Un navigateur pour le Web des données liées

National audienceLe web des documents et le web des données liées utilisent tous les deux les URL pour identifier les ressources et le protocole HTTP pour les échanger. Les navigateurs web actuels sont limités à l'affichage des documents HTML et, nativement, ils ne permettent pas l'affichage de données RDF. Nous proposons d'étendre les fonctionnalités des navigateurs pour parcourir le web dans son intégralité de la manière la plus intuitive possible, c'est-à-dire en suivant les liens entre ressources sans que leur format constitue un obstacle. Pour y parvenir, nous proposons une extension de navigateur permettant de visualiser les res-sources RDF et de naviguer sur le Web en passant d'une ressource HTML à une ressource RDF de manière transparente

Laboratory Hydro-mechanical Characterisation of Boom Clay at Essen and Mol

International audienceBoom clay has been selected as a potential host rock formation for the geological disposal of radioactive waste in Belgium. In the present work, the hydro-mechanical behaviour of Boom clay samples from the borehole Essen-1 at a depth of 220 - 260 m and from HADES that is the underground rock laboratory at Mol in Belgium, at 223-m depth was investigated in the laboratory by performing low pressure oedometer tests (vertical effective stress ranging from 0.05 to 3.2 MPa), high pressure oedometer tests (vertical effective stress ranging from 0.125 to 32 MPa), isotropic consolidation tests (confining effective stress ranging from the in-situ stress to 20 MPa) and triaxial shear tests. It has been observed that the mineralogy, geotechnical properties and hydro-mechanical behaviour of Boom clay from Essen at 227-m, 240-m and 248-m depths are similar to that of Boom clay from Mol. As in the case of Boom clay at Mol, the failure envelope of Boom clay at Essen in the p'-q plane is not linear. The slope of the portion beyond the pre-consolidation stress of Boom clay from Essen is almost the same as that from Mol, suggesting a similar internal friction angle of about 13°. The compression curves (void index Iv versus logarithm of vertical stress) beyond the pre-consolidation stress are the same for both samples from Mol and Essen, and situated between the intrinsic compression line (ICL) and the sedimentation compression line (SCL). The yield stress determined from oedometer tests seems to be stress-path dependent and lower than the pre-consolidation stress. Thus determining the over-consolidation ratio (OCR) using the yield stress value would lead to an incorrect estimate. From a practical point view, the laboratory test results from Essen and their comparison with those from Mol provide important information regarding the transferability of knowledge on Boom clay at different sites, taking into account the fact that most investigations have been carried out on Boom clay at Mol

Effects of propofol and sevoflurane on hepatic blood flow : a randomized controlled trial

Background Maintaining adequate perioperative hepatic blood flow (HBF) supply is essential for preservation of postoperative normal liver function. Propofol and sevoflurane affect arterial and portal HBF. Previous studies have suggested that propofol increases total HBF, primarily by increasing portal HBF, while sevoflurane has only minimal effect on total HBF. Primary objective was to compare the effect of propofol (group P) and sevoflurane (group S) on arterial, portal and total HBF and on the caval and portal vein pressure during major abdominal surgery. The study was performed in patients undergoing pancreaticoduodenectomy because - in contrast to hepatic surgical procedures - this is a standardized surgical procedure without potential anticipated severe hemodynamic disturbances, and it allows direct access to the hepatic blood vessels. Methods Patients were randomized according to the type of anesthetic drug used. For both groups, Bispectral Index (BIS) monitoring was used to monitor depth of anesthesia. All patients received goal-directed hemodynamic therapy (GDHT) guided by the transpulmonary thermodilution technique. Hemodynamic data were measured, recorded and guided by Pulsioflex (TM). Arterial, portal and total HBF were measured directly, using ultrasound transit time flow measurements (TTFM) and were related to hemodynamic variables. Results Eighteen patients were included. There was no significant difference between groups in arterial, portal and total HBF. As a result of the GDHT, pre-set hemodynamic targets were obtained in both groups, but MAP was significantly lower in group S (p = 0.01). In order to obtain these pre-set hemodynamic targets, group S necessitated a significantly higher need for vasopressor support (p < 0.01). Conclusion Hepatic blood flow was similar under a propofol-based and a sevoflurane-based anesthetic regimen. Related to the application of GDHT, pre-set hemodynamic goals were maintained in both groups, but sevoflurane-anaesthetized patients had a significantly higher need for vasopressor support

The Kasterlee Formation and its relation with the Diest and Mol Formations in the Belgian Campine

Stratigraphic analysis of cored and geophysically logged boreholes in the Kasterlee-Geel-Retie-Mol-Dessel area of the Belgian Campine has established the presence of two lithostratigraphic units between the classical Diest and Mol Formations, geometrically related to the type Kasterlee Sand occurring west of the Kasterlee village and the study area. A lower 'clayey Kasterlee' unit, equivalent to the lithology occurring at the top of the Beerzel and Heist-op-den-Berg hills, systematically occurs to the east of the Kasterlee village. An overlying unit has a pale colour making it lithostratigraphically comparable to Mol Sand although its fine grain size, traces of glauconite and geometrical position have traditionally led stratigraphers to consider it as a lateral variety of the type Kasterlee Sand; it has been named the 'lower Mol' or 'Kasterlee-sensu-Gulinck' unit in this study. In the present analysis, the greenish glauconitic Kasterlee Sand in its hilly stratotype area evolves eastwards into the lower 'clayey Kasterlee' unit and possibly also into an overlying 'lower Mol' or `Kasterlee-sensu-Gulinck' unit, although it is equally possible that the latter unit has an erosive contact and therefore is stratigraphically slightly younger than the type Kasterlee Sand west of the Kasterlee village. A lateral extension of this detailed stratigraphic succession into the faulted one of east Limburg is proposed

MENTOR ou une méthodologie et des outils opérationnels de conception et de qualification de sites de mesures en réseau d'assainissement

International audienceLe projet MENTOR (MEasurement sites conception method for sewer NeTwORks) a pour objectif principal d'aider les gestionnaires dans la mise en place d'une instrumentation intégrée de la chaîne de mesures visant à mieux surveiller en continu la quantité et la qualité des masses d'eau rejetées par les systèmes urbains d'assainissement. Ce projet permettra la mise au point d'outils opérationnels destinés aux gestionnaires et aux responsables de métrologie des réseaux d'assainissement urbains. Il fournira également des recommandations au niveau organisationnel qui aideront à l'acquisition de " bonnes pratiques métrologiques ". Nous présenterons le détail de la démarche puis nous illustrerons cela par quelques cas concrets traités par les partenaires du projet

Impact of model resolution for on-shelf heat transport along the West Antarctic Peninsula

The flux of warm deep water onto Antarctic continental shelves plays a vital role in determining water mass properties adjacent to the continent. A regional model, with two different grid resolutions, has been used to simulate ocean processes along the West Antarctic Peninsula. At both 4 km and 1.5 km resolution, the model reproduces the locations of warm intrusions, as shown through comparison with observations from instrumented seals. However, the 1.5 km simulation shows greater on‐shelf heat transport, leading to improved representation of heat content on the shelf. This increased heat transport is associated with increased eddy activity, both at the shelf‐break and in the deep ocean off‐shore. Cross‐shelf troughs are key locations of on‐shelf heat transport. Comparison of two troughs, Belgica and Marguerite, shows differing responses to increased resolution. At higher resolution, there is an increased on‐shelf volume transport at Belgica Trough, but not at Marguerite Trough. This is likely related to the differing structure of the shelf‐break jet between these two locations. The increased heat flux at Marguerite Trough is attributed to increased heat content in the on‐shelf transport. Increased eddy activity off‐shelf may lead to greater cross‐front heat transport, and therefore increased heat available above the continental slope. While these simulations differ in their magnitude of heat transport, both show similar patterns of variability. Variations in wind stress lead to variations in speed of the shelf‐break jet, and therefore on‐shelf heat transport. These results demonstrate the importance of model resolution for understanding cross‐shelf transport around Antarctica

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patients suffer from episodes of life-threatening necrosis, typically triggered by S. aureus infection. The disorder is phenocopied in patients with the 5p- (Cri-du-Chat) chromosomal deletion syndrome. OTULIN haploinsufficiency causes an accumulation of linear ubiquitin in dermal fibroblasts, but tumor necrosis factor receptor-mediated nuclear factor kappa B signaling remains intact. Blood leukocyte subsets are unaffected. The OTULIN-dependent accumulation of caveolin-1 in dermal fibroblasts, but not leukocytes, facilitates the cytotoxic damage inflicted by the staphylococcal virulence factor alpha-toxin. Naturally elicited antibodies against alpha-toxin contribute to incomplete clinical penetrance. Human OTULIN haploinsufficiency underlies life-threatening staphylococcal disease by disrupting cell-intrinsic immunity to alpha-toxin in nonleukocytic cells.Peer reviewe

Flavaglines Alleviate Doxorubicin Cardiotoxicity: Implication of Hsp27

Background: Despite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that flavaglines, a family of natural compounds that display potent neuroprotective effects, may also alleviate doxorubicininduced cardiotoxicity. Methodology/Principal Findings: Our in vitro data established that a pretreatment with flavaglines significantly increased viability of doxorubicin-injured H9c2 cardiomyocytes as demonstrated by annexin V, TUNEL and active caspase-3 assays. We demonstrated also that phosphorylation of the small heat shock protein Hsp27 is involved in the mechanism by which flavaglines display their cardioprotective effect. Furthermore, knocking-down Hsp27 in H9c2 cardiomyocytes completely reversed this cardioprotection. Administration of our lead compound (FL3) to mice attenuated cardiomyocyte apoptosis and cardiac fibrosis, as reflected by a 50 % decrease of mortality. Conclusions/Significance: These results suggest a prophylactic potential of flavaglines to prevent doxorubicin-induce

Patient Retention and Adherence to Antiretrovirals in a Large Antiretroviral Therapy Program in Nigeria: A Longitudinal Analysis for Risk Factors

Substantial resources and patient commitment are required to successfully scale-up antiretroviral therapy (ART) and provide appropriate HIV management in resource-limited settings. We used pharmacy refill records to evaluate risk factors for loss to follow-up (LTFU) and non-adherence to ART in a large treatment cohort in Nigeria.We reviewed clinic records of adult patients initiating ART between March 2005 and July 2006 at five health facilities. Patients were classified as LTFU if they did not return >60 days from their expected visit. Pharmacy refill rates were calculated and used to assess non-adherence. We identified risk factors associated with LTFU and non-adherence using Cox and Generalized Estimating Equation (GEE) regressions, respectively. Of 5,760 patients initiating ART, 26% were LTFU. Female gender (p < 0.001), post-secondary education (p = 0.03), and initiating treatment with zidovudine-containing (p = 0.004) or tenofovir-containing (p = 0.05) regimens were associated with decreased risk of LTFU, while patients with only primary education (p = 0.02) and those with baseline CD4 counts (cell/ml(3)) >350 and <100 were at a higher risk of LTFU compared to patients with baseline CD4 counts of 100-200. The adjusted GEE analysis showed that patients aged <35 years (p = 0.005), who traveled for >2 hours to the clinic (p = 0.03), had total ART duration of >6 months (p<0.001), and CD4 counts >200 at ART initiation were at a higher risk of non-adherence. Patients who disclosed their HIV status to spouse/family (p = 0.01) and were treated with tenofovir-containing regimens (p < or = 0.001) were more likely to be adherent.These findings formed the basis for implementing multiple pre-treatment visit preparation that promote disclosure and active community outreaching to support retention and adherence. Expansion of treatment access points of care to communities to diminish travel time may have a positive impact on adherence