508 research outputs found
Dynamic and Thermodynamic Influences on Precipitation in Northeast Mexico on Orbital to Millennial Timescales
The timing and mechanisms of past hydroclimate change in northeast Mexico are poorly constrained, limiting our ability to evaluate climate model performance. To address this, we present a multiproxy speleothem record of past hydroclimate variability spanning 62.5 to 5.1 ka from Tamaulipas, Mexico. Here we show a strong influence of Atlantic and Pacific sea surface temperatures on orbital and millennial scale precipitation changes in the region. Multiple proxies show no clear response to insolation forcing, but strong evidence for dry conditions during Heinrich Stadials. While these trends are consistent with other records from across Mesoamerica and the Caribbean, the relative importance of thermodynamic and dynamic controls in driving this response is debated. An isotope-enabled climate model shows that cool Atlantic SSTs and stronger easterlies drive a strong inter-basin sea surface temperature gradient and a southward shift in moisture convergence, causing drying in this region
Ogbu and the debate on educational achievement: an exploration of the links between education, migration, identity and belonging
This paper looks at some of the issues raised by Ogbuâs work in relation to the education of different minority ethnic groups. Ogbu poses questions such as the value attached to education,
its links to the future and its measurable outcomes in terms of âsuccessâ as experienced by black participants. The desire for better life chances leads families to consider migration to a new country or resettlement within the same country, thus making migration both a local and a global phenomenon. As an example, attention is drawn to the situation facing South Asian
children and their families in the UK. In terms of ethnicity and belonging, the wider question that is significant for many countries in the West after âNine-Elevenâ is the education of Muslim children. A consideration of this current situation throws Ogbuâs identification of âautonomous minorityâ into question. It is argued that a greater understanding of diverse needs has to be
accompanied by a concerted effort to confront racism and intolerance in schools and in society, thus enabling all communities to make a useful contribution and to avoid the âriskâ of failure and disenchantment
Directly Imaging Rocky Planets from the Ground
Over the past three decades instruments on the ground and in space have
discovered thousands of planets outside the solar system. These observations
have given rise to an astonishingly detailed picture of the demographics of
short-period planets, but are incomplete at longer periods where both the
sensitivity of transit surveys and radial velocity signals plummet. Even more
glaring is that the spectra of planets discovered with these indirect methods
are either inaccessible (radial velocity detections) or only available for a
small subclass of transiting planets with thick, clear atmospheres. Direct
detection can be used to discover and characterize the atmospheres of planets
at intermediate and wide separations, including non-transiting exoplanets.
Today, a small number of exoplanets have been directly imaged, but they
represent only a rare class of young, self-luminous super-Jovian-mass objects
orbiting tens to hundreds of AU from their host stars. Atmospheric
characterization of planets in the <5 AU regime, where radial velocity (RV)
surveys have revealed an abundance of other worlds, is technically feasible
with 30-m class apertures in combination with an advanced AO system,
coronagraph, and suite of spectrometers and imagers. There is a vast range of
unexplored science accessible through astrometry, photometry, and spectroscopy
of rocky planets, ice giants, and gas giants. In this whitepaper we will focus
on one of the most ambitious science goals --- detecting for the first time
habitable-zone rocky (<1.6 R_Earth) exoplanets in reflected light around nearby
M-dwarfsComment: 8 pages, 1 figure, Astro2020 Science White Pape
MS4A1 Dysregulation in Asbestos-Related Lung Squamous Cell Carcinoma Is Due to CD20 Stromal Lymphocyte Expression
Asbestos-related lung cancer accounts for 4â12% of lung cancers worldwide. We have previously identified ADAM28 as a putative oncogene involved in asbestos-related lung adenocarcinoma (ARLC-AC). We hypothesised that similarly gene expression profiling of asbestos-related lung squamous cell carcinomas (ARLC-SCC) may identify candidate oncogenes for ARLC-SCC. We undertook a microarray gene expression study in 56 subjects; 26 ARLC-SCC (defined as lung asbestos body (AB) counts >20AB/gram wet weight (gww) and 30 non-asbestos related lung squamous cell carcinoma (NARLC-SCC; no detectable lung asbestos bodies; 0AB/gww). Microarray and bioinformatics analysis identified six candidate genes differentially expressed between ARLC-SCC and NARLC-SCC based on statistical significance (p<0.001) and fold change (FC) of >2-fold. Two genes MS4A1 and CARD18, were technically replicated by qRT-PCR and showed consistent directional changes. As we also found MS4A1 to be overexpressed in ARLC-ACs, we selected this gene for biological validation in independent test sets (one internal, and one external dataset (2 primary tumor sets)). MS4A1 RNA expression dysregulation was validated in the external dataset but not in our internal dataset, likely due to the small sample size in the test set as immunohistochemical (IHC) staining for MS4A1 (CD20) showed that protein expression localized predominantly to stromal lymphocytes rather than tumor cells in ARLC-SCC. We conclude that differential expression of MS4A1 in this comparative gene expression study of ARLC-SCC versus NARLC-SCC is a stromal signal of uncertain significance, and an example of the rationale for tumor cell enrichment in preparation for gene expression studies where the aim is to identify markers of particular tumor phenotypes. Finally, our study failed to identify any strong gene candidates whose expression serves as a marker of asbestos etiology. Future research is required to determine the role of stromal lymphocyte MS4A1 dysregulation in pulmonary SCCs caused by asbestos
Suppressed Far-UV stellar activity and low planetary mass-loss in the WASP-18 system
WASP-18 hosts a massive, very close-in Jupiter-like planet. Despite its young age (RâČHK activity parameter lies slightly below the basal level; there is no significant time-variability in the log RâČHK value; there is no detection of the star in the X-rays. We present results of far-UV observations of WASP-18 obtained with COS on board of HST aimed at explaining this anomaly. From the starâs spectral energy distribution, we infer the extinction (E(B â V) â 0.01mag) and then the ISM column density for a number of ions, concluding that ISM absorption is not the origin of the anomaly. We measure the flux of the four stellar emission features detected in the COS spectrum (C II, C III, C IV, Si IV). Comparing the C II/C IV flux ratio measured for WASP-18 with that derived from spectra of nearby stars with known age, we see that the far-UV spectrum of WASP-18 resembles that of old (>5Gyr), inactive stars, in stark contrast with its young age. We conclude that WASP-18 has an intrinsically low activity level, possibly caused by star-planet tidal interaction, as suggested by previous studies. Re-scaling the solar irradiance reference spectrum to match the flux of the Si IV line, yields an XUV integrated flux at the planet orbit of 10.2 erg sâ1 cmâ2. We employ the rescaled XUV solar fluxes to model of the planetary upper atmosphere, deriving an extremely low thermal mass-loss rate of 10â20MJ Gyrâ1. For such high-mass planets, thermal escape is not energy limited, but driven by Jeans escape
Near-infrared proper motions and spectroscopy of infrared excess sources at the Galactic Center
There are a number of faint compact infrared excess sources in the central
stellar cluster of the Milky Way. Their nature and origin is unclear. In
addition to several isolated objects of this kind we find a small but dense
cluster of co-moving sources (IRS13N) about 3" west of SgrA* just 0.5" north of
the bright IRS13E cluster of WR and O-type stars. Based on their color and
brightness, there are two main possibilities: (1) they may be dust embedded
stars older than few Myr, or (2) extremely young, dusty stars with ages less
than 1Myr. We present fist H- and Ks-band identifications or proper motions of
the IRS13N members, the high velocity dusty S-cluster object (DSO), and other
infrared excess sources in the central field. We also present results of NIR H-
and Ks-band ESO-SINFONI integral field spectroscopy of ISR13N. We show that
within the uncertainties, the proper motions of the IRS13N sources in Ks- and
L'-band are identical. This indicates that the bright L'-band IRS13N sources
are indeed dust enshrouded stars rather than core-less dust clouds. The proper
motions show that the IRS13N sources are not strongly gravitationally bound to
each other implying that they have been formed recently. We also present a
first H- and Ks-band identification as well as proper motions and HKsL'-colors
of a fast moving DSO which was recently found in the cluster of high speed
S-stars that surround the super-massive black hole Sagittarius A* (SgrA*). Most
of the compact L'-band excess emission sources have a compact H- or Ks-band
counterpart and therefore are likely stars with dust shells or disks. Our new
results and orbital analysis from our previous work favor the hypothesis that
the infrared excess IRS13N members and other dusty sources close to SgrA* are
very young dusty stars and that star formation at the GC is a continuously
ongoing process.Comment: 20 pages, 18 figures, 4 tables plus appendix with 16 figures and 3
tables accepted by A&
Induced pseudoscalar coupling of the proton weak interaction
The induced pseudoscalar coupling is the least well known of the weak
coupling constants of the proton's charged--current interaction. Its size is
dictated by chiral symmetry arguments, and its measurement represents an
important test of quantum chromodynamics at low energies. During the past
decade a large body of new data relevant to the coupling has been
accumulated. This data includes measurements of radiative and non radiative
muon capture on targets ranging from hydrogen and few--nucleon systems to
complex nuclei. Herein the authors review the theoretical underpinnings of
, the experimental studies of , and the procedures and uncertainties
in extracting the coupling from data. Current puzzles are highlighted and
future opportunities are discussed.Comment: 58 pages, Latex, Revtex4, prepared for Reviews of Modern Physic
Mechanism of subunit interaction at ketosynthase-dehydratase junctions in trans-AT polyketide synthases
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products with diverse applications in medicine and agriculture. They typically consist of several multienzyme subunits that utilize structurally-defined docking domains (DDs) at their N- and C-termini to ensure correct assembly into functional multi-protein complexes. Here we report a fundamentally different mechanism for subunit assembly in trans-AT modular PKSs at the junction between ketosynthase (KS) and dehydratase (DH) domains. This involves direct interaction of a largely unstructured docking domain (DD) at the C-terminus of the KS with the surface of the downstream DH. Acyl transfer assays and mechanism-based cross-linking established that the DD is required for the KS to communicate with the acyl carrier protein appended to the DH. Two distinct regions for binding of the DD to the DH were identified using NMR spectroscopy, carbene foot-printing and mutagenesis, providing a foundation for future elucidation of the molecular basis for interaction specificity
Star Formation and Dynamics in the Galactic Centre
The centre of our Galaxy is one of the most studied and yet enigmatic places
in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre
(GC) is the ideal environment to study the extreme processes that take place in
the vicinity of a supermassive black hole (SMBH). Despite the hostile
environment, several tens of early-type stars populate the central parsec of
our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and
inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the
SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The
formation of such early-type stars has been a puzzle for a long time: molecular
clouds should be tidally disrupted by the SMBH before they can fragment into
stars. We review the main scenarios proposed to explain the formation and the
dynamical evolution of the early-type stars in the GC. In particular, we
discuss the most popular in situ scenarios (accretion disc fragmentation and
molecular cloud disruption) and migration scenarios (star cluster inspiral and
Hills mechanism). We focus on the most pressing challenges that must be faced
to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in
expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A.,
'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201
- âŠ