9,801 research outputs found

    Results of a novel screening tool measuring dietary sodium knowledge in patients with chronic kidney disease.

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    BackgroundReducing dietary sodium has potential to benefit patients with chronic kidney disease (CKD). Little research is available defining dietary sodium knowledge gaps in patients with pre-dialysis CKD. We designed a brief screening tool to rapidly identify patient knowledge gaps related to dietary sodium for patients with CKD not yet on dialysis.MethodsA Short Sodium Knowledge Survey (SSKS) was developed and administered to patients with pre-dialysis CKD. We also asked patients if they received counseling on dietary sodium reduction and about recommended intake limits. We performed logistic regression to examine the association between sodium knowledge and patient characteristics. Characteristics of patients who answered all SSKS questions correctly were compared to those who did not.ResultsOne-hundred fifty-five patients were surveyed. The mean (SD) age was 56.6 (15.1) years, 84 (54%) were men, and 119 (77%) were white. Sixty-seven patients (43.2%) correctly identified their daily intake sodium limit. Fifty-eight (37.4%) were unable to answer all survey questions correctly. In analysis adjusted for age, sex, race, education, health literacy, CKD stage, self-reported hypertension and attendance in a kidney education class, women and patients of non-white race had lower odds of correctly answering survey questions (0.36 [0.16,0.81]; p = 0.01 women versus men and 0.33 [0.14,0.76]; p = 0.01 non-white versus white, respectively).ConclusionsOur survey provides a mechanism to quickly identify dietary sodium knowledge gaps in patients with CKD. Women and patients of non-white race may have knowledge barriers impeding adherence to sodium reduction advice

    Numerical evaluation of shear strength of CFS shear wall panels for different height-to-width ratios

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    This paper presents a numerical evaluation of the shear strength of Cold Formed Steel Shear Wall Panels (CFS-SWPs) having 1.33:1 and 1:1 height-to-width aspect ratios with 0.76 mm steel plate sheathing thickness and 1:4,  1.33:1 and 1:1  height-to-width aspect ratios with 0.46 mm steel plate sheathing thickness, which are not provided by AISI S400. For this purpose, shell finite element (FE) models, validated with test results, are completed in ABAQUS v2018 with nonlinear geometry, material and connection. A good agreement is achieved between experimental and numerical results in terms of shear strength-lateral displacement and failure modes.It is concluded that, for a fixed height-to-width aspect ratio, the shear strength of SWPs having different screws spacing varying from 50.4 mm up to 152.4 can be assessed by interpolation using this FE method. However, by interloping the shear strength from 4:1 to 1:1 height-to-width aspect ratio, the shear strength can be underestimated; hence, it is more economical for practicing engineers to use the shear strength assessed by this proposed FE method for 1.33:1 and 1:1 height-to-width aspect ratios. Moreover, the effect of the sheathing thickness having 0.46 mm is evaluated and proposed as it lacks in data provided by the code (i.e., AISI S400)

    Reconfigurable phase-change meta-absorbers with on-demand quality factor control

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    This is the final version. Available on open access from Optical Society of America via the DOI in this recordData accessibility: Supporting data for this manuscript is available from the corresponding author.Perfect absorber type devices are well-suited to many applications, such as solar cells, spatial light modulators, bio-sensors, and highly-sensitive photo-detectors. In such applications, a method for the design and fabrication of devices in a simple and efficient way, while at the same time maintaining design control over the key performance characteristics of resonant frequency, reflection coefficient at resonance and quality factor, would be particularly advantageous. In this work we develop such a method, based on eigenmode analysis and critical coupling theory, and apply it to the design of reconfigurable phase-change metasurface absorber devices. To validate the method, the design and fabrication of a family of absorbers was carried out with a range of ‘on-demand’ quality factors, all operating at the same resonant frequency and able to be fabricated simply and simultaneously on the same chip. Furthermore, by switching the phase-change layer between its amorphous and crystalline states, we show that our devices can provide an active or reconfigurable functionality.Office of Naval Research (ONR)Engineering and Physical Sciences Research Council (EPSRC)Office of Naval Research (ONR

    CCR2⁺CD103⁻ intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells

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    The identification of intestinal macrophages (m phi s) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial. We show here that intestinal CD103(-)CD11b(+) MPs can be separated clearly into DCs and m phi s based on phenotype, gene profile, and kinetics. CD64(-)CD103(-)CD11b(+) MPs are classical DCs, being derived from Flt3 ligand-dependent, DC-committed precursors, not Ly6C hi monocytes. Surprisingly, a significant proportion of these CD103(-)CD11b(+) DCs express CCR2 and there is a selective decrease in CD103(-)CD11b(+) DCs in mice lacking this chemokine receptor. CCR2(+)CD103(-) DCs are present in both the murine and human intestine, drive interleukin (IL)-17a production by Tcells in vitro, and show constitutive expression of IL-12/IL-23p40. These data highlight the heterogeneity of intestinal DCs and reveal a bona fide population of CCR2(+) DCs that is involved in priming mucosal T helper type 17 (Th17) responses

    Transcription enhancement of a digitised multi-lingual pamphlet collection: a case study and guide for similar projects

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    UCL Library Services holds an extensive collection of over 9,000 Jewish pamphlets, many of these extremely rare. Over the past five years, UCL has embarked on a project to widen access to this collection through an extensive programme of cataloguing, conservation and digitisation. With the cataloguing complete and the most fragile items conserved, the focus is now on making these texts available to global audiences via UCL Digital Collections website. The pamphlets were ranked for rarity, significance and fragility and the highest-scoring selected for digitisation. Unique identifiers allocated at the point of cataloguing were used to track individual pamphlets through the stages of the project. This guide details the text-enhancement methods used, highlighting particular issues relating to Hebrew scripts and early-printed texts. Initial attempts to enable images of these pamphlets to be searched digitally relied on the Optical Character Recognition (OCR) embedded within the software used to create the PDF files. Whilst satisfactory for texts chiefly in Roman script, it provided no reliable means to search the extensive corpus of texts in Hebrew. Generous advice offered by the National Library of Israel led to our adoption of ABBYY FineReader software as a means of enhancing the transcriptions embedded within the PDF files. Following image capture, JPEG files were used to create multi-page PDF files of each pamphlet. Pre-processing in ABBYY FineReader consisted of: setting the language and colour mode; detecting page orientation; selecting and refining areas of the text to be read; reading the text to produce a transcription. The resultant files were stored in folders according to language of text. The software highlighted spelling errors and doubtful readings. A verification tool allowed transcribers to correct these as required. However, some erroneous or doubtful readings were nevertheless genuine words and not highlighted; it was therefore essential to proofread the text, particularly for early-printed scripts. Transcribers maintained logs of common errors; additionally, problems with Hebrew vocalisations, cursive and Gothic scripts were noted. During initial quality checks of the transcriptions, many text searches were unsuccessful due to previously unidentified spacings occurring within words. This was generally linked to the font size being too small. Maintaining logs of font sizes used led to the adoption of a minimum of Arial 8 or Times New Roman 10 in transcribed text. The methodology was revised to include the preliminary quality-checking of one page. We concluded that it was difficult to develop a standardised procedure applicable to all texts given the variance in language, script and typography. However, we concluded that the font Arial gave the most successful accuracy ratings for Hebrew script, minimum text size 17, minimum title size 25. ABBYY file preparation took a minimum of 1.5 hours per pamphlet; transcription correction took an average of 10.4 minutes per page; the final quality check took 30 minutes per pamphlet. On average, the work on each pamphlet took a minimum of 6 hours to complete. As a result of the project, average accuracy ratings improved from 60% to 89%, the greatest improvement being for pre-1800 and Hebrew script publications. We are therefore inclined to focus future transcription-enhancement activity on these types of publication for the remainder of our Jewish Pamphlet Collections

    A parametric level-set method for partially discrete tomography

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    This paper introduces a parametric level-set method for tomographic reconstruction of partially discrete images. Such images consist of a continuously varying background and an anomaly with a constant (known) grey-value. We represent the geometry of the anomaly using a level-set function, which we represent using radial basis functions. We pose the reconstruction problem as a bi-level optimization problem in terms of the background and coefficients for the level-set function. To constrain the background reconstruction we impose smoothness through Tikhonov regularization. The bi-level optimization problem is solved in an alternating fashion; in each iteration we first reconstruct the background and consequently update the level-set function. We test our method on numerical phantoms and show that we can successfully reconstruct the geometry of the anomaly, even from limited data. On these phantoms, our method outperforms Total Variation reconstruction, DART and P-DART.Comment: Paper submitted to 20th International Conference on Discrete Geometry for Computer Imager

    Multilevel ultrafast flexible nanoscale nonvolatile hybrid graphene oxide-titanium oxide memories

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    This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Graphene oxide (GO) resistive memories offer the promise of low-cost environmentally sustainable fabrication, high mechanical flexibility and high optical transparency, making them ideally suited to future flexible and transparent electronics applications. However, the dimensional and temporal scalability of GO memories, i.e., how small they can be made and how fast they can be switched, is an area that has received scant attention. Moreover, a plethora of GO resistive switching characteristics and mechanisms has been reported in the literature, sometimes leading to a confusing and conflicting picture. Consequently, the potential for graphene oxide to deliver high-performance memories operating on nanometer length and nanosecond time scales is currently unknown. Here we address such shortcomings, presenting not only the smallest (50 nm), fastest (sub-5 ns), thinnest (8 nm) GO-based memory devices produced to date, but also demonstrate that our approach provides easily accessible multilevel (4-level, 2-bit per cell) storage capabilities along with excellent endurance and retention performance-all on both rigid and flexible substrates. Via comprehensive experimental characterizations backed-up by detailed atomistic simulations, we also show that the resistive switching mechanism in our Pt/GO/Ti/Pt devices is driven by redox reactions in the interfacial region between the top (Ti) electrode and the GO layer.This work was carried out under the auspices of the EU FP7 project CareRAMM. This project received funding from the European Union Seventh Framework Programme (FP7/2007- 2013) under grant agreement no. 309980. The authors are grateful for helpful discussions with all CareRAMM partners, particularly Prof. Andrea Ferrari and Ms. Anna Ott at the University of Cambridge, and Drs. Abu Sebastian and Wabe Koelmans at IBM Research Zurich. We also gratefully acknowledge the assistance of the National EPSRC XPS User’s Service (NEXUS) at Newcastle University, U.K. (an EPSRC Mid-Range Facility) in carrying out the XPS measurement

    Complement C3 variant and the risk of age-related macular degeneration

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    Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis.Methods: We tested for an association between age-related macular degeneration and 13 single-nucleotide polymorphisms (SNPs) spanning the complement genes C3 and C5 in case subjects and control subjects from the southeastern region of England. All subjects were examined by an ophthalmologist and had independent grading of fundus photographs to confirm their disease status. To test for replication of the most significant findings, we genotyped a set of Scottish cases and controls.Results: The common functional polymorphism rs2230199 (Arg80Gly) in the C3 gene, corresponding to the electrophoretic variants C3S (slow) and C3F (fast), was strongly associated with age-related macular degeneration in both the English group (603 cases and 350 controls, P=5.9 x 10(sup -5)) and the Scottish group (244 cases and 351 controls, P=5.0 x 10(sup -5)). The odds ratio for age-related macular degeneration in C3 S/F heterozygotes as compared with S/S homozygotes was 1.7 (95% confidence interval [CI], 1.3 to 2.1); for F/F homozygotes, the odds ratio was 2.6 (95% CI, 1.6 to 4.1). The estimated population attributable risk for C3F was 22%.Conclusions: Complement C3 is important in the pathogenesis of age-related macular degeneration. This finding further underscores the influence of the complement pathway in the pathogenesis of this disease

    Recommendations for Combining Action Observation and Motor Imagery Interventions in Sport

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    Combined action observation and motor imagery (AOMI) interventions involve observing a movement demonstration, usually via video, whilst at the same time imagining the feelings and sensations involved in executing the observed action. Research findings indicate that AOMI interventions can be effective for improving sport performance, yet no guidelines currently exist within the literature to inform applied sport psychologists how to develop and implement AOMI interventions with athletes. The aim of this article is to address this gap in the applied sport psychology literature. Accordingly, the article provides an overview of the ‘Science of AOMI’ by discussing the neurophysiological, cognitive, psychological and performance effects of AOMI interventions to introduce the concept of AOMI and potential benefits of AOMI interventions in sport. The article then covers the ‘Practice of AOMI’ by discussing practical recommendations for applied sport psychologists on how to develop and implement AOMI interventions for performance enhancement purposes. Important considerations related to filming the action observation video are discussed, such as selection of the model and choice of visual perspective. Guidelines are then provided for developing and delivering personalized kinesthetic imagery instructions for use by the athlete in synchrony with action observation
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