Spectroscopic Hα and Hγ survey of field Be stars: 2004-2009

Massive O- and B-type stars are cosmic engines in the Universe and can be the dominant source of luminosity in a galaxy. The class of Be stars are rapidly rotating B-type stars that lose mass in an equatorial, circumstellar disk (Porter & Rivinius 2003) and cause Balmer and other line emission. Currently, we are unsure as to why these stars rotate so quickly but three scenarios are possible: they may have been born as rapid rotators, spun up by binary mass transfer, or spun up during the main-sequence evolution of B stars. In order to investigate these scenarios for this population of massive stars, we have been spectroscopically observing a set of 115 field Be stars with the Kitt Peak Coudè Feed telescope in both the Hα and Hγ wavelength regimes since 2004. This time baseline allows for examination of variability properties of the circumstellar disks as well as determine candidates for closer examination for binarity. We find that 90% of the observed stars show some variability with 8% showing significant variability over the 5-year baseline. Such values may be compared with the significant variability seen in some clusters such as NGC 3766 (McSwain 2008). Also, while ~20% of the sample consists of known binaries, we find that another 15-30% of the sample shows indications of binarity. © International Astronomical Union 2011

Binary and Multiple O-Type Stars in the Cas OB6 Association

We present the results of time-resolved spectroscopy of 13 O-type stars in the Cas OB6 stellar association. We conducted a survey for radial velocity variability in search of binary systems, which are expected to be plentiful in young OB associations. Here we report the discovery of two new single-lined binaries, and we present new orbital elements for three double-lined binaries (including one in the multiple star system HD 17505). One of the double-lined systems is the eclipsing binary system DN Cas, and we present a preliminary light curve analysis that yields the system inclination, masses, and radii. We compare the spectra of the single stars and the individual components of the binary stars with model synthetic spectra to estimate the stellar effective temperatures, gravities, and projected rotational velocities. We also make fits of the spectral energy distributions to derive E(B-V), R=A_V/E(B-V), and angular diameter. A distance of 1.9 kpc yields radii that are consistent with evolutionary models. We find that 7 of 14 systems with spectroscopic data are probable binaries, consistent with the high binary frequency found for other massive stars in clusters and associations.Comment: 40 pages, ApJ, in pres

Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10−7) and FNDC1 (p-value = 3.0×10−7) for UACR, and KCNQ1 with eGFR (p = 3.6×10−6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish

Genome-wide association and functional follow-up reveals new loci for kidney function

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD

Prevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca

Abstract The present study examined the safety and efficacy of the ceremonial use of ayahuasca in relation to reports of heightened life event reexperiencing under psychedelics. The study examined (1) the prevalence of specific types of adverse life event reexperiencing, (2) characteristics predictive of reexperiencing, (3) the psychological character of reexperiencing, and (4) the impact of reexperiencing on mental health. Participants were recruited from three ayahuasca healing and spiritual centers in South and Central America (N = 33 military veterans, 306 non-veterans) using self-report data at three timepoints (Pre-retreat, Post-retreat, 3-months post-retreat). Reexperiencing adverse life events under ayahuasca was common, with women showing particularly high probability of reexperiencing sexual assault, veterans reexperiencing combat-related trauma, and individuals with a self-reported lifetime diagnosis of post-traumatic stress disorder exhibiting a substantively higher prevalence of reexperiencing. Reexperiencing was associated with states of cognitive reappraisal, psychological flexibility, and discomfort during ceremonies, and participants who reexperienced adverse life events exhibited greater reductions in trait neuroticism following their ceremonies. Clinical implications of these results for the application of psychedelics to mood and stress disorders are discussed

Habermas’s moral cognitivism and the Frege-Geach challenge

Habermas’s Moral Cognitivism and the Frege-Geach challenge, JAMES GORDON FINLAYSON This article levels at Habermas’s discourse ethics a challenge more usually directed to theories denying moral discourse is truth-bearing. It argues that the same challenge applies to discourse ethics, because Habermas denies that moral utterances are truth-apt, and claims that they are only analogous to truth. Part I shows that Habermas’s view that there is only an analogy between truth and rightness rests on an unjustified worry that metaethical cognitivism implies moral realism. It concludes that Habermas simply assumes moral discourse is syntactically disciplined exactly like theoretical discourse, but cannot explain why this is. Part II argues that the only tenable responses open to Habermas are either 1. to combine deflationism about truth with the acceptance that moral utterances can be true, or 2. to refrain from offering any theory of truth and to prescind entirely from the metaethical question of cognitivism versus non-cognitvism. – Correspondence to James Gordon Finlayson, Department of Philosophy, University of Sussex, Arts B Building 340, Falmer, Brighton, BN1 9Q