análise das tendências de pesquisa no Congresso de Agroinformática da Argentina: um estudo regional

Dado o aumento do volume de dados de diferentes tipos e origem, e a viabilidade de análise e tendências através de técnicas de Mineração de Dados, é possível se obter maior conhecimento sobre os dados armazenados e com isso visualizar um cenário atual do contexto que representam estes dados estruturados ou não estruturados. Com este conceito, desenvolve-se em paralelo o uso de tecnologia representada por nuvens de palavras, cuja finalidade é representar em uma figura, as palavras mais frequentes dentro de um documento. Com o objetivo de identificar quais as tendências das pesquisas do Congresso Argentino de Agroinformática (CAI), este trabalho faz uma abordagem nos dados referentes aos títulos dos artigos publicados neste evento no período entre 2008 a 2018, apontando as quais as Províncias da Argentina que mais publicaram e suas as respectivas tendências de pesquisa dos autores dentro deste Congresso.Sociedad Argentina de Informática e Investigación Operativ

Análise das tendências de pesquisa no Congresso de Agroinformática da Argentina: um estudo regional

Dado o aumento do volume de dados de diferentes tipos e origem, e a viabilidade de análise e tendências através de técnicas de Mineração de Dados, é possível se obter maior conhecimento sobre os dados armazenados e com isso visualizar um cenário atual do contexto que representam estes dados estruturados ou não estruturados. Com este conceito, desenvolve-se em paralelo o uso de tecnologia representada por nuvens de palavras, cuja finalidade é representar em uma figura, as palavras mais frequentes dentro de um documento. Com o objetivo de identificar quais as tendências das pesquisas do Congresso Argentino de Agroinformática (CAI), este trabalho faz uma abordagem nos dados referentes aos títulos dos artigos publicados neste evento no período entre 2008 a 2018, apontando as quais as Províncias da Argentina que mais publicaram e suas as respectivas tendências de pesquisa dos autores dentro deste Congresso.Sociedad Argentina de Informática e Investigación Operativ

Flight initiation distance and refuge in urban birds

Risk-taking in birds is often measured as the flight initiation distance (FID), the distance at which individuals take flight when approached by a potential predator (typically a human). The ecological factors that affect avian FID have received great attention over the past decades and meta-analyses and comparative analyses have shown that FID is correlated with body mass, flock size, starting distance of the approaching human, density of potential predators, as well as varying along rural to urban gradients. However, surprisingly, only few studies (mainly on reptiles and mammals) have explored effects of different types of refugia and their availability on animal escape decisions. We used Bayesian regression models (controlling for the phylogenetic relatedness of bird species) to explore changes in escape behaviour recorded in European cities in relationship to the birds' distance to the nearest refuge and distance fled to the refuge. In our analyses, we also included information on the type of refuge, built-up and vegetation cover, starting distance, flock size, urbanization level, and type of urban habitat. We found that birds preferred tree refuges over artificial and bush refuges. Birds escaped earlier if the distance to the nearest refuge of any type was longer and if birds fled longer distances to the refuge. FID was shorter when birds used bushes as refugia or landed on the ground after flushing compared to using artificial refugia. Similarly, the distance fled to a refuge was shortest when using bushes, and increased when escaping to artificial substrates and trees. Birds were more timid in suburban than core areas of cities, cemeteries than parks, and in areas with higher bush cover but lower cover of built-up areas and trees. Our findings provide novel information regarding the importance of refuge proximity and type as factors affecting the escape behaviour of urban birds.MD was funded by MCIN/AEI/10.13039/501100011033 to the project URBILAND (PID2019-107423GA-I00).Peer reviewe

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10−11 for rs4733781; P = 1.0 × 10−10 for rs10956514). Dendritic cells (DCs) showed high ASAP1 expression that was reduced after Mycobacterium tuberculosis infection, and rs10956514 was associated with the level of reduction of ASAP1 expression. The ASAP1 protein is involved in actin and membrane remodeling and has been associated with podosomes. The ASAP1-depleted DCs showed impaired matrix degradation and migration. Therefore, genetically determined excessive reduction of ASAP1 expression in M. tuberculosis–infected DCs may lead to their impaired migration, suggesting a potential mechanism of predisposition to TB