Background noise levels measured in the NASA Lewis 9- by 15-foot low-speed wind tunnel

The acoustic capability of the NASA Lewis 9 by 15 Foot Low Speed Wind Tunnel has been significantly improved by reducing the background noise levels measured by in-flow microphones. This was accomplished by incorporating streamlined microphone holders having a profile developed by researchers at the NASA Ames Research Center. These new holders were fabricated for fixed mounting on the tunnel wall and for an axially traversing microphone probe which was mounted to the tunnel floor. Measured in-flow noise levels in the tunnel test section were reduced by about 10 dB with the new microphone holders compared with those measured with the older, less refined microphone holders. Wake interference patterns between fixed wall microphones were measured and resulted in preferred placement patterns for these microphones to minimize these effects. Acoustic data from a model turbofan operating in the tunnel test section showed that results for the fixed and translating microphones were equivalent for common azimuthal angles, suggesting that the translating microphone probe, with its significantly greater angular resolution, is preferred for sideline noise measurements. Fixed microphones can provide a local check on the traversing microphone data quality, and record acoustic performance at other azimuthal angles

Five Years of Mid-Infrared Evolution of the Remnant of SN 1987A: The Encounter Between the Blast Wave and the Dusty Equatorial Ring

We have used the Spitzer satellite to monitor the mid-IR evolution of SN 1987A over a 5 year period spanning the epochs between days 6000 and 8000 since the explosion. The supernova (SN) has evolved into a supernova remnant (SNR) and its radiative output is dominated by the interaction of the SN blast wave with the pre-existing equatorial ring (ER). The mid-IR spectrum is dominated by emission from ~180 K silicate dust, collisionally-heated by the hot X-ray emitting gas with a temperature and density of ~5x10^6 K and 3x10^4 cm-3, respectively. The mass of the radiating dust is ~1.2x10^(-6) Msun on day 7554, and scales linearly with IR flux. The infrared to soft-X-ray flux ratio is roughly constant with a value of 2.5. Gas-grain collisions therefore dominate the cooling of the shocked gas. The constancy of of this ratio suggests that very little grain processing or gas cooling have occurred throughout this epoch. The shape of the dust spectrum remained unchanged during the observations while the total flux increased with a time dependence of t^(0.87), t being the time since the first encounter between the blast wave and the ER. These observations are consistent with the transitioning of the blast wave from free expansion to a Sedov phase as it propagates into the main body of the ER.Comment: Accepted for publication in the ApJ, 11 pages, 11 figure

Infrared and X-Ray Evidence for Circumstellar Grain Destruction by the Blast Wave of Supernova 1987A

Multiwavelength observations of supernova remnant (SNR) 1987A show that its morphology and luminosity are rapidly changing at X-ray, optical, infrared, and radio wavelengths as the blast wave from the explosion expands into the circumstellar equatorial ring, produced by mass loss from the progenitor star. The observed infrared (IR) radiation arises from the interaction of dust grains that formed in mass outflow with the soft X-ray emitting plasma component of the shocked gas. Spitzer IRS spectra at 5 - 30 microns taken on day 6190 since the explosion show that the emission arises from approx. 1.1 x 10(exp -6) solar mass of silicate grains radiating at a temperature of approx. 180+/-(15-20) K. Subsequent observations on day 7137 show that the IR flux had increased by a factor of 2 while maintaining an almost identical spectral shape. The observed IR-to-X-ray flux ratio (IRX) is consistent with that of a dusty plasma with standard LMC dust abundances. This flux ratio has decreased by a factor of approx. 2 between days 6190 and 7137, providing the first direct observation of the ongoing destruction of dust in an expanding SN blast wave on dynamic time scales. Detailed models consistent with the observed dust temperature, the ionization fluence of the soft X-ray emission component, and the evolution of IRX suggest that the radiating si1icate grains are immersed in a 3.5 x 10(exp 6) K plasma with a density of (0.3 - 1) x 10(exp 4)/cu cm, and have a size distribution that is confined to a narrow range of radii between 0.02 and 0.2 microns. Smaller grains may have been evaporated by the initial UV flash from the supernova

Teprotumumab for Thyroid-Associated Ophthalmopathy

BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy. A total of 88 patients were randomly assigned to receive placebo or active drug administered intravenously once every 3 weeks for a total of eight infusions. The primary end point was the response in the study eye. This response was defined as a reduction of 2 points or more in the Clinical Activity Score (scores range from 0 to 7, with a score of ≥3 indicating active thyroid-associated ophthalmopathy) and a reduction of 2 mm or more in proptosis at week 24. Secondary end points, measured as continuous variables, included proptosis, the Clinical Activity Score, and results on the Graves' ophthalmopathy-specific quality-of-life questionnaire. Adverse events were assessed. RESULTS: In the intention-to-treat population, 29 of 42 patients who received teprotumumab (69%), as compared with 9 of 45 patients who received placebo (20%), had a response at week 24 (P<0.001). Therapeutic effects were rapid; at week 6, a total of 18 of 42 patients in the teprotumumab group (43%) and 2 of 45 patients in the placebo group (4%) had a response (P<0.001). Differences between the groups increased at subsequent time points. The only drug-related adverse event was hyperglycemia in patients with diabetes; this event was controlled by adjusting medication for diabetes. CONCLUSIONS: In patients with active ophthalmopathy, teprotumumab was more effective than placebo in reducing proptosis and the Clinical Activity Score. (Funded by River Vision Development and others; ClinicalTrials.gov number, NCT01868997 .)

Action–effect anticipation in infant action control

There is increasing evidence that action effects play a crucial role in action understanding and action control not only in adults but also in infants. Most of the research in infants focused on the learning of action–effect contingencies or how action effects help infants to infer goals in other persons’ actions. In contrast, the present research aimed at demonstrating that infants control their own actions by action–effect anticipation once they know about specific action–effect relations. About 7 and 9-month olds observed an experimenter demonstrating two actions that differed regarding the action–effect assignment. Either a red-button press or a blue-button press or no button press elicited interesting acoustical and visual effects. The 9-month olds produced the effect action at first, with shorter latency and longer duration sustaining a direct impact of action–effect anticipation on action control. In 7-month olds the differences due to action–effect manipulation were less profound indicating developmental changes at this age

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis.

BACKGROUND: Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland. Comparative analysis of the complete genome sequence of S. uberis strain 0140J was undertaken to help elucidate the biology of this effective bovine pathogen. RESULTS: The genome revealed 1,825 predicted coding sequences (CDSs) of which 62 were identified as pseudogenes or gene fragments. Comparisons with related pyogenic streptococci identified a conserved core (40%) of orthologous CDSs. Intriguingly, S. uberis 0140J displayed a lower number of mobile genetic elements when compared with other pyogenic streptococci, however bacteriophage-derived islands and a putative genomic island were identified. Comparative genomics analysis revealed most similarity to the genomes of Streptococcus agalactiae and Streptococcus equi subsp. zooepidemicus. In contrast, streptococcal orthologs were not identified for 11% of the CDSs, indicating either unique retention of ancestral sequence, or acquisition of sequence from alternative sources. Functions including transport, catabolism, regulation and CDSs encoding cell envelope proteins were over-represented in this unique gene set; a limited array of putative virulence CDSs were identified. CONCLUSION: S. uberis utilises nutritional flexibility derived from a diversity of metabolic options to successfully occupy a discrete ecological niche. The features observed in S. uberis are strongly suggestive of an opportunistic pathogen adapted to challenging and changing environmental parameters.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

The Transitional Stripped-Envelope SN 2008ax: Spectral Evolution and Evidence for Large Asphericity

Supernova (SN) 2008ax in NGC 4490 was discovered within hours after shock breakout, presenting the rare opportunity to study a core-collapse SN beginning with the initial envelope-cooling phase immediately following shock breakout. We present an extensive sequence of optical and near-infrared spectra, as well as three epochs of optical spectropolarimetry. Our initial spectra, taken two days after shock breakout, are dominated by hydrogen Balmer lines at high velocity. However, by maximum light, He I lines dominated the optical and near-infrared spectra, which closely resembled those of normal Type Ib supernovae (SNe Ib) such as SN 1999ex. This spectroscopic transition defines Type IIb supernovae, but the strong similarity of SN 2008ax to normal SNe Ib beginning near maximum light, including an absorption feature near 6270A due to H-alpha at high velocities, suggests that many objects classified as SNe Ib in the literature may have ejected similar amounts of hydrogen as SN 2008ax, roughly a few x 0.01 M_sun. Early-time spectropolarimetry (6 and 9 days after shock breakout) revealed strong line polarization modulations of 3.4% across H-alpha, indicating the presence of large asphericities in the outer ejecta. The continuum shares a common polarization angle with the hydrogen, helium, and oxygen lines, while the calcium and iron absorptions are oriented at different angles. This is clear evidence of deviations from axisymmetry even in the outer ejecta. Intrinsic continuum polarization of 0.64% only nine days after shock breakout shows that the outer layers of the ejecta were quite aspherical. A single epoch of late-time spectropolarimetry, as well as the shapes of the nebular line profiles, demonstrate that asphericities extended from the outermost layers all the way down to the center of this SN. [Abridged]Comment: 24 pages, 21 figures, 4 tables, appendix, minor revisions to match version accepted by Ap