A retrospective analysis of the relationshi between reading and math abilities and visual function in a Hispanic elementary age population

Although much research has been done on the relationship between vision and learning, there is still much debate regarding which tests should be done during a vision screening to accurately identify those children whose academic performance is being affected by their visual skills. In an attempt determine which tests would best predict academic performance, we analyzed records from a vision screening on a group of school aged children from San Blas, Mexico. 447 children, ages 5 to 13, were given a free vision screening. Their teachers were asked to rate each child\u27s performance in reading and math on scale of 1 to 5. Those findings were then compared to the child\u27s near visual acuity, near cover test, near point of convergence, stereo acuity, and refractive error. No clinically significant correlation was found between those visual skills measured and academic performance as rated by each child\u27s teacher. This could be partly due to the limited tests performed. Future screenings that include tests of visual skills, such as saccadic eye movements and visual motor integration, which directly affect a child\u27s ability to read and learn, would probably be better predictors of academic performance than those tests performed at our screening

Thomas G. Abernethy, Jamie L. Whitten, Arthur Winstead, John Bell Williams, William M. Colmer, James O. Eastland, John C. Stennis to President John F. Kennedy, 28 September 1962;

Press release dated 28 September 1962, re: letter from Thomas G. Abernethy, Jamie L. Whitten, Arthur Winstead, John Bell Williams, William M. Colmer, James O. Eastland, and John C. Stennis to Kennedy in regards to integration of the University of Mississippi by James Meredith.https://egrove.olemiss.edu/joecorr_d/1011/thumbnail.jp

Effects of Body Shape on Literal Objectification: When Ideal May Be Less Than Ideal

Objectification, or the tendency to adopt an externalized view of self/other, is a ubiquitous process disproportionately affecting women (Fredrickson & Roberts, 1997). Recent work has examined literal objectification, defined as “any outcome in which a person is perceived as, or behaves, objectlike, relative to humanlike” (Heflick & Goldenberg, 2014, p. 225). Focusing on women’s physical appearance heightens literal objectification, including reduced perceptions of warmth, competence, and morality (Heflick et al., 2011). We investigated whether participants’ ratings of literal objectification vary as a function of body type. Seventy-one college women (Mage = 19.23) viewed three photos of women, manipulated to depict low, average, and high ideal body shapes. Participants rated the degree to which each woman possessed competence, warmth and morality, and their desire to collaborate on a group project with them. Average images were rated as significantly higher on warmth, morality, and collaboration desirability than high ideal and low ideal images, and marginally more competent than high ideal images. High ideal images were rated as significantly lower on warmth and marginally lower on collaboration desirability than low ideal images. Future research should extend this work to evaluate behavioral manifestations of literal objectification and explore what other factors might moderate these effects

Everything You Need to Know about Grants: Beginning, Middle and End

“Everything You Need to Know about Grants: Beginning, Middle and End” was a 90-minute session presented at the Society of California Archivists Annual General Meeting in Berkeley, CA, on April 13, 2013. As a part of the archival community, many of us know that grants are an excellent way to reduce backlogs or accomplish projects we don\u27t have the resources to tackle. However, what many of us may not know is how much work goes into successfully implementing and completing a grant. The purpose of this session was to assemble a group of individuals who have been involved in various aspects of the grant application and implementation process to share their expertise with the archival community. The session utilized a question and answer format with a moderator asking pre-arranged questions. This article provides excerpts from the panelists’ responses

Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage.

UV damage to the skin leads to the release of noncoding RNA (ncRNA) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3). This release of ncRNA triggers inflammation in the skin following UV damage. Recently, TLR3 activation was also shown to aid wound repair and increase the expression of genes associated with permeability barrier repair. Here, we sought to test whether skin barrier repair after UVB damage is dependent on the activation of TLR3. We observed that multiple ncRNAs induced expression of skin barrier repair genes, that the TLR3 ligand Poly (I:C) also induced expression and function of tight junctions, and that the ncRNA U1 acts in a TLR3-dependent manner to induce expression of skin barrier repair genes. These observations were shown to have functional relevance as Tlr3-/- mice displayed a delay in skin barrier repair following UVB damage. Combined, these data further validate the conclusion that recognition of endogenous RNA by TLR3 is an important step in the program of skin barrier repair

An Alternative Futures Approach to Green Infrastructure Planning for an Increasing Population

In 2017, the U.S. Census Bureau announced Idaho to be the fastest growing state by population in the country. As these trends continue, this growth can have various impacts on socio-ecological systems such as increased development, pressure exerted on agricultural production, and increased effects of urban stream syndrome. Various scenarios, driven by stakeholders, can help effectively guide the designs of our green infrastructure networks. This project evokes stakeholder-defined key issues addressed within a National Science Foundation (NSF) funded project in Idaho’s Magic Valley. Innovations at the Nexus of Food, Energy, and Water Systems (INFEWS) is an interdisciplinary research initiative seeking to address issues concerning drought, water demand, water quality, and food security by using a stakeholder-driven alternative futures framework (Steinitz 2012). Researchers within the project seek to operationalize stakeholder-driven assumptions for various scenarios utilizing the planning and suitability of effective Best Management Practices (BMPs) for the Magic Valley in Idaho. The project will utilize an alternative futures methodology to interpret and represent rural and urban green infrastructure interventions at various locations within the watershed. This approach has the potential to operate at various scales and, through this project, we seek to construct the narrative at both the landscape and the site scale. The results aim to provide policy makers, planners, developers, and landscape architects about siting various BMP types through a framework for planning and design. These outputs will also depict modeled landscape change via various scenario solutions. The stakeholder group will substantiate plausible solutions and scenarios for the Valley, which will guide the green infrastructure network. Once validated, we will focus on the siting of three different structural BMP networks to address water quality, water quantity, soil health, and inclusion of public green space

Sociology of low expectations: Recalibration as innovation work in biomedicine

"This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm). "Social scientists have drawn attention to the role of hype and optimistic visions of the future in providing momentum to biomedical innovation projects by encouraging innovation alliances. In this article, we show how less optimistic, uncertain, and modest visions of the future can also provide innovation projects with momentum. Scholars have highlighted the need for clinicians to carefully manage the expectations of their prospective patients. Using the example of a pioneering clinical team providing deep brain stimulation to children and young people with movement disorders, we show how clinicians confront this requirement by drawing on their professional knowledge and clinical expertise to construct visions of the future with their prospective patients; visions which are personalized, modest, and tainted with uncertainty. We refer to this vision-constructing work as recalibration, and we argue that recalibration enables clinicians to manage the tension between the highly optimistic and hyped visions of the future that surround novel biomedical interventions, and the exigencies of delivering those interventions in a clinical setting. Drawing on work from science and technology studies, we suggest that recalibration enrolls patients in an innovation alliance by creating a shared understanding of how the “effectiveness” of an innovation shall be judged.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)

Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufacture, since the gene product (preproinsulin) undergoes substantial post-translational modification in pancreatic β cells before it becomes biologically active. The aim of the present study was to develop recombinant canine single chain insulin (SCI) analogues that could be produced in a prokaryotic expression system and which would require minimal processing. Three recombinant SCI constructs were developed in a prokaryotic expression vector, by replacing the insulin C-peptide sequence with one encoding a synthetic peptide (GGGPGKR), or with one of two insulin-like growth factor (IGF)-2 C-peptide coding sequences (human: SRVSRRSR; canine: SRVTRRSSR). Recombinant proteins were expressed in the periplasmic fraction of Escherichia coli and assessed for their ability to bind to the insulin and IGF-1 receptors, and to stimulate glucose uptake in 3T3-L1 adipocytes. All three recombinant SCI analogues demonstrated preferential binding to the insulin receptor compared to the IGF-1 receptor, with increased binding compared to recombinant canine proinsulin. The recombinant SCI analogues stimulated glucose uptake in 3T3-L1 adipocytes compared to negligible uptake using recombinant canine proinsulin, with the canine insulin/cIGF-2 chimaeric SCI analogue demonstrating the greatest effect. Thus, biologically-active recombinant canine SCI analogues can be produced relatively easily in bacteria, which could potentially be used for treatment of diabetic dogs