Protocol for Monitoring Fish Communities in Small Streams in the Heartland Inventory and Monitoring Network, Version 2.0

Executive Summary Fish communities are an important component of aquatic systems and are good bioindicators of ecosystem health. Land use changes in the Midwest have caused sedimentation, erosion, and nutrient loading that degrades and fragments habitat and impairs water quality. Because most small wadeable streams in the Heartland Inventory and Monitoring Network (HTLN) have a relatively small area of their watersheds located within park boundaries, these streams are at risk of degradation due to adjacent land use practices and other anthropogenic disturbances. Shifts in the physical and chemical properties of aquatic systems have a dramatic effect on the biotic community. The federally endangered Topeka shiner (Notropis topeka) and other native fishes have declined in population size due to habitat degradation and fragmentation in Midwest streams. By protecting portions of streams on publicly owned lands, national parks may offer refuges for threatened or endangered species and species of conservation concern, as well as other native species. This protocol describes the background, history, justification, methodology, data analysis and data management for long-term fish community monitoring of wadeable streams within nine HTLN parks: Effigy Mounds National Monument (EFMO), George Washington Carver National Monument (GWCA), Herbert Hoover National Historic Site (HEHO), Homestead National Monument of America (HOME), Hot Springs National Park (HOSP), Pea Ridge National Military Park (PERI), Pipestone National Monument (PIPE), Tallgrass Prairie National Preserve (TAPR), and Wilson\u27s Creek National Battlefield (WICR). The objectives of this protocol are to determine the status and long-term trends in fish richness, diversity, abundance, and community composition in small wadeable streams within these nine parks and correlate the long-term community data to overall water quality and habitat condition (DeBacker et al. 2005)

Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Adverse Birth Outcomes

BACKGROUND. Prior studies of prenatal exposure to tetrachloroethylene (PCE) have shown mixed results regarding its effect on birth weight and gestational age. OBJECTIVES. In this retrospective cohort study we examined whether PCE contamination of public drinking-water supplies in Massachusetts influenced the birth weight and gestational duration of children whose mothers were exposed before the child's delivery. METHODS. The study included 1,353 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 772 children of unexposed mothers. Birth records were used to identify subjects and provide information on the outcomes. Mothers completed a questionnaire to gather information on residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model. RESULTS. We found no meaningful associations between PCE exposure and birth weight or gestational duration. Compared with children whose mothers were unexposed during the year of the last menstrual period (LMP), adjusted mean differences in birth weight were 20.9, 6.2, 30.1, and 15.2 g for children whose mothers' average monthly exposure during the LMP year ranged from the lowest to highest quartile. Similarly, compared with unexposed children, adjusted mean differences in gestational age were -0.2, 0.1, -0.1, and -0.2 weeks for children whose mothers' average monthly exposure ranged from the lowest to highest quartile. Similar results were observed for two other measures of prenatal exposure. CONCLUSIONS. These results suggest that prenatal PCE exposure does not have an adverse effect on these birth outcomes at the exposure levels experienced by this population.National Institute of Environmental Health Sciences (5 P42 ES007381

Remote physiological monitoring: Clinical, financial, and behavioral outcomes in a heart failure population

This article reports on the outcomes associated with remote physiological monitoring (RPM) conducted as part of a heart failure disease management program. Claims data, medical records, data transmission records, and survey results for 91 individuals ages 50–92 (mean 74 years) successfully completing a heart failure RPM program were analyzed for time periods before, during, and after the monitoring intervention. The program was associated with significant reductions in per member per month costs and emergency room and hospital utilization. More detailed analyses were performed for specific gender and age subgroups. Participant surveys indicated high levels of satisfaction, and improvements in self-perceived health status, self-efficacy, and self-management behaviors. This study is the first to assess the impact of a RPM program following removal of the monitoring equipment. The results indicate that RPM, as a component of a traditional disease management program, has a sustained, beneficial effect on participants’ lifestyles after the monitoring period has ended

Multi-Scale Stellar Associations across the Star Formation Hierarchy in PHANGS-HST Nearby Galaxies: Methodology and Properties

We develop a method to identify and determine the physical properties of stellar associations using Hubble Space Telescope (HST) NUV-U-B-V-I imaging of nearby galaxies from the PHANGS-HST survey. We apply a watershed algorithm to density maps constructed from point source catalogues Gaussian smoothed to multiple physical scales from 8 to 64 pc. We develop our method on two galaxies that span the distance range in the PHANGS-HST sample: NGC 3351 (10 Mpc), NGC 1566 (18 Mpc). We test our algorithm with different parameters such as the choice of detection band for the point source catalogue (NUV or V), source density image filtering methods, and absolute magnitude limits. We characterise the properties of the resulting multi-scale associations, including sizes, number of tracer stars, number of associations, photometry, as well as ages, masses, and reddening from Spectral Energy Distribution fitting. Our method successfully identifies structures that occupy loci in the UBVI colour-colour diagram consistent with previously published catalogues of clusters and associations. The median ages of the associations increases from log(age/yr) = 6.6 to log(age/yr) = 6.9 as the spatial scale increases from 8 pc to 64 pc for both galaxies. We find that the youngest stellar associations, with ages < 3 Myr, indeed closely trace H ii regions in H$\alpha$ imaging, and that older associations are increasingly anti-correlated with the H$\alpha$ emission. Owing to our new method, the PHANGS-HST multi-scale associations provide a far more complete census of recent star formation activity than found with previous cluster and compact association catalogues. The method presented here will be applied to the full sample of 38 PHANGS-HST galaxies.Comment: Submitted to MNRAS. Referee report received with minor comments, and "request to clarify if the smaller associations are always included in the larger ones and how this may affect the photometric fitting of the larger association if the groups have different ages." Revision in progres

PHANGS-JWST: Data-processing Pipeline and First Full Public Data Release

The exquisite angular resolution and sensitivity of JWST are opening a new window for our understanding of the Universe. In nearby galaxies, JWST observations are revolutionizing our understanding of the first phases of star formation and the dusty interstellar medium. Nineteen local galaxies spanning a range of properties and morphologies across the star-forming main sequence have been observed as part of the PHANGS-JWST Cycle 1 Treasury program at spatial scales of ∼5–50 pc. Here, we describe pjpipe, an image-processing pipeline developed for the PHANGS-JWST program that wraps around and extends the official JWST pipeline. We release this pipeline to the community as it contains a number of tools generally useful for JWST NIRCam and MIRI observations. Particularly for extended sources, pjpipe products provide significant improvements over mosaics from the MAST archive in terms of removing instrumental noise in NIRCam data, background flux matching, and calibration of relative and absolute astrometry. We show that slightly smoothing F2100W MIRI data to 0.″9 (degrading the resolution by about 30%) reduces the noise by a factor of ≈3. We also present the first public release (DR1.1.0) of the pjpipe processed eight-band 2–21 μm imaging for all 19 galaxies in the PHANGS-JWST Cycle 1 Treasury program. An additional 55 galaxies will soon follow from a new PHANGS-JWST Cycle 2 Treasury program

Quantifying the energy balance between the turbulent ionised gas and young stars

We investigate the ionised gas morphology, excitation properties, and kinematics in 19 nearby star-forming galaxies from the PHANGS-MUSE survey. We directly compare the kinetic energy of expanding superbubbles and the turbulent motions in the interstellar medium with the mechanical energy deposited by massive stars in the form of winds and supernovae, with the aim to answer whether the stellar feedback is responsible for the observed turbulent motions and to quantify the fraction of mechanical energy retained in the superbubbles. Based on the distribution of the flux and velocity dispersion in the H$\alpha$ line, we select 1484 regions of locally elevated velocity dispersion ($\sigma$(H$\alpha$)>45 km/s), including at least 171 expanding superbubbles. We analyse these regions and relate their properties to those of the young stellar associations and star clusters identified in PHANGS-HST data. We find a good correlation between the kinetic energy of the ionised gas and the total mechanical energy input from supernovae and stellar winds from the stellar associations, with a typical efficiency of 10-20%. The contribution of mechanical energy by the supernovae alone is not sufficient to explain the measured kinetic energy of the ionised gas, which implies that pre-supernova feedback in the form of radiation/thermal pressure and winds is necessary. We find that the gas kinetic energy decreases with metallicity for our sample covering Z=0.5-1.0 Zsun, reflecting the lower impact of stellar feedback. For the sample of superbubbles, we find that about 40% of the young stellar associations are preferentially located in their rims. We also find a slightly higher (by ~15%) fraction of the youngest (1-2.5 Myr) stellar associations in the rims of the superbubbles than in the centres, and the opposite for older associations, which implies possible propagation or triggering of star formation.Comment: 31 pages (including 5 pages in appendix), 19 figures, the abstract is abridged; submitted to A&A (in mid May; awaiting report

Hidden Gems on a Ring: Infant Massive Clusters and Their Formation Timeline Unveiled by ALMA, HST, and JWST in NGC 3351

We use 0.1″ observations from the Atacama Large Millimeter Array (ALMA), Hubble Space Telescope (HST), and JWST to study young massive clusters (YMCs) in their embedded “infant” phase across the central starburst ring in NGC 3351. Our new ALMA data reveal 18 bright and compact (sub-)millimeter continuum sources, of which 8 have counterparts in JWST images and only 6 have counterparts in HST images. Based on the ALMA continuum and molecular line data, as well as ancillary measurements for the HST and JWST counterparts, we identify 14 sources as infant star clusters with high stellar and/or gas masses (∼105 M ⊙), small radii (≲ 5 pc), large escape velocities (6–10 km s−1), and short freefall times (0.5–1 Myr). Their multiwavelength properties motivate us to divide them into four categories, likely corresponding to four evolutionary stages from starless clumps to exposed H ii region–cluster complexes. Leveraging age estimates for HST-identified clusters in the same region, we infer an evolutionary timeline, ranging from ∼1–2 Myr before cluster formation as starless clumps, to ∼4–6 Myr after as exposed H ii region–cluster complexes. Finally, we show that the YMCs make up a substantial fraction of recent star formation across the ring, exhibit a nonuniform azimuthal distribution without a very coherent evolutionary trend along the ring, and are capable of driving large-scale gas outflows

PHANGS-HST Catalogs for ∼100,000 Star Clusters and Compact Associations in 38 Galaxies. I. Observed Properties

We present the largest catalog to date of star clusters and compact associations in nearby galaxies. We have performed a V-band-selected census of clusters across the 38 spiral galaxies of the PHANGS–Hubble Space Telescope (HST) Treasury Survey, and measured integrated, aperture-corrected near-ultraviolet-U-B-V-I photometry. This work has resulted in uniform catalogs that contain ∼20,000 clusters and compact associations, which have passed human inspection and morphological classification, and a larger sample of ∼100,000 classified by neural network models. Here, we report on the observed properties of these samples, and demonstrate that tremendous insight can be gained from just the observed properties of clusters, even in the absence of their transformation into physical quantities. In particular, we show the utility of the UBVI color–color diagram, and the three principal features revealed by the PHANGS-HST cluster sample: the young cluster locus, the middle-age plume, and the old globular cluster clump. We present an atlas of maps of the 2D spatial distribution of clusters and compact associations in the context of the molecular clouds from PHANGS–Atacama Large Millimeter/submillimeter Array. We explore new ways of understanding this large data set in a multiscale context by bringing together once-separate techniques for the characterization of clusters (color–color diagrams and spatial distributions) and their parent galaxies (galaxy morphology and location relative to the galaxy main sequence). A companion paper presents the physical properties: ages, masses, and dust reddenings derived using improved spectral energy distribution fitting techniques

PHANGS: Constraining Star Formation Timescales Using the Spatial Correlations of Star Clusters and Giant Molecular Clouds

In the hierarchical view of star formation, giant molecular gas clouds (GMCs) undergo fragmentation to form small-scale structures made up of stars and star clusters. Here we study the connection between young star clusters and cold gas across a range of extragalactic environments by combining the high resolution (1") PHANGS-ALMA catalogue of GMCs with the star cluster catalogues from PHANGS-HST. The star clusters are spatially matched with the GMCs across a sample of 11 nearby star-forming galaxies with a range of galactic environments (centres, bars, spiral arms, etc.). We find that after 4-6 Myr the star clusters are no longer associated with any gas clouds. Additionally, we measure the autocorrelation of the star clusters and GMCs as well as their cross-correlation to quantify the fractal nature of hierarchical star formation. Young ($\leq$ 10 Myr) star clusters are more strongly autocorrelated on kpc and smaller spatial scales than the >10 Myr stellar populations, indicating that the hierarchical structure dissolves over time.Comment: 15 pages, 11 figures, 4 tables. Accepted to MNRAS Sept 6 202

Nutrition and frailty:Opportunities for prevention and treatment

Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its pathophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future