The Effect of Step Frequency Training on a Male Runner with Patellofemoral Pain

Running is a very popular form of exercise. The most common site of injury for runners is the knee with patellofemoral pain being the most common complaint. Patellofemoral pain is described as pain around the patella that is worse with activities such as running, squatting, ascending or descending stairs, or sitting for long periods. Much of the recent work with the treatment of patellofemoral pain has involved strengthening of the hip musculature to reduce pain about the knee. However, the ability of these strengthening programs to change lower extremity mechanics or sustain long-term pain reduction has been unproven. More recently, researchers have started to examine the impact of step frequency modification on the forces encountered in the lower extremity, and specifically about the patellofemoral joint. The purpose of this study was to examine the short term effects of step frequency training in a recreational runner with PFP. Methods: This was a single-subject case study design. The subject completed a pre- and post-training assessment to determine the preferred step frequency. The subject also completed a Visual Analog Scale (VAS) and a Lower Extremity Functional Scale (LEFS). Results: After the initial evaluation, the subject completed training 2 times per week for 4 weeks using auditory feedback to increase their step frequency by 5% above their preferred step frequency. The subject experienced a decrease in pain as measured by the VAS and an increase in function as measured by the LEFS across the 4 week training. Discussion: Although the results of this case study may not be generalized, the positive findings support additional research to determine both the short and long-term effects of step frequency training on PFP

Towards modelling X-ray reverberation in AGN: Piecing together the extended corona

Models of X-ray reverberation from extended coronae are developed from general relativistic ray tracing simulations. Reverberation lags between correlated variability in the directly observed continuum emission and that reflected from the accretion disc arise due to the additional light travel time between the corona and reflecting disc. X-ray reverberation is detected from an increasing sample of Seyfert galaxies and a number of common properties are observed, including a transition from the characteristic reverberation signature at high frequencies to a hard lag within the continuum component at low frequencies, as well a pronounced dip in the reverberation lag at 3keV. These features are not trivially explained by the reverberation of X-rays originating from simple point sources. We therefore model reverberation from coronae extended both over the surface of the disc and vertically. Causal propagation through its extent for both the simple case of constant velocity propagation and propagation linked to the viscous timescale in the underlying accretion disc is included as well as stochastic variability arising due to turbulence locally on the disc. We find that the observed features of X-ray reverberation in Seyfert galaxies can be explained if the long timescale variability is dominated by the viscous propagation of fluctuations through the corona. The corona extends radially at low height over the surface of the disc but with a bright central region in which fluctuations propagate up the black hole rotation axis driven by more rapid variability arising from the innermost regions of the accretion flow

The high-Eddington NLS1 Ark 564 has the coolest corona

Ark 564 is an archetypal narrow-line Seyfert 1 that has been well observed in soft X-rays from 0.3–10 keV, revealing a steep spectrum, strong soft excess, iron K emission line and dramatic variability on the order of hours. Because of its very steep spectrum, observations of the source above 10 keV have been sparse. We report here on the first NuSTAR observation of Ark 564. The source was observed for 200 ks with NuSTAR, 50 ks of which were concurrent with Suzaku observations. NuSTAR and Suzaku observed a dramatic flare, in which the hard emission is clearly delayed with respect to the soft emission, consistent with previous detections of a low-frequency hard lag found in XMM–Newton data. The NuSTAR spectrum is well described by a low-temperature Comptonization continuum (with an electron temperature of 15 ± 2 keV), which irradiates a highly ionized disc. No further relativistic broadening or ionized absorption is required. These spectral results show that Ark 564 has one of the lowest temperature coronae observed by NuSTAR to date. We discuss possible reasons for low-temperature coronae in high-Eddington sources.European Research Council (340442

Play and metaphor in clinical supervision: keeping creativity alive

This article explores the use of play and metaphor in clinical supervision. The intention is not to attempt to cover the whole area of play, or the use of metaphor in clinical supervision, but rather to highlight particular aspects of their respective roles in the service of learning about therapeutic work. The relevance of the arts - especially the visual arts - in relation to this is also discussed. A number of brief clinical vignettes are included by way of illustration. All names, and some identifying details, have been changed to preserve confidentiality. (C) 2010 Elsevier Inc. All rights reserved

Wearable technology and the cardiovascular system: the future of patient assessment

The past decade has seen a dramatic rise in consumer technologies able to monitor a variety of cardiovascular parameters. Such devices initially recorded markers of exercise, but now include physiological and health-care focused measurements. The public are keen to adopt these devices in the belief that they are useful to identify and monitor cardiovascular disease. Clinicians are therefore often presented with health app data accompanied by a diverse range of concerns and queries. Herein, we assess whether these devices are accurate, their outputs validated, and whether they are suitable for professionals to make management decisions. We review underpinning methods and technologies and explore the evidence supporting the use of these devices as diagnostic and monitoring tools in hypertension, arrhythmia, heart failure, coronary artery disease, pulmonary hypertension, and valvular heart disease. Used correctly, they might improve health care and support research

Evolutionary relationships between Rhynchosporium lolii sp. nov. and other Rhynchosporium species on grass.

Copyright: 2013 King et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedThe fungal genus Rhynchosporium (causative agent of leaf blotch) contains several host-specialised species, including R. commune (colonising barley and brome-grass), R. agropyri (couch-grass), R. secalis (rye and triticale) and the more distantly related R. orthosporum (cocksfoot). This study used molecular fingerprinting, multilocus DNA sequence data, conidial morphology, host range tests and scanning electron microscopy to investigate the relationship between Rhynchosporium species on ryegrasses, both economically important forage grasses and common wild grasses in many cereal growing areas, and other plant species. Two different types of Rhynchosporium were found on ryegrasses in the UK. Firstly, there were isolates of R. commune that were pathogenic to both barley and Italian ryegrass. Secondly, there were isolates of a new species, here named R. lolii, that were pathogenic only to ryegrass species. R. lolii was most closely related to R. orthosporum, but exhibited clear molecular, morphological and host range differences. The species was estimated to have diverged from R. orthosporum ca. 5735 years before the present. The colonisation strategy of all of the different Rhynchosporium species involved extensive hyphal growth in the sub-cuticular regions of the leaves. Finally, new species-specific PCR diagnostic tests were developed that could distinguish between these five closely related Rhynchosporium species.Peer reviewedFinal Published versio

Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation

Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts to improve commercial breeds. As a step toward this goal we identified candidate regions to be under selection in genomes of nine Russian native cattle breeds adapted to survive in harsh climates. After comparing our data to other breeds of European and Asian origins we found known and novel candidate genes that could potentially be related to domestication, economically important traits and environmental adaptations in cattle. The Russian cattle breed genomes contained regions under putative selection with genes that may be related to adaptations to harsh environments (e.g., AQP5, RAD50, and RETREG1). We found genomic signatures of selective sweeps near key genes related to economically important traits, such as the milk production (e.g., DGAT1, ABCG2), growth (e.g., XKR4), and reproduction (e.g., CSF2). Our data point to candidate genes which should be included in future studies attempting to identify genes to improve the extant breeds and facilitate generation of commercial breeds that fit better into the environments of Russia and other countries with similar climates

Lithic technological responses to Late Pleistocene glacial cycling at Pinnacle Point Site 5-6, South Africa

There are multiple hypotheses for human responses to glacial cycling in the Late Pleistocene, including changes in population size, interconnectedness, and mobility. Lithic technological analysis informs us of human responses to environmental change because lithic assemblage characteristics are a reflection of raw material transport, reduction, and discard behaviors that depend on hunter-gatherer social and economic decisions. Pinnacle Point Site 5-6 (PP5-6), Western Cape, South Africa is an ideal locality for examining the influence of glacial cycling on early modern human behaviors because it preserves a long sequence spanning marine isotope stages (MIS) 5, 4, and 3 and is associated with robust records of paleoenvironmental change. The analysis presented here addresses the question, what, if any, lithic assemblage traits at PP5-6 represent changing behavioral responses to the MIS 5-4-3 interglacial-glacial cycle? It statistically evaluates changes in 93 traits with no a priori assumptions about which traits may significantly associate with MIS. In contrast to other studies that claim that there is little relationship between broad-scale patterns of climate change and lithic technology, we identified the following characteristics that are associated with MIS 4: increased use of quartz, increased evidence for outcrop sources of quartzite and silcrete, increased evidence for earlier stages of reduction in silcrete, evidence for increased flaking efficiency in all raw material types, and changes in tool types and function for silcrete. Based on these results, we suggest that foragers responded to MIS 4 glacial environmental conditions at PP5-6 with increased population or group sizes, 'place provisioning', longer and/or more intense site occupations, and decreased residential mobility. Several other traits, including silcrete frequency, do not exhibit an association with MIS. Backed pieces, once they appear in the PP5-6 record during MIS 4, persist through MIS 3. Changing paleoenvironments explain some, but not all temporal technological variability at PP5-6.Social Science and Humanities Research Council of Canada; NORAM; American-Scandinavian Foundation; Fundacao para a Ciencia e Tecnologia [SFRH/BPD/73598/2010]; IGERT [DGE 0801634]; Hyde Family Foundations; Institute of Human Origins; National Science Foundation [BCS-9912465, BCS-0130713, BCS-0524087, BCS-1138073]; John Templeton Foundation to the Institute of Human Origins at Arizona State Universit

The emerging structure of the Extended Evolutionary Synthesis: where does Evo-Devo fit in?

The Extended Evolutionary Synthesis (EES) debate is gaining ground in contemporary evolutionary biology. In parallel, a number of philosophical standpoints have emerged in an attempt to clarify what exactly is represented by the EES. For Massimo Pigliucci, we are in the wake of the newest instantiation of a persisting Kuhnian paradigm; in contrast, Telmo Pievani has contended that the transition to an EES could be best represented as a progressive reformation of a prior Lakatosian scientific research program, with the extension of its Neo-Darwinian core and the addition of a brand-new protective belt of assumptions and auxiliary hypotheses. Here, we argue that those philosophical vantage points are not the only ways to interpret what current proposals to ‘extend’ the Modern Synthesis-derived ‘standard evolutionary theory’ (SET) entail in terms of theoretical change in evolutionary biology. We specifically propose the image of the emergent EES as a vast network of models and interweaved representations that, instantiated in diverse practices, are connected and related in multiple ways. Under that assumption, the EES could be articulated around a paraconsistent network of evolutionary theories (including some elements of the SET), as well as models, practices and representation systems of contemporary evolutionary biology, with edges and nodes that change their position and centrality as a consequence of the co-construction and stabilization of facts and historical discussions revolving around the epistemic goals of this area of the life sciences. We then critically examine the purported structure of the EES—published by Laland and collaborators in 2015—in light of our own network-based proposal. Finally, we consider which epistemic units of Evo-Devo are present or still missing from the EES, in preparation for further analyses of the topic of explanatory integration in this conceptual framework

Globalisation and MA TESOL programs in the UK

This article reports the results of a mixed-methods approach to investigating the association between globalisation and MATESOL in UK universities. Qualitative and quantitative data collected from academic staff through eight emails, four interviews and 41 questionnaires indicate that the globalised context of higher education have affected these programmes in a number of ways including an increasing interest in recruiting more international students and a growing awareness about the need for curriculum and content modifications. The analysis of the data suggests that although change has been an inherent characteristic of these MAs over the past decade, it has been implemented gradually and conservatively, often relying on a dialectic relationship between academic staff and universities’ policies. The results imply that factors other than globalisation have also been at work. Many of the participants contend that globalisation has not lowered the quality of these MAs or standards of good practice