407 research outputs found
Correlation function of dyonic strings
We investigate the two- and three-point correlation functions of the dyonic
magnon and spike, which correspond to the solitonic string moving in the
Poincare AdS and three-dimensional sphere. We show that the coupling between
two dyonic magnons or spikes together with a marginal scalar operator in the
string theory is exactly the same as one obtained by the RG analysis in the
gauge theory.Comment: 15 pages, no figur
Interferometric inverse synthetic aperture radar experiment using an interferometric linear frequency modulated continuous wave millimetre-wave radar
D. Felguera-MartĂn,1 J.-T. GonzĂĄlez-Partida,1 P. Almorox-GonzĂĄlez,1 M. Burgos-GarcĂa,1 and B.-P. Dorta-Naranjo2
1Universidad Politécnica de Madrid, Ciudad Universitaria s/n, Grupo de Microondas y Radar. Departamento de Señales, Sistemas y Radiocomunicaciones, Madrid, Spain
2Universidad de Las Palmas de Gran Canaria, Departamento de Señales y Comunicaciones, Las Palmas de Gran Canaria, Spain
An interferometric linear frequency modulated continuous wave (LFMCW) millimetre-wave radar is presented, along with the results of an experiment conducted to study the feasibility of using it in a future millimetre-wave interferometric inverse synthetic aperture radar (InISAR) system. First, a description of the radar is given. Then, the signal processing chain is described, with special attention to the phase unwrapping technique. The interferometric phase is obtained by unwrapping the prominent target's phase in each antenna using a sliding frame processing technique. Cell migration issues in this method are also addressed. Simulations were carried out to illustrate and assess the processing chain and to show the effects of multipath echoes on the height measurement. In the real experiment, the range, speed and height of a moving target were tracked over consecutive inverse synthetic aperture radar (ISAR) image frames, verifying the performance of the whole system
Functional Properties of Human Auditory Cortical Fields
While auditory cortex in non-human primates has been subdivided into multiple functionally specialized auditory cortical fields (ACFs), the boundaries and functional specialization of human ACFs have not been defined. In the current study, we evaluated whether a widely accepted primate model of auditory cortex could explain regional tuning properties of fMRI activations on the cortical surface to attended and non-attended tones of different frequency, location, and intensity. The limits of auditory cortex were defined by voxels that showed significant activations to non-attended sounds. Three centrally located fields with mirror-symmetric tonotopic organization were identified and assigned to the three core fields of the primate model while surrounding activations were assigned to belt fields following procedures similar to those used in macaque fMRI studies. The functional properties of core, medial belt, and lateral belt field groups were then analyzed. Field groups were distinguished by tonotopic organization, frequency selectivity, intensity sensitivity, contralaterality, binaural enhancement, attentional modulation, and hemispheric asymmetry. In general, core fields showed greater sensitivity to sound properties than did belt fields, while belt fields showed greater attentional modulation than core fields. Significant distinctions in intensity sensitivity and contralaterality were seen between adjacent core fields A1 and R, while multiple differences in tuning properties were evident at boundaries between adjacent core and belt fields. The reliable differences in functional properties between fields and field groups suggest that the basic primate pattern of auditory cortex organization is preserved in humans. A comparison of the sizes of functionally defined ACFs in humans and macaques reveals a significant relative expansion in human lateral belt fields implicated in the processing of speech
Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication
<p>Abstract</p> <p>Background</p> <p>HIV-1 integrase (IN) is a key viral enzymatic molecule required for the integration of the viral cDNA into the genome. Additionally, HIV-1 IN has been shown to play important roles in several other steps during the viral life cycle, including reverse transcription, nuclear import and chromatin targeting. Interestingly, previous studies have demonstrated that the expression of HIV-1 IN induces the lethal phenotype in some strains of <it>Saccharomyces cerevisiae</it>. In this study, we performed mutagenic analyses of the C-terminal region of the catalytic core domain of HIV-1 IN in order to delineate the critical amino acid(s) and/or motif(s) required for the induction of the lethal phenotype in the yeast strain HP16, and to further elucidate the molecular mechanism which causes this phenotype.</p> <p>Results</p> <p>Our study identified three HIV-1 IN mutants, V165A, A179P and KR186,7AA, located in the C-terminal region of the catalytic core domain of IN that do not induce the lethal phenotype in yeast. Chromatin binding assays in yeast and mammalian cells demonstrated that these IN mutants were impaired for the ability to bind chromatin. Additionally, we determined that while these IN mutants failed to interact with LEDGF/p75, they retained the ability to bind Integrase interactor 1. Furthermore, we observed that VSV-G-pseudotyped HIV-1 containing these IN mutants was unable to replicate in the C8166 T cell line and this defect was partially rescued by complementation with the catalytically inactive D64E IN mutant.</p> <p>Conclusion</p> <p>Overall, this study demonstrates that three mutations located in the C-terminal region of the catalytic core domain of HIV-1 IN inhibit the IN-induced lethal phenotype in yeast by inhibiting the binding of IN to the host chromatin. These results demonstrate that the C-terminal region of the catalytic core domain of HIV-1 IN is important for binding to host chromatin and is crucial for both viral replication and the promotion of the IN-induced lethal phenotype in yeast.</p
MicroRNA-483 amelioration of experimental pulmonary hypertension.
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit. Lower levels of miR-483 were found in serum from patients with idiopathic pulmonary arterial hypertension (IPAH), particularly those with more severe disease. RNA-seq and bioinformatics analyses showed that miR-483 targets several PAH-related genes, including transforming growth factor-ÎČ (TGF-ÎČ), TGF-ÎČ receptor 2 (TGFBR2), ÎČ-catenin, connective tissue growth factor (CTGF), interleukin-1ÎČ (IL-1ÎČ), and endothelin-1 (ET-1). Overexpression of miR-483 in ECs inhibited inflammatory and fibrogenic responses, revealed by the decreased expression of TGF-ÎČ, TGFBR2, ÎČ-catenin, CTGF, IL-1ÎČ, and ET-1. In contrast, inhibition of miR-483 increased these genes in ECs. Rats with EC-specific miR-483 overexpression exhibited ameliorated pulmonary hypertension (PH) and reduced right ventricular hypertrophy on challenge with monocrotaline (MCT) or Sugen + hypoxia. A reversal effect was observed in rats that received MCT with inhaled lentivirus overexpressing miR-483. These results indicate that PAH is associated with a reduced level of miR-483 and that miR-483 might reduce experimental PH by inhibition of multiple adverse responses
Physical Response Functions of Strongly Coupled Massive Quantum Liquids
We study physical properties of strongly coupled massive quantum liquids from
their spectral functions using the AdS/CFT correspondence. The generic model
that we consider is dense, heavy fundamental matter coupled to SU(N_c) super
Yang-Mills theory at finite temperature above the deconfinement phase
transition but below the scale set by the baryon number density. In this setup,
we study the current-current correlators of the baryon number density using new
techniques that employ a scaling behavior in the dual geometry. Our results,
the AC conductivity, the quasi-particle spectrum and the Drude-limit parameters
like the relaxation time are simple temperature-independent expressions that
depend only on the mass-squared to density ratio and display a crossover
between a baryon- and meson-dominated regime. We concentrated on the
(2+1)-dimensional defect case, but in principle our results can also be
generalized straightforwardly to other cases.Comment: 21 pages, 10 figures, extra paragraph and figure are added in
response to referee's comment
Holographic Charged Fluid with Anomalous Current at Finite Cutoff Surface in Einstein-Maxwell Gravity
The holographic charged fluid with anomalous current in Einstein-Maxwell
gravity has been generalized from the infinite boundary to the finite cutoff
surface by using the gravity/fluid correspondence. After perturbing the boosted
Reissner-Nordstrom (RN)-AdS black brane solution of the Einstein-Maxwell
gravity with the Chern-Simons term, we obtain the first order perturbative
gravitational and Maxwell solutions, and calculate the stress tensor and
charged current of the dual fluid at finite cutoff surfaces which contains
undetermined parameters after demanding regularity condition at the future
horizon. We adopt the Dirichlet boundary condition and impose the Landau frame
to fix these parameters, finally obtain the dependence of transport
coefficients in the dual stress tensor and charged current on the arbitrary
radical cutoff . We find that the dual fluid is not conformal, but it has
vanishing bulk viscosity, and the shear viscosity to entropy density ratio is
universally . Other transport coefficients of the dual current turns
out to be cutoff-dependent. In particular, the chiral vortical conductivity
expressed in terms of thermodynamic quantities takes the same form as that of
the dual fluid at the asymptotic AdS boundary, and the chiral magnetic
conductivity receives a cutoff-dependent correction which vanishes at the
infinite boundary.Comment: 19 pages, v2: references added, v3: typos corrected, v5: typos
corrected, version accepted for publication in JHE
Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine
Genetic reassortment between influenza A viruses (IAVs) facilitate emergence of pandemic strains, and swine are proposed as a âmixing vesselâ for generating reassortants of avian and mammalian IAVs that could be of risk to mammals, including humans. However, how a transmissible reassortant emerges in swine are not well understood. Genomic analyses of 571 isolates recovered from nasal wash samples and respiratory tract tissues of a group of co-housed pigs (influenza-seronegative, avian H1N1 IAVâinfected, and swine H3N2 IAVâ infected pigs) identified 30 distinct genotypes of reassortants. Viruses recovered from lower respiratory tract tissues had the largest genomic diversity, and those recovered from turbinates and nasal wash fluids had the least. Reassortants from lower respiratory tracts had the largest variations in growth kinetics in respiratory tract epithelial cells, and the cold temperature in swine nasal cells seemed to select the type of reassortant viruses shed by the pigs. One reassortant in nasal wash samples was consistently identified in upper, middle, and lower respiratory tract tissues, and it was confirmed to be transmitted efficiently between pigs. Study findings suggest that, during mixed infections of avian and swine IAVs, genetic reassortments are likely to occur in the lower respiratory track, and tissue tropism is an important factor selecting for a transmissible reassortant
Measurement of high-p_T Single Electrons from Heavy-Flavor Decays in p+p Collisions at sqrt(s) = 200 GeV
The momentum distribution of electrons from decays of heavy flavor (charm and
beauty) for midrapidity |y| < 0.35 in p+p collisions at sqrt(s) = 200 GeV has
been measured by the PHENIX experiment at the Relativistic Heavy Ion Collider
(RHIC) over the transverse momentum range 0.3 < p_T < 9 GeV/c. Two independent
methods have been used to determine the heavy flavor yields, and the results
are in good agreement with each other. A fixed-order-plus-next-to-leading-log
pQCD calculation agrees with the data within the theoretical and experimental
uncertainties, with the data/theory ratio of 1.72 +/- 0.02^stat +/- 0.19^sys
for 0.3 < p_T < 9 GeV/c. The total charm production cross section at this
energy has also been deduced to be sigma_(c c^bar) = 567 +/- 57^stat +/-
224^sys micro barns.Comment: 375 authors from 57 institutions, 6 pages, 3 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Suppression of back-to-back hadron pairs at forward rapidity in d+Au Collisions at sqrt(s_NN)=200 GeV
Back-to-back hadron pair yields in d+Au and p+p collisions at sqrt(s_NN)=200
GeV were measured with the PHENIX detector at the Relativistic Heavy Ion
Collider. Rapidity separated hadron pairs were detected with the trigger hadron
at pseudorapidity |eta|<0.35 and the associated hadron at forward rapidity
(deuteron direction, 3.0<eta<3.8). Pairs were also detected with both hadrons
measured at forward rapidity; in this case the yield of back-to-back hadron
pairs in d+Au collisions with small impact parameters is observed to be
suppressed by a factor of 10 relative to p+p collisions. The kinematics of
these pairs is expected to probe partons in the Au nucleus with low fraction x
of the nucleon momenta, where the gluon densities rise sharply. The observed
suppression as a function of nuclear thickness, p_T, and eta points to cold
nuclear matter effects arising at high parton densities.Comment: 381 authors, 6 pages, 4 figures. Published in Phys. Rev. Lett.
(http://link.aps.org/doi/10.1103/PhysRevLett.107.172301). v3 has minor
changes to match published version
(http://www.phenix.bnl.gov/phenix/WWW/info/pp1/128/PhysRevLett.107.172301)
Plain text data tables for points plotted in figures are publicly available
at http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg128_data.htm
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