In silico toxicology protocols

The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It highlights the need to develop standardized protocols when conducting toxicity-related predictions. This contribution articulates the information needed for protocols to support in silico predictions for major toxicological endpoints of concern (e.g., genetic toxicity, carcinogenicity, acute toxicity, reproductive toxicity, developmental toxicity) across several industries and regulatory bodies. Such novel in silico toxicology (IST) protocols, when fully developed and implemented, will ensure in silico toxicological assessments are performed and evaluated in a consistent, reproducible, and well-documented manner across industries and regulatory bodies to support wider uptake and acceptance of the approaches. The development of IST protocols is an initiative developed through a collaboration among an international consortium to reflect the state-of-the-art in in silico toxicology for hazard identification and characterization. A general outline for describing the development of such protocols is included and it is based on in silico predictions and/or available experimental data for a defined series of relevant toxicological effects or mechanisms. The publication presents a novel approach for determining the reliability of in silico predictions alongside experimental data. In addition, we discuss how to determine the level of confidence in the assessment based on the relevance and reliability of the information

Edexcel IGCSE Physic. Student Book

Recurso que ofrece una cobertura completa de las especificaciones de Edexcel International General Certificate of Secondary Education (IGCSE) Física. Está estructurado en siete secciones temáticas, cada una con diferentes números de capítulos, y cuatro apéndices finales. Cada capítulo tiene una breve introducción que permite saber su contenido, preguntas para poner a prueba la comprensión de la materia y secciones de revisión. Al final de cada sección hay preguntas tipo examen que cubren todos los temas de sus capítulos.SCBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel. +34917748000; [email protected]

Conceptualising poker machine gambling as a technological zone

Australia’s commercial gambling industry is a significant economic and social phenomenon. In particular, poker machine gambling in club and hotel venues has grown into a consumption market worth ten billion dollars. Yet little effort has been made to understand the emergence of this market from a theoretical point of view. This article adapts the concept of the ‘technological zone developed by Andrew Barry, to the formation of club and hotel poker machine gambling consumption markets. It is argued that these markets are socio-technical achievements based on the dispersal of technical devices throughout social space. Key theoretical elements of technological zones, including metrology, infrastructure and qualification are applied to poker machine gambling markets to shed light on their material basis. It is argued that instituting material forms of technological government and commodity circulation simultaneously enables fast, continuous consumption, the micro-management of economic activity and reduction in costs associated with innovation and entry into multiple markets. It is also suggested that the formation of a technological zone forges something of a separation from historical concerns about the probity and fairness of gambling business

An investigation into the moisture content of the walls of a straw-bale building

This paper examines the use and accuracy of a moisture probe used in the walls of a straw-bale building. The performance of the moisture probe is assessed against laboratory-based measurements. The measurements from a number of moisture probes placed in the walls of a case study straw-bale building over a 2-year period are presented. The moisture content measurements from the building are discussed in the light of laboratory findings and the condition of the straw in the lower part of the most exposed wall. Potential influences upon the readings obtained from the moisture probes along with possible alternative assessment methods are discussed

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