Changing Interchanges: Educating Hoosiers on Alternative Designs

Alternative intersections improve traffic flow and safety, but the public can be unsure of new solutions. Learn best practices for educating the public on displaced lefts, median U-turns and roundabouts, and building support for these important improvements. You’ll hear examples from TheLloyd4U in Evansville and other projects across the stat. Strategic, specialized outreach to the public means thinking outside the box

Giving Voice to Silent Stakeholders

Only the most motivated stakeholders attend public meetings or submit written comments. To ensure that more people and quieter voices are heard, transportation agencies are supplement-ing public-involvement efforts with interactive, mobile-friendly surveys and in-person inter-views. Learn how tech tools are being used on projects such as the Sherman Minton Renewal to involve the public and provide more data to decision makers

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas

Studies have suggested that an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may contribute to the malignant phenotype of gliomas. In this study, we have undertaken a detailed analysis of expression of the TIMP family in normal human brain and malignant gliomas at both the mRNA and protein level. Reverse transcription-PCR (RT-PCR) analyses of total RNA from surgical tumour specimens revealed unique expression patterns for the 4 members of the TIMP family, with TIMP-1 and -4 showing positive and negative correlations, respectively, with glioma malignancy. By RT-PCR, TIMP-2 and TIMP-3 expression did not change with tumour grade. In situ hybridization localized TIMP-1 to glial tumour cells and also to the surrounding tumour vasculature. TIMP-4 transcripts were predominantly localized to tumour cells, though minor expression was found in vessels. Recombinant TIMP-4 reduced invasion of U251 glioma cells through Matrigel, and U87 clones overexpressing TIMP-4 showed reduced invasive capacity in vitro. TIMP-4, but not TIMP-1, blocked Membrane Type-1-MMP-mediated progelatinase-A (MMP-2) activation in human umbilical vein endothelial cells. The differential expression and localization of individual TIMPs may contribute to the pathophysiology of human malignant gliomas, particularly with regard to tumour vascularization. © 2001 Cancer Research Campaign http://www.bjcancer.co

A UK practitioner view of domestic energy performance measurement

There is a growing body of evidence concerning the energy efficiency performance of domestic buildings in the UK, driven by policy-based agenda, such as the need for zero carbon dioxide homes by 2016 for new build homes, and Green Deal and energy company obligation for sustainable refurbishment. While there have been a number of studies funded and results presented in this area, little work has been done to understand the drivers, practices and issues of data collection and analysis. There are a number of major building performance evaluation (BPE) studies in the UK, yet behind many of these research projects are practical issues of data loss, experimental error, data analysis variances and resident issues that are common when studies move from the actual to the living lab. In this paper the issues of domestic energy are addressed by leading BPE practitioners in the UK. They identify issues of client demands, technical failure, costs and implementation. The work provides insights of both academic and industry-based practitioners and considers not only the practicalities of building performance studies, but also implications for these types of studies in the future

Keeping Customers Informed: The South Split Experience

Through the Joint Transportation Research Program, INDOT and Purdue used existing low-cost consumer technology and social media in lieu of an expensive advertising campaign to inform the public of the need for and progress during the downtown Indianapolis I-65/I-70 closure. Key players will show you how to take advantage of what we learned

Public Involvement After COVID-19: Panel Discussion

The world has changed since Road School 2020. Project communications and public involvement look diferent, but they’re more important than ever. Learn how public and private leaders are using virtual methods to keep stakeholders, including traditionally underserved populations, informed and engaged. This session will discuss tips, tools, and lessons learned for moving forward with both virtual and in-person public involvement