Development of a 1.6-kW, 2000-volt, high- frequency dc-dc converter for ion thrustors using a modular design and an inductive energy pumping technique for conversion, regulation and protection Summary report

High-frequency dc-dc converter for ion thrustors using modular design and inductive energy pumping technique for conversion, regulation, and protectio

Investigation of the role of selenium in the nutrition and physiology of neural tissues of chickens and turkeys

Endogenous selenium concentrations in selected tissue of chickens, turkeys, and coturni

What Can Quantitative Gait Analysis Tell Us about Dementia and Its Subtypes? A Structured Review

Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia. This structured review explores the differences in quantitative gait characteristics between dementia and healthy controls, and between four dementia subtypes under single-task conditions: Alzheimer’s disease (AD), dementia with Lewy bodies and Parkinson’s disease dementia, and vascular dementia. Twenty-six papers out of an initial 5,211 were reviewed and interpreted using a validated model of gait. Dementia was associated with gait characteristics grouped by slower pace, impaired rhythm, and increased variability compared to normal aging. Only four studies compared two or more dementia subtypes. People with AD are less impaired in pace, rhythm, and variability domains of gait compared to non-AD dementias. Results demonstrate the potential of gait as a clinical marker to discriminate between dementia subtypes. Larger studies using a more comprehensive battery of gait characteristics and better characterized dementia sub-types are required

Chemical reactivity of hydrogen, nitrogen and oxygen atoms at temperatures below 100 deg K Fifth semiannual technical report

Chemical reactivity of hydrogen, nitrogen, and oxygen atoms at temperatures below 100 deg

Stellar mass function of cluster galaxies at z ~ 1.5: evidence for reduced quenching efficiency at high redshift

Indexación: Web of ScienceWe present the stellar mass functions (SMFs) of passive and star-forming galaxies with a limiting mass of 10(10.1) M-circle dot in four spectroscopically confirmed Spitzer Adaptation of the Red-sequence Cluster Survey (SpARCS) galaxy clusters at 1 : 37 < z < 1 : 63. The clusters have 113 spectroscopically confirmed members combined, with 8-45 confirmed members each. We construct Ks-bandselected photometric catalogs for each cluster with an average of 11 photometric bands ranging from u to 8 mu m. We compare our cluster galaxies to a field sample derived from a similar Ks-band-selected catalog in the UltraVISTA / COSMOS field. The SMFs resemble those of the field, but with signs of environmental quenching. We find that 30 +/- 20% of galaxies that would normally be forming stars in the field are quenched in the clusters. The environmental quenching e ffi ciency shows little dependence on projected cluster-centric distance out to similar to 4 Mpc, providing tentative evidence of pre-processing and/or galactic conformity in this redshift range. We also compile the available data on environmental quenching efficiencies from the literature, and find that the quenching e ffi ciency in clusters and in groups appears to decline with increasing redshift in a manner consistent with previous results and expectations based on halo mass growth.http://www.aanda.org/articles/aa/abs/2016/08/aa28663-16/aa28663-16.htm

Inverse Landau-Khalatnikov Transformation and Infrared Critical Exponents of (2+1)-dimensional Quantum Electrodynamics

By applying an inverse Landau-Khalatnikov transformation, connecting (resummed) Schwinger-Dyson treatments in non-local and Landau gauges of $QED_3$, we derive the infrared behaviour of the wave-function renormalization in the Landau gauge, and the associated critical exponents in the normal phase of the theory (no mass generation). The result agrees with the one conjectured in earlier treatments. The analysis involves an approximation, namely an expansion of the non-local gauge in powers of momenta in the infrared. This approximation is tested by reproducing the critical number of flavours necessary for dynamical mass generation in the chiral-symmetry-broken phase of $QED_3$.Comment: 13 pages LATEX, 1 Figure (included automatically

Providing surgical care in Somalia: A model of task shifting.

ABSTRACT

Tuning protein mechanics through an ionic cluster graft from an extremophilic protein.

Proteins from extremophilic organisms provide excellent model systems to determine the role of non-covalent interactions in defining protein stability and dynamics as well as being attractive targets for the development of robust biomaterials. Hyperthermophilic proteins have a prevalence of salt bridges, relative to their mesophilic homologues, which are thought to be important for enhanced thermal stability. However, the impact of salt bridges on the mechanical properties of proteins is far from understood. Here, a combination of protein engineering, biophysical characterisation, single molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulations directly investigates the role of salt bridges in the mechanical stability of two cold shock proteins; BsCSP from the mesophilic organism Bacillus subtilis and TmCSP from the hyperthermophilic organism Thermotoga maritima. Single molecule force spectroscopy shows that at ambient temperatures TmCSP is mechanically stronger yet, counter-intuitively, its native state can withstand greater deformation before unfolding (i.e. it is mechanically soft) compared with BsCSP. MD simulations were used to identify the location and quantify the population of salt bridges, and reveal that TmCSP contains a larger number of highly occupied salt bridges than BsCSP. To test the hypothesis that salt-bridges endow these mechanical properties on the hyperthermophilic CSP, a charged triple mutant (CTM) variant of BsCSP was generated by grafting an ionic cluster from TmCSP into the BsCSP scaffold. As expected CTM is thermodynamically more stable and mechanically softer than BsCSP. We show that a grafted ionic cluster can increase the mechanical softness of a protein and speculate that it could provide a mechanical recovery mechanism and that it may be a design feature applicable to other proteins

The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity

Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70), ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for plasma membrane (PM) expression and activity. Here we use site-directed mutagenesis and expression in COS cells or Xenopus oocytes to investigate whether this glutamate (Glu218 in basigin) may charge-pair with a positively charged TM-residue of MCT1. Such residues were predicted using a new molecular model of MCT1 based upon the published structure of the E. coli glycerol-3-phosphate transporter. No evidence was obtained for Arg306 (TM 8) of MCT1 and Glu218 of basigin forming a charge-pair; indeed E218Q-basigin could replace WT-basigin, although E218R-basigin was inactive. No PM expression of R306E-MCT1 or D302R-MCT1 was observed but D302R/R306D-MCT1 reached the PM, as did R306K-MCT1. However, both were catalytically inactive suggesting that Arg306 and Asp302 form a charge-pair in either orientation, but their precise geometry is essential for catalytic activity. Mutation of Arg86 to Glu or Gln within TM3 of MCT1 had no effect on plasma membrane expression or activity of MCT1. However, unlike WT-MCT1, these mutants enabled expression of E218R-basigin at the plasma membrane of COS cells. We propose that TM3 of MCT1 lies alongside the TM of basigin with Arg86 adjacent to Glu218 of basigin. Only when both these residues are positively charged (E218R-basigin with WT-MCT1) is this interaction prevented; all other residue pairings at these positions may be accommodated by charge-pairing or stabilization of unionized residues through hydrogen bonding or local distortion of the helical structure

Teachers’ Adoption of Embodied Learning Digital Games with an Inclusive Education Approach: Lessons Learnt from the INTELed Project in Spain

Producción CientíficaEmbodied learning digital games have been used with success in the past to support students with special education needs, but their application by teachers in mainstream classes with an inclusive approach is still a challenge. This paper presents the results of a set of pilots in which a suite of embodied digital games was applied into pre-school and primary school classrooms. The findings of the studies provide insights into the conditions that facilitated and/or impeded the adoption of the technology by the participant teachers. These results are then elaborated to define a first set of strategies that could be used by third-party teachers to fulfill the same objectives, and to identify concrete design challenges for the application of embodied digital games in classrooms.Ministerio de Ciencia, Innovación y Universidades (Project TIN2017-85179-C3-2-R)Junta de Castilla y León (Project VA257P18 (CASSUALearn