The far-infrared/radio correlation and radio spectral index of galaxies in the SFR-M* plane up to z 2

[Abridged] We study the evolution of the radio spectral index and far-infrared/radio correlation (FRC) across the star-formation rate-stellar masse (i.e. SFR-M*) plane up to z 2. We start from a M*-selected sample of galaxies with reliable SFR and redshift estimates. We then grid the SFR-M* plane in several redshift ranges and measure the infrared luminosity, radio luminosity, radio spectral index, and ultimately the FRC index (i.e. qFIR) of each SFR-M*-z bin. The infrared luminosities of our SFR-M*-z bins are estimated using their stacked far-infrared flux densities inferred from observations obtained with Herschel. Their radio luminosities and radio spectral indices (i.e. alpha, where Snu nu^-alpha) are estimated using their stacked 1.4GHz and 610MHz flux densities from the VLA and GMRT, respectively. Our far-infrared and radio observations include the most widely studied blank extragalactic fields -GOODS-N/S, ECDFS, and COSMOS- covering a sky area of 2deg^2. Using this methodology, we constrain the radio spectral index and FRC index of star-forming galaxies with M*>10^10Msun and 0<z<2.3. We find that alpha^1.4GHz_610MHz does not evolve significantly with redshift or with the distance of a galaxy with respect to the main sequence (MS) of the SFR-M* plane (i.e. Delta_log(SSFR)_MS=log[SSFR(galaxy)/SSFR_MS(M*,z)]). Instead, star-forming galaxies have a radio spectral index consistent with a canonical value of 0.8, which suggests that their radio spectra are dominated by non-thermal optically thin synchrotron emission. We find that qFIR displays a moderate but statistically significant redshift evolution as qFIR(z)=(2.35+/-0.08)*(1+z)^(-0.12+/-0.04), consistent with some previous literature. Finally, we find no significant correlation between qFIR and Delta_log(SSFR)_MS, though a weak positive trend, as observed in one of our redshift bins, cannot be firmly ruled out using our dataset.Comment: Accepted for publication in A&A; 18 pages, 10 figure

Optimizing transcranial magnetic stimulation for spaceflight applications

As space agencies aim to reach and build installations on Mars, the crews will face longer exposure to extreme environments that may compromise their health and performance. Transcranial magnetic stimulation (TMS) is a painless non-invasive brain stimulation technique that could support space exploration in multiple ways. However, changes in brain morphology previously observed after long-term space missions may impact the efficacy of this intervention. We investigated how to optimize TMS for spaceflight-associated brain changes. Magnetic resonance imaging T1-weighted scans were collected from 15 Roscosmos cosmonauts and 14 non-flyer participants before, after 6 months on the International Space Station, and at a 7-month follow-up. Using biophysical modeling, we show that TMS generates different modeled responses in specific brain regions after spaceflight in cosmonauts compared to the control group. Differences are related to spaceflight-induced structural brain changes, such as those impacting cerebrospinal fluid volume and distribution. We suggest solutions to individualize TMS to enhance its efficacy and precision for potential applications in long-duration space missions. © 2023, The Author(s)

Cobalt toxicity in humans-A review of the potential sources and systemic health effects

Cobalt (Co) and its compounds are widely distributed in nature and are part of numerous anthropogenic activities. Although cobalt has a biologically necessary role as metal constituent of vitamin B12, excessive exposure has been shown to induce various adverse health effects. This review provides an extended overview of the possible Co sources and related intake routes, the detection and quantification methods for Co intake and the interpretation thereof, and the reported health effects. The Co sources were allocated to four exposure settings: occupational, environmental, dietary and medical exposure. Oral intake of Co supplements and internal exposure through metal-on-metal (MoM) hip implants deliver the highest systemic Co concentrations. The systemic health effects are characterized by a complex clinical syndrome, mainly including neurological (e.g. hearing and visual impairment), cardiovascular and endocrine deficits. Recently, a biokinetic model has been proposed to characterize the dose-response relationship and effects of chronic exposure. According to the model, health effects are unlikely to occur at blood Co concentrations under 300 μg/l (100 μg/l respecting a safety factor of 3) in healthy individuals, hematological and endocrine dysfunctions are the primary health endpoints, and chronic exposure to acceptable doses is not expected to pose considerable health hazards. However, toxic reactions at lower doses have been described in several cases of malfunctioning MoM hip implants, which may be explained by certain underlying pathologies that increase the individual susceptibility for Co-induced systemic toxicity. This may be associated with a decrease in Co bound to serum proteins and an increase in free ionic Co2+. As the latter is believed to be the primary toxic form, monitoring of the free fraction of Co2+ might be advisable for future risk assessment. Furthermore, future research should focus on longitudinal studies in the clinical setting of MoM hip implant patients to further elucidate the dose-response discrepancies

Dust temperature and CO-to-H2 conversion factor variations in the SFR-M* plane

Deep Herschel imaging and 12CO(2-1) line luminosities from the IRAM PdBI are combined for a sample of 17 galaxies at z>1 from the GOODS-N field. The sample includes galaxies both on and above the main sequence (MS) traced by star-forming galaxies in the SFR-M* plane. The far-infrared data are used to derive dust masses, Mdust. Combined with an empirical prescription for the dependence of the gas-to-dust ratio on metallicity (GDR), the CO luminosities and Mdust values are used to derive for each galaxy the CO-to-H2 conversion factor, alpha_co. Like in the local Universe, the value of alpha_co is a factor of ~5 smaller in starbursts compared to normal star-forming galaxies (SFGs). We also uncover a relation between alpha_co and dust temperature (Tdust; alpha_co decreasing with increasing Tdust) as obtained from modified blackbody fits to the far-infrared data. While the absolute normalization of the alpha_co(Tdust) relation is uncertain, the global trend is robust against possible systematic biases in the determination of Mdust, GDR or metallicity. Although we cannot formally distinguish between a step and a smooth evolution of alpha_co with the dust temperature, we can conclude that in galaxies of near-solar metallicity, a critical value of Tdust=30K can be used to determine whether the appropriate alpha_co is closer to the starburst value (1.0 Msun(K kms pc^2)^-1, if Tdust>30K) or closer to the Galactic value (4.35 Msun (K kms pc^2)^-1, if Tdust<30K). This indicator has the great advantage of being less subjective than visual morphological classifications of mergers/SFGs, which can be difficult at high z because of the clumpy nature of SFGs. In the absence of far-infrared data, the offset of a galaxy from the main sequence (i.e., log[SSFR(galaxy)/SSFR_MS(M*,z)]) can be used to identify galaxies requiring the use of an alpha_co conversion factor lower than the Galactic value.Comment: Accepted for publication in Astronomy and Astrophysics (A&A); 15 pages, 6 figures; V2: updated reference lis

A Substantial Population of Red Galaxies at z > 2: Modeling of the Spectral Energy Distributions of an Extended Sample

We investigate the nature of the substantial population of high-z galaxies with Js-Ks>2.3 discovered as part of our FIRES survey. This colour cut efficiently isolates z>2 galaxies with red rest-frame optical colors ("Distant Red Galaxies" or DRGs). We select objects in the 2.5'x2.5' HDF-South (HDF-S) and 5'x5' field around the MS1054-03 cluster; the surface densities at Ks<21 are 1.6+-0.6 and 1.0+-0.2 arcmin^-2. We discuss the 34 DRGs at 2<z<3.5: 11 at Ks<22.5 in HDF-S and 23 at Ks<21.7 in the MS1054-03 field. We analyze the SEDs constructed from our deep near-infrared (NIR) and optical imaging from the ESO VLT and HST. We develop diagnostics involving I-Js, Js-H, and H-Ks to argue that the red NIR colors of DRGs cannot be attributed solely to extinction and require for many an evolved stellar population with prominent Balmer/4000A break. In the rest-frame, the optical colours of DRGs fall within the envelope of normal nearby galaxies and the UV colours suggest a wide range in star formation activity and/or extinction. This contrasts with the much bluer and more uniform SEDs of Lyman break galaxies (LBGs). From evolutionary synthesis models with constant star formation, solar metallicity, Salpeter IMF, and Calzetti et al. extinction law, we derive for the HDF-S (MS1054-03 field) DRGs median ages of 1.7(2.0) Gyr, A_V = 2.7(2.4) mag, stellar masses 0.8(1.6)x10^11 Msun, M/L_V = 1.2(2.3) Msun/LVsun, and SFR = 120(170) Msun/yr. Models assuming declining SFRs with e-folding timescales of 10Myr-1Gyr generally imply younger ages, lower A_V's and SFRs, but similar stellar masses within a factor of two. Compared to LBGs at similar redshifts and rest-frame L_V's, DRGs are older, more massive, and more obscured for any given star formation history. [ABRIDGED]Comment: Accepted for publication in the Astrophysical Journal. 27 pages, 14 b/w figure

Panchromatic spectral energy distributions of Herschel sources

(abridged) Far-infrared Herschel photometry from the PEP and HerMES programs is combined with ancillary datasets in the GOODS-N, GOODS-S, and COSMOS fields. Based on this rich dataset, we reproduce the restframe UV to FIR ten-colors distribution of galaxies using a superposition of multi-variate Gaussian modes. The median SED of each mode is then fitted with a modified version of the MAGPHYS code that combines stellar light, emission from dust heated by stars and a possible warm dust contribution heated by an AGN. The defined Gaussian grouping is also used to identify rare sources. The zoology of outliers includes Herschel-detected ellipticals, very blue z~1 Ly-break galaxies, quiescent spirals, and torus-dominated AGN with star formation. Out of these groups and outliers, a new template library is assembled, consisting of 32 SEDs describing the intrinsic scatter in the restframe UV-to-submm colors of infrared galaxies. This library is tested against L(IR) estimates with and without Herschel data included, and compared to eight other popular methods often adopted in the literature. When implementing Herschel photometry, these approaches produce L(IR) values consistent with each other within a median absolute deviation of 10-20%, the scatter being dominated more by fine tuning of the codes, rather than by the choice of SED templates. Finally, the library is used to classify 24 micron detected sources in PEP GOODS fields. AGN appear to be distributed in the stellar mass (M*) vs. star formation rate (SFR) space along with all other galaxies, regardless of the amount of infrared luminosity they are powering, with the tendency to lie on the high SFR side of the "main sequence". The incidence of warmer star-forming sources grows for objects with higher specific star formation rates (sSFR), and they tend to populate the "off-sequence" region of the M*-SFR-z space.Comment: Accepted for publication in A&A. Some figures are presented in low resolution. The new galaxy templates are available for download at the address http://www.mpe.mpg.de/ir/Research/PEP/uvfir_temp

DOCK6 Mutations Are Responsible for a Distinct Autosomal-Recessive Variant of Adams-Oliver Syndrome Associated with Brain and Eye Anomalies

Author contacted for file

Combined CO & Dust Scaling Relations of Depletion Time and Molecular Gas Fractions with Cosmic Time, Specific Star Formation Rate and Stellar Mass

We combine molecular gas masses inferred from CO emission in 500 star forming galaxies (SFGs) between z=0 and 3, from the IRAM-COLDGASS, PHIBSS1/2 and other surveys, with gas masses derived from Herschel far-IR dust measurements in 512 galaxy stacks over the same stellar mass/redshift range. We constrain the scaling relations of molecular gas depletion time scale (tdepl) and gas to stellar mass ratio (Mmolgas/M*) of SFGs near the star formation main-sequence with redshift, specific star formation rate (sSFR) and stellar mass (M*). The CO- and dust-based scaling relations agree remarkably well. This suggests that the CO-H2 mass conversion factor varies little within 0.6dex of the main sequence (sSFR(ms,z,M*)), and less than 0.3dex throughout this redshift range. This study builds on and strengthens the results of earlier work. We find that tdepl scales as (1+z)^-0.3 *(sSFR/sSFR(ms,z,M*))^-0.5, with little dependence on M*. The resulting steep redshift dependence of Mmolgas/M* ~(1+z)^3 mirrors that of the sSFR and probably reflects the gas supply rate. The decreasing gas fractions at high M* are driven by the flattening of the SFR-M* relation. Throughout the redshift range probed a larger sSFR at constant M* is due to a combination of an increasing gas fraction and a decreasing depletion time scale. As a result galaxy integrated samples of the Mmolgas-SFR rate relation exhibit a super-linear slope, which increases with the range of sSFR. With these new relations it is now possible to determine Mmolgas with an accuracy of 0.1dex in relative terms, and 0.2dex including systematic uncertainties.Comment: ApJ accepte

PHIBSS: molecular gas content and scaling relations in z~1-3 normal star forming galaxies

We present PHIBSS, the IRAM Plateau de Bure high-z blue sequence CO 3-2 survey of the molecular gas properties in normal star forming galaxies (SFGs) near the cosmic star formation peak. PHIBSS provides 52 CO detections in two redshift slices at z~1.2 and 2.2, with log(M*(M_solar))>10.4 and log(SFR(M_solar/yr))>1.5. Including a correction for the incomplete coverage of the M*-SFR plane, we infer average gas fractions of ~0.33 at z~1.2 and ~0.47 at z~2.2. Gas fractions drop with stellar mass, in agreement with cosmological simulations including strong star formation feedback. Most of the z~1-3 SFGs are rotationally supported turbulent disks. The sizes of CO and UV/optical emission are comparable. The molecular gas - star formation relation for the z=1-3 SFGs is near-linear, with a ~0.7 Gyrs gas depletion timescale; changes in depletion time are only a secondary effect. Since this timescale is much less than the Hubble time in all SFGs between z~0 and 2, fresh gas must be supplied with a fairly high duty cycle over several billion years. At given z and M*, gas fractions correlate strongly with the specific star formation rate. The variation of specific star formation rate between z~0 and 3 is mainly controlled by the fraction of baryonic mass that resides in cold gas.Comment: Submitted to the Astrophysical Journal; 14 figure