185 research outputs found
Microscopic calculation of the spin-dependent neutron scattering lengths on 3He
We report on the spin.dependent neutron scattering length on 3He from a
microscopic calculation of p-3H, n-3He, and d-2H scattering employing the
Argonne v18 nucleon-nucleon potential with and without additional three-nucleon
force. The results and that of a comprehensive R-matrix analysis are compared
to a recent measurement. The overall agreement for the scattering lengths is
quite good. The imaginary parts of the scattering lengths are very sensitive to
the inclusion of three-nucleon forces, whereas the real parts are almost
insensitive.Comment: 9 pages, 1 figur
Elastic p-3He and n-3H scattering with two- and three-body forces
We report on a microscopic calculation of n-3H and p-3He scattering employing
the Argonne v_{18} and v_8' nucleon-nucleon potentials with and without
additional three-nucleon force. An R-matrix analysis of the p-3He and n-3H
scattering data is presented. Comparisons are made for the phase shifts and a
selection of measurements in both scattering systems. Differences between our
calculation and the R-matrix results or the experimental data can be attributed
to only two partial waves (3P0 and 3P2). We find the effect of the Urbana IX
and the Texas-Los Alamos three-nucleon forces on the phase shifts to be
negligible.Comment: submitted to Phys. Rev.
Universal Correlations in Pion-less EFT with the Resonating Group Model: Three and Four Nucleons
The Effective Field Theory "without pions" at next-to-leading order is used
to analyze universal bound state and scattering properties of the 3- and
4-nucleon system. Results of a variety of phase shift equivalent nuclear
potentials are presented for bound state properties of 3H and 4He, and for the
singlet S-wave 3He-neutron scattering length a_0(3He-n). The calculations are
performed with the Refined Resonating Group Method and include a full treatment
of the Coulomb interaction and the leading-order 3-nucleon interaction. The
results compare favorably with data and values from AV18(+UIX) model
calculations. A new correlation between a_0(3He-n) and the 3H binding energy is
found. Furthermore, we confirm at next-to-leading order the correlations,
already found at leading-order, between the 3H binding energy and the 3H charge
radius, and the Tjon line. With the 3H binding energy as input, we get
predictions of the Effective Field Theory "without pions" at next-to-leading
order for the root mean square charge radius of 3H of (1.6\pm 0.2) fm, for the
4He binding energy of (28\pm 2.5) MeV, and for Re(a_0(3He-n)) of (7.5\pm
0.6)fm. Including the Coulomb interaction, the splitting in binding energy
between 3H and 3He is found to be (0.66\pm 0.03) MeV. The discrepancy to data
of (0.10\mp 0.03) MeV is model independently attributed to higher order charge
independence breaking interactions. We also demonstrate that different results
for the same observable stem from higher order effects, and carefully assess
that numerical uncertainties are negligible. Our results demonstrate the
convergence and usefulness of the pion-less theory at next-to-leading order in
the 4He channel. We conclude that no 4-nucleon interaction is needed to
renormalize the theory at next-to-leading order in the 4-nucleon sector.Comment: 24 pages revtex4, including 8 figures as .eps files embedded with
includegraphicx, leading-order results added, calculations include the LO
three-nucleon interaction explicitly, comment on Wigner bound added, minor
modification
Inverse flux quantum periodicity of magnetoresistance oscillations in two-dimensional short-period surface superlattices
Transport properties of the two-dimensional electron gas (2DEG) are
considered in the presence of a perpendicular magnetic field and of a {\it
weak} two-dimensional (2D) periodic potential modulation in the 2DEG plane. The
symmetry of the latter is rectangular or hexagonal. The well-known solution of
the corresponding tight-binding equation shows that each Landau level splits
into several subbands when a rational number of flux quanta pierces the
unit cell and that the corresponding gaps are exponentially small. Assuming the
latter are closed due to disorder gives analytical wave functions and
simplifies considerably the evaluation of the magnetoresistivity tensor
. The relative phase of the oscillations in and
depends on the modulation periods involved. For a 2D modulation
with a {\bf short} period nm, in addition to the Weiss oscillations
the collisional contribution to the conductivity and consequently the tensor
show {\it prominent peaks when one flux quantum passes
through an integral number of unit cells} in good agreement with recent
experiments. For periods nm long used in early experiments, these
peaks occur at fields 10-25 times smaller than those of the Weiss oscillations
and are not resolved
Thermodynamics of pyrope-majorite, Mg3Al2Si3O12-Mg4Si4O12, solid solution from atomistic model calculations
Static lattice energy calculations, based on empirical pair potentials have been performed for a large set of different structures with compositions between pyrope and majorite, and with different states of order of octahedral cations. The energies have been cluster expanded using pair and quaternary terms. The derived ordering constants have been used to constrain Monte Carlo simulations of temperature-dependent properties in the ranges of 1073 3673K and 0 20 GPa. The free energies of mixing have been calculated using the method of thermodynamic integration. At zero pressure the cubic/tetragonal transition is predicted for pure majorite at 3300 K. The transition temperature decreases with the increase of the pyrope mole fraction. A miscibility gap associated with the transition starts to develop at about 2000K and xmaj 0.8, and widens with the decrease in temperature and the increase in pressure. Activity composition relations in the range of 0 20 GPa and 1073 2673K are described with the help of a high-order Redlich Kister polynomial
Snipe taxonomy based on vocal and non-vocal sound displays: the South American Snipe is two species
We analysed breeding sounds of the two subspecies of South American Snipe Gallinago paraguaiae paraguaiae and Gallinago paraguaiae magellanica to determine whether they might be different species: loud vocalizations given on the ground, and the tail‐generated Winnow given in aerial display. Sounds of the two taxa differ qualitatively and quantitatively. Both taxa utter two types of ground call. In G. p. paraguaiae, the calls are bouts of identical sound elements repeated rhythmically and slowly (about five elements per second (Hz)) or rapidly (about 11 Hz). One call of G. p. magellanica is qualitatively similar to those of G. p. paraguaiae but sound elements are repeated more slowly (about 3 Hz). However, its other call type differs strikingly: it is a bout of rhythmically repeated sound couplets, each containing two kinds of sound element. The Winnow of G. p. paraguaiae is a series of sound elements that gradually increase in duration and energy; by contrast, that of G. p. magellanica has two or more kinds of sound element that roughly alternate and are repeated as sets, imparting a stuttering quality. Sounds of the related Puna Snipe (Gallinago andina) resemble but differ quantitatively from those of G. p. paraguaiae. Differences in breeding sounds of G. p. paraguaiae and G. p. magellanica are strong and hold throughout their geographical range. Therefore we suggest that the two taxa be considered different species: G. paraguaiae east of the Andes in much of South America except Patagonia, and G. magellanica in central and southern Chile, Argentina east of the Andes across Patagonia, and Falklands/Malvinas.Fil: Miller, Edward H.. Memorial University Of Newfoundland; CanadáFil: Areta, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Jaramillo, Alvaro. San Francisco Bay Bird Observatory; Estados UnidosFil: Imberti, Santiago. Asociación Ambiente Sur, Rio Gallegos; ArgentinaFil: Matus, Ricardo. Kilómetro 7 Sur; Chil
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Effect of dimethylamine on the gas phase sulfuric acid concentration measured by Chemical Ionization Mass Spectrometry
Sulfuric acid is widely recognized as a very important substance driving atmospheric aerosol nucleation. Based on quantum chemical calculations it has been suggested that the quantitative detection of gas phase sulfuric acid (H2SO4) by use of Chemical Ionization Mass Spectrometry (CIMS) could be biased in the presence of gas phase amines such as dimethylamine (DMA). An experiment (CLOUD7 campaign) was set up at the CLOUD (Cosmics Leaving OUtdoor Droplets) chamber to investigate the quantitative detection of H2SO4 in the presence of dimethylamine by CIMS at atmospherically relevant concentrations. For the first time in the CLOUD experiment, the monomer sulfuric acid concentration was measured by a CIMS and by two CI-APi-TOF (Chemical Ionization-Atmospheric Pressure interface-Time Of Flight) mass spectrometers. In addition, neutral sulfuric acid clusters were measured with the CI-APi-TOFs. The CLOUD7 measurements show that in the presence of dimethylamine (<5 to 70 pptv) the sulfuric acid monomer measured by the CIMS represents only a fraction of the total H2SO4, contained in the monomer and the clusters that is available for particle growth. Although it was found that the addition of dimethylamine dramatically changes the H2SO4 cluster distribution compared to binary (H2SO4-H2O) conditions, the CIMS detection efficiency does not seem to depend substantially on whether an individual H2SO4 monomer is clustered with a DMA molecule. The experimental observations are supported by numerical simulations based on A Self-contained Atmospheric chemistry coDe coupled with a molecular process model (Sulfuric Acid Water NUCleation) operated in the kinetic limit
Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer.
The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)-positive breast cancer (BC) is currently unknown.
To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT).
This was a prospective, observational, cohort study conducted from August 2018 to June 2022. This was a preplanned study within the phase 3 randomized clinical OPBC-03/TAXIS trial. Included were patients with confirmed cN-positive BC from 44 private, public, and academic breast centers in 6 European countries. After NACT, residual nodal disease was mandatory, and a minimum follow-up of 2 months was required.
All patients underwent tailored axillary surgery (TAS) followed by ALND or axillary radiotherapy (ART) according to TAXIS randomization. TAS removed suspicious palpable and sentinel nodes, whereas imaging-guidance was optional. Systemic therapy recommendations were at the discretion of the local investigators.
A total of 500 patients (median [IQR] age, 57 [48-69] years; 487 female [97.4%]) were included in the study. In the upfront surgery setting, 296 of 335 patients (88.4%) had hormone receptor (HR)-positive and Erb-B2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 or HER2/neu)-negative disease: 145 (49.0%) underwent ART, and 151 (51.0%) underwent ALND. The median (IQR) number of removed positive lymph nodes without ALND was 3 (1-4) nodes compared with 4 (2-9) nodes with ALND. There was no association of ALND with the proportion of patients undergoing adjuvant chemotherapy (81 of 145 [55.9%] vs 91 of 151 [60.3%]; adjusted odds ratio [aOR], 0.72; 95% CI, 0.19-2.67) and type of systemic therapy. Of 151 patients with NACT, 74 (51.0%) underwent ART, and 77 (49.0%) underwent ALND. The ratio of removed to positive nodes was a median (IQR) of 4 (3-7) nodes to 2 (1-3) nodes and 15 (12-19) nodes to 2 (1-5) nodes in the ART and ALND groups, respectively. There was no observed association of ALND with the proportion of patients undergoing postneoadjuvant systemic therapy (57 of 74 [77.0%] vs 55 of 77 [71.4%]; aOR, 0.86; 95% CI, 0.43-1.70), type of postneoadjuvant chemotherapy (eg, capecitabine: 10 of 74 [13.5%] vs 10 of 77 [13.0%]; trastuzumab emtansine-DM1: 9 of 74 [12.2%] vs 11 of 77 [14.3%]), or endocrine therapy (eg, aromatase inhibitors: 41 of 74 [55.4%] vs 36 of 77 [46.8%]; tamoxifen: 8 of 74 [10.8%] vs 6 of 77 [7.8%]).
Results of this cohort study suggest that patients without ALND were significantly understaged. However, ALND did not inform systemic therapy recommendations
A Multitrait Locus Regulates Sarbecovirus Pathogenesis
Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genomewide Association Studies (GWAS) approaches to study these infectious outcomes challenging. In contrast, mouse models of infectious diseases provide an experimental control and precision, which facilitates analyses and mechanistic studies of the role of genetic variation on infection. Here we use a genetic mapping cross between two distinct Collaborative Cross mouse strains with respect to severe acute respiratory syndrome coronavirus (SARS-CoV) disease outcomes. We find several loci control differential disease outcome for a variety of traits in the context of SARS-CoV infection. Importantly, we identify a locus on mouse chromosome 9 that shows conserved synteny with a human GWAS locus for SARS-CoV-2 severe disease. We follow-up and confirm a role for this locus, and identify two candidate genes, CCR9 and CXCR6, that both play a key role in regulating the severity of SARS-CoV, SARS-CoV-2, and a distantly related bat sarbecovirus disease outcomes. As such we provide a template for using experimental mouse crosses to identify and characterize multitrait loci that regulate pathogenic infectious outcomes across species. IMPORTANCE Host genetic variation is an important determinant that predicts disease outcomes following infection. In the setting of highly pathogenic coronavirus infections genetic determinants underlying host susceptibility and mortality remain unclear. To elucidate the role of host genetic variation on sarbecovirus pathogenesis and disease outcomes, we utilized the Collaborative Cross (CC) mouse genetic reference population as a model to identify susceptibility alleles to SARS-CoV and SARS-CoV-2 infections. Our findings reveal that a multitrait loci found in chromosome 9 is an important regulator of sarbecovirus pathogenesis in mice. Within this locus, we identified and validated CCR9 and CXCR6 as important regulators of host disease outcomes. Specifically, both CCR9 and CXCR6 are protective against severe SARS-CoV, SARS-CoV-2, and SARS-related HKU3 virus disease in mice. This chromosome 9 multitrait locus may be important to help identify genes that regulate coronavirus disease outcomes in humans
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