Coincidence between transcriptome analyses on different microarray platforms using a parametric framework

A parametric framework for the analysis of transcriptome data is demonstrated to yield coincident results when applied to data acquired using two different microarray platforms. Discrepancies among transcriptome studies are frequently reported, casting doubt on the reliability of collected data. The inconsistency among observations can be largely attributed to differences among the analytical frameworks employed for data analysis. The existing frameworks normalizes data against a standard determined from the data to be analyzed. In the present study, a parametric framework based on a strict model for normalization is applied to data acquired using an in-house printed chip and GeneChip. The framework is based on a common statistical characteristic of microarray data, and each data is normalized on the basis of a linear relationship with this model. In the proposed framework, the expressional changes observed and genes selected are coincident between platforms, achieving superior universality of data compared to other methods

Top-gated graphene field-effect-transistors formed by decomposition of SiC

Top-gated, few-layer graphene field-effect transistors (FETs) fabricated on thermally-decomposed semi-insulating 4H-SiC substrates are demonstrated. Physical vapor deposited SiO2 is used as the gate dielectric. A two-dimensional hexagonal arrangement of carbon atoms with the correct lattice vectors, observed by high-resolution scanning tunneling microscopy, confirms the formation of multiple graphene layers on top of the SiC substrates. The observation of n-type and p-type transition further verifies Dirac Fermions unique transport properties in graphene layers. The measured electron and hole mobility on these fabricated graphene FETs are as high as 5400 cm2/Vs and 4400 cm2/Vs respectively, which are much larger than the corresponding values from conventional SiC or silicon

Morphology and density of post-CME current sheets

Eruption of a coronal mass ejection (CME) drags and "opens" the coronal magnetic field, presumably leading to the formation of a large-scale current sheet and the field relaxation by magnetic reconnection. We analyze physical characteristics of ray-like coronal features formed in the aftermath of CMEs, to check if the interpretation of this phenomenon in terms of reconnecting current sheet is consistent with the observations. The study is focused on measurements of the ray width, density excess, and coronal velocity field as a function of the radial distance. The morphology of rays indicates that they occur as a consequence of Petschek-like reconnection in the large scale current sheet formed in the wake of CME. The hypothesis is supported by the flow pattern, often showing outflows along the ray, and sometimes also inflows into the ray. The inferred inflow velocities range from 3 to 30 km s$^{-1}$, consistent with the narrow opening-angle of rays, adding up to a few degrees. The density of rays is an order of magnitude larger than in the ambient corona. The density-excess measurements are compared with the results of the analytical model in which the Petschek-like reconnection geometry is applied to the vertical current sheet, taking into account the decrease of the external coronal density and magnetic field with height. The model results are consistent with the observations, revealing that the main cause of the density excess in rays is a transport of the dense plasma from lower to larger heights by the reconnection outflow

A Survey on Biometrics and Cancelable Biometrics Systems

Now-a-days, biometric systems have replaced the password or token based authentication system in many fields to improve the security level. However, biometric system is also vulnerable to security threats. Unlike password based system, biometric templates cannot be replaced if lost or compromised. To deal with the issue of the compromised biometric template, template protection schemes evolved to make it possible to replace the biometric template. Cancelable biometric is such a template protection scheme that replaces a biometric template when the stored template is stolen or lost. It is a feature domain transformation where a distorted version of a biometric template is generated and matched in the transformed domain. This paper presents a review on the state-of-the-art and analysis of different existing methods of biometric based authentication system and cancelable biometric systems along with an elaborate focus on cancelable biometrics in order to show its advantages over the standard biometric systems through some generalized standards and guidelines acquired from the literature. We also proposed a highly secure method for cancelable biometrics using a non-invertible function based on Discrete Cosine Transformation (DCT) and Huffman encoding. We tested and evaluated the proposed novel method for 50 users and achieved good results

IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury.

Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the brain. Here we show that transgenic mice expressing HIV-1 envelope glycoprotein 120 in their central nervous system (HIVgp120tg) mount a transient IFNβ response and provide evidence that IFNβ confers neuronal protection against HIVgp120 toxicity. In cerebrocortical cell cultures, neuroprotection by IFNβ against gp120 toxicity is dependent on IFNα receptor 1 (IFNAR1) and the β-chemokine CCL4, as IFNAR1 deficiency and neutralizing antibodies against CCL4, respectively, abolish the neuroprotective effects. We find in vivo that IFNβ mRNA is significantly increased in HIVgp120tg brains at 1.5, but not 3 or 6 months of age. However, a four-week intranasal IFNβ treatment of HIVgp120tg mice starting at 3.5 months of age increases expression of CCL4 and concomitantly protects neuronal dendrites and pre-synaptic terminals in cortex and hippocampus from gp120-induced damage. Moreover, in vivo and in vitro data suggests astrocytes are a major source of IFNβ-induced CCL4. Altogether, our results suggest exogenous IFNβ as a neuroprotective factor that has potential to ameliorate in vivo HIVgp120-induced brain injury

Domain wall fermion zero modes on classical topological backgrounds

The domain wall approach to lattice fermions employs an additional dimension, in which gauge fields are merely replicated, to separate the chiral components of a Dirac fermion. It is known that in the limit of infinite separation in this new dimension, domain wall fermions have exact zero modes, even for gauge fields which are not smooth. We explore the effects of finite extent in the fifth dimension on the zero modes for both smooth and non-smooth topological configurations and find that a fifth dimension of around ten sites is sufficient to clearly show zero mode effects. This small value for the extent of the fifth dimension indicates the practical utility of this technique for numerical simulations of QCD.Comment: Updated fig. 3-7, small changes in sect. 3, added fig. 8, added more reference

Intertwining personal and reward relevance: evidence from the drift-diffusion model.

In their seminal paper 'Is our self nothing but reward', Northoff and Hayes (Biol Psychiatry 69(11):1019-1025, Northoff, Hayes, Biological Psychiatry 69(11):1019-1025, 2011) proposed three models of the relationship between self and reward and opened a continuing debate about how these different fields can be linked. To date, none of the proposed models received strong empirical support. The present study tested common and distinct effects of personal relevance and reward values by de-componenting different stages of perceptual decision making using a drift-diffusion approach. We employed a recently developed associative matching paradigm where participants (N = 40) formed mental associations between five geometric shapes and five labels referring personal relevance in the personal task, or five shape-label pairings with different reward values in the reward task and then performed a matching task by indicating whether a displayed shape-label pairing was correct or incorrect. We found that common effects of personal relevance and monetary reward were manifested in the facilitation of behavioural performance for high personal relevance and high reward value as socially important signals. The differential effects between personal and monetary relevance reflected non-decisional time in a perceptual decision process, and task-specific prioritization of stimuli. Our findings support the parallel processing model (Northoff & Hayes, Biol Psychiatry 69(11):1019-1025, Northoff, Hayes, Biological Psychiatry 69(11):1019-1025, 2011) and suggest that self-specific processing occurs in parallel with high reward processing. Limitations and further directions are discussed