Spin and Quadrupole Couplings for High Spin Equatorial Intermediate Mass-ratio Coalescences

Intermediate mass-ratio coalescences are potential signals of ground-based and space-based gravitational observatories. Accurate modeling of their waveforms within general relativity can be achieved within black hole perturbation theory including self-force and finite size effects. In this paper, we present analytic results to the Teukolsky perturbation of equatorial orbits in the near-horizon region of an extremely high spin black hole including spin coupling and finite size effects at leading order in the high spin limit while neglecting the self-force. We detail the critical behavior occuring close to the smallest specific angular momentum, and we discuss features of spin and quadrupole couplings.Comment: 43 pages, 2 ancillary files: data of Appendix A and B, published versio

Activation of aldehyde dehydrogenase-2 improves ischemic random skin flap survival in rats

ObjectiveRandom skin flaps have many applications in plastic and reconstructive surgeries. However, distal flap necrosis restricts wider clinical utility. Mitophagy, a vital form of autophagy for damaged mitochondria, is excessively activated in flap ischemia/reperfusion (I/R) injury, thus inducing cell death. Aldehyde dehydrogenase-2 (ALDH2), an allosteric tetrameric enzyme, plays an important role in regulating mitophagy. We explored whether ALDH2 activated by N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1) could reduce the risk of ischemic random skin flap necrosis, and the possible mechanism of action.MethodsModified McFarlane flap models were established in 36 male Sprague-Dawley rats assigned randomly to three groups: a low-dose Alda-1 group (10 mg/kg/day), a high-dose Alda-1 group (20 mg/kg/day) and a control group. The percentage surviving skin flap area, neutrophil density and microvessel density (MVD) were evaluated on day 7. Oxidative stress was quantitated by measuring the superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Blood perfusion and skin flap angiogenesis were assessed via laser Doppler flow imaging and lead oxide-gelatin angiography, respectively. The expression levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α), vascular endothelial growth factor (VEGF), ALDH2, PTEN-induced kinase 1 (PINK1), and E3 ubiquitin ligase (Parkin) were immunohistochemically detected. Indicators of mitophagy such as Beclin-1, p62, and microtubule-associated protein light chain 3 (LC3) were evaluated by immunofluorescence.ResultsAlda-1 significantly enhanced the survival area of random skin flaps. The SOD activity increased and the MDA level decreased, suggesting that Alda-1 reduced oxidative stress. ALDH2 was upregulated, and mitophagy-related proteins (PINK1, Parkin, Beclin-1, p62, and LC3) were downregulated, indicating that ALDH2 inhibited mitophagy through the PINK1/Parkin signaling pathway. Treatment with Alda-1 reduced neutrophil infiltration and expressions of inflammatory cytokines. Alda-1 significantly upregulated VEGF expression, increased the MVD, promoted angiogenesis, and enhanced blood perfusion.ConclusionALDH2 activation can effectively enhance random skin flap viability via inhibiting PINK1/Parkin-dependent mitophagy. Moreover, enhancement of ALDH2 activity also exerts anti-inflammatory and angiogenic properties

Studies on the Properties of the Anodic Films Formed on Lead- Lanthanum and Lead-Samarium Alloys in Sulfuric Acid Solution

应用交流伏安法和线性电位扫描法研究了Pb ,Pb 1.0at%La和Pb 1.0at%Sm电极在硫酸溶液中以 0 .9V(vs .Hg/Hg2 SO4 )生长的阳极Pb(Ⅱ )膜增长率和膜的阻抗实部变化 ,并采用循环伏安法研究了它们在 0 .6～ 1.6V(vs.Hg/Hg2 SO4 )间的循环伏安特性 ,结果表明 :在铅中添加Sm有利于抑制铅的阳极腐蚀和降低阳极Pb(Ⅱ )膜的阻抗 ,La亦可降低阳极Pb(Ⅱ )膜的阻抗 ,但其作用不如Sm明显AC voltammetry,linear sweep voltammetry,and cyclic voltammetry were applied to study the anodic corrosion of Pb,Pb 1.0at%La and Pb 1.0at%Sm electrodes in 4.5 mol·dm -3 H 2SO 4 solution (25 ℃).The experiment results show that samarium can inhibit the anodic corrosion of lead and decrease the impedance of anodic Pb(Ⅱ) film. Lanthanum can also decrease the impedance of the anodic Pb(Ⅱ)film, but the effect is smaller.作者联系地址：复旦大学化学系,复旦大学化学系,复旦大学化学系,复旦大学化学系,复旦大学化学系 上海200433 ,上海200433 ,上海200433 ,上海200433 ,上海200433Author's Address: Dept. of Chem., Fudan Univ., Shanghai 200433, Chin