68 research outputs found
Self-Consistent Sources and Conservation Laws for a Super Broer-Kaup-Kupershmidt Equation Hierarchy
Based on the matrix Lie superalgebras and supertrace identity, the integrable super
Broer-Kaup-Kupershmidt hierarchy with self-consistent sources is established. Furthermore, we
establish the infinitely many conservation laws for the integrable super Broer-Kaup-Kupershmidt
hierarchy. In the process of computation especially, Fermi variables also play an important role in
super integrable systems
Self-Consistent Sources and Conservation Laws for a Super Broer-Kaup-Kupershmidt Equation Hierarchy
Based on the matrix Lie superalgebras and supertrace identity, the integrable super Broer-Kaup-Kupershmidt hierarchy with self-consistent sources is established. Furthermore, we establish the infinitely many conservation laws for the integrable super Broer-Kaup-Kupershmidt hierarchy. In the process of computation especially, Fermi variables also play an important role in super integrable systems
A Integrable Generalized Super-NLS-mKdV Hierarchy, Its Self-Consistent Sources, and Conservation Laws
A generalized super-NLS-mKdV hierarchy is proposed related to Lie superalgebra B(0,1); the resulting supersoliton hierarchy is put into super bi-Hamiltonian form with the aid of supertrace identity. Then, the super-NLS-mKdV hierarchy with self-consistent sources is set up. Finally, the infinitely many conservation laws of integrable super-NLS-mKdV hierarchy are presented
A New Soliton Hierarchy Associated with so
Based on the three-dimensional real special orthogonal Lie algebra so(3,R), we construct a new hierarchy of soliton equations by zero curvature equations and show that each equation in the resulting hierarchy has a bi-Hamiltonian structure and thus integrable in the Liouville sense. Furthermore, we present the infinitely many conservation laws for the new soliton hierarchy
Fractional-Order Modeling and Sliding Mode Control of Energy-Saving and Emission-Reduction Dynamic Evolution System
Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer
Bladder cancer is the ninth most common cause of cancer-related deaths worldwide. Although cisplatin is used routinely in treating bladder cancer, refractory disease remains lethal for many patients. The recent addition of immunotherapy has improved patient outcomes; however, a large cohort of patients does not respond to these treatments. Therefore, identification of innovative molecular targets for bladder cancer is crucial. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in both DNA repair and activation of transcription factors through reduction-oxidation (redox) regulation. High APE1/Ref-1 expression is associated with shorter patient survival time in many cancer types. In this study, we found high APE1/Ref-1 expression in human bladder cancer tissue relative to benign urothelium. Inhibition of APE1/Ref-1 redox signaling using APE1/Ref-1-specific inhibitors attenuates bladder cancer cell proliferation in monolayer, in three-dimensional cultures, and in vivo. This inhibition corresponds with an increase in apoptosis and decreased transcriptional activity of NF-κB and STAT3, transcription factors known to be regulated by APE1/Ref-1, resulting in decreased expression of downstream effectors survivin and Cyclin D1 in vitro and in vivo. We also demonstrate that in vitro treatment of bladder cancer cells with APE1/Ref-1 redox inhibitors in combination with standard-of-care chemotherapy cisplatin is more effective than cisplatin alone at inhibiting cell proliferation. Collectively, our data demonstrate that APE1/Ref-1 is a viable drug target for the treatment of bladder cancer, provide a mechanism of APE1/Ref-1 action in bladder cancer cells, and support the use of novel redox-selective APE1/Ref-1 inhibitors in clinical studies. SIGNIFICANCE: This work identifies a critical mechanism for APE1/Ref-1 in bladder cancer growth and provides compelling preclinical data using selective redox activity inhibitors of APE1/Ref-1 in vitro and in vivo
GLM-130B: An Open Bilingual Pre-trained Model
We introduce GLM-130B, a bilingual (English and Chinese) pre-trained language
model with 130 billion parameters. It is an attempt to open-source a 100B-scale
model at least as good as GPT-3 (davinci) and unveil how models of such a scale
can be successfully pre-trained. Over the course of this effort, we face
numerous unexpected technical and engineering challenges, particularly on loss
spikes and divergence. In this paper, we introduce the training process of
GLM-130B including its design choices, training strategies for both efficiency
and stability, and engineering efforts. The resultant GLM-130B model offers
significant outperformance over GPT-3 175B (davinci) on a wide range of popular
English benchmarks while the performance advantage is not observed in OPT-175B
and BLOOM-176B. It also consistently and significantly outperforms ERNIE TITAN
3.0 260B -- the largest Chinese language model -- across related benchmarks.
Finally, we leverage a unique scaling property of GLM-130B to reach INT4
quantization without post training, with almost no performance loss, making it
the first among 100B-scale models and more importantly, allowing its effective
inference on 4RTX 3090 (24G) or 8RTX 2080 Ti (11G) GPUs, the
most affordable GPUs required for using 100B-scale models. The GLM-130B model
weights are publicly accessible and its code, training logs, related toolkit,
and lessons learned are open-sourced at
\url{https://github.com/THUDM/GLM-130B/}.Comment: Accepted to ICLR 202
Chalcogenide Glass-on-Graphene Photonics
Two-dimensional (2-D) materials are of tremendous interest to integrated
photonics given their singular optical characteristics spanning light emission,
modulation, saturable absorption, and nonlinear optics. To harness their
optical properties, these atomically thin materials are usually attached onto
prefabricated devices via a transfer process. In this paper, we present a new
route for 2-D material integration with planar photonics. Central to this
approach is the use of chalcogenide glass, a multifunctional material which can
be directly deposited and patterned on a wide variety of 2-D materials and can
simultaneously function as the light guiding medium, a gate dielectric, and a
passivation layer for 2-D materials. Besides claiming improved fabrication
yield and throughput compared to the traditional transfer process, our
technique also enables unconventional multilayer device geometries optimally
designed for enhancing light-matter interactions in the 2-D layers.
Capitalizing on this facile integration method, we demonstrate a series of
high-performance glass-on-graphene devices including ultra-broadband on-chip
polarizers, energy-efficient thermo-optic switches, as well as graphene-based
mid-infrared (mid-IR) waveguide-integrated photodetectors and modulators
Expert consensus on spontaneous ventilation video-assisted thoracoscopic surgery in primary spontaneous pneumothorax (Guangzhou)
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