Synergistic Effect of Cypermethrin and Sodium Fluoride on Kidney Histo Pathology of Albino Mice

The aim of the resent study is to understand the renal toxicity, induced by cypermethrin and sodium fluoride (NaF) separately and combined in albino mice. Albino mice were treated with cypermethrin and sodium fluoride (NaF), separately and in combination, with 1/10th of the LD50 dosage of cypermethrin and NaF for individual administration by oral gavage (i.e., 8.5 mg/kg bw and 5.6 mg/kg bw, respectively) and 1/20th of the LD50dose of cypermethrin and NaF for combined administration (i.e., 4.25 mg/kg bw and 2.8 mg/kg bw, respectively). Separate or combined treatment resulted in histopathological changes in the kidney tissue such as degenerative changes in bowman’s capsule (DGBC), distal convoluted tubules (DGDCT),necrotic changes in glomerulus (NCG), atrophied glomerulus (ATG), necrotic change in distal convoluted tubules (NCDCT), necrotic change in bowman’s capsule (NCBC) and necrosis in proximal convoluted tubules (NCPCT), severe necrotic changes in proximal convoluted tubules (SNCPCT) and distal convoluted tubules ( SNCDCT) were observed. The changes were more in combination than individual treatment, this may be because of a synergistic effect of cypermethrin and NaF

VOLTAMMETRIC DETERMINATION OF DESLORATADINE IN PHARMACEUTICAL AND HUMAN URINE SAMPLES USING GLASSY CARBON ELECTRODE

Objective: The electrochemical behaviour of Desloratadine (DLTD) in pharmaceutical and human urine samples at glassy carbon electrode was investigated by cyclic voltammetry (CV) and square wave voltammetry (SWV). Methods: A well defined reduction peak was observed at potential -1.55V in phosphate buffer solution (PBS) in basic medium. The reduction process was observed to be irreversible over the pH range from pH 2.0 to pH 10.0. The influence of different parameters such as the effect of pH, scan rate and concentration of the drug was studied. The probable reaction mechanism involved in the reduction of DLTD was also proposed. A SWV method with good recovery and accuracy was obtained for the determination of DLTD in pharmaceutical formulations and urine samples. Results: The peak currents were found to be linearly dependent on the concentration range of 2.55x10-5to 1.5x10-3M of DLTD. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 2.75x 10-9M, 3.20x 10-7 M respectively. Conclusion: The proposed method was successfully applied for determination of DLTD in pharmaceutical and human urine samples

Radar Thickness Measurements over the Southern Part of the Greenland Ice Sheet

We performed ice thickness measurements over the southern part of the Greenland ice sheet during June and July 1993. We used an airborne coherent radar depth sounder for these measurements. The radar was operated from a NASA P-3 aircraft equipped with GPS receivers. Radar data were collected in conjunction with laser altimeter and microwave altimeter measurements of ice surface elevation. This report provides radio echograms and thickness profiles from data collected during 1993

Negative phenotypic and genetic associations between copulation duration and longevity in male seed beetles

Reproduction can be costly and is predicted to trade-off against other characters. However, while these trade-offs are well documented for females, there has been less focus on aspects of male reproduction. Furthermore, those studies that have looked at males typically only investigate phenotypic associations, with the underlying genetics often ignored. Here, we report on phenotypic and genetic trade-offs in male reproductive effort in the seed beetle, Callosobruchus maculatus. We find that the duration of a male's first copulation is negatively associated with subsequent male survival, phenotypically and genetically. Our results are consistent with life-history theory and suggest that like females, males trade-off reproductive effort against longevity

Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Third molars: A review

Background: Third molars are teeth that have little functional value and a relatively high rate of associated pain and disease. Their value, as part of the dentition of modern people, is dubious. Types of Studies Reviewed: The authors review the evolution, development. moribidity and treatment of third molars. They access the value of third molars in the 21st century and describe the risks these teeth pose when they develop in the dentition. Conclusions: There is a mandate for the dental profession to improve health outcomes and quality of life. The prevention of third molar-related morbidity should be included in dental research efforts. The authors suggest that novel preventive methodologies be developed to alleviate the problems third molars pose. One potential methodology suggested is intentional therapeutic agenesis of this tooth. Clinical Implications: Prevention of third molar development early in life, even before tooth bud initiation, could dramatically improve healthcare outcomes for millions of peoples