Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty

The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23–36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, P < .01 ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH (r = 0.14, P = .10). These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight

Tunneling construction technology of shafts and cross-passages under strictly controlling deformation of the existing railway

Underground construction will have more or less adverse effects on adjacent existing buildings with more and more existing buildings above ground. However, this situation has only been reported by a small number of researchers. In view of this, this article takes the existing airport line shaft and horizontal passage project in the western suburb of Beijing Metro Line 12 as the background to study the impact of the construction of subway station and shaft passage on the adjacent existing railway. Based on the above project reality, under the action of pavement load, the effects of different parameters (the distance between the surface measuring point and the middle line of the transverse passage and the substep of construction loading sup step) on the surface settlement and track deformation of the shaft and cross-passage through the existing railway are studied by numerical analysis method. The calculation results show that the construction method of shaft and cross passage is reasonable. The comprehensive reinforcement measures of subgrade, rail and hole are effective, effectively controlling the deformation of subgrade and rail within the standard value (surface settlement ≤60 mm, rail deformation ≤6 mm). In addition, the numerical simulation data can better represent the actual situation as a whole

Bayesian statistical analysis on energy for consumption of large-scale public buildings in shanghai

In the process of measuring the power consumed in buildings,massive quantity of real-time energy consumption data have been accumulated.Salient features of these data include large samples,noise accumulations and the presence of measurement errors,etc.Thus,how to analyze and apply these massive data becomes a very challengeable problem.In this paper,based on the dataset which include the consumption of large-scale public buildings in Shanghai for 2015,we establish a hierarchical Bayesian model to estimate the average monthly consumption and the average annual consumption of large public-scale buildings in 2015.The results will help government regulators to conduct effective evaluation on energy saving for buildings

Effects of SiO2 Filler in the Shell and Wood Fiber in the Core on the Thermal Expansion of Core–Shell Wood/Polyethylene Composites

The influence of nano-silica (nSiO2) and micro-silica (mSiO2) in the shell and wood fiber filler in the core on the thermal expansion behavior of co-extruded wood/polyethylene composites (Co-WPCs) was investigated to optimize the thermal expansion resistance. The cut Co-WPCs samples showed anisotropic thermal expansion, and the thermal expansion strain and linear coefficient of thermal expansion (LCTE) decreased by filling the shell layer with rigid silica, especially nSiO2. Finite element analysis indicated that the polymer-filled shell was mainly responsible for the thermal expansion. The entire Co-WPCs samples exhibited a lower thermal expansion strain than the cut Co-WPCs samples due to protection by the shell. Increasing the wood fiber content in the core significantly decreased the thermal expansion strain and LCTE of the Co-WPCs. The Co-WPCs whose core layer was filled with 70% wood fiber exhibited the greatest anisotropic thermal expansion

Response of MG63 osteoblast cells to surface modification of Ti-6Al-4V implant alloy by laser interference lithography

The response of human osteoblast-like osteosarcoma cells (MG63) to surface modification of Ti-6Al-4V implant alloy was investigated by Laser Interference Lithography (LIL). In this work, laser interference lithography was employed to fabricate the microstructures of grooves, dots and dimples onto the surfaces of Ti-6Al-4V samples. Two and three beam LIL systems were developed to carry out the experiments. The laser treatment resulted in the increases of the roughness and the contact angle of water on the implant alloy surfaces. The proliferation of osteoblasts was analyzed by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay for the time periods of 4 hours, 2 days, 3 days, and 6 days. The MTT test results demonstrated that the laser treatment surfaces had a positive impact on the proliferation of osteoblast cells after 24 hours. The alloy surface morphology and the morphological changes of MG63 cells cultured on the laser textured Ti-6Al-4V surface were observed by Scanning Electron Microscope (SEM). The SEM results indicated that the osteoblast cells were aligned on grooved surfaces and they were prolonged with the structures. Enzymatic detachment results showed that the 20 µm grooved structures provided the better cell adhesion to the textured Ti-6Al-4V surfaces