Making the Most of Repetitive Mistakes: An Investigation into Heuristics for Selecting and Applying Feedback to Programming Coursework

In the acquisition of software-development skills, feedback that pinpoints errors and explains means of improvement is important in achieving a good student learning experience. However, it is not feasible to manually provide timely, consistent, and helpful feedback for large or complex coursework tasks, and/or to large cohorts of students. While tools exist to provide feedback to student submissions, their automation is typically limited to reporting either test pass or failure or generating feedback to very simple programming tasks. Anecdotal experience indicates that clusters of students tend to make similar mistakes and/or successes within their coursework. Do feedback comments applied to students' work support this claim and, if so, to what extent is this the case? How might this be exploited to improve the assessment process and the quality of feedback given to students? To help answer these questions, we have examined feedback given to coursework submissions to a UK level 5, university-level, data structures and algorithms course to determine heuristics used to trigger particular feedback comments that are common between submissions and cohorts. This paper reports our results and discusses how the identified heuristics may be used to promote timeliness and consistency of feedback without jeopardising the quality

Business Intelligence Solution for an SME: A Case Study.

Business Intelligence (BI) leverages the usefulness of existing information. It equips business users with relevant information to perform various analyses to make key business decisions. Over the last two decades, BI has become a core strategy for the growth of many companies, in particular large corporations. However, studies show that small and medium-sized enterprises (SMEs) lag behind in implementation and exploitation of BI solutions. To stay ahead of the competition, SMEs must be able to monitor and effectively use all of their resources, in particular information resources, to assist them in making important business decisions. In this paper, we examine the challenges such as lack of technical expertise and limited budget when implementing a BI solution within an SME in the UK. In light of our experiences in tackling these issues, we discuss how these challenges can be overcome through applying various tools and strategies and the potential benefits

Nuclear Stopping as A Probe to In-medium Nucleon-nucleon Cross Section in Intermediate Energy Heavy Ion Collisions

Using an isospin-dependent quantum molecular dynamics, nuclear stopping in intermediate heavy ion collisions has been studied. The calculation has been done for colliding systems with different neutron-proton ratios in beam energy ranging from 15MeV/u to 150MeV/u. It is found that, in the energy region from above Fermi energy to 150MeV/u, nuclear stopping is very sensitive to the isospin dependence of in-medium nucleon-nucleon cross section, but insensitive to symmetry potential. From this investigation, we propose that nuclear stopping can be used as a new probe to extract the information on the isospin dependence of in-medium nucleon-nucleon cross section in intermediate energy heavy ion collisions

How Deep is the Antinucleon Optical Potential at FAIR energies

The key question in the interaction of antinucleons in the nuclear medium concerns the deepness of the antinucleon-nucleus optical potential. In this work we study this task in the framework of the non-linear derivative (NLD) model which describes consistently bulk properties of nuclear matter and Dirac phenomenology of nucleon-nucleus interactions. We apply the NLD model to antinucleon interactions in nuclear matter and find a strong decrease of the vector and scalar self-energies in energy and density and thus a strong suppression of the optical potential at zero momentum and, in particular, at FAIR energies. This is in agreement with available empirical information and, therefore, resolves the issue concerning the incompatibility of G-parity arguments in relativistic mean-field (RMF) models. We conclude the relevance of our results for the future activities at FAIR.Comment: 13 pages, 5 figures, accepted version to appear in Phys. Lett.

An \u3cem\u3eIL1RL1\u3c/em\u3e genetic variant lowers soluble ST2 levels and the risk effects of \u3cem\u3eAPOE\u3c/em\u3e-ε4 in female patients with Alzheimer’s disease

Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 level is associated with more severe pathological changes in female individuals with AD. Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 levels lower AD risk and related endophenotypes in females carrying the Apolipoprotein E (APOE)-ε4 genotype; the association is stronger in Chinese than in European-descent populations. Human and mouse transcriptome and immunohistochemical studies showed that rs1921622/sST2 regulates amyloid-beta (Aβ) pathology through the modulation of microglial activation and Aβ clearance. These findings demonstrate how sST2 level is modulated by a genetic variation and plays a disease-causing role in females with AD

WALLABY Pilot Survey:The Diversity of Ram Pressure Stripping of the Galactic H I Gas in the Hydra Cluster

This study uses HI image data from the WALLABY pilot survey with the ASKAP telescope, covering the Hydra cluster out to 2.5$r_{200}$. We present the projected phase-space distribution of HI-detected galaxies in Hydra, and identify that nearly two thirds of the galaxies within $1.25r_{200}$ may be in the early stages of ram pressure stripping. More than half of these may be only weakly stripped, with the ratio of strippable HI (i.e., where the galactic restoring force is lower than the ram pressure in the disk) mass fraction (over total HI mass) distributed uniformly below 90%. Consequently, the HI mass is expected to decrease by only a few 0.1 dex after the currently strippable portion of HI in these systems has been stripped. A more detailed look at the subset of galaxies that are spatially resolved by WALLABY observations shows that, while it typically takes less than 200 Myr for ram pressure stripping to remove the currently strippable portion of HI, it may take more than 600 Myr to significantly change the total HI mass. Our results provide new clues to understanding the different rates of HI depletion and star formation quenching in cluster galaxies.Comment: 25 pages, 10 figures, 1 table. Accepted for publication at Ap

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 level is associated with more severe pathological changes in female individuals with AD. Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 levels lower AD risk and related endophenotypes in females carrying the Apolipoprotein E (APOE)-ε4 genotype; the association is stronger in Chinese than in European-descent populations. Human and mouse transcriptome and immunohistochemical studies showed that rs1921622/sST2 regulates amyloid-beta (Aβ) pathology through the modulation of microglial activation and Aβ clearance. These findings demonstrate how sST2 level is modulated by a genetic variation and plays a disease-causing role in females with AD

FAST-ASKAP Synergy: Quantifying Coexistent Tidal and Ram-Pressure Strippings in the NGC 4636 Group

Combining new HI data from a synergetic survey of ASKAP WALLABY and FAST with the ALFALFA data, we study the effect of ram-pressure and tidal interactions in the NGC 4636 group. We develop two parameters to quantify and disentangle these two effects on gas stripping in HI-bearing galaxies: the strength of external forces at the optical-disk edge, and the outside-in extents of HI-disk stripping. We find that gas stripping is widespread in this group, affecting 80% of HI-detected non-merging galaxies, and that 34% are experiencing both types of stripping. Among the galaxies experiencing both effects, the strengths (and extents) of ram-pressure and tidal stripping are independent of each other. Both strengths are correlated with HI-disk shrinkage. The tidal strength is related to a rather uniform reddening of low-mass galaxies ($M_*<10^9\,\text{M}_\odot$) when tidal stripping is the dominating effect. In contrast, ram pressure is not clearly linked to the color-changing patterns of galaxies in the group. Combining these two stripping extents, we estimate the total stripping extent, and put forward an empirical model that can describe the decrease of HI richness as galaxies fall toward the group center. The stripping timescale we derived decreases with distance to the center, from $\mathord{\sim}1\,\text{Gyr}$ around $R_{200}$ to $\mathord{\lesssim}10\,\text{Myr}$ near the center. Gas-depletion happens $\mathord{\sim}3\,\text{Gyr}$ since crossing $2R_{200}$ for HI-rich galaxies, but much quicker for HI-poor ones. Our results quantify in a physically motivated way the details and processes of environmental-effects-driven galaxy evolution, and might assist in analyzing hydrodynamic simulations in an observational way.Comment: 44 pages, 22 figures, 5 tables, accepted for publication in ApJ. Tables 4 and 5 are also available in machine-readable for

MicroRNA-145 Regulates Human Corneal Epithelial Differentiation

Epigenetic factors, such as microRNAs, are important regulators in the self-renewal and differentiation of stem cells and progenies. Here we investigated the microRNAs expressed in human limbal-peripheral corneal (LPC) epithelia containing corneal epithelial progenitor cells (CEPCs) and early transit amplifying cells, and their role in corneal epithelium.Human LPC epithelia was extracted for small RNAs or dissociated for CEPC culture. By Agilent Human microRNA Microarray V2 platform and GeneSpring GX11.0 analysis, we found differential expression of 18 microRNAs against central corneal (CC) epithelia, which were devoid of CEPCs. Among them, miR-184 was up-regulated in CC epithelia, similar to reported finding. Cluster miR-143/145 was expressed strongly in LPC but weakly in CC epithelia (P = 0.0004, Mann-Whitney U-test). This was validated by quantitative polymerase chain reaction (qPCR). Locked nucleic acid-based in situ hybridization on corneal rim cryosections showed miR-143/145 presence localized to the parabasal cells of limbal epithelium but negligible in basal and superficial epithelia. With holoclone forming ability, CEPCs transfected with lentiviral plasmid containing mature miR-145 sequence gave rise to defective epithelium in organotypic culture and had increased cytokeratin-3/12 and connexin-43 expressions and decreased ABCG2 and p63 compared with cells transfected with scrambled sequences. Global gene expression was analyzed using Agilent Whole Human Genome Oligo Microarray and GeneSpring GX11.0. With a 5-fold difference compared to cells with scrambled sequences, miR-145 up-regulated 324 genes (containing genes for immune response) and down-regulated 277 genes (containing genes for epithelial development and stem cell maintenance). As validated by qPCR and luciferase reporter assay, our results showed miR-145 suppressed integrin β8 (ITGB8) expression in both human corneal epithelial cells and primary CEPCs.We found expression of miR-143/145 cluster in human corneal epithelium. Our results also showed that miR-145 regulated the corneal epithelium formation and maintenance of epithelial integrity, via ITGB8 targeting