Wind-tunnel Tests of a Cyclogiro Rotor

During an extensive study of all types of rotating wings, the NACA examined the cyclogiro rotor and made an aerodynamic analysis of that system (reference 1). The examination disclosed that such a machine had sufficient promise to justify an experimental investigation; a model with a diameter and span of 8 feet was therefore constructed and tested in the 20-foot wind tunnel during 1934. The experimental work included tests of the effect of the motion upon the rotor forces during the static-lift and forward-flight conditions at several rotor speeds and the determination of the relations between the forces generated by the rotor and the power required by it

Kritik der Strumaepidemiologie: II. Altersabhängigkeit

Röntgen-Thoraxbilder (n = 2000) des Gesundheitsamtes Eutin wurden ausgewertet, um einen Anhalt für die Strumahäufigkeit in Norddeutschland zu gewinnen. Bis zum 40. Lebensjahr liegt die Häufigkeit bei 5 %. Danach steigt die Prävalenz strumaverdächtiger Röntgenbefunde allmählich auf bis zu 25 % und nach dem 65. Lebensjahr auf über 50 % an. Die angewandte radiologische Methode zeigt offenbar an, daß es auch in Schleswig-Holstein endemische Strumen gibt, was aufgrund des früher gezeigten alimentären Jodmangels auch zu erwarten war.Chest radiographs (n = 2000) of the public health office of Eutin were evaluated for the frequency of goitre in northern West-Germany. Up to the 40th year of age the frequency was 5 %. Thereafter the prevalence of goitre-suspect radiographs gradually rose to 25 % and to 50 % after the 65th year of life. The radiographic method indicates that endemic goitre exists in Schleswig-Holstein as was to be expected due to formerly demonstrated alimentary iodine deficiency

Preparation and characterization of cotton fabrics with antimicrobial properties through the application of chitosan/silver-zeolite film

The development of antimicrobial cotton fabrics using chitosan/silver-zeolite film has been investigated in the present work. The film was applied to 100% cotton fabric using a common pad-dry-cure technique and citric acid was used as crosslinking agent. The resulting fabrics were characterized through infrared spectroscopy (FTIR), contact angle and scanning electron microscopy with X-ray microanalysis (SEM/EDS). The antimicrobial activity of the fabrics was assessed through the viable-cell counting method and the materials showed activity against S. aureus and T. rubrum. The textile performance of the fabrics was analysed regarding their characteristics of hydrophilicity and breathability. The finishing did not change the hydrophilic behaviour of the material. Although the permeability to air has reduced 20%, the permeability to water vapour remained practically unchanged. Therefore, the results suggested that the process approach of applying chitosan/silver-zeolite film is recommended to produce textiles with antibacterial properties.CNPq-Brazil (Conselho Nacional de Desenvolvimento Científico e Tecnológico – Brazil/National Council of Scientific and Technological Development – Brazil) for the doctoral scholarship (233550/2014-3). This work is also financed by FEDER funds through the Competitivity Factors Operational Programme – COMPETE and by national funds through FCT – Foundation for Science and Technology within the scope of the project POCI-01-0145-FEDER-007136. This research was partially supported by the Strategic Funding UID/Multi/04423/2013 through national funds provided by FCT - Foundation for Science and Technology and European Regional Development Fund (ERDF), in the framework of the program PT2020.info:eu-repo/semantics/publishedVersio

The Functions of Auxilin and Rab11 in Drosophila Suggest That the Fundamental Role of Ligand Endocytosis in Notch Signaling Cells Is Not Recycling

Notch signaling requires ligand internalization by the signal sending cells. Two endocytic proteins, epsin and auxilin, are essential for ligand internalization and signaling. Epsin promotes clathrin-coated vesicle formation, and auxilin uncoats clathrin from newly internalized vesicles. Two hypotheses have been advanced to explain the requirement for ligand endocytosis. One idea is that after ligand/receptor binding, ligand endocytosis leads to receptor activation by pulling on the receptor, which either exposes a cleavage site on the extracellular domain, or dissociates two receptor subunits. Alternatively, ligand internalization prior to receptor binding, followed by trafficking through an endosomal pathway and recycling to the plasma membrane may enable ligand activation. Activation could mean ligand modification or ligand transcytosis to a membrane environment conducive to signaling. A key piece of evidence supporting the recycling model is the requirement in signaling cells for Rab11, which encodes a GTPase critical for endosomal recycling. Here, we use Drosophila Rab11 and auxilin mutants to test the ligand recycling hypothesis. First, we find that Rab11 is dispensable for several Notch signaling events in the eye disc. Second, we find that Drosophila female germline cells, the one cell type known to signal without clathrin, also do not require auxilin to signal. Third, we find that much of the requirement for auxilin in Notch signaling was bypassed by overexpression of both clathrin heavy chain and epsin. Thus, the main role of auxilin in Notch signaling is not to produce uncoated ligand-containing vesicles, but to maintain the pool of free clathrin. Taken together, these results argue strongly that at least in some cell types, the primary function of Notch ligand endocytosis is not for ligand recycling

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotein C-III variant, D25V. Despite their uremic state, the D25V-carriers exhibit low triglyceride (TG) and apolipoprotein C-III levels, and low very-low-density lipoprotein (VLDL)/high high-density lipoprotein (HDL) profile. Amyloid fibrils comprise the D25V-variant only, showing that wild-type apolipoprotein C-III does not contribute to amyloid deposition in vivo. The mutation profoundly impacts helical structure stability of D25V-variant, which is remarkably fibrillogenic under physiological conditions in vitro producing typical amyloid fibrils in its lipid-free form. D25V apolipoprotein C-III is a new human amyloidogenic protein and the first conferring cardioprotection even in the unfavourable context of renal failure, extending the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency. Thus, fibrate therapy, which reduces hepatic APOC3 transcription, may delay amyloid deposition in affected patients