Reversible self-assembly of patchy particles into monodisperse icosahedral clusters

We systematically study the design of simple patchy sphere models that reversibly self-assemble into monodisperse icosahedral clusters. We find that the optimal patch width is a compromise between structural specificity (the patches must be narrow enough to energetically select the desired clusters) and kinetic accessibility (they must be sufficiently wide to avoid kinetic traps). Similarly, for good yields the temperature must be low enough for the clusters to be thermodynamically stable, but the clusters must also have enough thermal energy to allow incorrectly formed bonds to be broken. Ordered clusters can form through a number of different dynamic pathways, including direct nucleation and indirect pathways involving large disordered intermediates. The latter pathway is related to a reentrant liquid-to-gas transition that occurs for intermediate patch widths upon lowering the temperature. We also find that the assembly process is robust to inaccurate patch placement up to a certain threshold, and that it is possible to replace the five discrete patches with a single ring patch with no significant loss in yield.Comment: 12 pages, 12 figure

Two New Species and Temporal Changes in the Prevalence of Eimerians in a Free-Living Population of Townsend\u27s Ground Squirrels (\u3ci\u3eSpermophilus townsendii\u3c/i\u3e) in Idaho

More than 1,180 fecal samples were collected from 253 juvenile and 384 adult Townsend\u27s ground squirrels (Spermophilus townsendii) at the Snae Snake River Birds of Prey Area near Boise, Idaho, from February to June 1992. Oocysts of 7 eimerians were observed. Five are new host records (Eimeria beecheyi, Eimeria bilamellata, Eimeria callospermophili, Eimeria lateralis, and Eimeria morainensis), 2 species are described here as new, and new structural information on E. morainensis is added. Sporulated oocysts of Eimeria adaensis n. sp. are ovoidal, 19.6 x 22.7 (16-22 x 18-26) μm with sporocysts ellipsoidal 7.2 x 11.9 (6-10 x 9-15) μm. No micropyle or oocyst residuum, but polar bodies, Stieda bodies, and sporocyst residua are present. Sporulated oocysts of Eimeria pseudospermophili n. sp. are ovoidal, 24.7 x 28.5 (21-27 x 25-32) μm with sporocysts ellipsoidal 8.8 x 14.2 (8-10 x 12-17) μm. Micropyle and oocyst residuum are absent, but polar bodies and Stieda bodies are present. Sporulated oocysts of E. morainensis are more variable in size and shape than originally described and contain 2 distinctly different residua not previously described. Temporal changes in the prevalence of eimerians of all 7 species combined in adult squirrels showed significant decline (r2 = 0.79, P \u3c 0.001). We hypothesize that this decline was due to drought during the period of squirrel activity. No significant temporal change in the prevalence of eimerians in juvenile squirrels was observed. The prevalence of E. callospermophili, E. adaensis, and all eimerians combined in adults was significantly greater than in juveniles. There was no significant difference in eimerian prevalence between male and female squirrels (P \u3c 0.05)

The role of oxygen ions in the formation of a bifurcated current sheet in the magnetotail

Cluster observations in the near-Earth magnetotail have shown that sometimes the current sheet is bifurcated, i.e. it is divided in two layers. The influence of magnetic turbulence on ion motion in this region is investigated by numerical simulation, taking into account the presence of both protons and oxygen ions. The magnetotail current sheet is modeled as a magnetic field reversal with a normal magnetic field component $B_n$, plus a three-dimensional spectrum of magnetic fluctuations $\delta {\bf B}$, which represents the observed magnetic turbulence. The dawn-dusk electric field E$_y$ is also included. A test particle simulation is performed using different values of $\delta {\bf B}$, E$_y$ and injecting two different species of particles, O$^+$ ions and protons. O$^+$ ions can support the formation of a double current layer both in the absence and for large values of magnetic fluctuations ($\delta B/B_0 = 0.0$ and $\delta B/B_0 \geq 0.4$, where B$_0$ is the constant magnetic field in the magnetospheric lobes).Comment: 8 pages, 8 figures. J. Geophys. Res., in pres

‘I actually know that things will get better’:The many pathways to resilience of LGBTQIA+ youth in out-of-home care

Research on the lives of lesbian, gay, bisexual, transgender, queer, intersex, asexual and other forms of sexual identities and orientations (LGBTQIA+) youth in care has mainly examined their experiences from a risk-based approach, while few studies have explored their resilience experiences. Using in-depth interviews, the present study aims to illuminate the resilience experiences of 13 LGBTQIA+ young people in out-of-home care in the Netherlands. Four themes emerged from their narratives: relationships that support and empower; construction of a positive identity around their sexual orientation and gender identity and expression (SOGIE); community involvement and self-relying strategies. Our findings support the view of resilience as a complex process that shows at an individual, interpersonal and social level

Warped diffusive radio halo around the quiescent spiral edge-on galaxy NGC 4565

Context. Cosmic rays play a pivotal role in launching galactic winds, particularly in quiescently star-forming galaxies where the hot gas alone is not sufficient to drive a wind. Except for the Milky Way, not much is known about the transport of cosmic rays in galaxies. Aims. In this Letter, we present low-frequency observations of the nearby edge-on spiral galaxy NGC 4565 using the LOw-Frequency ARray (LOFAR). With our deep 144 MHz observations, we obtain a clean estimate of the emission originating from old cosmic-ray electrons (CRe), which is almost free from contamination by thermal emission. Methods. We measured vertical profiles of the non-thermal radio continuum emission that we fitted with Gaussian and exponential functions. The different profile shapes correspond to 1D cosmic-ray transport models of pure diffusion and advection, respectively. Results. We detect a warp in the radio continuum that is reminiscent of the previously known H 

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive

Controlling crystallization and its absence: Proteins, colloids and patchy models

The ability to control the crystallization behaviour (including its absence) of particles, be they biomolecules such as globular proteins, inorganic colloids, nanoparticles, or metal atoms in an alloy, is of both fundamental and technological importance. Much can be learnt from the exquisite control that biological systems exert over the behaviour of proteins, where protein crystallization and aggregation are generally suppressed, but where in particular instances complex crystalline assemblies can be formed that have a functional purpose. We also explore the insights that can be obtained from computational modelling, focussing on the subtle interplay between the interparticle interactions, the preferred local order and the resulting crystallization kinetics. In particular, we highlight the role played by ``frustration'', where there is an incompatibility between the preferred local order and the global crystalline order, using examples from atomic glass formers and model anisotropic particles.Comment: 11 pages, 7 figure

Can A Quantum Field Theory Ontology Help Resolve the Problem of Consciousness?

The hard problem of consciousness arises in most incarnations of present day physicalism. Why should certain physical processes necessarily be accompanied by experience? One possible response is that physicalism itself should be modified in order to accommodate experience: But, modified how? In the present work, we investigate whether an ontology derived from quantum field theory can help resolve the hard problem. We begin with the assumption that experience cannot exist without being accompanied by a subject of experience (SoE). While people well versed in Indian philosophy will not find that statement problematic, it is still controversial in the analytic tradition. Luckily for us, Strawson has elaborately defended the notion of a thin subject—an SoE which exhibits a phenomenal unity with different types of content (sensations, thoughts etc.) occurring during its temporal existence. Next, following Stoljar, we invoke our ignorance of the true physical as the reason for the explanatory gap between present day physical processes (events, properties) and experience. We are therefore permitted to conceive of thin subjects as related to the physical via a new, yet to be elaborated relation. While this is difficult to conceive under most varieties of classical physics, we argue that this may not be the case under certain quantum field theory ontologies. We suggest that the relation binding an SoE to the physical is akin to the relation between a particle and (quantum) field. In quantum field theory, a particle is conceived as a coherent excitation of a field. Under the right set of circumstances, a particle coalesces out of a field and dissipates. We suggest that an SoE can be conceived as akin to a particle—a SelfOn—which coalesces out of physical fields, persists for a brief period of time and then dissipates in a manner similar to the phenomenology of a thin subject. Experiences are physical properties of selfons with the constraint (specified by a similarity metric) that selfons belonging to the same natural kind will have similar experiences. While it is odd at first glance to conceive of subjects of experience as akin to particles, the spatial and temporal unity exhibited by particles as opposed to fields and the expectation that selfons are new kinds of particles, paves the way for cementing this notion. Next, we detail the various no-go theorems in most versions of quantum field theory and discuss their impact on the existence of selfons. Finally, we argue that the time is ripe for a rejuvenated Indian philosophy to begin tackling the three-way relationship between SoEs (which may become equivalent to jivas in certain Indian frameworks), phenomenal content and the physical world. With analytic philosophy still struggling to come to terms with the complex worlds of quantum field theory and with the relative inexperience of the western world in arguing the jiva-world relation, there is a clear and present opportunity for Indian philosophy to make a worldcentric contribution to the hard problem of experience

Radio observations of the merging galaxy cluster system Abell 3391-Abell 3395

The pre-merging system of galaxy clusters Abell 3391-Abell 3395 located at a mean redshift of 0.053 has been observed at 1 GHz in an ASKAP/EMU Early Science observation as well as in X-rays with eROSITA. The projected separation of the X-ray peaks of the two clusters is $\sim$50$'$ or $\sim$ 3.1 Mpc. Here we present an inventory of interesting radio sources in this field around this cluster merger. While the eROSITA observations provide clear indications of a bridge of thermal gas between the clusters, neither ASKAP nor MWA observations show any diffuse radio emission coinciding with the X-ray bridge. We derive an upper limit on the radio emissivity in the bridge region of $\langle J \rangle_{1\,{\rm GHz}}< 1.2 \times 10^{-44} {\rm W}\, {\rm Hz}^{-1} {\rm m}^{-3}$. A non-detection of diffuse radio emission in the X-ray bridge between these two clusters has implications for particle-acceleration mechanisms in cosmological large-scale structure. We also report extended or otherwise noteworthy radio sources in the 30 deg$^2$ field around Abell 3391-Abell 3395. We identified 20 Giant Radio Galaxies, plus 7 candidates, with linear projected sizes greater than 1 Mpc. The sky density of field radio galaxies with largest linear sizes of $>0.7$ Mpc is $\approx 1.7$ deg$^{-2}$, three times higher than previously reported. We find no evidence for a cosmological evolution of the population of Giant Radio Galaxies. Moreover, we find seven candidates for cluster radio relics and radio halos.Comment: Astronomy & Astrophysics, in pres

Comparing Rawlsian Justice and the Capabilities Approach to Justice from a Spiritually Sensitive Social Work Perspective

‘This is an electronic version of an article published in the March, 2012 special issue of the Journal of Religion and Spirituality and Social Work entitled Spirituality and Social Justice volume 31, (1-2), pp. 9-31. It is available online at http://dx.doi.org/10.1080/15426432.2012.647874This article examines two social justice theories, Rawlsian Justice and the Capabilities Approach of Sen and Nussbaum, in relation to congruence with four principles of spiritually sensitive social work. We find that although Rawlsian justice has valuable insights, it has some gaps for promoting spiritually sensitive practice. In contrast, the Capabilities Approach bears more promise for promoting spiritually sensitive social work as it meets all these ethical principles. Scholars could build on its insights to articulate a vision for spiritually sensitive social justice that can guide our profession’s approaches to macro practice and social polic